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1. 发明授权

US08504149B2 System and method to deliver therapy in presence of another therapy 有权
公开(公告)号：US08504149B2
公开(公告)日：2013-08-06
申请号：US13397115
申请日：2012-02-15
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/05
CPC分类号： A61N1/37 , A61N1/36114 , A61N1/36125 , A61N1/362 , A61N1/36514 , A61N1/36564 , A61N1/36592 , A61N1/3987
摘要： Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.

2. 发明授权

US08593123B2 Switching voltage regulators with hysteretic control for enhanced mode-transition speed and stability 有权
标题翻译：开关稳压器具有迟滞控制，提高了模式转换速度和稳定性
公开(公告)号：US08593123B2
公开(公告)日：2013-11-26
申请号：US12979167
申请日：2010-12-27
申请人： Jia Chen , Bin Shao
发明人： Jia Chen , Bin Shao
IPC分类号： G05F1/40
CPC分类号： H02M3/1563
摘要： Switching voltage regulator embodiments are provided with hysteretic control to thereby switch between pulse-width modulation and pulse-frequency modulation operational modes. The switching is in response to different levels of an error voltage Verr in the feedback loop of voltage regulators. The hysteretic control is configured to provide a dc hysteretic response to changes in the error voltage Verr and also an ac hysteretic response to these changes. These two responses can be independently set to thereby enhance operational speed of the voltage regulators and also enhance immunity to transient noise signals that are generated by the mode switching. The voltage regulator embodiments facilitate instant return from the pulse-frequency modulation operational mode to the pulse-width modulation operational mode so that the stability of the feedback control of the regulator is enhanced. This feature is especially useful when the feedback loop is configured to include current-mode control as it minimizes the time duration in which the feedback loop operates in a voltage-mode control. The instant return insures that the feedback loop is immediately returned to the greater stability of the current-mode control.
摘要翻译：开关稳压器实施例具有迟滞控制，从而在脉冲宽度调制和脉冲 - 频率调制操作模式之间切换。开关响应于电压调节器的反馈回路中的不同电平的误差电压Verr。迟滞控制被配置为对误差电压Verr的变化提供直流迟滞响应，并且还对对这些变化的迟滞响应。可以独立地设置这两个响应，从而提高电压调节器的操作速度，并且还增强对由模式切换产生的瞬态噪声信号的抗扰性。电压调节器实施例便于从脉冲 - 频率调制操作模式到脉宽调制操作模式的即时返回，从而增强了调节器的反馈控制的稳定性。当反馈回路配置为包括电流模式控制时，该功能特别有用，因为它使反馈回路在电压模式控制中工作的持续时间最小化。即时返回确保反馈回路立即返回到电流模式控制的更大稳定性。

3. 发明授权

US08131363B2 Closed-loop control of intermittent excitatory cardiac stimulation for therapeutic effect 有权
标题翻译：间歇兴奋性心脏刺激闭环控制治疗效果
公开(公告)号：US08131363B2
公开(公告)日：2012-03-06
申请号：US11860957
申请日：2007-09-25
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Christopher Hartemink
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.
摘要翻译：用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

4. 发明授权

US09855431B2 Systems and methods for monitoring for nerve damage 有权
公开(公告)号：US09855431B2
公开(公告)日：2018-01-02
申请号：US13771964
申请日：2013-02-20
申请人： Cardiac Pacemakers, Inc.
发明人： David J. Ternes , Jason J. Hamann , Stephen Ruble
IPC分类号： A61N1/00 , A61N1/372 , A61N1/36 , A61B5/11 , A61B5/00 , A61B5/0488 , A61B5/053
CPC分类号： A61N1/372 , A61B5/0488 , A61B5/053 , A61B5/1107 , A61B5/4029 , A61B5/686 , A61B2562/0219 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/36142 , A61N1/365 , A61N1/36542
摘要： Various device embodiments may comprise an implantable medical device for implantation in a body and for applying neural stimulation to a neural target in the body. The device may comprise a neural stimulation electrode configured for use in stimulating the neural target, a neural stimulator configured to deliver neural stimulation through the electrode to the neural target, a sensor configured to sense a physiological response to stimulation of motor fibers at the neural target, and a controller operatively connected to the neural stimulator to control the neural stimulation and operatively connected to the sensor to receive a signal indicative of the physiological response. The controller may be configured to detect a potential neural injury and perform an action in response to the detected potential neural injury.

5. 发明授权

US07939091B2 Biorational repellents obtained from terpenoids for use against arthropods 失效
标题翻译：从萜类化合物获得的用于节肢动物的生物驱避剂
公开(公告)号：US07939091B2
公开(公告)日：2011-05-10
申请号：US11277122
申请日：2006-03-21
申请人： Joel R. Coats , Gretchen Elizabeth Schultz , Junwei Zhu
发明人： Joel R. Coats , Gretchen Elizabeth Schultz , Junwei Zhu
IPC分类号： A01N25/32 , A01N31/06
CPC分类号： A01N43/16 , A01N31/04 , A01N65/00 , A01N65/08 , A01N65/22 , A01N65/36 , Y02A50/322 , Y02A50/326 , Y02A50/328 , Y02A50/337 , Y02A50/347 , Y10S424/10 , Y10S514/919 , A01N2300/00 , A01N49/00
摘要： The compositions comprise an effective repellent amount of one or more monoterpenoids, one or more sesquiterpenoids or a blend of one or more monoterpenoids and one or more sesquiterpenoids in combination with a carrier, wherein the compositions are formulated to repel a target pest from a target area. In one embodiment, the one or more monoterpenoids, and/or one or more sesquiterpenoids are from a biorational source, such as a plant volatile. In one embodiment, the one or more sesquiterpenoids are oxygen-containing sesquiterpenoids. In a particular embodiment, the plant volatile is a monoterpenoid, such as “nepetalactone” (or the individual nepetalactone isomers) derived from catnip (Nepeta cataria). In another embodiment, the plant volatile is additionally or alternatively a sesquiterpenoid derived from the fruit of the Osage orange tree (Maclura pomifera), Siam wood or the Amyris plant. Such compositions have repellency, including long term repellency, against arthropods.
摘要翻译：组合物包含一种或多种单萜类化合物的有效排斥量，一种或多种倍半萜类化合物或一种或多种单萜类化合物与一种或多种倍半萜类化合物与载体组合的共混物，其中所述组合物被配制成从目标区域排斥目标害虫。在一个实施方案中，一种或多种单萜类化合物和/或一种或多种倍半萜类化合物来自生物来源，例如植物挥发物。在一个实施方案中，一种或多种倍半萜类化合物是含氧倍半萜类化合物。在一个具体的实施方案中，挥发性植物是单萜，例如来自猫ip（Nepeta cataria）的“荆芥内酯”（或各种荆芥内酯异构体）。在另一个实施方案中，植物挥发物是额外地或替代地衍生自Osage橙树（Maclura pomifera），暹罗木或Amyris植物的果实的倍半萜。这种组合物对节肢动物具有排斥性，包括长期排斥性。

6. 发明授权

US12095259B2 Protection circuit, battery pack, and protection circuit operating method 有权
公开(公告)号：US12095259B2
公开(公告)日：2024-09-17
申请号：US17755373
申请日：2020-11-09
申请人： DEXERIALS CORPORATION
发明人： Yuji Furuuchi , Chisato Komori
IPC分类号： H02H7/18 , H01H37/76 , H02H5/04 , H02J7/00
CPC分类号： H02H7/18 , H01H37/76 , H02H5/047 , H02J7/00304 , H02J7/0031
摘要： Provided is a protection circuit capable of reliably preventing an overcurrent or a sneak current after cutoff to improve safety, implementing cost reduction with a device configuration simpler than conventional device configurations, and further reducing a failure rate of a device. In a protection circuit, after one of two fuse elements provided in each of a plurality of protection elements is blown due to an overcurrent flowing along a current-carrying path, a heater provided in at least one of the plurality of protection elements generates heat due to a sneak current flowing via the plurality of protection elements on the current-carrying path which is remained and the current-carrying path which is remained is cut off due to destruction of the heater.

7. 发明授权

US08285389B2 Automatic neural stimulation modulation based on motion and physiological activity 有权
标题翻译：基于运动和生理活动的自动神经刺激调制
公开(公告)号：US08285389B2
公开(公告)日：2012-10-09
申请号：US12840981
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/36 , A61B5/0205
CPC分类号： A61N1/36139 , A61N1/3601 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36135 , A61N1/3627 , A61N1/36535 , A61N1/36542 , A61N1/3655 , A61N1/36564 , A61N1/36571 , A61N1/37288
摘要： An embodiment of a method uses an implantable device to deliver a heart failure therapy to a patient. The device is used to sense unintended motion of the patient caused by the neural stimulation and identify a sensed motion level for the sensed unintended motion, and to sense physiological activity of the patient, different than the sensed motion, and identify a sensed physiological activity level. Delivering the heart failure therapy includes delivering neural stimulation through an electrode to a neural target in an autonomic nervous system of the patient using the implantable device. The sensed motion level, the sensed physiological activity level, and the programmed mapping are used to determine the neural stimulation intensity level of the neural stimulation to be delivered for the motion level.
摘要翻译：方法的一个实施例使用可植入装置将心力衰竭治疗递送给患者。该装置用于感测由神经刺激引起的患者的非预期运动，并且识别感测到的非预期运动的感测运动水平，并且感测不同于所感测运动的患者的生理活动，并且识别感测到的生理活动水平。提供心力衰竭治疗包括通过电极将神经刺激传递到使用可植入装置的患者的自主神经系统中的神经靶标。感测的运动水平，感测到的生理活动水平和编程的映射用于确定要为运动水平递送的神经刺激的神经刺激强度水平。

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