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1. 发明申请

WO2021229093A1 A METHOD FOR IMPROVING THE NUTRITIONAL VALUE OF ANIMAL FEED 审中-公开
公开(公告)号：WO2021229093A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062927
申请日：2021-05-17
申请人： DSM IP ASSETS B.V.
发明人： COWIESON, Aaron
IPC分类号： A23K50/75 , A23K50/10 , A23K50/30 , A23K20/189 , A23K20/26
摘要： Offering broiler chickens a low protein diet supplemented with an array of synthetic amino acids is not fully effective in promoting maximal growth and both bodyweight and feed conversion ratio (FCR). However the present invention shows, growth rate and FCR can be promoted by the addition of available Phosphorus to the low protein diet and that this strategy is effective in restoring performance losses associated with the diet with low protein concentration. Therefore, the present invention relates to a method for improving the nutritional value of animal feed comprising a marginal protein content. More specifically, the invention relates to a method for improving weight gain and feed conversion ratio, which method comprises feeding the animal with a low protein diet and an extra supplementation of phosphorous.

2. 发明申请

WO2021224295A1 A PROCESS FOR PRODUCING D-BIOTIN INTERMEDIATES 审中-公开
公开(公告)号：WO2021224295A1
公开(公告)日：2021-11-11
申请号：PCT/EP2021/061781
申请日：2021-05-05
申请人： DSM IP ASSETS B.V.
发明人： BONRATH, Werner , HAERTER, Ralph , KODIMUTHALI, Arumugam , KOTALA, Mani, Bushan , NITSCHKE, Claudia
IPC分类号： C07D495/04
摘要： The present invention provides a process for producing a biotin intermediate compound of formula (I), or a geometrical isomer thereof or a geometrical isomeric mixture thereof in the presence of a catalyst, wherein R1 and R1' are independently H, lower alkyl, aryl or acyl group, optionally substituted by one or more substituents; and R2 is lower alkyl optionally substituted by lower alkoxyl or carboxyl group. According to the present invention, the process surprisingly reduces the reaction pressure while maintaining high yield and selectivity in industrial scale, and thus saves investment on facility and increases safety in industry.

3. 发明申请

WO2021130055A1 FISH FEED PELLETS LOADED WITH A MICROBIAL OIL 审中-公开
公开(公告)号：WO2021130055A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/086142
申请日：2020-12-15
申请人： DSM IP ASSETS B.V. , EVONIK OPERATIONS GMBH
发明人： CLASADONTE, Laure , HAGEMANN, Nicholas , PALAZOGLU KURK, Pelin
IPC分类号： A23K20/158 , A23K40/25 , A23K40/30 , A23K50/80
摘要： The present invention relates to a quick-sinking fish feed in the form of pellets. It has been found that pellets, the diameter of which is

4. 发明申请

WO2021023756A1 A METHOD FOR IMPROVING THE NUTRITIONAL VALUE OF ANIMAL FEED 审中-公开
公开(公告)号：WO2021023756A1
公开(公告)日：2021-02-11
申请号：PCT/EP2020/071962
申请日：2020-08-05
申请人： DSM IP ASSETS B.V.
发明人： COWIESON, Aaron , SORBARA, Jose-Otavio
IPC分类号： A23K20/189 , A23K50/75 , C12N9/16 , C12N9/52
摘要： The invention relates to the use of at least one bacterial phytase in combination with one or more protease(s) in animal feed for improving nutrient and E ileal digestibility of animal feed, in particular an improved digestibility of Threonine, Proline and Cysteine, the method comprising the step of applying to the animal a feed with an efficient amount of one or more proteolytic enzyme in combination with at least one phytase.

5. 发明申请

WO2019122031A1 OIL COMPRISING AT LEAST ONE POLYUNSATURATED FATTY ACID HAVING AT LEAST 20 CARBON ATOMS (LC-PUFA) 审中-公开
公开(公告)号：WO2019122031A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086009
申请日：2018-12-19
申请人： DSM IP ASSETS B.V. , EVONIK DEGUSSA GMBH
发明人： HEINING, Martin , TARWADE, Vinod , WALLIMANN, Viktor, Stefan
IPC分类号： C11B1/10 , C12P7/64 , C12N1/00 , C11B3/00
CPC分类号： C12P7/6427 , A23D9/02 , A23K20/158 , A23K50/80 , C11B1/04 , C11B1/08 , C12N1/005
摘要： The present invention relates to an oil comprising at least one polyunsaturated fatty acid having at least 20 carbon atoms (LC-PUFA). It is found that LC-PUFA-containing oil are susceptible to gelling by formation of microscopic crystals during storage ultimately resulting in unfavorable quality and handling properties. This problem has been particularly observed with a microbial oil comprising at least about 25% by weight LC-PUFA and a moisture content of 0,2 to 5% by weight. Surprisingly, it has been found that a LC-PUFA-containing oil as described above is effectively stable and does not show gelling properties under conventional storage conditions, if the oil composition as such contains less than about 8% preferably less than about 5% by weight of free fatty acid in the residual moisture of the oil. Therefore, the present invention is directed to an oil comprising at least about 25% by weight LC-PUFA and a moisture content comprising less than about 8% preferably less than about 5% by weight of free fatty acid.

6. 发明申请

WO2017102592A1 EGG QUALITY INDEX INSPECTION DEVICE 审中-公开
标题翻译： EGG质量指标检测装置
公开(公告)号：WO2017102592A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/080474
申请日：2016-12-09
申请人： DSM IP ASSETS B.V.
发明人： CISNEROS, Fernando
IPC分类号： G01N33/08 , G01B5/02
CPC分类号： G01N33/08 , G01B3/20 , G01B5/061
摘要： The present invention relates to an egg quality inspection device for use in determining egg yolk index. The inspection device (1) comprises two main parts, a stationary part as the first part (2) and a moving part (slider) as the second measuring part (3). The stationary part (2) comprises a punched hole (4) and an opening or cutout (5) at the smaller edge of part (2). The stationary part 2 further includes two markings (6 and 7) for measurement and scaling purposes, wherein marking( 6) is placed along one edge of the square-cut hole (5) and the marking (represented by 7a and 7b) on both sides of the cutout (5) and wherein each of the markings have a metric measuring rule. The slider (3), which is the moving part of the device, is mounted on the stationary part (2) and movable along the longitudinal axis of part (2).
摘要翻译：本发明涉及用于确定蛋黄指数的蛋品质量检查装置。检查装置（1）包括两个主要部分，即作为第一部分（2）的固定部分和作为第二测量部分（3）的移动部分（滑动件）。固定部件（2）包括冲孔（4）和在部件（2）的较小边缘处的开口或切口（5）。静止部分2还包括用于测量和缩放目的的两个标记（6和7），其中标记（6）沿方形孔（5）的一个边缘和标记（由7a和7b表示）放置在两个（5）的侧面，并且其中每个标记具有公制测量规则。作为该装置的移动部件的滑块（3）安装在固定部件（2）上并可沿部件（2）的纵向轴线移动。

7. 发明申请

WO2014009862A2 COSMETIC COMPOSITION COMPRISING BENZYLSULFONYL-D-SER-HOMOPHE-(4-AMIDINO-BENZYLAMIDE) AND A POLYALCOHOL 审中-公开
标题翻译：包含苯甲酰基-D-顺式 - 顺式 - （4-氨基-N-苄基酰胺）和多元醇的化妆品组合物
公开(公告)号：WO2014009862A2
公开(公告)日：2014-01-16
申请号：PCT/IB2013/055564
申请日：2013-07-08
申请人： DSM IP ASSETS B.V.
发明人： CAMPICHE, Remo , VOEGELI, Rainer , WIKSTROEM, Peter
CPC分类号： A61K8/345 , A61K8/64 , A61K2800/5922 , A61K2800/782 , A61Q5/006 , A61Q19/00 , A61Q19/007
摘要： The present invention relates to the field of active compositions for use in cosmetic products for humans. More particularly, the present invention relates to a cosmetic composition comprising benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, and a polyalcohol. Moreover, it relates to the use of said composition for maintaining, restoring, and/or improving the skin hydration, and/or the transepidermal water loss level in human skin. The present invention further relates to the use of benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, in combination with a polyalcohol for the co-inhibition of both plasmin and urokinase activity in the skin and/or the scalp.
摘要翻译：本发明涉及用于人类化妆品的活性组合物领域。更具体地，本发明涉及包含苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐和多元醇的化妆品组合物。此外，它涉及所述组合物在人皮肤中维持，恢复和/或改善皮肤水合和/或经表皮水分损失水平的用途。本发明还涉及苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐与多元醇的组合在皮肤中共同抑制纤溶酶和尿激酶活性的用途，以及 /或头皮。

8. 发明申请

WO2014006532A1 CAPSULES CONTAINING THYMOQUINONE 审中-公开
标题翻译：包含三羟甲基纤维素的胶囊
公开(公告)号：WO2014006532A1
公开(公告)日：2014-01-09
申请号：PCT/IB2013/055167
申请日：2013-06-24
申请人： DSM IP ASSETS B.V.
发明人： ETHEVE, Stephane , PRUDENCE, Kevin , SCHWEIKERT, Loni , SZEPES, Aniko
IPC分类号： A61K47/14 , A61K9/48 , A61K36/00
CPC分类号： A61K31/122 , A23L33/105 , A23P10/30 , A61K9/4816 , A61K9/4825 , A61K9/4858 , A61K31/05 , A61K36/00 , A61K36/53 , A61K47/14
摘要： This invention relates to stable capsule formulations for pharmaceutical, nutraceuticals or food supplements which contain thymoquinone (THQ) as an active ingredient, and which can be stored at room temperature without significant loss of THQ during the shelf life of the capsules. The preferred capsules have a hydroxypropylmethylcellulose (HPMC) shell and may contain carvacrol as an additional active ingredient, either in synthetic form, or as part of a plant extract. Optionally, the capsules may contain a viscosity agent.
摘要翻译：本发明涉及含有胸腺醌（THQ）作为活性成分的药物，营养保健品或食品添加剂的稳定的胶囊制剂，并且可以在室温下保存而不会在胶囊保质期内显着损失THQ。优选的胶囊具有羟丙基甲基纤维素（HPMC）壳，并且可以以合成形式或作为植物提取物的一部分含有作为附加活性成分的香芹酚。任选地，胶囊可以含有粘度剂。

9. 发明申请

WO2013076258A2 P450 BM3 MUTANTS AND THEIR USE FOR REGIO- AND STEREOSELECTIVE HYDROXYLATION OF ALPHA-AND BETA-IONONE 审中-公开
标题翻译： P450 BM3突变体及其用于ALPHA和BETA-IONONE的注射和立体选择性羟化的用途
公开(公告)号：WO2013076258A2
公开(公告)日：2013-05-30
申请号：PCT/EP2012/073490
申请日：2012-11-23
申请人： DSM IP ASSETS B.V.
发明人： COMMANDEUR, Jan , VENKATARAMAN H., M. , VERMEULEN, Nico
IPC分类号： C12N9/02
CPC分类号： C12N9/0042 , C12N9/0071 , C12Y106/02004 , C12Y114/14001
摘要： Selective hydroxylation is a crucial reaction in the synthesis of fine chemicals like hydroxylated isoprenoids. The present invention discloses cytochrome P450 BM3 mutants able to perform regio- and stereoselective hydroxylation of α- and β-ionone. Therefore, the present invention relates to isolated polypeptides having oxidative activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as a process for the microbiological hydroxylation of isoprenoids, in particular ionones.
摘要翻译：选择性羟基化是合成精细化学品如羟基化类异戊二烯的关键反应。本发明公开了能够进行α-和β-紫罗兰酮的区域和立体选择性羟基化的细胞色素P450 BM3突变体。因此，本发明涉及具有氧化活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及类异戊二烯，特别是紫罗兰酮的微生物羟基化的方法。

10. 发明申请

WO2013000985A2 MODULAR MULTI-STORY PRODUCTION PLANT AND METHODS FOR CONSTRUCTING SAME 审中-公开
标题翻译：多模多用途生产设备及其构造方法
公开(公告)号：WO2013000985A2
公开(公告)日：2013-01-03
申请号：PCT/EP2012/062527
申请日：2012-06-28
申请人： DSM IP Assets B.V. , DRIESS, Markus
发明人： DRIESS, Markus
CPC分类号： E04H5/00 , A23N17/00 , B66B9/00 , E04F11/02 , E04H1/005 , E04H5/02 , E04H5/08 , E04H14/00
摘要： A multistory modular production plant includes a vertical stack of production modules for supporting production equipment, and a vertical stack of operator access modules adjacently connected to the vertically stacked production modules to allow operator access to the production modules. The adjacently connected vertical stacks of production modules and operator access modules thereby establish multiple stories of the modular production plant. Stairs and/or an elevator may be provided in the vertical stack of operator access modules to allow an operator to ascent/descend between stories of the plant. In especially preferred embodiments, each production module and operator access module is in the form of a rectangular parallelepiped which is sized so as to be accommodated within a standard 20- foot shipping container. This configuration of modular units thus allows the plant to be more quickly shipped and constructed on site.
摘要翻译：多层模块化生产工厂包括用于支持生产设备的垂直堆叠生产模块，以及与垂直堆叠的生产模块相邻连接的操作员访问模块的垂直堆叠，以允许操作者访问生产模块。相邻连接的垂直堆叠的生产模块和操作员访问模块因此建立了模块化生产工厂的多个故事。楼梯和/或电梯可以设置在操作者访问模块的垂直堆叠中，以允许操作员在工厂的故事之间上升/下降。在特别优选的实施例中，每个生产模块和操作人员访问模块是长方体的形式，其尺寸被设计成容纳在标准的20英尺的运输容器内。因此，这种模块化设备的配置允许工厂在现场更快地运输和建造。

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