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1. 发明申请

WO2011084659A1 TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF 审中-公开
标题翻译：转基因非人类动物及其用途
公开(公告)号：WO2011084659A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060909
申请日：2010-12-17
申请人： SANOFI-AVENTIS , DRESSLER, Holly , ECONOMIDES, Kyriakos D. , PANG, Zhen , POLITES, Harry Gregory
发明人： DRESSLER, Holly , ECONOMIDES, Kyriakos D. , PANG, Zhen , POLITES, Harry Gregory
IPC分类号： C12N9/02 , A01K67/027 , C12N15/85 , C12Q1/66 , G01N33/50
CPC分类号： G01N33/74 , A01K67/0275 , A01K2217/052 , A01K2217/203 , A01K2227/105 , A01K2267/0393 , C12N9/0069 , C12N15/8509 , C12N2800/107 , C12N2830/002 , C12N2830/15 , C12N2830/40 , C12N2830/46 , C12N2830/50 , C12N2830/60 , C12N2830/85 , G01N2333/726
摘要： The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway modulation following ligand binding of GPCR receptors.
摘要翻译：本发明一般涉及转基因构建体，包含转基因构建体的转基因非人动物，制备方法和使用包含转基因构建体的转基因非人动物的方法。本发明的一个实施方案涉及使用含有生物发光转基因报告系统的转基因模型，在全部动物，组织切片或天然细胞中非侵入性地测定GPCR配体的活化方法，所述转基因模型对GPCR配体结合后的途径调节有反应受体。

2. 发明申请

WO2008086325A8 METHOD FOR DETERMINING THE STABILITY OF ORGANIC METHYLENEAMINES IN THE PRESENCE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE 审中-公开
公开(公告)号：WO2008086325A8
公开(公告)日：2008-07-17
申请号：PCT/US2008/050456
申请日：2008-01-08
申请人： SANOFI-AVENTIS , ADEDOYIN, Adedayo , ANGELASTRO, Michael, R. , BICK, Julie, Ann , CAIRNS, Jennifer , HUANG, Yongqing , LIANG, Guyan , LIM, Heng-Keang
发明人： ADEDOYIN, Adedayo , ANGELASTRO, Michael, R. , BICK, Julie, Ann , CAIRNS, Jennifer , HUANG, Yongqing , LIANG, Guyan , LIM, Heng-Keang
IPC分类号： C12Q1/26
摘要： The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.

3. 发明申请

WO2014043068A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2014043068A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/058896
申请日：2013-09-10
申请人： GENZYME CORPORATION
发明人： BOURQUE, Elyse , CABRERA-SALAZAR, Mario, A. , CELATKA, Cassandra , CHENG, Seng, H. , HIRTH, Bradford , GOOD, Andrew , JANCSICS, Katherine , MARSHALL, John , METZ, Markus , SCHEULE, Ronald, K. , SKERLJ, Renato , XIANG, Yibin , ZHAO, Zhong , LEONARD, John , NATOLI, Thomas , MAKINO, Elina , HUSSON, Herve , BESKROVNAYA, Oxana
IPC分类号： C07D453/02 , C07D471/08 , A61K31/439 , A61P25/00 , A61P35/00
CPC分类号： C07D453/02 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D471/08
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
摘要翻译：本发明涉及可用于单独或与酶替代疗法，囊性疾病和癌症治疗组合治疗代谢性疾病如溶酶体贮积病的葡萄糖神经酰胺合成酶（GCS）抑制剂。

4. 发明申请

WO2007149896A2 DNA FRAGMENTATION ASSAY 审中-公开
标题翻译： DNA分析测定
公开(公告)号：WO2007149896A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071619
申请日：2007-06-20
申请人： SANOFI-AVENTIS , GARYANTES, Tina , LI, Zhuyin , YAN, Yongping , YU, Justin Anthony , ZILBERSTEIN, Asher
发明人： GARYANTES, Tina , LI, Zhuyin , YAN, Yongping , YU, Justin Anthony , ZILBERSTEIN, Asher
CPC分类号： G01N33/582 , G01N33/5014 , G01N33/57426 , G01N2500/00
摘要： The present invention provides methods for the detection of agents that modify the formation of DNA fragmentation in cells. The disclosed methods are configured in an assay format amendable to high throughput screening applications.
摘要翻译：本发明提供了用于检测改变细胞中DNA断裂形成的试剂的方法。所公开的方法被配置成可修改为高通量筛选应用的测定形式。

5. 发明申请

WO2014150873A1 SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS 审中-公开
标题翻译：高级糖果终产品（AGE）前身的序列
公开(公告)号：WO2014150873A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/024436
申请日：2014-03-12
申请人： GENZYME CORPORATION
发明人： HOLMES-FARLEY, Stephen, Randall , DHAL, Pradeep , BESEV, Magnus , MILLER, Robert, J.
IPC分类号： A61K31/785 , A61P13/12 , A61P9/10 , A61P25/28 , A61P27/12
CPC分类号： C08F126/02 , A61K31/785
摘要： Sequestrants of AGE precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for the treatment of ailments such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.
摘要翻译： AGE前体的螯合剂包括被2,3或4个碳分开的胺。 AGE前体的螯合剂可用作药剂和药物组合物。 AGE前体的多价螯合剂在胃肠道的哺乳动物中特异性地结合AGE前体和膳食二羰基用于治疗疾病如糖尿病性肾病，慢性肾脏病，动脉粥样硬化，中风，白内障和阿尔茨海默病。

6. 发明申请

WO2014066471A1 ELUTION OF BIOMOLECULES FROM MULTI-MODAL RESINS USING MES AND MOPS AS MOBILE PHASE MODIFIERS 审中-公开
标题翻译：使用MES和MOPS作为移动相位改性剂的多模态树脂生物分子的提取
公开(公告)号：WO2014066471A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066319
申请日：2013-10-23
申请人： GENZYME CORPORATION
发明人： GODAWAT, Rahul , CUMMINGS, Daniel , WARIKOO, Veena
IPC分类号： B01D15/38 , C07K1/16
CPC分类号： C12N9/2465 , A61B50/00 , A61B50/30 , A61J1/16 , B01D15/3847 , B01D15/426 , C07K1/165 , C12Y302/01022
摘要： The present invention relates to methods for purifying or enriching a biomolecule using multimodal resins and an elution buffer containing a Good's buffer.
摘要翻译：本发明涉及使用多峰树脂纯化或富集生物分子的方法和含有Good's缓冲液的洗脱缓冲液。

7. 发明申请

WO2013095905A1 THYROID STIMULATING HORMONE COMPOSITIONS 审中-公开
标题翻译：甲状腺刺激激素组合物
公开(公告)号：WO2013095905A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/067705
申请日：2012-12-04
申请人： GENZYME CORPORATION , PAN, Clark , PARK, Sunghae , QIU, Huawei
发明人： PAN, Clark , PARK, Sunghae , QIU, Huawei
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/48215 , A61K38/00 , A61K38/24 , A61K47/60
摘要： Described herein are compositions of Thyroid Stimulating Hormone (TSH), wherein at least one polyalkylene glycol polymer is attached to a carbohydrate site of the TSH. Also described are compositions of mutated Thyroid Stimulating Hormone (TSH) and at least one polyalkylene glycol polymer, wherein the mutated TSH comprises a TSH in which one or more amino acid residues has been substituted with cysteine residue, and the polyalkylene glycol polymer is attached to the mutated TSH at the site of the substituted cysteine residue. Pharmaceutical compositions comprising these TSH compositions and method of treating a thyroid condition in a patient in need thereof, by administering to the patient an effective amount of the pharmaceutical compositions are also described.
摘要翻译：本文描述的是甲状腺刺激激素（TSH）的组合物，其中至少一种聚亚烷基二醇聚合物连接到TSH的碳水化合物位点。还描述了突变的甲状腺刺激激素（TSH）和至少一种聚亚烷基二醇聚合物的组合物，其中突变的TSH包含其中一个或多个氨基酸残基被半胱氨酸残基取代的TSH，并且聚亚烷基二醇聚合物附着于在取代的半胱氨酸残基的位点处的突变的TSH。还描述了包含这些TSH组合物的药物组合物和在有需要的患者中治疗甲状腺疾病的方法，通过向患者施用有效量的药物组合物。

8. 发明申请

WO2008014296A2 COMPOSITION AND METHOD FOR TREATMENT OF TUMORS 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO2008014296A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074277
申请日：2007-07-25
申请人： SANOFI-AVENTIS , AUGUST, Paul , HUANG, Waan Jeng , NATESAN, Sridaran , LIEBERMAN, Soyan
发明人： AUGUST, Paul , HUANG, Waan Jeng , NATESAN, Sridaran , LIEBERMAN, Soyan
IPC分类号： C12N15/113
CPC分类号： A61K31/7105 , A61K9/0019 , A61K48/00 , C12N9/0055 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2799/027 , C12Y110/02002
摘要： The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.
摘要翻译：本发明涉及一种可用于治疗肿瘤的组合物，该组合物的制备方法和使用该组合物的方法。本发明还涉及用于测定线粒体呼吸复合物III的核心蛋白1和/或其它蛋白质的活性抑制剂的方法。

9. 发明申请

WO2014151291A1 METHOD OF PREPARING GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：制备葡萄糖酸合成酶抑制剂的方法
公开(公告)号：WO2014151291A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/025384
申请日：2014-03-13
申请人： GENZYME CORPORATION
发明人： SIEGEL, Craig , GIMI, Rayomand , REARDON, Michael , ZHAO, Jin
IPC分类号： C07D453/02 , C07D417/06 , C07D277/30
CPC分类号： C07D453/02 , C07D277/30 , C07D417/06 , C07D417/12
摘要： The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
摘要翻译：本发明涉及一种制备用于治疗代谢疾病如溶酶体贮积病的葡萄糖神经酰胺合成酶（GCS）抑制剂的方法，其单独或与酶替代疗法组合，以及用于治疗癌症。

10. 发明申请

WO2012125775A1 USES OF A DUAL V REGION ANTIBODY-LIKE PROTEIN 审中-公开
标题翻译：使用双V区抗体样蛋白
公开(公告)号：WO2012125775A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029147
申请日：2012-03-15
申请人： SANOFI , BENDER, Florent C. , LI, Danxi , MINNICH, Anne , NAADIMUTHU, Amirtha , RAO, Ercole , SWANSON, Brian N. , TANG, Lei , YU, Haixin
发明人： BENDER, Florent C. , LI, Danxi , MINNICH, Anne , NAADIMUTHU, Amirtha , RAO, Ercole , SWANSON, Brian N. , TANG, Lei , YU, Haixin
IPC分类号： A61K39/395
CPC分类号： C07K16/247 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/64 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Uses of a dual V region antibody-like protein or a fragment of a dual V region antibody-like region.
摘要翻译：使用双V区抗体样蛋白或双V区抗体样区域的片段。

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