专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023081413A2 METHODS AND SYSTEMS FOR DISCOVERY OF EMBEDDED TARGET GENES IN BIOSYNTHETIC GENE CLUSTERS 审中-公开
公开(公告)号：WO2023081413A2
公开(公告)日：2023-05-11
申请号：PCT/US2022/049040
申请日：2022-11-04
申请人： LIFEMINE THERAPEUTICS, INC.
发明人： HADJITHOMAS, Michalis , WYKA, Stephen Andrew , KIM, Jinwoo , LIN, Yu-Cheng , MCFADYEN, Iain James , VERDINE, Greg
IPC分类号： G16B20/00
摘要： The present disclosure relates to computer-based methods and systems for identifying genes associated with biosynthetic gene clusters (BGCs), including embedded target genes (ETaGs) that are homologs of potential therapeutic targets, using comparative genomics techniques and machine learning models.

2. 发明申请

WO2023019120A2 METHODS AND SYSTEMS FOR ARTIFICIAL INTELLIGENCE-ASSISTED DOCUMENT ANNOTATION 审中-公开
公开(公告)号：WO2023019120A2
公开(公告)日：2023-02-16
申请号：PCT/US2022/074685
申请日：2022-08-09
申请人： PRICEWATERHOUSECOOPERS LLP
发明人： WILSON, Jacob T. , HARRINGTON, Joseph D. , SIGAMANI, Vinston Sundara Pandiyan , SANGHAVI, Abhishek , PILLAI, Jayakumar , CUNNINGHAM, Benjamin , LEWIS, Lindsey P.
IPC分类号： G06F3/0482 , G06F40/117 , G06F40/169 , G06F40/205 , G06F40/279 , G06V30/413 , G06F40/284 , G06F40/216 , G06F40/30 , G06N20/00
摘要： Methods and systems for artificial intelligence (Al)-assisted document annotation and training of machine learning-based models for document data extraction are described. The methods and systems described herein take advantage of a continuous machine learning approach to create document processing pipelines that provide accurate and efficient data extraction from documents that include structured text, semi-structured text, unstructured text, or any combination thereof.

3. 发明申请

WO2019161114A1 FLUIDIZED BED EXTRACTORS FOR CAPTURE OF CO2 FROM AMBIENT AIR 审中-公开
公开(公告)号：WO2019161114A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018086
申请日：2019-02-14
申请人： CARBON SINK, INC.
发明人： BOURHIS, Alain L. , STECKLER, David K. , SORDELLA, Raffaella , O'KEEFE, Frank
IPC分类号： B01D53/00 , B01D53/02 , B01D53/04 , B01D53/14
摘要： Methods and apparatus for capturing carbon dioxide from ambient air and delivering said carbon dioxide to an enclosed environment are described. In general, the methods and apparatus comprise contacting a packed bed or fluidized bed device with a stream of ambient air, wherein the packed bed or fluidized bed device comprises a humidity-sensitive sorbent material that adsorbs carbon dioxide from the ambient air; contacting the packed bed or fluidized bed device with a stream of humid air to release the adsorbed carbon dioxide; delivering the released carbon dioxide to an enclosed environment; and optionally, repeating the steps of contacting the packed bed or fluidized bed device with ambient air and humid air in an alternating fashion.

4. 发明申请

WO2018204135A3 METHODS OF DETERMINING PROTEIN STRUCTURE USING TWO-PHOTON FLUORESCENCE MEASUREMENTS 审中-公开
公开(公告)号：WO2018204135A3
公开(公告)日：2018-11-08
申请号：PCT/US2018/029234
申请日：2018-04-24
申请人： BIODESY, INC.
发明人： CLANCY, Bason , SALAFSKY, Joshua
IPC分类号： G01N33/53 , G01N33/533 , G01N33/52 , G01N33/58 , G01N21/63 , G01B11/00
摘要： Methods, devices, and systems for using two-photon fluorescence measurements, either alone or in combination with other nonlinear optical measurements such as second harmonic generation, sum frequency generation, or difference frequency generation, to determine structural parameters such as mean tilt angle and distribution width for tethered nonlinear-active biomolecules are described. The disclosed methods, devices, and systems may also be used to perform structural comparisons of two or more biomolecular samples; to detect changes in biomolecule conformation upon binding of a ligand; and to screen candidate binding partners to identify compounds that modulate the conformation of the biomolecule.

5. 发明申请

WO2016100976A2 METHODS FOR IDENTIFYING MULTIPLE EPITOPES IN SELECTED SUB-POPULATIONS OF CELLS 审中-公开
标题翻译：在细胞的某些亚群体中鉴定多种表位的方法
公开(公告)号：WO2016100976A2
公开(公告)日：2016-06-23
申请号：PCT/US2015/067147
申请日：2015-12-21
申请人： APPRISE BIO, INC. , NOLAN, Garry, P.
发明人： NOLAN, Garry, P.
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/686 , C12Q1/703 , G01N33/56966 , G01N2458/10 , C12Q2537/143 , C12Q2563/179
摘要： A method for identifying a sub-population within a mixed population of cells is disclosed. The method involves contacting the mixed population of cells with at least one unique binding agent, wherein the at least one unique binding agent is designed to bind to a target molecule present in the sub-population, and wherein the at least one unique binding agent is attached to an epitope specific barcode that represents the identity of the target molecule. The method further involves sequentially attaching two or more assayable polymer subunits to the epitope specific barcode to create unique cell origination barcodes that represent the identities of individual cells to which the at least one unique binding agent has bound; and decoding the epitope specific barcode and cell origination barcodes, thereby identifying the sub-population within the mixed population of cells.
摘要翻译：公开了用于鉴定混合细胞群体内的亚群体的方法。该方法包括使混合的细胞群与至少一种独特的结合剂接触，其中至少一种独特的结合剂被设计成结合存在于亚群中的靶分子，并且其中至少一种独特的结合剂是连接到表示靶分子身份的表位特异性条形码。该方法进一步涉及将两种或更多种可测定聚合物亚基依次附着至表位特异性条形码以产生独特的细胞起源条形码，所述条形码表示至少一种独特结合剂所结合的单个细胞的身份; 并解码表位特异性条形码和细胞起源条形码，从而鉴定混合细胞群体内的亚群。

6. 发明申请

WO2023060261A1 METHODS AND SYSTEMS FOR DETECTING AND REMOVING CONTAMINATION FOR COPY NUMBER ALTERATION CALLING 审中-公开
公开(公告)号：WO2023060261A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077800
申请日：2022-10-07
申请人： FOUNDATION MEDICINE, INC.
发明人： HUGHES, Jason D. , NEWBERG, Justin
IPC分类号： G16B30/00 , C12Q1/6886 , G16B20/10 , G16B20/20 , G16H50/20
摘要： Methods and systems for performing iterative contamination detection and segmentation of sequence read data are described. The methods are based on comparing a distribution of minor allele frequencies (MAPs) for a plurality of single nucleotide polymorphisms (SNPs) detected in the sample to an expected distribution of minor allele frequencies for a plurality of selected SNP loci, and adjusting a MAP threshold used to discriminate between aberrant SNPs (SNPs exhibiting a different distribution of MAP values than that expected for the plurality of selected SNPs) and those conforming to the expected distribution of minor allele frequencies for the plurality of selected SNP loci. The methods may be used to estimate the degree of contamination in a sample and to provide segmentation of sequence read data for the sample, and may further comprise building a copy number model that predicts a copy number for one or more gene loci.

7. 发明申请

WO2023060091A1 ENHANCED RESOLUTION IMAGING 审中-公开
公开(公告)号：WO2023060091A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077551
申请日：2022-10-04
申请人： ULTIMA GENOMICS, INC.
发明人： SCHWARTZ, Osip , ALMOGY, Gilad , LU, Rongwen , POLOVY, Gene , FRANTZ, Amy Elizabeth
IPC分类号： G02B21/36 , G02B21/06 , H04N5/372 , G01N21/01
摘要： Disclosed herein are systems and methods that combine: (i) the use of a first optical transformation to create patterned illumination that is directed to an imaged object such that light reflected, transmitted, scattered, or emitted by the object comprises high-resolution spatial information about the object that would not otherwise be obtained, and (ii) the use of a second optical transformation that generates an enhanced resolution optical image at a time delay and integration (TDl) image sensor that comprises all or a portion of the high-resolution information contained in said light due to the patterned illumination.

8. 发明申请

WO2023010131A1 METHODS AND SYSTEMS FOR OBTAINING AND PROCESSING SEQUENCING DATA 审中-公开
公开(公告)号：WO2023010131A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/074349
申请日：2022-07-29
申请人： ULTIMA GENOMICS, INC.
发明人： FAIGLER, Simchon , NEISTEIN, Eyal , PRATT, Mark
IPC分类号： C12Q1/6869 , C12Q1/6874
摘要： The present disclosure relates generally to sequencing techniques, and more specifically to methods, systems, devices, and non-transitory computer-readable storage media for processing images of biological samples (e.g., to obtain sequencing data). An exemplary method of determining nucleic acid sequences of a plurality of sequencing colonies comprises: obtaining an input image of a surface, wherein the plurality of sequencing colonies are attached to the surface; detecting a set of sequencing colonies of the plurality of sequencing colonies in the input image; executing in parallel, using a graphics processor, a plurality of iterative processes to obtain signal amplitudes for the detected set of sequencing colonies, wherein each iterative process corresponds to a respective detected sequencing colony in the set; and determining, at least partially based on the signal amplitudes for the detected set of sequencing colonies, portions of nucleic acid sequences of the plurality of sequencing colonies.

9. 发明申请

WO2021247902A2 METHODS AND SYSTEMS FOR DISTINGUISHING SOMATIC GENOMIC SEQUENCES FROM GERMLINE GENOMIC SEQUENCES 审中-公开
公开(公告)号：WO2021247902A2
公开(公告)日：2021-12-09
申请号：PCT/US2021/035751
申请日：2021-06-03
申请人： FOUNDATION MEDICINE, INC.
发明人： HUANG, Yanmei , HUGHES, Jason D. , GOWEN, Kyle
IPC分类号： C12Q1/6827 , C12Q1/6806 , G16B20/00 , G16B20/20 , G16H50/20
摘要： Described herein are methods for distinguishing between somatic and germline variants, and devices for implementing such methods. In certain implementation of the methods, the method can include identifying a genomic sequence of interest in a patient sample at a genomic locus; identifying one or more proxy genomic sequences for the sequence of interest; comparing an observed frequency of the sequence of interest to a centrality measure of observed frequencies of the one or more proxy genomic sequences; and based on the comparison, characterizing the genomic sequence of interest as either germline or somatic.

10. 发明申请

WO2021007360A1 HIGH FRAMERATE AND HIGH DYNAMIC RANGE ELECTRON MICROSCOPY 审中-公开
公开(公告)号：WO2021007360A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/041266
申请日：2020-07-08
申请人： INTEGRATED DYNAMIC ELECTRON SOLUTIONS, INC.
发明人： BLOOM, Ruth , PARK, Sang Tae , REED, Bryan , MASIEL, Daniel
IPC分类号： H01J37/26 , G01N23/04 , H01J37/147 , H01J3/26 , G02B21/00 , G02B21/36
摘要： Methods and systems for acquiring transmission electron microscope video data on a rolling-shutter detector at an enhanced frame rate and without temporal distortions are described. Also described are methods to enhance the dynamic range of image and diffraction data acquired using a transmission electron microscope. The disclosed methods and systems may also be applicable to photon detection and imaging systems.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式