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1. 发明申请

WO2013139987A1 CHEMICAL PROCESS FOR PREPARING SPIROINDOLONES AND INTERMEDIATES THEREOF 审中-公开
标题翻译：用于制备螺旋体的化学方法及其中间体
公开(公告)号：WO2013139987A1
公开(公告)日：2013-09-26
申请号：PCT/EP2013/056170
申请日：2013-03-22
申请人： NOVARTIS AG , CROWE, Michael , FOULKES, Michael , FRANCESE, Giancarlo , GRIMLER, Dominique , KUESTERS, Ernst , LAUMEN, Kurt , LI, Yunzhong , LIN, Changxue , NAZOR, Jovana , RUCH, Thomas , SMITH, Derek , SONG, Shiwei , TENG, Shangjun
发明人： CROWE, Michael , FOULKES, Michael , FRANCESE, Giancarlo , GRIMLER, Dominique , KUESTERS, Ernst , LAUMEN, Kurt , LI, Yunzhong , LIN, Changxue , NAZOR, Jovana , RUCH, Thomas , SMITH, Derek , SONG, Shiwei , TENG, Shangjun
IPC分类号： C07D405/06 , C07D471/20 , C07D209/12 , C07D209/14 , C07D209/34 , C12P17/10
CPC分类号： C12P17/10 , C07D209/12 , C07D209/14 , C07D209/34 , C07D209/38 , C07D405/06 , C07D471/20 , C12N9/1096 , Y02P20/52
摘要： The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3, 4-b]indol]-2-one and salts and hydrates and solvates thereof.
摘要翻译：本发明涉及可用于制备螺旋体酮化合物的方法和中间体，例如（1'R，3'S）-5,7'-二氯-6'-氟-3'-甲基-2'，3'，4' ，9'-四氢螺[二氢吲哚-3,1'-吡啶并[3,4-b]吲哚] -2-酮及其盐和水合物和溶剂化物。

2. 发明申请

WO2015140709A1 SOLID PHARMACEUTICAL DOSAGE FORMS 审中-公开
标题翻译：固体药物剂型
公开(公告)号：WO2015140709A1
公开(公告)日：2015-09-24
申请号：PCT/IB2015/051944
申请日：2015-03-17
申请人： NOVARTIS AG , DEODHAR, Unmesh , ZHANG, Lei , BABU, Sreehari
发明人： DEODHAR, Unmesh , ZHANG, Lei , BABU, Sreehari
IPC分类号： A61K9/20 , A61K31/135 , A61K31/352
CPC分类号： A61K31/357 , A61K9/2077 , A61K31/137 , A61K31/366 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to the use of active pharmaceutical ingredients (API) as lubricant and/or antiadherent in the manufacturing of solid pharmaceutical dosage forms. It further relates to solid pharmaceutical dosage forms the production of which involves a granulation process step followed by a capsule filling or tablet compression step. Said pharmaceutical dosage form is comprised of an intragranular phase and an extragranular phase wherein the latter is comprised of one or more active pharmaceutical ingredients (API) which functions as lubricants and/or antiadherents in the manufacturing of said solid dosage form. Specifically, the API Artemether with its endoperoxide structural element was surprisingly found to exhibit lubricant and/or antiadherent effects when used extragranularly. In further aspects, the present invention relates to the manufacturing process to produce said pharmaceutical dosage forms as well as to a test method to determine whether an API functions as lubricant and/or antiadherent.
摘要翻译：本发明涉及在制备固体药物剂型中使用活性药物成分（API）作为润滑剂和/或抗粘附剂。它还涉及固体药物剂型，其生产包括造粒工艺步骤，随后是胶囊填充或片剂压片步骤。所述药物剂型由晶内相和颗粒外晶相组成，其中后者由制备所述固体剂型的一种或多种活性药物成分（API）组成，其作为润滑剂和/或抗粘附剂起作用。具体地说，具有其内过氧化物结构元件的API蒿甲醚被惊奇地发现在粒子外使用时表现出润滑剂和/或抗附着效应。在其它方面，本发明涉及生产所述药物剂型的制备方法以及用于确定API是否用作润滑剂和/或抗粘附剂的测试方法。

3. 发明公开

EP4002385A3 MOTOR TASK ANALYSIS SYSTEM AND METHOD 无效
公开(公告)号：EP4002385A3
公开(公告)日：2022-08-03
申请号：EP21215778.8
申请日：2015-09-03
申请人： Novartis AG
发明人： KONTSCHIEDER, Peter , ZIKIC, Darko , CRIMINSI, Antonio , DORN, Jonas , DAHLKE, Frank, Kurt
IPC分类号： G16H50/20 , G16H20/30
摘要： Video processing for motor task analysis is described. In various examples, a video of a person carrying out a motor task, such as placing the forefinger on the nose, is input to a trained machine learning system to classify the motor task into one of a plurality of classes. In an example, motion descriptors such as optical flow are computed from pairs of frames of the video and the motion descriptors are input to the machine learning system. The motor task analysis may be used to assess or evaluate neurological conditions such as multiple sclerosis and/or Parkinson's.

4. 发明授权

EP2872204B1 AUTOINJECTOR 有权
公开(公告)号：EP2872204B1
公开(公告)日：2020-09-09
申请号：EP13734457.8
申请日：2013-07-09
申请人： Novartis AG
发明人： BRYANT, Andrew , BUETTGEN, Heinrich
IPC分类号： A61M5/46 , A61M5/32 , A61M5/20

5. 发明公开

EP4054494A1 METHOD FOR DELIVERING THE FLUID FORMULATION AS A SPRAY OR A JET OF DROPLETS TO A TARGET AREA ON AN EYE 审中-公开
公开(公告)号：EP4054494A1
公开(公告)日：2022-09-14
申请号：EP20807117.5
申请日：2020-10-30
申请人： Novartis AG
发明人： WICKS, Ben , SMETHAM, Grant , HORRELL, Adrian , CHANDLER, Matt , DAVIES, Graeme , MYERS, Rachel , WHITWORTH-SMITH, Gabrielle
IPC分类号： A61F9/00

6. 发明授权

EP2790761B1 PASSIVE POWDER AEROSOLIZATION APPARATUS 有权
公开(公告)号：EP2790761B1
公开(公告)日：2022-05-11
申请号：EP12809952.0
申请日：2012-12-14
发明人： CHAN, Leo , UNG, Try Keith , WEERS, Jeffry
IPC分类号： A61M15/00 , A61K31/66 , A61M11/00

7. 发明公开

EP2828256A1 CHEMICAL PROCESS FOR PREPARING SPIROINDOLONES AND INTERMEDIATES THEREOF 有权
标题翻译：化工生产工艺SPIROINDOLONEN及其中间体
公开(公告)号：EP2828256A1
公开(公告)日：2015-01-28
申请号：EP13714246.9
申请日：2013-03-22
申请人： Novartis AG
发明人： CROWE, Michael , FOULKES, Michael , FRANCESE, Giancarlo , GRIMLER, Dominique , KUESTERS, Ernst , LAUMEN, Kurt , LI, Yunzhong , LIN, Changxue , NAZOR, Jovana , RUCH, Thomas , SMITH, Derek , SONG, Shiwei , TENG, Shangjun
IPC分类号： C07D405/06 , C07D471/20 , C07D209/12 , C07D209/14 , C07D209/34 , C12P17/10
CPC分类号： C12P17/10 , C07D209/12 , C07D209/14 , C07D209/34 , C07D209/38 , C07D405/06 , C07D471/20 , C12N9/1096 , Y02P20/52
摘要： The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
摘要翻译：本发明涉及的方法和中间体螺吲哚酮化合物的制造中有用：如（1'R，3'S）-5,7'二氯-6'-氟-3'-甲基-2”，3' ， 4”，9'-四氢螺[二氢吲哚-3,1'-吡啶并[3,4-b]吲哚] -2-酮及其盐和水合物和溶剂化物。

8. 发明授权

EP2668970B1 Powder dispersion apparatus 有权
标题翻译： Pulverdispersionsvorrichtung
公开(公告)号：EP2668970B1
公开(公告)日：2016-07-06
申请号：EP13178800.2
申请日：2007-10-25
申请人： Novartis AG
发明人： Glusker, Mark , Alston, William , Axford, George , Palmer-Felgate, John , Wilkins, Jonathan , Foss, Willard , Rao, Nagaraja , Postich, Mark , Pakala, Neeraf , Maltz, David , Ung, Keith
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0036 , A61M15/0041 , A61M15/0048 , A61M15/0051 , A61M15/0081 , A61M15/0093 , A61M15/0096 , A61M2016/0015 , A61M2202/064 , A61M2205/43 , A61M2205/581 , A61M2205/582

9. 发明授权

EP2847096B1 DISPENSING DEVICE 有权转让
公开(公告)号：EP2847096B1
公开(公告)日：2016-03-16
申请号：EP13721757.6
申请日：2013-05-09
申请人： Novartis AG
发明人： DESSET-BRETHES, Sabine , FRELON REGIS , HIRSCH, Stefan , JENSEN, Hans , JOHANSSEN, Esben , MATHIASEN, Peter , OLESEN, Jan
IPC分类号： B65D83/04 , B65D83/06
CPC分类号： B65D83/04 , B65D83/049 , B65D83/06

10. 发明公开

EP2968110A1 DEAMORPHIZATION OF SPRAY-DRIED FORMULATIONS VIA SPRAY-BLENDING 无效
标题翻译： DEAMORPHISIERUNGSPRÜHGETROCKNETERFORMULIERUNGEN MITTELSSPRÜHMISCHUNG
公开(公告)号：EP2968110A1
公开(公告)日：2016-01-20
申请号：EP14713918.2
申请日：2014-03-11
申请人： Novartis AG
发明人： WEERS, Jeffry , HUANG, Daniel , TARARA, Thomas , MILLER, Danforth
IPC分类号： A61K9/00 , A61K9/16 , A61K31/00
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , A61K31/40 , A61K31/4704 , A61K31/573 , A61K31/58 , A61M15/0045 , A61M2202/064 , A61K2300/00
摘要： Dry powder formulations for inhalation and their use in the treatment diseases and conditions. The formulation contains a uniform blend of a first spray-dried powder and a second spray-dried powder. The first spray-dried powder contains spray-dried particles of a therapeutically active ingredient dispersed in a pharmaceutically acceptable hydrophobic excipient. The second spray-dried powder contains spray-dried particles formed from a pharmaceutically acceptable hydrophobic excipient but are substantially free of any therapeutically active ingredient. The active ingredient in the first spray-dried powder is loaded sufficiently high to compensate for the second spray-dried powder being substantially free of any active ingredient. A process for preparing such formulations is also described.
摘要翻译：用于吸入的干粉配方及其用于治疗疾病和病症。该制剂含有第一喷雾干燥粉末和第二喷雾干燥粉末的均匀混合物。第一喷雾干燥粉末含有分散在药学上可接受的疏水性赋形剂中的治疗活性成分的喷雾干燥颗粒。第二喷雾干燥粉末含有由药学上可接受的疏水赋形剂形成的喷雾干燥颗粒，但基本上不含任何治疗活性成分。将第一喷雾干燥的粉末中的活性成分加载得足够高以补偿基本上不含任何活性成分的第二喷雾干燥粉末。还描述了制备这种制剂的方法。

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