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1. 发明申请

WO2019164670A1 COMPOSITIONS FOR PROVIDING SKIN CARE BENEFITS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019164670A1
公开(公告)日：2019-08-29
申请号：PCT/US2019/016982
申请日：2019-02-07
申请人： DANISCO US INC
发明人： GHERARDI, Carole , KROUWER, Andreas J. , PERICU, Piera Mattia , PUTAALA, Heli , WORTEL, Vincent A.L.
IPC分类号： A61K8/44 , A61K8/60 , A61Q19/00
摘要： The present disclosure is directed to compositions and methods for providing increased skin care benefits and/or multiple skin care benefits. The methods and compositions disclosed herein are directed to skin care compositions and skin care products comprising at least four osmolytes selected from amino acids, methyl-amines and polyols. More specifically, the methods and compositions disclosed herein are directed to skin care compositions and skin care products comprising a combination of at least four osmolytes selected from the group consisting of betaine, inositol, proline and serine.

2. 发明申请

WO2017155714A1 NOVEL CAS9 SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：新型CAS9系统和使用方法
公开(公告)号：WO2017155714A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/019624
申请日：2017-02-27
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： CIGAN, Andrew Mark , KING, Matthew G. , LIN, Haining , YOUNG, Joshua K.
IPC分类号： C12N15/113 , C12N9/22 , C12N15/82
摘要： Compositions and methods are provided for novel Cas9 systems, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The novel Cas9 systems described herein are derived from a CRISPR-Cas locus that differs from type II CRISPR-Cas loci, in that the novel CRISPR-Cas locus described herein contains multiple CRISPR arrays flanking a tracrRNA encoding region and cas9 gene and does not contain a cas1 gene and a cas2 gene. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell.
摘要翻译：为新的Cas9系统提供了组合物和方法，包括但不限于新的指导性多核苷酸/ Cas9内切核酸酶复合物，单或双引导RNA，引导RNA元件和Cas9内切核酸酶。本文描述的新型Cas9系统来源于不同于II型CRISPR-Cas基因座的CRISPR-Cas基因座，因为本文所述的新型CRISPR-Cas基因座包含侧接tracrRNA编码区和cas9基因且不含有多个CRISPR阵列 cas1基因和cas2基因。本公开还描述了用于基因组修饰细胞基因组中的靶序列，用于基因编辑以及用于将目的多核苷酸插入细胞基因组中的方法。

3. 发明申请

WO2016186946A1 RAPID CHARACTERIZATION OF CAS ENDONUCLEASE SYSTEMS, PAM SEQUENCES AND GUIDE RNA ELEMENTS 审中-公开
标题翻译： CAS内切酶系统的快速表征，PAM序列和指导RNA元件
公开(公告)号：WO2016186946A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/032028
申请日：2016-05-12
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： CIGAN, Andrew, Mark , GASIUNAS, Giedrius , KARVELIS, Tautvydas , SIKSNYS, Virginijus , YOUNG, Joshua, K.
IPC分类号： C12N9/22 , C12N15/113 , C12N15/90 , C12N15/10
CPC分类号： C12N15/1093 , C12N9/22 , C12N15/102 , C12N15/1051 , C12N15/113 , C12N15/8213 , C12N15/902 , C12N2310/20 , C12N2320/10 , C12Q1/6811 , C12Q2521/301 , C12Q2525/179 , C12Q2525/191 , C12Q2535/122
摘要： Compositions and methods are provided for rapid characterization of Cas endonuclease systems and the elements comprising such a systems, including, but not limiting to, rapid characterization of PAM sequences, guide RNA elements and Cas endonucleases. Type II Cas9 endonuclease systems originating from Brevibacillus laterosporus, Lactobacillus reuteri Mlc3, Lactobacillus rossiae DSM 15814, Pediococcus pentosaceus SL4, Lactobacillus nodensis JCM 14932, Sulfurospirillum sp . SCADC, Bifidobacterium thermophilum DSM 20210, Loktanella vestfoldensis, Sphingomonas sanxanigenens NX02, Epilithonimonas tenax DSM 16811, Sporocytophaga myxococcoides are described herein. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell.
摘要翻译：提供组合物和方法用于快速表征Cas内切核酸酶系统和包含这种系统的元件，包括但不限于PAM序列，引导RNA元件和Cas内切核酸酶的快速表征。 II型Cas9内切核酸酶系统来源于短孢杆菌（Brevibacillus soosporus），罗伊氏乳杆菌（Luterobacillus reuteri）Mlc3，罗氏假丝酵母（DSM）15814，戊糖片球菌SL4，乳酸乳杆菌JCM 14932， SCADC，双歧杆菌嗜热乳杆菌DSM 20210，Loktanella vestfoldensis，Sphingomonas sanxanigenens NX02，Epilithonimonas tenax DSM 16811，孢子体孢子虫粘球菌在本文中描述。本公开还描述了用于基因组修饰细胞基因组中的靶序列，用于基因编辑以及将感兴趣的多核苷酸插入细胞基因组的方法。

4. 发明申请

WO2016160389A1 SOYBEAN U6 SMALL NUCLEAR RNA GENE PROMOTERS AND THEIR USE IN CONSTITUTIVE EXPRESSION OF SMALL RNA GENES IN PLANTS 审中-公开
标题翻译：大豆U6小核RNA基因启动子及其在植物中小RNA基因组成表达中的应用
公开(公告)号：WO2016160389A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/023374
申请日：2016-03-21
申请人： E I DU PONT DE NEMOURS AND COMPANY
发明人： LI, Zhongsen
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8213
摘要： The invention relates to gene expression regulatory sequences from soybean, specifically to promoters of U6 small nuclear RNA genes, and fragments thereof, and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.
摘要翻译：本发明涉及从大豆，特别是U6小核RNA基因的启动子及其片段的基因表达调节序列及其在植物中以组成型促进一种或多种异源核酸片段的表达的用途。本发明进一步公开了组合物，多核苷酸构建体，转化的宿主细胞，转基因植物和含有重组构建体与启动子的种子，以及制备和使用该重组构建体的方法。

5. 发明申请

WO2016137774A1 COMPOSITION AND METHODS FOR REGULATED EXPRESSION OF A GUIDE RNA/CAS ENDONUCLEASE COMPLEX 审中-公开
标题翻译：用于指导RNA / CAS内切酶复合物的调节表达的组合物和方法
公开(公告)号：WO2016137774A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/017937
申请日：2016-02-15
申请人： PIONEER HI-BRED INTERNATIONAL INC
发明人： CIGAN, Andrew Mark , SVITASHEV, Sergei
IPC分类号： C12N15/82 , C12N9/22 , A01H1/04
CPC分类号： C12N15/8237 , C12N9/22 , C12N15/8212 , C12N15/8213
摘要： Compositions and methods are provided for regulated expression of a guide RNA/Cas endonuclease system in a plant cell, plant and seed. Compositions and methods are also provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a regulated guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
摘要翻译：提供组合物和方法用于在植物细胞，植物和种子中调控RNA / Cas内切核酸酶系统的表达。还提供组合物和方法用于基因组修饰植物或植物细胞基因组中的靶序列。所述方法和组合物使用调控的引导RNA / Cas内切核酸酶系统来提供用于修饰或改变植物，植物细胞或种子基因组内的靶位点的有效系统。

6. 发明申请

WO2015061158A1 SOYBEAN PIP1 PROMOTER AND ITS USE IN CONSTITUTIVE EXPRESSION OF TRANSGENIC GENES IN PLANTS 审中-公开
标题翻译：大豆PIP1促销剂及其在植物中转基因表达的表达
公开(公告)号：WO2015061158A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061062
申请日：2014-10-17
申请人： E. I. DU PONT DE NEMOURS AND COMPANY
发明人： LI, Zhongsen
IPC分类号： C12N15/82 , C12N5/04 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8216 , C12N15/8245 , C12N15/8247 , C12N15/8251 , C12N15/8273 , C12N15/8274 , C12N15/8279 , C12N15/8286
摘要： The disclosure relates to gene expression regulatory sequences from soybean, specifically to recombinant DNA constructs comprising the promoter of a soybean plasma membrane intrinsic protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.
摘要翻译：本公开涉及来自大豆的基因表达调控序列，特别是涉及包含大豆质膜内在蛋白质基因及其片段的启动子的重组DNA构建体及其在以组成型方式促进一种或多种异源核酸片段的表达中的用途植物。本公开进一步公开了组合物，多核苷酸构建体，转化的宿主细胞，转基因植物和含有重组构建体与启动子的种子，以及制备和使用该重组构建体的方法。

7. 发明申请

WO2014025858A1 SOYBEAN ADF1 PROMOTER AND ITS USE IN CONSTITUTIVE EXPRESSION OF TRANSGENIC GENES IN PLANTS 审中-公开
标题翻译：大豆ADF1促销剂及其在植物中转基因表达的表达
公开(公告)号：WO2014025858A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/053907
申请日：2013-08-07
申请人： E. I. DU PONT DE NEMOURS AND COMPANY
发明人： LI, Zhongsen
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8245 , C12N15/8247 , C12N15/8251 , C12N15/8257 , C12N15/8261 , C12N15/8273 , C12N15/8274 , C12N15/8279 , C12N15/8286
摘要： The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean actin depolymerizing factor gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.
摘要翻译：本发明涉及大豆，特别是大豆肌动蛋白解聚因子基因及其片段的启动子的基因表达调控序列及其在植物中以组成型促进一种或多种异源核酸片段的表达的用途。本发明还公开了组合物，多核苷酸构建体，转化的宿主细胞，转基因植物和含有重组构建体的启动子的种子，以及制备和使用该重组构建体的方法。

8. 发明申请

WO2021041361A1 METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2021041361A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/047715
申请日：2020-08-25
申请人： DANISCO US INC
发明人： JÄRVINEN, Juho , KOIVIKKO, Hannu , KUUSISTO, Jyrki , MENTUNEN, Tero Tuomas , NURMI, Juha , SÄRELÄ, Pertti Matias , SIITONEN, Jani , WHITED, Gregory M.
IPC分类号： B01D9/00 , B01D61/02 , B01J39/00 , C07C51/43 , A61K8/49 , A61K31/366
摘要： Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.

9. 发明申请

WO2020206197A1 METHODS FOR POLYNUCLEOTIDE INTEGRATION INTO THE GENOME OF BACILLUS USING DUAL CIRCULAR RECOMBINANT DNA CONSTRUCTS AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2020206197A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026503
申请日：2020-04-03
申请人： DANISCO US INC
发明人： SUH, Wonchul , FRISCH, Ryan L. , STUBBS, Stacey Irene Robida , ZIMMER, Derek Joseph
IPC分类号： C12N9/00 , C12N9/22 , C12N15/10 , C40B50/04
摘要： Methods and compositions are provided for integrating genes of interest into the genome of a Bacillus sp. cell without the integration of a selectable marker into said genome. The methods employ a dual circular recombinant DNA system for introduction of a guide RNA/Cas endonuclease system (also referred to as an RNA guided endonuclease, RGEN) as well as a donor DNA into a Bacillus sp. cell, and providing a highly effective system for inserting genes of interest into the genome of said Bacillus sp. cell.

10. 发明申请

WO2017218185A1 USE OF CPF1 ENDONUCLEASE FOR PLANT GENOME MODIFICATIONS 审中-公开
标题翻译： CPF1内切核酸酶在植物基因组修饰中的应用
公开(公告)号：WO2017218185A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/035175
申请日：2017-05-31
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： CIGAN, Andrew Mark , DJUKANOVIC, Vesna , YOUNG, Joshua K.
IPC分类号： C12N9/22 , C12N15/10 , C12N15/82
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, for genome editing of a nucleotide sequence in the genome of a plant or plant cell, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a plant. The methods and compositions employ a guide polynucleotide/ Cpf1 endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a plant, plant cell or seed. Also provided are guide polynucleotides/Cpf1 endonucleases complexes, guide polynucleotides, plant-optimized Cpf1 endonuclease sequences, recombinant DNA constructs comprising plant-optimized Cpf1 endonucleases genes, and combinations thereof.
摘要翻译：提供组合物和方法用于基因组修饰植物或植物细胞基因组中的靶序列，用于基因组编辑植物或植物细胞基因组中的核苷酸序列，和/或用于将目的多核苷酸插入或从植物基因组中缺失。该方法和组合物使用引导多核苷酸/ Cpf1内切核酸酶系统来提供用于修饰或改变植物，植物细胞或种子的基因组内的靶序列的有效系统。还提供了指导性多核苷酸/ Cpf1内切核酸酶复合物，指导性多核苷酸，植物优化的Cpf1核酸内切酶序列，包含植物优化的Cpf1内切核酸酶基因的重组DNA构建体，以及它们的组合。

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