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1. 发明申请

WO2021011762A1 METHODS, DEVICES AND SYSTEMS FOR HOLISTIC INTEGRATED HEALTHCARE PATIENT MANAGEMENT 审中-公开
公开(公告)号：WO2021011762A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042308
申请日：2020-07-16
申请人： PACESETTER, INC.
发明人： BHARMI, Rupinder , AGARWAL, Rahul , ADAMSON, Philip B. , HELLMAN, Heidi , DALAL, Nirav
IPC分类号： G16H40/63 , G16H50/20 , G16H50/30
摘要： A method for managing a treatment is provided. The method is under control of a processor. The method obtains a body generated analyte (BGA) indicative of a malnutrition state (MS) characteristic of interest (COI) of a patient and obtains implantable medical device (IMD) data indicative of a physiologic COI from the patient. The method assigns a health risk index based on the MS COI and the physiologic COI. The health risk index is indicative of a chronic disease state and malnutrition state currently exhibited by the patient. The method generates a treatment notification based on the health risk index.

2. 发明申请

WO2020142254A3 METHOD AND DEVICE FOR DELIVERING MULTI-PHASE DEFIBRILLATION THERAPY 审中-公开
公开(公告)号：WO2020142254A3
公开(公告)日：2020-07-09
申请号：PCT/US2019/067748
申请日：2019-12-20
申请人： PACESETTER, INC.
发明人： SHAHANDEH, Reza , LI, Wenwen , BORNZIN, Gene , MOUCHAWAR, Gabriel , VOGEL, Alan , RYU, Kyungmoo
IPC分类号： A61N1/39 , A61N1/362
摘要： Methods and systems are provided that comprise: sensing cardiac events of a heart; utilizing one or more processors to perform: declaring a ventricular fibrillation (VF) episode based on the cardiac events charging a single charge storage capacitor; delivering a multi-phase VF therapy that includes phase I and phase II therapies, wherein: a) during the phase I therapy, a combination of two or more medium voltage (MV) shocks are delivered entirely from the single charge storage capacitor; and b) during the phase II therapy, a low voltage pulse train is delivered at least partially from the single charge storage capacitor. Methods and systems are provided that comprise delivering first and second pulses of at least a first biphasic shock, wherein a parallel - series reconfiguration circuit connects and configures the capacitors of the capacitor bank in a parallel configuration to deliver a parallel biphasic shock; connecting the capacitors of the capacitor bank in a series configuration; and delivering first and second pulses of a second biphasic shock while the capacitors are connected in series to deliver a series biphasic shock.

3. 发明申请

WO2020142254A2 METHOD AND DEVICE FOR DELIVERING MULTI-PHASE DEFIBRILLATION THERAPY 审中-公开
公开(公告)号：WO2020142254A2
公开(公告)日：2020-07-09
申请号：PCT/US2019/067748
申请日：2019-12-20
申请人： PACESETTER, INC.
发明人： SHAHANDEH, Reza , LI, Wenwen , BORNZIN, Gene , MOUCHAWAR, Gabriel , VOGEL, Alan , RYU, Kyungmoo
IPC分类号： A61N1/39
摘要： Methods and systems are provided that comprise: sensing cardiac events of a heart; utilizing one or more processors to perform: declaring a ventricular fibrillation (VF) episode based on the cardiac events charging a single charge storage capacitor; delivering a multi-phase VF therapy that includes phase I and phase II therapies, wherein: a) during the phase I therapy, a combination of two or more medium voltage (MV) shocks are delivered entirely from the single charge storage capacitor; and b) during the phase II therapy, a low voltage pulse train is delivered at least partially from the single charge storage capacitor. Methods and systems are provided that comprise delivering first and second pulses of at least a first biphasic shock, wherein a parallel - series reconfiguration circuit connects and configures the capacitors of the capacitor bank in a parallel configuration to deliver a parallel biphasic shock; connecting the capacitors of the capacitor bank in a series configuration; and delivering first and second pulses of a second biphasic shock while the capacitors are connected in series to deliver a series biphasic shock.

4. 发明申请

WO2020131356A1 IMPLANTABLE MEDICAL DEVICE WITH SECURE CONNECTION TO AN EXTERNAL INSTRUMENT 审中-公开
公开(公告)号：WO2020131356A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/064202
申请日：2019-12-03
申请人： PACESETTER, INC.
发明人： YOUNG, Chaowen , WU, Yongjian , BHAYANA, Jyoti , SHAH, Samir , SHAHANDEH, Reza
IPC分类号： A61N1/372 , G16H40/63 , H04W12/00 , H04L29/06 , H04W4/80 , H04W84/18 , H04W12/06 , H04W76/11
摘要： An implantable medical device (IMD) that includes a transceiver configured to broadcast an advertising data packet that includes a unique identifier, and to receive a scan request data packet from an external device. A memory stores program instructions, and stores an approved device list, and one or more processors are configured to execute the program instructions to identify a device identifier (ID) from the scan request data packet received, apply an advertising filter to determine if the scan request data packet is from an authorized external device based on the device ID and the approved device list, based on the determination by the advertising filter, deny transmission of a scan response data packet from the transceiver when the advertising filter determines that the scan request data packet is from an unauthorized external device, and establish a communication session with an authorized external device independent of the scan request data packet.

5. 发明申请

WO2020096736A1 CARDIAC STIMULATION SYSTEM WITH AUTOMATED OPTIMIZATION OF HIS BUNDLE PACING FOR CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
公开(公告)号：WO2020096736A1
公开(公告)日：2020-05-14
申请号：PCT/US2019/056171
申请日：2019-10-15
申请人： PACESETTER, INC.
发明人： LI, Wenwen , BORNZIN, Gene, A. , BADIE, Nima , ROSENBERG, Stuart , MCSPADDEN, Luke, C. , RYU, Kyungmoo
IPC分类号： A61N1/362 , A61N1/368
摘要： Systems and methods of performing cardio resynchronization therapy (CRT) on a patient heart include the use of a stimulation system having at least one processor, at least one memory, a pulse generator, a stimulating electrode disposed in proximity to a His bundle of the patient heart, and a sensing electrode adapted to sense electrical activity of the left ventricle (LV) of the patient heart. CRT is provided by applying, using the pulse generator and through the stimulating electrode, a His bundle pacing (HBP) impulse having a first impulse energy. The sensing electrode is then used to measure an LV activation time in response to the HBP impulse. At least one setting of the pulse generator is modified based on the LV activation time such that a subsequent HBP impulse may be provided by the pulse generator via the stimulating electrode using a modified impulse energy.

6. 发明申请

WO2020047204A9 METHODS AND SYSTEMS TO DETERMINE CANCER MOLECULAR SUBTYPES BASED ON ULTRASOUND AND-OR OPTOACOUSTIC ( OA/US) FEATURES 审中-公开
公开(公告)号：WO2020047204A9
公开(公告)日：2020-03-05
申请号：PCT/US2019/048733
申请日：2019-08-29
申请人： SENO MEDICAL INSTRUMENTS, INC.
发明人： STAVROS, Anthony, Thomas
IPC分类号： A61B8/08
摘要： Methods, devices and systems are provided that utilize one or more processors in connection with, receiving OA/US feature scores in connection with OA/US images collected from a patient examination for a volume of interest. The methods, devices and systems apply the OA/US feature scores to a feature score to molecular subtype (FSMS) model. The methods, devices and systems determine, from the FSMS model, an indication of at least one of a molecular subtype or histologic grade of a pathology experienced by the patient.

7. 发明申请

WO2017095917A1 DIGITAL MICROFLUIDIC SYSTEM FOR SINGLE-CELL ISOLATION AND CHARACTERIZATION OF ANALYTES 审中-公开
标题翻译：数字微流体系统的单细胞分离和分析表征
公开(公告)号：WO2017095917A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064206
申请日：2016-11-30
申请人： ILLUMINA, INC.
发明人： JAMSHIDI, Arash , LIN, Yan-you , ABSALAN, Farnaz , STUART, Sarah , CANN, Gordon , WU, Yir-Shyuan , KHURANA, Tarun , FISHER, Jeffrey, S.
IPC分类号： C12Q1/68 , G01N1/28 , B01L3/00 , G01N15/10
CPC分类号： G01N1/28 , B01L3/502761 , B01L3/502784 , B01L3/5088 , B01L2200/0605 , B01L2200/0642 , B01L2200/0668 , B01L2300/0819 , B01L2400/0427 , B01L2400/043 , C12Q1/6806 , C12Q1/6869 , C12Q2563/143 , C12Q2563/149 , C12Q2563/185 , G01N33/54333 , G01N2015/1006 , C12Q2535/122
摘要： In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.
摘要翻译：根据本文的实施例，提供了一种用于捕捉数字微流体系统中感兴趣的细胞的方法，包括利用微滴致动器将样本微滴传送到微孔装置。微孔装置包括具有多个微孔的基底，所述多个微孔通向微孔装置的微滴操作表面。样品液滴包括进入微孔的感兴趣的细胞。该方法将捕获珠引入到微孔中，并且捕获元件被固定在捕获珠上。该方法利用液滴致动器将细胞裂解试剂液滴传送到微孔设备。细胞裂解试剂液滴的部分进入微孔，并且在潜伏期期间，导致感兴趣的细胞释放由捕获珠捕获元件捕获的分析物。

8. 发明申请

WO2017095845A1 LIQUID STORAGE AND DELIVERY MECHANISMS AND METHODS 审中-公开
标题翻译：液体储存和输送机制和方法
公开(公告)号：WO2017095845A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064075
申请日：2016-11-30
申请人： ILLUMINA, INC.
发明人： CRIVELLI, Paul , WATTS, Gary
IPC分类号： B01L3/00 , F15C3/00 , F15C4/00
CPC分类号： B65D51/002 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/502792 , B01L3/527 , B01L2200/027 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/142 , B01L2300/023 , B01L2300/043 , B01L2300/044 , B01L2300/045 , B01L2300/0672 , B01L2300/0809 , B01L2300/0874 , B01L2300/0887 , B01L2300/161 , B01L2300/18 , B01L2400/0478 , B01L2400/0655 , B05C5/02
摘要： A liquid storage and delivery mechanism and method of use are provided. The mechanism comprises shells that include corresponding reservoirs to hold individual quantities of liquid. The shells include filling ends and discharge ends. The filling ends include fill ports that open to the reservoirs in order to receive the corresponding quantity of liquid. The discharge ends are covered with closure lids to seal bottoms of the corresponding reservoirs. A shell management module is provided comprising a cover and a platform. The platform includes shell retention chambers to receive corresponding shells. The shell retention chambers are arranged in a predetermined pattern on the platform. The shell retention chambers are to orient shells with the fill ports exposed from the platform. The cover is mounted onto the platform to close the fill ports. The shells are to move individually, along the shell retention chambers, between non- actuated and actuated positions.
摘要翻译：提供了一种液体储存和输送机构及其使用方法。该机构包括壳体，壳体包括用于容纳单独数量液体的相应储存器。壳包括填充端和排出端。填充端包括填充端口，其通向储存器以接收相应量的液体。卸料端盖上封闭盖以密封相应储存器的底部。提供一种壳体管理模块，其包括盖子和平台。该平台包括壳体保持室以接收相应的壳体。壳体保持室在平台上以预定图案布置。壳体保持室将使壳体定向，其中填充端口暴露于平台。盖子安装在平台上以关闭加油口。外壳将沿着壳体保持腔室在非致动位置和致动位置之间单独移动。

9. 发明申请

WO2017034868A1 IN-LINE PRESSURE ACCUMULATOR AND FLOW-CONTROL SYSTEM FOR BIOLOGICAL OR CHEMICAL ASSAYS 审中-公开
标题翻译：用于生物或化学测试的在线压力累加器和流量控制系统
公开(公告)号：WO2017034868A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/047253
申请日：2016-08-17
申请人： ILLUMINA, INC.
发明人： STONE, Michael, J. , DREWS, Brad , WILLIAMSON, Erik
IPC分类号： G01N35/10
CPC分类号： G01N35/1095
摘要： Flow-control system includes a fluid reservoir configured to store a fluid, a pressure accumulator in flow communication with and positioned downstream from the fluid reservoir, and a loading zone that is configured to receive and fluidly couple to a flow cell having a biological or chemical sample. The loading zone is in flow communication with and positioned downstream from the pressure accumulator. The flow-control system also includes a system pump in flow communication with and positioned downstream from the loading zone. The system pump is configured to induce a flow of the fluid from the fluid reservoir and through the pressure accumulator and the loading zone. The pressure accumulator is configured to receive fluid from the fluid reservoir during a filling operation. The pressure accumulator is configured to impart pressure on the fluid and drive the fluid toward the loading zone during a pressure-assist operation.
摘要翻译：流量控制系统包括被配置为存储流体的流体储存器，与流体储存器流动连通并位于流体储存器下游的压力存储器，以及被配置为接收流体耦合到具有生物或化学物质的流动池的装载区样品。装载区与蓄压器流动连通并位于压力蓄能器的下游。流量控制系统还包括与装载区域流动连通并位于装载区域下游的系统泵。系统泵被配置为引起流体从流体储存器流过并通过压力蓄能器和装载区域的流动。压力蓄能器构造成在填充操作期间从流体储存器接收流体。压力蓄能器构造成在压力辅助操作期间向流体施加压力并将流体驱动到装载区域。

10. 发明申请

WO2017007757A1 BALANCED AC MODULATION FOR DRIVING DROPLET OPERATIONS ELECTRODES 审中-公开
标题翻译：用于驱动DROPLET操作的平衡交流调节电极
公开(公告)号：WO2017007757A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/040966
申请日：2016-07-05
申请人： ILLUMINA, INC.
发明人： NORTON, Kirkpatrick, W.
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/50273 , B01L2200/143 , B01L2400/0427
摘要： A droplet actuator device for conducting droplet operations is provided that comprises a substrate defines a device channel to conduct droplet operations. Electrodes are arranged proximate to the substrate. A drive circuit is connected to the electrodes. The drive circuit generates an electrode drive signal to drive the droplet operations based on a reference waveform. The electrode drive signal is partitioned into an AC modulated drive cycle formed of sub-cycles. The electrode drive signal switches, during the sub-cycle, between at least first and second states where a degree of modulation with respect to the reference waveform forms a balanced modulation pattern.
摘要翻译：提供用于进行液滴操作的液滴致动器装置，其包括衬底限定用于进行液滴操作的装置通道。电极靠近基板设置。驱动电路连接到电极。驱动电路基于参考波形产生电极驱动信号以驱动液滴操作。电极驱动信号被划分为由子循环形成的AC调制驱动周期。电极驱动信号在子周期期间在至少第一和第二状态之间切换，其中相对于参考波形的调制程度形成平衡的调制图案。

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