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1. 发明申请

WO2017162887A1 USE OF NOOTKATONE TO KILL SAP-SUCKING INSECTS 审中-公开
标题翻译：用NOOTKATONE杀死吸食SAP的昆虫
公开(公告)号：WO2017162887A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/057138
申请日：2017-03-24
申请人： EVOLVA SA
发明人： AMICK, Jean Davin , JULIEN, Bryan N. , MEYER, Henrik
IPC分类号： A01N35/06 , A01P7/02 , A01P7/04 , A01P17/00
CPC分类号： A01N35/06
摘要： Compositions comprising nootkatone and a carrier as well as methods for treating and preventing infestations of sap-sucking insects in plants are disclosed herein.
摘要翻译：本文公开了包含诺卡酮和载体的组合物，以及用于治疗和预防植物中侵染树液的昆虫侵袭的方法。

2. 发明申请

WO2017085028A9 PRODUCTION OF GLYCOSYLATED NOOTKATOL IN RECOMBINANT HOSTS 审中-公开
公开(公告)号：WO2017085028A9
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077614
申请日：2016-11-14
申请人： EVOLVA SA
发明人： SARAN, Dayal , HANSEN, Jorgen , PROCHASSON, Philippe , ROUSSEL, Patrick , OCCHIPINTI, Laura , OUSPENSKI, Alexei , MALCA, Sumire, Honda
IPC分类号： C12P19/44 , C12N9/10 , C12N15/63 , A23L29/00 , A01N43/00
摘要： The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and/or insect repellents.

3. 发明申请

WO2016180956A1 A METHOD FOR PRODUCING RESVERATROL 审中-公开
标题翻译：一种生产RESVERATROL的方法
公开(公告)号：WO2016180956A1
公开(公告)日：2016-11-17
申请号：PCT/EP2016/060798
申请日：2016-05-12
申请人： EVOLVA SA
发明人： SIMON VECILLA, Ernesto , VAZQUEZ, Carlos Casado , JENSEN, Niels Bjerg
IPC分类号： C12P7/22 , C12N15/81
CPC分类号： C12N15/81 , C12P7/22 , C12Y205/01054 , C12Y207/11027 , C12Y504/99005
摘要： Recombinant hosts and methods for producing resveratrol in recombinant hosts are disclosed herein.
摘要翻译：本文公开了用于在重组宿主中产生白藜芦醇的重组宿主和方法。

4. 发明申请

WO2016107920A1 PRODUCTION OF MACROCYCLIC DITERPENES IN RECOMBINANT HOSTS 审中-公开
标题翻译：在重组家园生产大环萜类化合物
公开(公告)号：WO2016107920A1
公开(公告)日：2016-07-07
申请号：PCT/EP2015/081457
申请日：2015-12-30
申请人： EVOLVA SA , UNIVERSITY OF COPENHAGEN , MOLLER, Birger Lindberg , LUO, Dan , NIELSEN, Morten Thrane
发明人： MOLLER, Birger Lindberg , NIELSEN, Morten Thrane , CALLARI, Roberta
IPC分类号： C12N9/02 , C12N15/82 , C12N9/04 , C12N9/88 , C12N9/10
CPC分类号： C12N9/0077 , C12N9/0006 , C12N9/1022 , C12N9/1085 , C12N9/88 , C12N15/8243
摘要： The invention relates to recombinant microorganisms and methods for producing macrocyclic diterpene or oxidized macrocyclic diterpene.
摘要翻译：本发明涉及重组微生物和生产大环二萜或氧化大环二萜的方法。

5. 发明申请

WO2015132411A2 METHODS FOR RECOMBINANT PRODUCTION OF SAFFRON COMPOUNDS 审中-公开
标题翻译：重组生产SAFFRON化合物的方法
公开(公告)号：WO2015132411A2
公开(公告)日：2015-09-11
申请号：PCT/EP2015/054792
申请日：2015-03-06
申请人： EVOLVA SA
发明人： KUMAR, A.S. Sathish
IPC分类号： C12N1/00
CPC分类号： C12N15/52 , C12N9/0008 , C12N9/001 , C12N9/0069 , C12N9/1085 , C12N15/81 , C12P7/24 , C12P7/44 , C12Y102/01003 , C12Y103/99 , C12Y113/11071 , C12Y205/01 , C12Y205/01029
摘要： Recombinant microorganisms and methods for producing saffron compounds including crocetin, crocetin dialdehyde, crocin or picrocrocin are disclosed herein.
摘要翻译：本文公开了用于生产番红花化合物的重组微生物和方法，所述番红花化合物包括番红花素，番茄红素二醛，番红花酸或picrocrocin。

6. 发明申请

WO2015082915A1 PROCESS FOR THE PREPARATION OF SUCCINIC ACID ESTER 审中-公开
标题翻译：制备酸性酯的方法
公开(公告)号：WO2015082915A1
公开(公告)日：2015-06-11
申请号：PCT/GB2014/053588
申请日：2014-12-02
申请人： JOHNSON MATTHEY DAVY TECHNOLOGIES LIMITED
发明人： SMIDT, Martin Lucas , CAMPBELL, Ian , REED, Graham , GORDON, Paul , FERGUSON, Christopher
IPC分类号： C07C67/08
CPC分类号： C07C67/08 , B01D3/009 , B01D3/143 , B01D17/0208 , C07C67/54 , C07C69/40
摘要： A process for the production of dialkyl succinate from a bio-succinic acid feedstock comprising the steps of: feeding bio-succinic acid to a point at or near the bottom of a reaction distillation zone column operated at temperatures and pressures to enable esterification of the succinic acid and passing said stream co-currently with upflowing alkanol such that said esterification reaction occurs: removing an overhead vapour stream from at or near the top of the reaction distillation zone column comprising di-ester, alkanol, water of esterification and organic components and passing said stream to an alkanol separation column where the alkanol is separated from the water of esterification and from the organic components; removing a side draw from the alkanol separation column from a point below the feed point thereto, said side draw comprising partially immiscible organic and aqueous phases; passing said side draw to phase separation apparatus where the partially immiscible organic and aqueous phases are separated; passing said organic phase to a column where the dialkyl succinate is separated from residual water and other organic components; and recovering the dialkyl succinate.
摘要翻译：一种从生物琥珀酸原料生产琥珀酸二烷基酯的方法，包括以下步骤：将生物琥珀酸加入反应蒸馏区塔底部附近的一点或在其附近的温度和压力下操作以使琥珀酸酯化酸和通过所述流与向上流动的链烷醇共同进行，使得发生所述酯化反应：从反应蒸馏区柱顶部或附近除去塔顶蒸气物流，其包含二酯，链烷醇，酯化水和有机组分并通过所述物流进入链烷醇分离塔，其中链烷醇与酯化水和有机组分分离; 从链烷醇分离柱的进料点以下的点除去侧馏分，所述侧馏分包含部分不混溶的有机相和水相; 将所述侧馏分通过相分离装置，其中部分不混溶的有机相和水相分离; 将所述有机相通过其中琥珀酸二烷基酯与残留水和其它有机组分分离的柱; 并回收琥珀酸二烷基酯。

7. 发明申请

WO2013041836A1 APPARATUS AND METHOD 审中-公开
标题翻译：装置和方法
公开(公告)号：WO2013041836A1
公开(公告)日：2013-03-28
申请号：PCT/GB2012/052098
申请日：2012-08-24
申请人： DAVY PROCESS TECHNOLOGY LIMITED , MCKINLEY, Donald Hugh , HENSMAN, John Richard , KIPPAX, John Wilson
发明人： MCKINLEY, Donald Hugh , HENSMAN, John Richard , KIPPAX, John Wilson
IPC分类号： B01J8/22 , B01J8/00 , C07C67/08 , B01D3/16
CPC分类号： B01J8/0492 , B01J8/003 , B01J8/0035 , B01J8/22 , B01J8/228 , B01J2208/00752 , B01J2208/00761 , B01J2208/00893 , B01J2208/02 , C07C67/08 , C07C67/54 , Y02P20/127
摘要： An apparatus for use in heterogeneous catalytic reactions comprising a column reactor comprising a plurality of trays mounted one above another, each adapted to hold a predetermined liquid volume and a charge of particles of a solid catalyst thereon; means for introducing a liquid phase reactant above the uppermost tray; means for introducing a vapour phase reactant below the lowermost tray; means for removing a liquid phase post-reaction stream from below the lowermost tray; means for removing a vapour phase post-reaction stream from above the uppermost tray; vapour upcomer means associated with each tray adapted to allow vapour to enter that tray from below; underflow means associated with each tray adapted to remove liquid from that tray and the column reactor before being introduced into the column reactor at a lower tray; means for temporarily directing said liquid removed from a tray to bypass at least one lower tray and be reintroduced to the column reactor at a tray located below said at least one bypassed tray; means for removing the liquid and catalyst from said at least one bypassed tray: and means for replacing a liquid and catalyst inventory on said at least one bypassed tray.
摘要翻译：一种用于非均相催化反应的装置，包括塔反应器，该塔反应器包括多个安装在另一塔板上的托盘，每个托盘适于保持预定液体体积和固体催化剂颗粒的装料; 用于在最上面的托盘上引入液相反应物的装置; 用于在最下面的塔板下方引入汽相反应物的装置; 用于从最下面的塔盘下面除去液相后反应物流的装置; 用于从最上面的托盘上方除去气相后反应物流的装置; 与适于允许蒸汽从下方进入该托盘的每个托盘相关联的蒸气升降装置; 与每个托盘相关联的下溢装置，其适于在下塔板引入塔式反应器之前从该托盘和塔式反应器中除去液体; 用于临时引导从托盘移除的所述液体绕过至少一个下托盘的装置，并在位于所述至少一个旁路托盘下方的托盘处重新引入塔反应器; 用于从所述至少一个旁路托盘去除液体和催化剂的装置;以及用于更换所述至少一个旁路托盘上的液体和催化剂库存的装置。

8. 发明申请

WO2012146904A1 PROCESS FOR THE SYNTHESIS OF METHANOL 审中-公开
标题翻译：甲醇合成方法
公开(公告)号：WO2012146904A1
公开(公告)日：2012-11-01
申请号：PCT/GB2012/050330
申请日：2012-02-14
申请人： DAVY PROCESS TECHNOLOGY LIMITED , GAMLIN, Timothy Douglas
发明人： GAMLIN, Timothy Douglas
IPC分类号： B01J8/04 , B01J19/24 , C07C29/152 , B01J35/04
CPC分类号： C07C29/152 , B01J8/0415 , B01J8/0496 , B01J8/067 , B01J19/2485 , B01J35/04 , B01J2208/00814 , B01J2219/00038 , B01J2219/0004 , Y02P20/52 , C07C31/04
摘要： A process for the conversion of synthesis gas to methanol by contacting a gaseous stream comprising synthesis gas with a particulate catalyst, said process being carried out in a tubular reactor having an inlet and an outlet, said outlet being located downstream of the inlet, said reactor comprising one or more tubes having located therein one or more carriers for said particulate catalyst and cooling medium in contact with said tubes; wherein said catalyst carrier comprises: an annular container for holding catalyst in use, said container having a perforated inner wall defining a tube, a perforated outer wail, a top surface closing the annular- container and a bottom surface closing the annular container; a surface closing the bottom of said tube formed by the inner wall of the annular container; a skirt extending upwardly from the perforated outer wall of the annular container from a position at or near- the bottom surface of said container to a position below the location of a seal; and a seal located at or near the top surface and extending from the container by a distance which extends beyond an outer surface of the skirt; said process comprising: (a) introducing the gaseous reactants through the inlet; (b) passing said reactants downwardly through said at least one tube to the upper surface of the, or the first catalyst carrier where they pass into the passage defined by the inner perforated wall of the container before passing radially through the catalyst bed towards the perforated outer wall; (c) allowing reaction to occur as the synthesis gas contacts the catalyst; (d) passing unreacted reactant and product out of the container though the perforated outer wail and then upwardly between the inner surface of the skirt and the outer wall of the annular container until they reach the seal where they are directed over the end of the skirt and caused to flow downwardly between the outer surface of the skirt and the inner surface of the reactor tube where heat transfer takes place; (e) repeating steps (b) to (d) at any subsequent catalyst carrier; and (f) removing product from the outlet.
摘要翻译：通过使包含合成气的气流与颗粒催化剂接触来将合成气转化为甲醇的方法，所述方法在具有入口和出口的管式反应器中进行，所述出口位于入口的下游，所述反应器包括一个或多个管，其中定位有用于所述颗粒催化剂的一个或多个载体和与所述管接触的冷却介质; 其中所述催化剂载体包括：用于在使用中保持催化剂的环形容器，所述容器具有限定管的穿孔内壁，穿孔外壁，封闭环形容器的顶表面和封闭环形容器的底表面; 封闭由所述环形容器的内壁形成的所述管的底部的表面; 从所述环形容器的穿孔外壁向上延伸的裙部从所述容器的底表面处或靠近所述容器的底表面处的位置到位于所述密封件的位置下方的位置; 以及密封件，其位于或靠近顶部表面并且从容器延伸超过裙部的外表面的距离; 所述方法包括：（a）通过入口引入气态反应物; （b）将所述反应物向下通过所述至少一个管至所述第一催化剂载体的上表面，在所述第一催化剂载体的上表面进入通过所述容器的内部多孔壁所限定的通道中，然后通过所述催化剂床朝向穿孔外墙; （c）当合成气与催化剂接触时，使反应发生; （d）将未反应的反应物和产品通过穿孔的外壁，然后在裙部的内表面和环形容器的外壁之间向上传递到容器中，直到它们到达密封件，在那里它们被引导到裙部的端部并且在裙部的外表面和发生热传递的反应器管的内表面之间向下流动; （e）在任何后续催化剂载体上重复步骤（b）至（d）; 和（f）从出口移除产品。

9. 发明申请

WO2012146902A1 PROCESS FOR THE PRODUCTION OF ANHYDRIDES 审中-公开
标题翻译：生产无机盐的方法
公开(公告)号：WO2012146902A1
公开(公告)日：2012-11-01
申请号：PCT/GB2012/050233
申请日：2012-02-03
申请人： DAVY PROCESS TECHNOLOGY LIMITED , TILLEY, Simon Nicholas
发明人： TILLEY, Simon Nicholas
IPC分类号： B01J8/06 , B01J19/24 , C07C51/31
CPC分类号： C07C51/54 , B01J8/0285 , B01J8/067 , B01J19/2485 , B01J23/22 , B01J27/198 , B01J35/04 , B01J2208/00814 , C07D307/60
摘要： A process for the production of anhydrides by contacting a gaseous feed stream with a particulate catalyst, said process being carried out in a tubular reactor having an inlet and an outlet, said outlet being located downstream of the inlet, said reactor comprising one or more tubes having located therein one or more carriers for said particulate catalyst and cooling medium in contact with said tubes; wherein said catalyst carrier comprises: an annular container for holding catalyst in use, said container having a perforated inner wall defining a tube, a perforated outer wall, a top surface closing the annular container and a bottom surface closing the annular container; a surface closing the bottom of said tube formed by the inner wall of the annular container; a skirt extending upwardly from the perforated outer wail of the annular container from a position at or near the bottom surface of said container to a position below the location of a seal; and a seal located at or near the top surface and extending from the container by a distance which extends beyond an outer surface of the skirt; said process comprising: (a) introducing the gaseous reactants through the inlet; (b) passing said reactants downwardly through said at least one tube to the upper surface of the, or the first catalyst carrier where they pass into the passage defined by the inner perforated wall of the container before passing radially through the catalyst bed towards the perforated outer wall; (c) allowing reaction to occur as the gas contacts the catalyst; (d) passing unreacted reactant and product out of the container though the perforated outer wall and then upwardly between the inner surface of the skirt and the outer wall of the annular container until they reach the seal where they are directed over the end of the skirt and caused to flow downwardly between the outer surface of the skirt and the inner surface of the reactor tube where heat transfer takes place; (e) repeating steps (b) to (d) at any subsequent catalyst carrier; and (f) removing product from the outlet.
摘要翻译：一种通过使气体进料流与颗粒催化剂接触来生产酸酐的方法，所述方法在具有入口和出口的管式反应器中进行，所述出口位于入口的下游，所述反应器包括一个或多个管在其中设置有一个或多个用于所述颗粒催化剂的载体和与所述管接触的冷却介质; 其中所述催化剂载体包括：用于在使用中保持催化剂的环形容器，所述容器具有限定管的穿孔内壁，穿孔的外壁，封闭所述环形容器的顶表面和封闭所述环形容器的底表面; 封闭由所述环形容器的内壁形成的所述管的底部的表面; 从所述环形容器的穿孔外壁向上延伸的裙部，从所述容器的底表面处或附近的位置向下延伸到密封位置下方的位置; 以及密封件，其位于或靠近顶部表面并且从容器延伸超过裙部的外表面的距离; 所述方法包括：（a）通过入口引入气态反应物; （b）将所述反应物向下通过所述至少一个管至所述第一催化剂载体的上表面，在所述第一催化剂载体的上表面进入通过所述容器的内部多孔壁所限定的通道中，然后通过所述催化剂床朝向穿孔外墙; （c）当气体与催化剂接触时，允许发生反应; （d）通过穿孔的外壁将未反应的反应物和产物从容器中通过，然后在裙部的内表面和环形容器的外壁之间向上延伸，直到它们到达密封件，在那里它们被引导到裙部的端部并且在裙部的外表面和发生热传递的反应器管的内表面之间向下流动; （e）在任何后续催化剂载体上重复步骤（b）至（d）; 和（f）从出口移除产品。

10. 发明申请

WO2007010299A1 PROCESS 审中-公开
标题翻译：处理
公开(公告)号：WO2007010299A1
公开(公告)日：2007-01-25
申请号：PCT/GB2006/050181
申请日：2006-06-30
申请人： DAVY PROCESS TECHNOLOGY LTD , TUCK, Michael William Marshall , TILLEY, Simon Nicholas
发明人： TUCK, Michael William Marshall , TILLEY, Simon Nicholas
IPC分类号： C07C29/132 , C07C31/10 , C07C31/20
CPC分类号： C07C29/60 , C07C31/10 , C07C31/205
摘要： A process for hydrogenation of glycerol in which a feed comprising glycerol is contacted with a stream of a hydrogen-containing gas and subjected to hydrogenation in the vapour phase in the presence of a catalyst at a temperature of from about 160°C to about 260°C, a pressure of from about 10 to about 30 bar. a hydrogen to glycerol ratio of from 400: 1 to about 600: 1 and a residence time of from about 0.01 to about 2.5 hr -
摘要翻译：甘油的氢化方法，其中将包含甘油的进料与含氢气体流接触，并在催化剂存在下在约160℃至约260℃的温度下在气相中进行氢化约10至约30巴的压力。氢至甘油的比例为400:1至约600:1，停留时间为约0.01至约2.5小时。

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