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1. 发明申请

WO2020118109A2 MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE OR CYSTEINE PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020118109A2
公开(公告)日：2020-06-11
申请号：PCT/US2019/064779
申请日：2019-12-05
申请人： CYTOMX THERAPEUTICS, INC.
发明人： VASILJEVA, Olga , WINTER, Michael B.
IPC分类号： A61K38/05 , C07K16/28
摘要： The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP) or at least one cysteine protease (CP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease or at least one cysteine protease (CP), and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease or at least one cysteine protease (CP) in a variety of therapeutic, diagnostic and prophylactic indications.

2. 发明申请

WO2014043143A1 NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：核酸放大
公开(公告)号：WO2014043143A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059093
申请日：2013-09-10
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： LI, Chieh-Yuan , RUFF, David , CHEN, Shiaw-Min , O'NEIL, Jennifer , KASINSKAS, Rachel , ROTHBERG, Jonathan , HINZ, Wolfgang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2521/507 , C12Q2527/119 , C12Q2535/122 , C12Q2565/537 , C12Q2565/607
摘要： In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer. The polymer can include a sieving agent and/or a diffusion-reducing agent.
摘要翻译：在一些实施方案中，本发明提供核酸扩增方法，包括形成反应混合物，并使反应混合物经受适合于核酸扩增的条件。在一些实施方案中，用于核酸扩增的方法包括将待扩增的核酸进行部分变性的条件。在一些实施方案中，用于核酸扩增的方法包括扩增而不完全变性扩增的核酸。在一些实施方案中，用于核酸扩增的方法使用催化同源重组的酶和聚合酶。在一些实施方案中，用于核酸扩增的方法可以在单个反应容器中进行。在一些实施方案中，用于核酸扩增的方法可以在反应混合物的单个连续液相中进行，而不需要分隔反应混合物或固定反应组分。在一些实施方案中，用于核酸扩增的方法包括在等温扩增条件下任选地在聚合物存在下在表面上扩增至少一种多核苷酸。聚合物可以包括筛分剂和/或扩散还原剂。

3. 发明申请

WO2021142029A1 AURISTATIN-RELATED COMPOUNDS, CONJUGATED AURISTATIN-RELATED COMPOUNDS, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021142029A1
公开(公告)日：2021-07-15
申请号：PCT/US2021/012364
申请日：2021-01-06
申请人： CYTOMX THERAPEUTICS, INC.
发明人： SCHLEYER, Siew , MENDELSOHN, Brian, A. , CHALLITA-EID, Pia , JACKSON, Dowdy , KEMBALL, Christopher
IPC分类号： C07K5/02 , C07K16/00 , A61K47/68 , A61K2039/505 , A61K47/6803 , A61K47/6869 , A61P35/00 , C07K16/3069 , C07K2317/33 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K5/0205
摘要： The invention relates generally to novel compounds of the auristatin family, to novel linkers for coupling a payload to another molecule, such a target-binding molecule, to novel linker-toxin molecules, and to novel antibody molecules that allow controlled, site-specific conjugation.

4. 发明申请

WO2020118109A3 MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE OR CYSTEINE PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020118109A3
公开(公告)日：2020-06-11
申请号：PCT/US2019/064779
申请日：2019-12-05
申请人： CYTOMX THERAPEUTICS, INC.
发明人： VASILJEVA, Olga , WINTER, Michael B.
IPC分类号： A61K38/05 , C07K16/28
摘要： The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP) or at least one cysteine protease (CP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease or at least one cysteine protease (CP), and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease or at least one cysteine protease (CP) in a variety of therapeutic, diagnostic and prophylactic indications.

5. 发明申请

WO2020092881A1 ACTIVATABLE ANTI-CD166 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020092881A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059363
申请日：2019-11-01
申请人： CYTOMX THERAPEUTICS, INC.
发明人： CARMAN, Lori , HUMPHREY, Rachel , KAVANAUGH, W., Michael , TERRETT, Jonathan, A. , WEAVER, Annie, Yang , WILL, Matthias
IPC分类号： A61K47/65 , A61K47/64 , A61K47/68 , A61P35/00
摘要： Provided herein are activatable antibodies that when activated specifically bind to CD166 and conjugated activatable antibodies that specifically bind to CD166. Also provided are methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

6. 发明申请

WO2021142039A1 ANTI-PSMA ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021142039A1
公开(公告)日：2021-07-15
申请号：PCT/US2021/012379
申请日：2021-01-06
申请人： CYTOMX THERAPEUTICS, INC.
发明人： HUBERT, Rene , KEMBALL, Christopher , CHALLITA-EID, Pia
IPC分类号： A61P35/00 , C07K16/30 , A61K39/395 , A61K2039/505 , A61K47/6803 , A61K47/6869 , C07K16/3069 , C07K2317/33 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K5/0205
摘要： The invention relates generally to antibodies that bind PSMA, and methods of making and using these anti-PSMA antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

7. 发明申请

WO2020176672A1 COMBINED THERAPIES OF ACTIVATABLE IMMUNE CHECKPOINT INHIBITORS AND CONJUGATED ACTIVATABLE ANTIBODIES 审中-公开
公开(公告)号：WO2020176672A1
公开(公告)日：2020-09-03
申请号：PCT/US2020/019978
申请日：2020-02-26
申请人： CYTOMX THERAPEUTICS, INC.
发明人： LE SCOLAN, Erwan , TSE, Tiffany , KRIMM, Michael, A. , GARNER, Will
IPC分类号： A61K47/68 , C07K16/28 , A61P35/00
摘要： Provided herein are compositions and methods relating to therapies that combine a conjugated activatable anti-CD 166 antibody that when activated specifically binds to CD 166 and an activatable immune checkpoint inhibitor. Also provided herein are compositions and methods relating to therapies that combine an activatable anti -immune checkpoint antibody that when activated specifically binds to the immune checkpoint and a conjugated activatable antibody, where the immune checkpoint is mammalian PD-l or mammalian PD-L1.

8. 发明申请

WO2015175691A1 SYSTEMS AND METHODS FOR VALIDATION OF SEQUENCING RESULTS 审中-公开
标题翻译：用于确认序列结果的系统和方法
公开(公告)号：WO2015175691A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030615
申请日：2015-05-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： BRINZA, Dumitru
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6858 , C12Q1/6869 , G06F19/22 , C12Q2525/161 , C12Q2525/173
摘要： Systems and method for validation of sequencing results can amplify a target region of a nucleic acid sample in the presence of a primer pool including target specific and variant specific primers. The variant specific primers can include variant specific barcodes and variant specific sequences. An amplicon can be sequenced to determine the sequence of the variant specific barcode. The variant can be identified based on the sequence of the variant specific barcode, and the location of the variant can be determined by mapping the amplicon to a reference sequence.
摘要翻译：用于验证测序结果的系统和方法可以在包含靶特异性和变异特异性引物的引物库的存在下扩增核酸样品的靶区域。变体特异性引物可以包括变体特异性条形码和变体特异性序列。可以对扩增子进行测序以确定变体特异性条形码的序列。可以基于变体特异性条形码的序列来鉴定变体，并且可以通过将扩增子映射到参考序列来确定变体的位置。

9. 发明申请

WO2013112956A1 SYSTEMS AND METHODS FOR PROTEIN MELT ANALYSIS USING DIPYRROMETHENEBORON DIFLUORIDE COMPOUNDS 审中-公开
标题翻译：使用二氯二苯并二恶英化合物进行蛋白质熔融分析的系统和方法
公开(公告)号：WO2013112956A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/023321
申请日：2013-01-25
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： ERGY, Levente , GEE, Kyle
IPC分类号： G01N33/68
CPC分类号： G01N33/6803 , C07F5/022 , C09B23/04 , C09B57/00 , G01N33/52 , G01N33/582 , G01N33/68
摘要： Systems and methods for protein melt analysis are provided that utilize a dye of formula (I). In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating while recording the fluorescence emission of the sample.
摘要翻译：提供了利用式（I）染料的蛋白质熔融分析的系统和方法。在一些实施方案中，方法包括通过将至少一种蛋白质与染料混合来制备样品，并在记录样品的荧光发射的同时施加受控加热。

10. 发明申请

WO2021142043A1 ANTI-SLC34A2 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021142043A1
公开(公告)日：2021-07-15
申请号：PCT/US2021/012383
申请日：2021-01-06
申请人： CYTOMX THERAPEUTICS, INC.
发明人： JACKSON, Dowdy , SHOSTAK, Yuriy , KEMBALL, Christopher , CHALLITA-EID, Pia
IPC分类号： A61K47/68 , C07K16/30 , A61K39/395 , A61P35/00 , A61K2039/505 , A61K47/6803 , A61K47/6869 , C07K16/3069 , C07K2317/33 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K5/0205
摘要： The invention relates generally to antibodies that bind SLC34A2, and methods of making and using these anti-SLC34A2 antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

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