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1. 发明申请

WO2022073754A1 DEVICE FOR PROVIDING A CELL SUSPENSION 审中-公开
公开(公告)号：WO2022073754A1
公开(公告)日：2022-04-14
申请号：PCT/EP2021/075893
申请日：2021-09-21
申请人： LONZA COLOGNE GMBH
发明人： GLEISSNER, Timo , TODOR, Claudiu
IPC分类号： C12M1/24 , C12M1/00 , C12M3/00
摘要： The invention relates to a device for providing a cell suspension to an apparatus for treating the cells, wherein the device comprises at least one internal space 16 for holding the suspension, and wherein the internal space 16 is at least partially surrounded by a wall 15. The device further comprises at least one inlet port 2 comprising at least one first opening 3 for introducing the suspension into the internal space 16 and at least one outlet port comprising at least one second opening for removing the suspension from said internal space 16. The inlet port 2 further comprises at least one barrier element 6 bordering the first opening 3 at a side furthest to the wall 15 and is partially arranged between the first opening 3 and the internal space 16.

2. 发明申请

WO2018202669A1 VERFAHREN ZUR BESTIMMUNG DER ZELLZAHL VON EUKARYOTISCHEN ZELLEN 审中-公开
公开(公告)号：WO2018202669A1
公开(公告)日：2018-11-08
申请号：PCT/EP2018/061124
申请日：2018-05-02
申请人： RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
发明人： WAGNER, Wolfgang , BOZIC, Tanja
IPC分类号： C12Q1/6881
CPC分类号： C12Q1/6881 , C12Q2600/154
摘要： Die Erfindung betrifft ein Verfahren und ein Nukleinsäuremolekülzur Bestimmung der Zellzahl von eukaryotischen Zellen in einer Probe. Das erfindungsgemäße Verfahrenberuht auf der Analyse der DNA-Methylierung (DNAm), wobei genomische Bereiche adressiertwerden, die in den zu untersuchenden Zellen grundsätzlich methyliert sind. Das erfindungsgemäße Verfahren umfasst dabeiim Wesentlichen die Identifikation eines Genombereichs,der in den zu messenden Zelltypenzuverlässig methyliert ist,und die Verwendung einerunmethylierten Referenz-Nukleinsäure, die diesen Bereich umfasst.Werden unterschiedliche Mengen der Referenz-Nukleinsäure verwendet, nehmen die Methylierungsgrade mit steigender Konzentrationder Referenz-Nukleinsäure kontinuierlichab.Die Genauigkeit des erfindungsgemäßen Verfahrens istinsbesondere dann besonders hoch, wenn die Methylierungsgrade zwischen 20% und 80% liegen, d. h. wenn die Anzahl der Referenz-Nukleotidsequenzen in etwa der Anzahl der genomischen Nukleinsäuremoleküle entspricht.

3. 发明申请

WO2018041828A1 METHOD FOR DETECTING MICROORGANISMS IN A SAMPLE 审中-公开
标题翻译：检测样品中微生物的方法
公开(公告)号：WO2018041828A1
公开(公告)日：2018-03-08
申请号：PCT/EP2017/071658
申请日：2017-08-29
申请人： MIACOM DIAGNOSTICS GMBH
发明人： VON STEIN, Walter , STANGE, Mirko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6841 , C12Q2565/107 , C12Q2525/301 , C12Q2565/1015
摘要： A method for detecting at least one specific microorganism in a sample is disclosed,wherein a probe nucleic acid sequence comprising at least one detectable label which is capable of emitting at least one detectable signal is provided, and wherein the detectable signal takes a first value when the probe sequence is not bound to the target sequence and a second value when the probe sequence is bound to the target sequence. At least one value of the detectable signal for the probe nucleic acid sequence is measured and analyzed, wherein it is indicated that the sample contains the microorganism if the measured value corresponds to the second value of the detectable signal. A significant difference between a probe sequence that hybridizes with a target sequence (signal (2)) and a control sequence which does not bind to any target (signal (1)) can be detected. Throughout all phases (heating, stationary and cooling)of a hybridization process, the value of the detectable signal (2) is higher than the value of the control signal (1), wherein the most significant difference can be observed at the end of the cooling phase (Δ3) so that measuring and analyzing the detectable signal (2) during this period provides the most reliable result. Alternatively or optionally, additional measuring points in other phases (Δ1 and/or Δ2) can be set in order to enhance reliability of the result.
摘要翻译：公开了用于检测样品中至少一种特定微生物的方法，其中提供包含至少一种能够发出至少一种可检测信号的可检测标记的探针核酸序列，并且其中当探针序列未与目标序列结合时，可检测信号取第一个值，当探针序列与目标序列结合时，第二个值取第二个值。测量和分析探针核酸序列的可检测信号的至少一个值，其中如果测量值对应于可检测信号的第二值，则表明样品含有微生物。可以检测与靶序列（信号（2））杂交的探针序列与不与任何靶标结合的控制序列（信号（1））之间的显着差异。在杂交过程的所有阶段（加热，静止和冷却）中，可检测信号（2）的值高于控制信号（1）的值，其中最显着的差异可以在冷却阶段（Δ3），以便在此期间测量和分析可检测信号（2）提供最可靠的结果。替代地或可选地，可以设置其他阶段的附加测量点（Δ1和/或Δ2）以提高结果的可靠性。

4. 发明申请

WO2018029365A1 FILTRATION DEVICE 审中-公开
标题翻译：过滤装置
公开(公告)号：WO2018029365A1
公开(公告)日：2018-02-15
申请号：PCT/EP2017/070506
申请日：2017-08-11
申请人： FREIE UNIVERSITÄT BERLIN , LARGENTEC GMBH
发明人： LANDAU, Uwe , GROHMANN, Elisabeth , HAAG, Rainer , Ql, Zhenhui
IPC分类号： B01J20/02 , B01J20/22 , B01J20/28 , B01J20/282 , B01J20/286 , B01J20/289 , B01J20/30 , B01J20/32 , B01J20/20
CPC分类号： B01J20/205 , A61L9/16 , A61L2209/14 , B01D39/18 , B01D53/44 , B01D2239/04 , B01D2239/0442 , B01D2239/0478 , B01D2239/0654 , B01D2253/102 , B01D2253/25 , B01D2257/91 , B01J20/02 , B01J20/0225 , B01J20/0233 , B01J20/22 , B01J20/28033 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3219 , B01J20/3236 , B01J20/324 , B01J20/3242 , B01J20/3289 , B01J2220/42 , C02F1/283 , C02F1/288 , C02F1/50 , C02F1/505 , C02F2303/04
摘要： The invention relates to a filtration device1comprising at least one active layer 2 and at least one antimicrobial composite3. The invention further concerns a method for producing a filtration device and filter systems comprising at least two substrates or components. The filtration device 1 may comprise two substrates, substrate A being provided with a chemically functionalized graphene or graphene oxide layer (active layer 2) and substrate B being coated with an antimicrobial composite 3 comprising silver and ruthenium ("AGXX"). The active layer 2 comprises graphene or graphene oxide functionalized by ionic groups so that it can attract microorganisms 4 and endotoxins (Step I), which are then captured and bound by the active layer 2 (Step II). The antimicrobial composite 3 produces and releases reactive oxygen species ("ROS") which kill microorganisms present in the surroundings (Step III). As the cell structure of the microorganisms is destroyed during the killing process, the cell debris is at least in part removed from the active layer 2 (Step IV).
摘要翻译：本发明涉及一种过滤装置1，其包括至少一个活性层2和至少一个抗菌复合物3。本发明还涉及一种用于制造包括至少两个基底或部件的过滤装置和过滤器系统的方法。过滤装置1可以包括两个基底，基底A具有化学功能化的石墨烯或氧化石墨烯层（活性层2），并且基底B涂覆有包含银和钌（“AGXX”）的抗微生物复合物3。活性层2包含由离子基团官能化的石墨烯或石墨烯氧化物，从而它可以吸引微生物4和内毒素（步骤I），然后被活性层2捕获并结合（步骤II）。抗微生物复合材料3产生并释放杀死周围环境中存在的微生物的活性氧（“ROS”）（步骤III）。由于微生物的细胞结构在杀死过程中被破坏，所以细胞碎片至少部分从活性层2上被除去（步骤IV）。

5. 发明申请

WO2016045988A1 USE OF A COMPOSITION AND METHOD FOR SEED TREATMENT 审中-公开
标题翻译：组合物的使用和种子处理方法
公开(公告)号：WO2016045988A1
公开(公告)日：2016-03-31
申请号：PCT/EP2015/070798
申请日：2015-09-11
申请人： MULTIBIND BIOTEC GMBH
发明人： LISOWSKY, Thomas , ESSER, Karlheinz
IPC分类号： A01P1/00 , A01P21/00 , A01N25/00 , A01N43/08 , A01N59/16 , A01N59/20
CPC分类号： A01N43/08 , A01N25/00 , A01N59/16 , A01N59/20
摘要： The present invention relates to a composition and method for the treatment of seeds, which allow efficient decontamination of seeds from unwanted external nucleic acids, viruses, bacteria and microorganisms. A comparison of the medium length of the shoots from seeds after 6 days of germination shows the positive effect of the method according to the invention on seed germination and development. That is, treatment of seeds with the composition according to the invention surprisingly also results in enhancement of seedling development. The composition may be applied as a water-based solution or solid carrier or in combination with other seed treatment additives like nutrients, fungicides or pesticides. The composition according to the invention also allows coating of seeds.
摘要翻译：本发明涉及用于处理种子的组合物和方法，其允许从不需要的外部核酸，病毒，细菌和微生物有效地去除种子。发芽6天后种子芽的中等长度比较显示根据本发明的方法对种子发芽和发育的积极作用。也就是说，用根据本发明的组合物处理种子出人意料地也导致幼苗发育的增强。组合物可以作为水溶液或固体载体或与其它种子处理添加剂如营养物，杀真菌剂或杀虫剂组合使用。根据本发明的组合物还允许涂覆种子。

6. 发明申请

WO2015181271A1 VERWENDUNG EINER ANTIMIKROBIELLEN ZUSAMMENSETZUNG 审中-公开
标题翻译：使用抗微生物组合物
公开(公告)号：WO2015181271A1
公开(公告)日：2015-12-03
申请号：PCT/EP2015/061797
申请日：2015-05-28
申请人： AGXX INTELLECTUAL PROPERTY HOLDING GMBH
发明人： LANDAU, Uwe , LAUENROTH, Michael
IPC分类号： A61K31/375 , A61K33/24 , A61K33/38 , A61P31/04 , A61P31/10 , A61P31/12
CPC分类号： A61K33/38 , A61K9/0014 , A61K31/375 , A61K33/24 , A61L15/18 , A61L15/44 , A61L15/46 , A61L26/0066 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/428 , Y02A50/473 , A61K2300/00
摘要： Die Erfindung betrifft die Verwendung einer antimikrobiellen Zusammensetzung, welchemetallisches Silber und metallisches Ruthenium sowie mindestens ein Vitamin oder mindestens ein Derivat eines Vitamins umfasst, zur topischen Behandlung oder Vermeidung von Erkrankungen der Haut, Hautanhangsgebilde oder Schleimhaut, die durch die Infektion mit mindestens einem Mikroorganismus verursacht werden. Die Erfindung betrifft ferner ein Verbandmaterial oder einen Wundschnellverband,das oder dereine antimikrobielle Zusammensetzung umfasst, welchemetallisches Silber und metallisches Ruthenium sowie mindestens ein Vitamin oder mindestens ein Derivat eines Vitamins umfasst. Die antimikrobielle Zusammensetzung („AgXX") zeigt eine Breitbandwirkung gegen Bakterien (a: E. coli) und Pilze (b: pathogene Hefe und c: Pinselschimmel). a) Escherichia coli (zusätzlich Silber („Ag") als Kontrolle), b) Candida parapsilosis, c) Penicillium notatum;
摘要翻译：本发明涉及使用含有金属银和金属钌和至少一种维生素或维生素的至少一种衍生物的抗微生物组合物包括，由感染引起的与至少一种微生物的局部治疗或预防皮肤疾病，皮肤附件，或粘膜，本发明还涉及一种敷料材料或Wundschnellverband包括dereine或抗微生物组合物包含银和金属金属钌和至少一种维生素或维生素的至少一种衍生物。抗微生物组合物（“AgXX”）是对细菌具有广谱活性（一个：大肠杆菌）和真菌（B：致病酵母和c：刷模具）a）大肠杆菌（除银（“AG”的）作为对照），B。）近平滑念珠菌，C）青霉;

7. 发明申请

WO2015165881A1 DEVICE AND METHOD FOR LARGE VOLUME TRANSFECTION 审中-公开
标题翻译：用于大容量转移的装置和方法
公开(公告)号：WO2015165881A1
公开(公告)日：2015-11-05
申请号：PCT/EP2015/059152
申请日：2015-04-28
申请人： LONZA COLOGNE GMBH
发明人： ALTROGGE, Ludger , GLEISSNER, Timo , HEINZE, Andreas , HERMSMEIER, Sven
IPC分类号： C12M1/42 , A61N1/30 , C12N15/87 , G01N35/10
CPC分类号： C12N13/00 , A61N1/0412 , C12M35/02 , C12N15/87
摘要： The invention relates to a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. The invention further concerns a method,wherein voltage is applied to at least one active electrode (43, 44) while the electrodes (43, 44, 45) or electrode segments next and/or opposite to the active electrode (43, 44) are set to ground potential. Setting neighboring electrodes that surround the active electrode to ground potential results in decreased scattering of the electric field within the internal space so that the electrically active area is locally limited and the field lines are focused near the active electrode and thus control of the process is enhanced.
摘要翻译：本发明涉及一种用于向电池悬浮液施加电场的装置，包括至少一个腔室，该腔室包括用于保持悬架的至少一个内部空间（40），所述内部空间（40）包括至少两个段（41 ，42），其中每个段（41,42）包括至少一个电极（43,44），并且其中相邻电极（43,44）通过至少一个间隙（47）彼此分开，所述间隙至少部分地被填充具有绝缘材料（46），并且其中在内部空间（40）内彼此面对的电极（43,44）的边缘是圆形的。将电极的边缘朝向相邻电极四舍五入会导致现场梯度的显着降低，从而导致电弧的风险。本发明还涉及一种方法，其中电压被施加到至少一个有效电极（43,44），而与有源电极（43,44）相邻和/或相对的电极（43,44,45）或电极段是设定为地电位。将围绕有源电极的相邻电极设置为接地电位导致电场在内部空间内的散射减少，使得电活性区域局部受限并且场线聚焦在有源电极附近，从而增强了该过程的控制。

8. 发明申请

WO2015058910A1 SYNERGISTIC COMPOSITIONS WITH PLANT PROTECTION AGENTS 审中-公开
标题翻译：具有植物保护剂的协同组合物
公开(公告)号：WO2015058910A1
公开(公告)日：2015-04-30
申请号：PCT/EP2014/069921
申请日：2014-09-18
申请人： MULTIBIND BIOTEC GMBH
发明人： LISOWSKY, Thomas , ESSER, Karlheinz
IPC分类号： A01N37/40 , A01N43/34 , A01N43/54 , A01N43/653 , A01N47/12 , A01N47/14 , A01N59/02 , A01N59/16 , A01N59/20 , A01N65/00 , A01N37/36
CPC分类号： A01N25/22 , A01N25/24 , A01N37/34 , A01N37/36 , A01N43/54 , A01N43/653 , A01N47/12 , A01N47/14 , A01N47/34 , A01N55/02 , A01N59/16 , A01N59/20 , A01N65/00 , A01N65/22 , A01N65/28 , A01N2300/00
摘要： The present invention relates to new, highly efficient synergistic compositions comprising mixtures of essential oils, metal ions, detergents and organic acids in combination with plant protection agents. That is, applied as an adjuvans or additive, said mixtures significantly increase the efficacy and biocompatibility of conventional plant protection agents for plant protection products. The new synergistic composition thereby allows significant reduction of active ingredients of conventional plant protection agents.
摘要翻译：本发明涉及包含精油，金属离子，洗涤剂和有机酸与植物保护剂组合的混合物的新的，高效的协同组合物。也就是说，作为佐剂或添加剂应用，所述混合物显着提高了用于植物保护产品的常规植物保护剂的功效和生物相容性。新的协同组合物因此允许显着降低常规植物保护剂的活性成分。

9. 发明申请

WO2014184199A1 METHOD FOR DETERMINING A HUMAN INDIVIDUAL'S PREDISPOSITION TO CONTRACT A MALIGNANT DISEASE 审中-公开
标题翻译：确定人类个体预防与恶性疾病合作的方法
公开(公告)号：WO2014184199A1
公开(公告)日：2014-11-20
申请号：PCT/EP2014/059784
申请日：2014-05-13
申请人： RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
发明人： BRUEMMENDORF, Tim Henrik , JOST, Edgar , WAGNER, Wolfgang , WALENDA, Thomas , WEIDNER, Carola
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154
摘要： The invention concerns a method for determining a human individual's predisposition to contract a hematopoietic malignant myeloid disease, wherein a methylation level of at least one specific region of a nucleic acid comprising at least one CpG-dinucleotide is determined, wherein the specific region comprises at least one gene selected from the group consisting of DNA-methyltransferases, and wherein the determined methylation level is compared with at least one reference methylation level of the specific region, wherein the risk of the human individual to contract the myeloid disease is increased if the determined methylation level is altered in respect of the reference methylation level. The invention further concerns the use of said nucleic acid molecule and a kit for determining a human individual's predisposition to contract a malignant disease according to said method.
摘要翻译：本发明涉及一种用于确定人类患有造血恶性骨髓病的易感性的方法，其中确定至少一种包含至少一个CpG-二核苷酸的核酸的至少一个特定区域的甲基化水平，其中该特定区域至少包括一个选自DNA甲基转移酶的基因，其中将确定的甲基化水平与特定区域的至少一个参考甲基化水平进行比较，其中如果确定的甲基化程度增加了人类收缩骨髓病的风险相对于参考甲基化水平而言，水平被改变。本发明还涉及使用所述核酸分子和试剂盒来确定人类根据所述方法收缩恶性疾病的倾向。

10. 发明申请

WO2013017573A1 METHOD FOR DETECTING ANTIBIOTIC RESISTANCE 审中-公开
标题翻译：检测抗生素耐药性的方法
公开(公告)号：WO2013017573A1
公开(公告)日：2013-02-07
申请号：PCT/EP2012/064904
申请日：2012-07-30
申请人： MIACOM DIAGNOSTICS GMBH , STANGE, Mirko , STEIN, FREIHERR VON, Walter
发明人： STANGE, Mirko , STEIN, FREIHERR VON, Walter
IPC分类号： C12Q1/68 , C12Q1/18
CPC分类号： C12Q1/18 , C12Q1/34 , G01N2333/31 , G01N2333/936 , G01N2415/00
摘要： The invention relates to a method for detecting a resistance of at least one cell of a microorganism to at least one antibiotic substance. More specifically, the invention concerns a method for detection of resistance of pathogen bacteria to β-lactam antibiotics. According to the invention a patient's probe is treated with at least one disrupting agent that at least partially damages the cell wall of the microorganism. The concentration of the disrupting agent needed to detectably damage the cell is a measure for the sensitivity of the cell to the antibiotic substance. Surprisingly, it turned out that the cell wall of resistant strains is weakened so that treatment with a disrupting agent in low concentrations results in partial cell wall destruction. Due to cell wall destruction, marker substances can easily enter the cells so that they can be detected by standard methods. This effect is not observed with strains that are sensitive to the antibiotic so that, depending on the concentration of the disrupting agent, a clear distinction between resistant and sensitive cells can be accomplished.
摘要翻译：本发明涉及一种用于检测至少一种微生物细胞对至少一种抗生素物质的抗性的方法。更具体地，本发明涉及用于检测病原体细菌对β-内酰胺抗生素的抗性的方法。根据本发明，用至少一种至少部分损伤微生物细胞壁的破坏剂处理患者的探针。可检测地损伤细胞所需的破坏剂的浓度是细胞对抗生素物质的敏感性的量度。令人惊讶的是，证明抗性菌株的细胞壁被削弱，使得用低浓度的破坏剂处理导致部分细胞壁破坏。由于细胞壁破坏，标记物质可以容易地进入细胞，以便通过标准方法检测。对抗生素敏感的菌株没有观察到这种效果，因此根据破坏剂的浓度，可以实现抗性和敏感细胞之间的明确区别。

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