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1. 发明申请

WO2016203404A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开
公开(公告)号：WO2016203404A1
公开(公告)日：2016-12-22
申请号：PCT/IB2016/053548
申请日：2016-06-15
申请人： NOVARTIS AG , BAGDANOFF, Jeffrey T. , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KATO, Misunori , LAMARCHE, Matthew J. , SARVER, Patrick James , SHULTZ, Michael , SMITH, Troy Douglas , WILLIAMS, Sarah
发明人： BAGDANOFF, Jeffrey T. , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KATO, Misunori , LAMARCHE, Matthew J. , SARVER, Patrick James , SHULTZ, Michael , SMITH, Troy Douglas , WILLIAMS, Sarah
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.

2. 发明申请

WO2016071856A1 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE 审中-公开
标题翻译：作为RNA聚合酶抑制剂的AMATOXIN衍生物和结合物
公开(公告)号：WO2016071856A1
公开(公告)日：2016-05-12
申请号：PCT/IB2015/058537
申请日：2015-11-05
申请人： NOVARTIS AG , GRUNEWALD, Jan , JIN, Yunho , OU, Weijia , UNO, Tetsuo
发明人： GRUNEWALD, Jan , JIN, Yunho , OU, Weijia , UNO, Tetsuo
IPC分类号： C07K7/64 , A61K38/12 , A61P35/00
CPC分类号： C07K7/64 , C07K16/22 , C07K16/30 , C07K2319/30
摘要： The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates: Formula (I).
摘要翻译：本文公开的本发明涉及式（I）的细胞毒性环肽，用这种环肽抑制RNA聚合酶的方法，包含这种环肽的免疫缀合物（即抗体药物偶联物），包含这种环肽免疫偶联物的药物组合物，包含这种环肽使用治疗性助剂的免疫缀合物和使用这种环肽免疫缀合物的治疗方法：式（I）。

3. 发明申请

WO2015189791A1 AURISTATIN DERIVATIVES AND CONJUGATES THEREOF 审中-公开
标题翻译： AURISTATIN衍生物及其结合物
公开(公告)号：WO2015189791A1
公开(公告)日：2015-12-17
申请号：PCT/IB2015/054400
申请日：2015-06-11
申请人： NOVARTIS AG , GEIERSTANGER, Bernhard , GRUNEWALD, Jan , OU, Weijia , PAN, Shifeng , UNO, Tetsuo , WAN, Yongqin , WANG, Xing
发明人： GEIERSTANGER, Bernhard , GRUNEWALD, Jan , OU, Weijia , PAN, Shifeng , UNO, Tetsuo , WAN, Yongqin , WANG, Xing
IPC分类号： C07K5/02 , A61K47/48
CPC分类号： C07D207/09 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07K5/0205 , C07K16/32
摘要： Disclosed herein are novel compounds of formula (I) as described herein, and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
摘要翻译：本文公开的是本文所述的新颖的式（I）化合物，并且这些肽在制备免疫偶联物中的用途（即抗体药物偶联物）本文还描述了包含与抗原结合部分连接的这种新化合物的免疫偶联物（即抗体药物偶联物），如抗体; 其中这种免疫偶联物可用于治疗细胞增殖性疾病。本发明还提供包含这些免疫缀合物的药物组合物，包含免疫偶联物与治疗性助剂的组合物，以及使用这些免疫缀合物和组合物治疗细胞增殖障碍的方法。

4. 发明申请

WO2015168269A1 COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS 审中-公开
标题翻译：化合物和组合物作为类似感受器7的激素
公开(公告)号：WO2015168269A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028264
申请日：2015-04-29
申请人： NOVARTIS AG , LI, Yongkai , MO, Tingting , VA, Porino , WU, Tom Yao-Hsiang , ZHANG, Xiaoyue
发明人： LI, Yongkai , MO, Tingting , VA, Porino , WU, Tom Yao-Hsiang , ZHANG, Xiaoyue
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P31/12 , A61P37/00 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides a compounds of formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.
摘要翻译：本发明提供式（I）化合物，包含这些化合物的免疫原性组合物和药物组合物以及使用这些化合物治疗与Toll样受体7活性相关的疾病或病症的方法。

5. 发明申请

WO2014205549A1 A METHOD OF ORDERING BASED ON ESTIMATED TIME OF ARRIVAL 审中-公开
标题翻译：基于估计的到达时间的订购方法
公开(公告)号：WO2014205549A1
公开(公告)日：2014-12-31
申请号：PCT/CA2014/000522
申请日：2014-06-26
申请人： GILFOYLE, Christopher, James
发明人： GILFOYLE, Christopher, James
IPC分类号： G06Q30/06
CPC分类号： G06Q20/3224 , G06Q10/08 , H04W4/027
摘要： A method for prioritizing a transmitted order based upon a customer's estimated time of arrival comprises the steps of: transmitting an order to a vendor by a customer via a localization-capable device; identifying the location of the customer via the localization-capable device; calculating the estimated time of arrival of the customer at the vendor based upon the customer's location; and placing the order in a queue with the vendor. The queue is arranged according to such criteria as the anticipated completion time of pending orders, and the anticipated completion time of the customer's order corresponds to the customer's estimated time of arrival at the vendor. While on route to the vendor, a new location of the customer via the localization-capable device is identified and an updated estimated time of arrival of the customer at the vendor is calculated based upon the customer's new location. Thereafter the position of the order in the queue based upon the updated estimated time of arrival is adjusted and the order is completed in relation to the updated estimated time of arrival.
摘要翻译：一种基于客户的估计到达时间对发送订单进行优先排序的方法包括以下步骤：由客户通过本地化设备向订单发送订单; 通过本地化设备识别客户的位置; 根据客户的位置计算客户在供应商处的估计到达时间; 并将订单放在与供应商的队列中。队列根据等待订单的预期完成时间等标准排列，客户订单的预计完成时间对应于客户预计到达供应商的时间。在通往供应商的路线上，识别通过本地化设备的客户的新位置，并且基于客户的新位置来计算客户在供应商处的更新的估计到达时间。此后，调整基于更新的估计到达时间的队列中的顺序的位置，并且相对于更新的预计到达时间完成订单。

6. 发明申请

WO2011057148A1 COMPOUNDS AND COMPOSITIONS AS TLR-7 ACTIVITY MODULATORS 审中-公开
标题翻译：作为TLR-7活性调节剂的化合物和组合物
公开(公告)号：WO2011057148A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055731
申请日：2010-11-05
申请人： IRM LLC , CORTEZ, Alex , LI, Yongkai , LIAO, Xuebin , WU, Tom Yao-Hsiang , ZHANG, Xiaoyue
发明人： CORTEZ, Alex , LI, Yongkai , LIAO, Xuebin , WU, Tom Yao-Hsiang , ZHANG, Xiaoyue
IPC分类号： C07D471/04 , A61P37/02 , A61K31/4985
CPC分类号： C07D471/04
摘要： The invention provides compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译：本发明提供了包含这些化合物的化合物，免疫原性组合物和药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强a 疫苗。

7. 发明申请

WO2010127152A2 COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS 审中-公开
标题翻译：化合物和组合物作为MICROSOMAL PROSTAGLANDIN E SYNTHASE-1抑制剂
公开(公告)号：WO2010127152A2
公开(公告)日：2010-11-04
申请号：PCT/US2010/033022
申请日：2010-04-29
申请人： IRM LLC , CHIANELLI, Donatella , MOLTENI, Valentina , ALBAUGH, Pamela A. , CHOI, Ha-Soon , LOREN, Jon , WANG, Zhicheng , MISHRA, Pranab
发明人： CHIANELLI, Donatella , MOLTENI, Valentina , ALBAUGH, Pamela A. , CHOI, Ha-Soon , LOREN, Jon , WANG, Zhicheng , MISHRA, Pranab
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D487/04
摘要： Provided herein are compounds, and pharmaceutical compositions comprising such compounds, wherein the compounds are inhibitors of mPGES-1 activity. Also provided herein are methods of using such compounds and composition to treat or prevent diseases or disorders associated with the activity of mPGES-1.
摘要翻译：本文提供化合物和包含这些化合物的药物组合物，其中所述化合物是mPGES-1活性的抑制剂。本文还提供了使用这些化合物和组合物来治疗或预防与mPGES-1的活性相关的疾病或病症的方法。

8. 发明申请

WO2010027746A2 HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译： HEDGEHOG路径调制器
公开(公告)号：WO2010027746A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/054802
申请日：2009-08-24
申请人： IRM LLC , CHENG, Dai , HAN, Dong , ZHANG, Guobao , WAN, Yongqin , XIE, Yun Feng , JIANG, Jiqing , GAO, Wenqi , PAN, Shifeng
发明人： CHENG, Dai , HAN, Dong , ZHANG, Guobao , WAN, Yongqin , XIE, Yun Feng , JIANG, Jiqing , GAO, Wenqi , PAN, Shifeng
IPC分类号： A61K31/47 , C07D401/02
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译：本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑功能增益或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触与足量的式（I）化合物反应。

9. 发明申请

WO2009097287A9 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS 审中-公开
公开(公告)号：WO2009097287A9
公开(公告)日：2009-08-06
申请号：PCT/US2009/032148
申请日：2009-01-27
申请人： IRM LLC , OKRAM, Barun , UNO, Tetsuo , DING, Qiang , LIU, Yahua , JIN, Yunho , JIN, Qihui , WU, Xu , CHE, Jianwei , YAN, S. Frank , HAO, Xueshi
发明人： OKRAM, Barun , UNO, Tetsuo , DING, Qiang , LIU, Yahua , JIN, Yunho , JIN, Qihui , WU, Xu , CHE, Jianwei , YAN, S. Frank , HAO, Xueshi
IPC分类号： C07D471/04 , A61K31/4375
摘要： The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity,particulary Syk,ZAP70,KDR,FMS,FLT*,c-Kit,RET,TrkA,TrkB,TrkC-GR-1R,Alk,c- FMS.or combinations thereof.

10. 发明申请

WO2005076894A2 ENVIRONMENTALLY FRIENDLY, 100% SOLIDS, ACTINIC RADIATION CURABLE COATING COMPOSITIONS AND COATED SURFACES AND COATED ARTICLES AND COATING METHODS AND ASSEMBLAGES THEREOF 审中-公开
标题翻译：环境友好，100％固体，抗紫外线可固化涂料组合物和涂层表面和涂层物品，涂料方法及其组合
公开(公告)号：WO2005076894A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003394
申请日：2005-02-04
申请人： ECOLOGY COATINGS, INC. , RAMSEY, Sally, Judith, Weine
发明人： RAMSEY, Sally, Judith, Weine
IPC分类号： C08F2/46 , C08F2/50 , C08L33/06 , C09D133/06
CPC分类号： C08F2/46 , C08F2/50 , C08L33/062 , C09D133/062 , C08L2666/04
摘要： Disclosed are environmentally friendly, substantially all solids coating compositions which are curable using ultra violet and visible radiation. In addition, methods, processes, production lines, and factories, incorporating environmentally friendly, ultra violet and visible radiation curable substantially all solids coating compositions, for coating surfaces, or at least a portion of the surfaces, and curing of the coated surface to obtain partially or fully cured coated surfaces are disclosed. Articles of manufacture incorporating fully cured coated surfaces, in particular motor vehicles and motor vehicle parts or accessories, are also disclosed.
摘要翻译：公开的是环境友好的，基本上所有的固体涂料组合物，其可以使用紫外线和可见光辐射固化。另外，方法，工艺，生产线和工厂，结合环境友好型，紫外线和可见辐射可固化的基本上所有的固体涂料组合物，用于涂布表面，或至少部分表面，以及固化涂覆表面以获得公开了部分或完全固化的涂覆表面。还公开了包括完全固化的涂覆表面的制品，特别是汽车和汽车零件或附件。

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