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1. 发明申请

WO2023064638A2 COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS 审中-公开
公开(公告)号：WO2023064638A2
公开(公告)日：2023-04-20
申请号：PCT/US2022/046921
申请日：2022-10-17
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , CORNISH, Virginia , JAFARIYAN, Amirhossein
发明人： CORNISH, Virginia , JAFARIYAN, Amirhossein
IPC分类号： A61K36/06 , A61K48/00
摘要： The disclosed subject matter provides for genetically modified cells, e.g., fungal cells, that autonomously generates and/or secretes one or more skin therapeutics, and methods of use thereof. In certain embodiments, the present disclosure provides genetically-engineered fungal cells that generate and secrete growth factors, protease inhibitors, cytokines and/or chemokines and methods of use thereof, e.g., for treating skin conditions.

2. 发明申请

WO2023034602A2 NUCLEIC ACID SEQUENCES RESPONSIVE TO CREATININE IN CLINICALLY USEFUL RANGES 审中-公开
公开(公告)号：WO2023034602A2
公开(公告)日：2023-03-09
申请号：PCT/US2022/042518
申请日：2022-09-02
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： STOJANOVIC, Milan , MILOSAVIC, Nenad , MOHAN, Sumit , JOVICIC, Jovan , STEVENS, Jacob
IPC分类号： C12Q1/6876 , C07D277/66
摘要： Aptamers and methods for detecting a target molecule/analyte in a sample are disclosed herein. The aptamer can include a single-stranded deoxyribonucleic acid (DNA) strand that includes an oligonucleotide sequence with bases identical at least about 60% to TAATTGTGGTTCGTGTAAA. The aptamer can be configured to bind the target molecule/analyte with a dissociation constant between about 10-9 and about 10-3 M.

3. 发明申请

WO2019191111A1 SYSTEMS AND METHODS FOR MULTILANE VASCULATURE 审中-公开
公开(公告)号：WO2019191111A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024093
申请日：2019-03-26
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： HUH, Dan Dongeun , GEORGESCU, Andrei
IPC分类号： C12M3/00 , C12N5/00 , C12N5/071
摘要： Systems and methods for multilane vasculature and multiorgan vascular-vessel fluidic interfaces in in vitro models. The method includes embedding at least one tissue into a 3D structure, forming a vascular interface for nutrient perfusion into the tissue or tissues, tuning the vascular interface or interfaces together or separately to possess a property of a native biological target tissue or target environment by modifying a vessel attribute; and lining a fluidic interface channel, for providing a growth fluid in a physiologically recapitulating manner. The 3D structure includes a vasculogenic element for angiogenesis or vasculogenesis.

4. 发明申请

WO2019112629A9 DEVICES AND METHODS FOR RADIATIVE COOLING 审中-公开
公开(公告)号：WO2019112629A9
公开(公告)日：2019-06-13
申请号：PCT/US2018/000277
申请日：2018-08-15
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： YU, Nanfang , SHI, Norman , TIAN, Meng
IPC分类号： F28F3/00 , F28F13/18 , B23P15/26
摘要： Devices for radiative cooling and optical waveguiding are provided, wherein the devices comprise a fabric including one or more fibers extending for a length in a longitudinal direction and a plurality of void structures positioned within each of the one or more fibers and extended over the length of each of the one or more fibers. Each of the plurality of void structures is configured to scatter at least a portion of an electromagnetic radiation received thereon to thereby radiatively cool the object.

5. 发明申请

WO2017177128A1 SYSTEMS AND METHODS FOR DEEP REINFORCEMENT LEARNING USING A BRAIN-ARTIFICIAL INTELLIGENCE INTERFACE 审中-公开
标题翻译：用脑部人工智能接口进行深度加固学习的系统和方法
公开(公告)号：WO2017177128A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026585
申请日：2017-04-07
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , SAJDA, Paul , SAPROO, Sameer , SHIH, Victor , ROY, Sonakshi, Bose , JANGRAW, David
发明人： SAJDA, Paul , SAPROO, Sameer , SHIH, Victor , ROY, Sonakshi, Bose , JANGRAW, David
IPC分类号： B25J13/00 , G05B13/02 , G06F15/18 , G06N3/00 , G06N3/08 , G06N3/12
摘要： The present disclosure relates to systems and methods for providing a hybrid brain-computer-interface (hBCI) that can detect an individual's reinforcement signals (e.g., level of interest, arousal, emotional reactivity, cognitive fatigue, cognitive state, or the like) in and/or response to objects, events, and/or actions in an environment by generating reinforcement signals for improving an AI agent controlling the environment, such as an autonomous vehicle. Although the disclosed subject matter is discussed within the context of an autonomous vehicle virtual reality game in the exemplary embodiments of the present disclosure, the disclosed system can be applicable to any other environment in which the human user's sensory input is to be used to influence actions within the environment. Furthermore, the systems and methods disclosed can use neural, physiological, or behavioral signatures to inform deep reinforcement learning based AI systems to enhance user comfort and trust in automation.
摘要翻译：本公开涉及用于提供可以检测个体的强化信号（例如，兴趣水平，唤起，情绪反应性，认知疲劳等）的混合脑 - 计算机接口（hBCI）的系统和方法。认知状态等）通过生成用于改进控制环境的AI代理的增强信号（例如自主车辆）来对环境中的对象，事件和/或动作进行响应和/或响应。虽然在本公开的示例性实施例中在公开的主题在自主车辆虚拟现实游戏的背景下被讨论，但是所公开的系统可以应用于任何其他环境，其中人类用户的感觉输入将被用于影响动作在环境中。此外，所公开的系统和方法可以使用神经，生理或行为签名来通知基于深度强化学习的AI系统，以增强用户对自动化的舒适度和信任度。

6. 发明申请

WO2017035530A1 FLEXIBLE COMPLEMENTARY METAL-OXIDE-SEMICONDUCTOR PROBES FOR CHRONIC, LARGE-SCALE NEURAL STIMULATION AND RECORDING 审中-公开
标题翻译：用于慢性，大规模神经刺激和记录的柔性补充金属氧化物半导体探针
公开(公告)号：WO2017035530A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/049278
申请日：2016-08-29
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： SHEPARD, Kenneth , TSAI, David , KANG, Hongki , THIMOT, Jordan
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61N1/37223 , A61B5/0031 , A61B5/0478 , A61B5/7225 , A61B2560/0219 , A61N1/00 , A61N1/0529 , A61N1/0551 , A61N1/3787 , H04B5/0081
摘要： Systems and methods for providing neural stimulation and recording on a subject using flexible complementary CMOS probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion. The tail portion can include a plurality of electrodes configured to be coupled to the brain and a plurality of front-end amplifiers. Each of the plurality of front-end amplifiers can be configured to amplify a signal received from a corresponding electrode of the plurality of electrodes. The head portion can include one or more inductors configured to enable two-way communication with a wireless reader through a near-field inductive link.
摘要翻译：提供了使用灵活的互补CMOS探针在受试者身上提供神经刺激和记录的系统和方法。公开的系统可以包括适于插入到受试者的脑的一部分中的柔性探针，所述柔性探针包括尾部和头部。尾部可以包括被配置为耦合到大脑的多个电极和多个前端放大器。多个前端放大器中的每一个可被配置为放大从多个电极的对应电极接收的信号。磁头部分可以包括一个或多个电感器，其被配置为通过近场感应链路实现与无线读取器的双向通信。

7. 发明申请

WO2017019796A1 FIBROSIS MODEL ON A CHIP 审中-公开
标题翻译：芯片上的FIBROSIS模型
公开(公告)号：WO2017019796A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044313
申请日：2016-07-27
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： HUH, Dongeun , MONDRINOS, Mark
IPC分类号： C12M1/14 , B01L3/00
CPC分类号： C12M23/20 , A61L27/18 , A61L27/3804 , A61L27/50 , A61L27/52 , C12M21/08 , C12M25/14 , C08L83/04
摘要： The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five- layer model including a first and second microchannel with a membrane-gel layer- membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
摘要翻译：目前公开的主题提供仿生器官模型及其生产和使用的方法。在一个示例性实施方案中，生物仿真器官模型可以是包括至少两个微通道的多层模型和至少一个室板，其中至少一个膜涂覆有设置在至少一个微通道和至少一个室板之间的细胞。在另一示例性实施方案中，仿生性器官疾病模型可以是包括第一和第二微通道的五层模型，其中膜 - 膜 - 膜包被的膜或包围的细胞设置在微通道之间。在某些实施方案中，至少一个装置可以耦合到生物仿真器官模型，其将药剂递送至至少一个微通道。

8. 发明申请

WO2016164874A1 SYSTEM AND METHOD FOR DETERMINIG AND UTILIZING PRIORITY MAPS IN VIDEO 审中-公开
标题翻译：用于确定和利用视频中优先级的系统和方法
公开(公告)号：WO2016164874A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026875
申请日：2016-04-11
申请人： VIDEOPURA, LLC
发明人： ADZIC, Velibor
IPC分类号： G06K9/00 , H04N7/00 , H04N9/00
CPC分类号： H04N19/115 , H04N7/035 , H04N7/0881 , H04N19/139 , H04N19/154 , H04N19/179 , H04N19/40 , H04N19/46 , H04N21/23
摘要： A system for video streaming may include a video receiver configured to receive a video sequence. The system may further include a video priority analyzer configured to calculate coefficients that correlate cognitive or perceptual priority with spatial, temporal, or audio elements of the video sequence. The video priority analyzer may further determine a priority map using the calculated coefficients. The priority map may include a set of coefficients that is associated with a video interval of the video sequence. A video decision router may be configured to select a transcoding technique or bitrate level for each video packet based on the determined priority map. Further, the video decision router may transmit the packet according to the selected transcoding technique or bitrate level.
摘要翻译：用于视频流的系统可以包括被配置为接收视频序列的视频接收器。该系统还可以包括视频优先级分析器，其被配置为计算将认知或感知优先级与视频序列的空间，时间或音频元素相关联的系数。视频优先级分析器可以使用所计算的系数进一步确定优先级映射。优先级映射可以包括与视频序列的视频间隔相关联的一组系数。视频决策路由器可以被配置为基于所确定的优先级映射来为每个视频分组选择代码转换技术或比特率级别。此外，视频决策路由器可以根据选择的代码转换技术或比特率级别发送分组。

9. 发明申请

WO2016112079A1 MICROFLUIDIC APTASENSOR INCLUDING A GRAPHENE NANOSENSOR 审中-公开
标题翻译：包含石墨纳米传感器的微流感传感器
公开(公告)号：WO2016112079A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012297
申请日：2016-01-06
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： LIN, Qiao , WANG, Xuejun , YANG, Jaeyoung , WANG, Cheng
IPC分类号： G01N27/00 , G01N27/414 , G01N33/487
CPC分类号： G01N27/4146 , G01N27/4145
摘要： Graphene nanosensors for monitoring a target analyte utilizing anti-target analyte aptamers can include a single conductance sensor on a substrate platform, where the graphene sensor can be functionalized with aptamers for binding the target analyte, or alternatively, a nonosensor can include microbeads functionalized with aptamers which can allow for selective enrichment and isocratic elution of the target analyte, where the concentration of the enriched target analyte can be measured on a graphene surface functionalized with a target analyte of interest.
摘要翻译：用于使用抗靶分析物适体监测目标分析物的石墨烯纳米传感器可以包括在基板平台上的单个电导传感器，其中石墨烯传感器可以用用于结合目标分析物的适体进行功能化，或者，非传感器可以包括用适配体官能化的微珠其可以允许目标分析物的选择性富集和等度洗脱，其中可以在目标分析物官能化的石墨烯表面上测量富集的靶分析物的浓度。

10. 发明申请

WO2016011383A1 METHODS FOR USING EXOSOMES TO MONITOR TRANSPLANTED ORGAN STATUS 审中-公开
标题翻译：使用EXOSOMES监控移动机构状态的方法
公开(公告)号：WO2016011383A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040956
申请日：2015-07-17
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： VALLABHJOSYULA, Prashanth , TAYLOR, Douglas
IPC分类号： C07G15/00
CPC分类号： G01N33/56977 , C07K14/47 , C12Q1/6881 , G01N33/5434 , G01N2333/70539
摘要： This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ- derived microvesicles from a biological sample of a subject. In certain embodiments, a method for isolating, purifying and/or identifying donor organ-derived microvesicles includes obtaining a biological sample from the subject and isolating, purifying or identifying a donor organ-derived microvesicle from the biological sample by the detection of a protein specific for the donor.
摘要翻译：本公开涉及供体器官衍生的微泡用于监测受试者中移植的器官的状态的用途。因此，本公开提供了用于从受试者的生物样品中分离，纯化和/或鉴定供体器官衍生的微泡的方法和试剂盒。在某些实施方案中，分离，纯化和/或鉴定供体器官衍生的微泡的方法包括从受试者获得生物样品，并通过检测蛋白质特异性从生物样品中分离，纯化或鉴定供体器官衍生的微泡为捐赠者。

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