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1. 发明申请

WO2012052179A1 AMINO DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE SKIN DISORDERS 审中-公开
标题翻译：用于治疗增生性皮肤病的氨基衍生物
公开(公告)号：WO2012052179A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/005302
申请日：2011-10-20
申请人： ALMIRALL, S.A. , GODESSART MARINA, Nuria , BALAGUE PELAEZ, Cristina
发明人： GODESSART MARINA, Nuria , BALAGUE PELAEZ, Cristina
IPC分类号： A61K31/455 , A61K31/505 , A61P17/00 , A61P35/00
CPC分类号： A61K31/455 , A61K31/505
摘要： Compositions comprising specific amino derivatives for their use in treating proliferative skin diseases or disorders and the use of specific amino derivatives in such a treatment is disclosed.
摘要翻译：公开了包含用于治疗增殖性皮肤疾病或病症的特定氨基衍生物的组合物和在这种治疗中使用特定氨基衍生物。

2. 发明申请

WO2005115462A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS 审中-公开
标题翻译：包含抗精神病药和PDE4抑制剂的组合
公开(公告)号：WO2005115462A1
公开(公告)日：2005-12-08
申请号：PCT/EP2005/005836
申请日：2005-05-31
申请人： ALMIRALL PRODESFARMA S.A. , GRAS ESCARDO, Jordi , LLENAS CALVO, Jesus , RYDER, Hamish , ORVIZ DIAZ, Pio
发明人： GRAS ESCARDO, Jordi , LLENAS CALVO, Jesus , RYDER, Hamish , ORVIZ DIAZ, Pio
IPC分类号： A61K45/00
CPC分类号： A61K31/439 , A61K9/0073 , A61K9/0075 , A61K31/137 , A61K31/138 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/277 , A61K31/407 , A61K31/44 , A61K31/4439 , A61K31/46 , A61K31/56 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/655 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： A combination which comprises (a) a PDE4 inhibitor and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid.
摘要翻译：包含（a）PDE4抑制剂和（b）3（R） - （2-羟基-2,2-二噻吩-2-基乙酰氧基）-1-（3-苯氧基丙基） - 哌嗪的M3毒蕈碱受体的拮抗剂的组合， 1-氮杂双环[2.2.2]辛烷，其为具有阴离子X的盐，其为单价或多价酸的药学上可接受的阴离子。

3. 发明申请

WO2006058724A1 NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES 审中-公开
标题翻译：新的吡啶并吡啶衍生物
公开(公告)号：WO2006058724A1
公开(公告)日：2006-06-08
申请号：PCT/EP2005/012774
申请日：2005-11-30
申请人： ALMIRALL PRODESFARMA, S.A. , PAGES SANTACANA, Lluis, Miquel , TALTAVULL MOLL, Joan
发明人： PAGES SANTACANA, Lluis, Miquel , TALTAVULL MOLL, Joan
IPC分类号： C07D495/14 , C07D495/22 , A61K31/519 , A61P11/06
CPC分类号： C07D495/14 , A61K31/519
摘要： Use of a pyridothienopyrimidine derivative of formula (I), and the pharmaceutically acceptable salts and N-oxides thereof, wherein G 1 represents a group selected from -CR 6 R 7 - or -NR 6 being R 6 and R 7 independently selected from hydrogen atoms and C 1-4 alkyl groups m and n are integers selected from 0 or 1 R 1 and R 2 are independently selected from hydrogen atoms and C 1-4 alkyl groups R 3 represents a group selected from alkyl, amino, monoalkylamino, dialkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groups bound through the nitrogen atom to the piridine ring, all of them being optionally substituted by one or more substituents selected from the group consisting of halogen atoms and alkyl, alkoxyalkyl, arylalkyl, R 8 OCO-, alkoxy, R 8 R 9 N-CO-, -CN, -CF 3 , -NR 8 R 9 , -SR 8 and - SO 2 NH 2 groups wherein R 8 and R 9 are independently selected from hydrogen atoms and C 1-4 alkyl groups R 4 and R 5 are independently selected from the group consisting of hydrogen atoms alkyl groups and groups of formula (II), wherein p and q are integers selected from 1, 2 and 3; A is either a direct bond or a group selected from -CONR 14 -, -NR 14 CO-, -O-, -COO-, -OCO-, -NR 14 OCO-, - OCONR 14 -, -NR 14 CONR 15 -, -S-, -SO-, -SO 2 -, -COS- and -SCO-; and G 2 is a group selected from aryl, heteroaryl or heterocyclyl; wherein the alkyl groups and the group G 2 are optionally substituted by one or more substituents selected from group consisting of halogen atoms and alkyl, alkoxyalkyl, arylalkyl, R 16 OCO-, hydroxy, alkoxy, oxo, R 16 R 17 NCO-, -CN, -CF 3 , -NR 16 R 17 , -SR 16 and -SO 2 NH 2 groups; wherein R 10 to R 17 are independently selected from hydrogen atoms and C 1-4 alkyl groups; in the manufacture of a medicament for the treatment or prevention of a pathological condition or disease susceptible to amelioration by inhibition of phosphodiesterase 4.
摘要翻译：式（I）的吡啶并噻吩并嘧啶衍生物及其药学上可接受的盐和N-氧化物的用途，其中G 1表示选自-CR 6， > 7 - 或-NR 6 - ，其中R 6和R 7独立地选自氢原子和C 1〜 4个烷基m和n是选自0或1的整数，R 1和R 2独立地选自氢原子和C 1-4 烷基R 3表示选自通过氮原子与吡啶环结合的烷基，氨基，单烷基氨基，二烷基氨基，芳基，杂芳基和饱和的含N的杂环基的基团，全部是它们任选地被一个或多个选自卤素原子和烷基，烷氧基烷基，芳基烷基，R 8 OCO-，烷氧基，R 8 O， > 9个N-CO-，-CN，-CF 3，-NR 8 R 9，-SR 8和 - SO

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