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1. 发明申请

WO2013015793A1 METHOD FOR DETERMINING THE PRESENCE OR ABSENCE OF DIFFERENT ANEUPLOIDIES IN A SAMPLE 审中-公开
标题翻译：确定样品中不同反应物存在或不存在的方法
公开(公告)号：WO2013015793A1
公开(公告)日：2013-01-31
申请号：PCT/US2011/045412
申请日：2011-07-26
申请人： VERINATA HEALTH, INC. , RAVA, Richard P. , COMSTOCK, David A. , RHEES, Brian K.
发明人： RAVA, Richard P. , COMSTOCK, David A. , RHEES, Brian K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6883 , C12Q2545/101 , C12Q2535/122 , C12Q2531/113
摘要： ABSTRACT OF THE DISCLOSURE The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the present method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample. Any aneuploidy can be determined from sequencing information that is obtained by sequencing only once the nucleic acids of a test sample.
摘要翻译：发明内容本发明提供了一种确定测试样品中感兴趣的序列的拷贝数变异（CNV）的方法，该方法包括已知或怀疑在一个或多个序列的量中不同的核酸的混合物利益。该方法包括统计方法，其考虑了由过程相关的染色体间和序列间变异性引起的应变变异性。该方法适用于确定任何胎儿非整倍性的CNV，以及已知或怀疑与各种医学状况相关的CNV。可以根据本方法确定的CNV包括染色体1-22，X和Y中的任何一个或多个的三体和单体，其他染色体多糖体，以及任何一个或多个染色体的区段的缺失和/或重复，其可以通过仅测试一次测试样品的核酸来检测。任何非整倍体都可以从通过测序一次核酸测试获得的测序信息来确定。

2. 发明申请

WO2008079227A1 STORAGE-STABLE GLUCOSE OXIDASE 审中-公开
标题翻译：储存稳定的葡萄糖氧化酶
公开(公告)号：WO2008079227A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/025923
申请日：2007-12-18
申请人： DANISCO US, INC., GENENCOR DIVISION , KELEMEN, Bradley, R. , LANTZ, Suzanne, E.
发明人： KELEMEN, Bradley, R. , LANTZ, Suzanne, E.
IPC分类号： C12N9/04 , A61K8/66
CPC分类号： C12Y101/03004 , A61K8/66 , A61Q19/00 , C12N9/0006 , C12N9/96
摘要： The present invention provides methods and compositions comprising at least one glucose oxidase enzyme, wherein the glucose oxidase has improved storage stability. In some preferred embodiments, the glucose oxidase enzyme is stable after exposure to elevated temperatures. In some alternative preferred embodiments, the glucose oxidase has improved storage stability in liquid formulations. In some particularly preferred embodiments, the present invention provides methods and compositions comprising glucose oxidase(s) obtained from Aspergillus sp. In some more particularly preferred embodiments, the glucose oxidase is obtained from A. niger. The present invention finds use in applications involving cleaning, including personal care applications.
摘要翻译：本发明提供包含至少一种葡萄糖氧化酶的方法和组合物，其中葡萄糖氧化酶具有改善的储存稳定性。在一些优选的实施方案中，葡萄糖氧化酶在暴露于升高的温度之后是稳定的。在一些替代的优选实施方案中，葡萄糖氧化酶在液体制剂中具有改善的储存稳定性。在一些特别优选的实施方案中，本发明提供了包含从曲霉属（Aspergillus sp。）获得的葡萄糖氧化酶的方法和组合物。在一些更特别优选的实施方案中，葡萄糖氧化酶得自黑曲霉。本发明用于涉及清洁的应用，包括个人护理应用。

3. 发明申请

WO2009094084A1 ENHANCED PROTEIN PRODUCTION IN BACILLUS 审中-公开
标题翻译：芽孢杆菌增强蛋白质产量
公开(公告)号：WO2009094084A1
公开(公告)日：2009-07-30
申请号：PCT/US2008/087633
申请日：2008-12-19
申请人： DANISCO US INC., GENENCOR DIVISION , CERVIN, Marguerite A. , FERRARI, Eugenio , POWER, Scott D.
发明人： CERVIN, Marguerite A. , FERRARI, Eugenio , POWER, Scott D.
IPC分类号： C12N15/09 , C12N15/67
CPC分类号： C12N15/63 , C07K14/32 , C12N15/75
摘要： The present invention relates to cells that have been genetically manipulated to have an altered capacity to express and/or produce proteins of interest. In particular, the present invention relates to modified host cells of Gram-positive microorganisms, such as Bacillus species that are capable of overexpressing ymaH. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode YmaH, and the modified host cells comprising them. In particular, the present invention relates to compositions and methods of overexpressing YmaH for enhancing the expression and production of proteins of interest (e.g., proteases) in Bacillus species.
摘要翻译：本发明涉及已被遗传操作以具有改变的表达和/或产生感兴趣的蛋白质的能力的细胞。具体而言，本发明涉及能够过表达ymaH的革兰氏阳性微生物的修饰宿主细胞，例如芽孢杆菌属物种。本发明包括含有编码YmaH的多核苷酸序列的多核苷酸构建体和表达载体，以及包含它们的修饰的宿主细胞。特别地，本发明涉及过表达YmaH用于增强芽孢杆菌属物种中感兴趣的蛋白质（例如蛋白酶）表达和产生的组合物和方法。

4. 发明申请

WO2014015319A1 SYSTEM FOR DETERMINING A COPY NUMBER VARIATION 审中-公开
标题翻译：用于确定复制数变化的系统
公开(公告)号：WO2014015319A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/051399
申请日：2013-07-19
申请人： VERINATA HEALTH, INC.
发明人： RAVA, Richard, P.
IPC分类号： C12Q1/68 , G06F19/22
CPC分类号： G06F19/3431 , C12Q1/6883 , G06F19/00 , G06F19/22 , G06F19/24 , G16H50/30
摘要： The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined accord ing to the method include trisomies and monosomies of any one or more of chromosomes 1 -22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.
摘要翻译：本发明提供了一种用于确定测试样品中感兴趣的序列的拷贝数变异（CNV）的方法，其包括已知或怀疑在一个或多个感兴趣序列的量上不同的核酸的混合物。该方法包括统计方法，其考虑了由过程相关的染色体间和序列间变异性引起的应变变异性。该方法适用于确定任何胎儿非整倍性的CNV，以及已知或怀疑与各种医学状况相关的CNV。可以根据该方法确定的CNV包括染色体1-22，X和Y中的任何一个或多个的三体和单体，其他染色体多糖，以及任何一个或多个染色体的区段的缺失和/或重复，其可以通过仅测试一次测试样品的核酸来检测。

5. 发明申请

WO2014014498A1 DETECTING AND CLASSIFYING COPY NUMBER VARIATION IN A FETAL GENOME 审中-公开
标题翻译：检测和分类在基因组中的复制数变化
公开(公告)号：WO2014014498A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/023909
申请日：2013-01-30
申请人： VERINATA HEALTH, INC. , RAVA, Richard, P. , CHINNAPPA, Manjula , COMSTOCK, David, A. , SRINIVASAN, Anupama
发明人： RAVA, Richard, P. , CHINNAPPA, Manjula , COMSTOCK, David, A. , SRINIVASAN, Anupama
IPC分类号： C12Q1/68 , G06F19/22
CPC分类号： C12Q1/6809 , G06F19/18 , G06F19/22 , C12Q2537/16 , C12Q2537/165 , C12Q2545/101
摘要： The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.
摘要翻译：本发明提供了一种用于确定测试样品中感兴趣的序列的拷贝数变异（CNV）的方法，其包括已知或怀疑在一个或多个感兴趣序列的量上不同的核酸的混合物。该方法包括统计方法，其考虑了由过程相关的染色体间和序列间变异性引起的应变变异性。该方法适用于确定任何胎儿非整倍性的CNV，以及已知或怀疑与各种医学状况相关的CNV。可以根据该方法确定的CNV包括染色体1-22，X和Y，其他染色体多糖体中的任何一个或多个的三体和单体，以及任何一个或多个染色体的区段的缺失和/或重复，其中只能通过测试一次测试样品的核酸来检测。

6. 发明申请

WO2009096916A1 EXPRESSION OF STREPTOMYCES SUBTILISIN INHIBITOR (SSI) PROTEINS IN BACILLUS AND STREPTOMYCES SP. 审中-公开
标题翻译：表达在BACILLUS和STREPTOMYCES中的溶血素抑制剂（SSI）蛋白质SP。
公开(公告)号：WO2009096916A1
公开(公告)日：2009-08-06
申请号：PCT/US2008/001250
申请日：2008-01-29
申请人： GENENCOR INTERNATIONAL, INC. , FOX, Bryan, P. , WANG, Huaming
发明人： FOX, Bryan, P. , WANG, Huaming
IPC分类号： C07K14/81
CPC分类号： C07K14/811
摘要： Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell that has a genome that contains inactivated protease genes.
摘要翻译：提供了包含编码含有信号序列和Streptomyces枯草杆菌蛋白酶抑制剂（SSI）蛋白的融合蛋白的重组核酸的链霉菌和芽孢杆菌宿主细胞，以及使用这些细胞产生SSI蛋白的方法。在某些实施方案中，宿主细胞是链霉菌宿主细胞，信号序列是celA信号序列。在其他实施方案中，宿主细胞是具有含有灭活的蛋白酶基因的基因组的芽孢杆菌宿主细胞。

7. 发明申请

WO2009058303A2 PRODUCTION OF THERMOLYSIN AND VARIANTS THEREOF AND USE IN LIQUID DETERGENTS 审中-公开
标题翻译：生产热变性蛋白酶及其变体，并用于液体洗涤剂
公开(公告)号：WO2009058303A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/012276
申请日：2008-10-28
申请人： DANISCO US INC., GENENCOR DIVISION , ESTELL, David A. , HOMMES, Ronaldus W. J. , LIU, Amy D. , SHAW, Andrew
发明人： ESTELL, David A. , HOMMES, Ronaldus W. J. , LIU, Amy D. , SHAW, Andrew
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性和/或催化活性的嗜热菌蛋白酶样中性蛋白酶的方法和组合物。在一些实施方案中，嗜热菌蛋白酶可用于清洁和其它包含洗涤剂的应用。在一些特别优选的实施方案中，本发明提供包含热溶菌素的方法和组合物，其配制和/或工程化以抵抗洗涤剂诱导的失活。

8. 发明申请

WO2012141712A1 NORMALIZING CHROMOSOMES FOR THE DETERMINATION AND VERIFICATION OF COMMON AND RARE CHROMOSOMAL ANEUPLOIDIES 审中-公开
标题翻译：正常化染色体用于确定和验证常见和罕见的染色体异常
公开(公告)号：WO2012141712A1
公开(公告)日：2012-10-18
申请号：PCT/US2011/032554
申请日：2011-04-14
申请人： VERINATA HEALTH, INC. , RAVA, Richard, P.
发明人： RAVA, Richard, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , G06F19/18 , C12Q2535/122 , C12Q2537/16 , C12Q2539/113
摘要： The present invention provides a method capable of detecting single or multiple fetal chromosomal aneuploidies in a maternal sample comprising fetal and maternal nucleic acids, and verifying that the correct determination has been made. The method is applicable to determining copy number variations (CNV) of any sequence of interest in samples comprising mixtures of genomic nucleic acids derived from two different genomes, and which are known or are suspected to differ in the amount of one or more sequence of interest. The method is applicable at least to the practice of noninvasive prenatal diagnostics, and to the diagnosis and monitoring of conditions associated with a difference in sequence representation in healthy versus diseased individuals.
摘要翻译：本发明提供了一种能够检测包含胎儿和母体核酸的母体样品中的单胎或多胎胎儿染色体非整倍体的方法，并验证是否进行了正确的确定。该方法适用于确定样品中的任何感兴趣的序列的拷贝数变异（CNV），其包含衍生自两个不同基因组的基因组核酸的混合物，其已知或被怀疑在一个或多个感兴趣序列的量上不同。该方法至少适用于无创产前诊断的实践，以及与健康与患病个体中序列表现差异相关的病症的诊断和监测。

9. 发明申请

WO2009023271A2 KAPPA-CARRAGEENASE AND KAPPA-CARRAGEENASE-CONTAINING COMPOSITIONS 审中-公开
标题翻译： KAPPA-CARRAGEENASE和含KAPPA-CARRAGEENASE的组合物
公开(公告)号：WO2009023271A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/009789
申请日：2008-08-15
申请人： DANISCO US INC., GENENCOR DIVISION , MCDONALD, Hugh, C. , SCHMIDT, Brian
发明人： MCDONALD, Hugh, C. , SCHMIDT, Brian
IPC分类号： C07K14/43
CPC分类号： C12Y302/01083 , C11D3/38636 , C12N9/2402
摘要： The present invention provides cleaning compositions comprising at least one carrageenase enzyme, methods for producing carrageenase enzymes in host cells, host cells comprising recombinant polynucleotides encoding at least one carrageenase, and recombinant polynucleotides encoding carrageenase.
摘要翻译：本发明提供了包含至少一种角叉菜
酶的清洁组合物，在宿主细胞中产生角叉菜
聚酶的方法，包含编码至少一种角叉菜
胶的重组多核苷酸的宿主细胞和编码角叉菜
酶的重组多核苷酸。

10. 发明申请

WO2008112258A3 MODIFIED PROTEASES 审中-公开
公开(公告)号：WO2008112258A3
公开(公告)日：2008-09-18
申请号：PCT/US2008/003291
申请日：2008-03-12
申请人： DANISCO US, INC., GENENCOR DIVISION , ESTELL, David, A. , FERRARI, Eugenio
发明人： ESTELL, David, A. , FERRARI, Eugenio
IPC分类号： C12N9/54
摘要： This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as Bacillus species. The invention discloses modified polynucleotides, vectors, modified polypeptides, and processes for enhancing the production of proteases.

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