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1. 发明申请

WO2007035271A1 BLOOD PRESSURE MEASURING APPARATUS 审中-公开
标题翻译：血压测量仪
公开(公告)号：WO2007035271A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/034909
申请日：2006-09-08
申请人： WELCH ALLYN, INC. , LIA, Raymond, A. , KARLA, Sean, R. , BURNETT, Stephen, W. , WHITAKER, Tyson, B. , GRANT, Thomas, J.
发明人： LIA, Raymond, A. , KARLA, Sean, R. , BURNETT, Stephen, W. , WHITAKER, Tyson, B. , GRANT, Thomas, J.
IPC分类号： A61B5/02
CPC分类号： A61B5/02233 , A61B5/02141 , A61B5/022 , G01L7/102 , G01L7/104 , G01L19/0007 , Y10T29/49826
摘要： Adaptive attachments used in combination with a blood pressure cuff enable various blood pressure measurements to be taken in a hospital or other setting having various single and/or dual lumen manual or electronic blood pressure measuring equipment with a single, patient-worn cuff.
摘要翻译：与血压套管结合使用的自适应附件使得能够在具有单个患者佩戴的袖带的具有各种单个和/或双流明手动或电子血压测量设备的医院或其他设置中进行各种血压测量。

2. 发明申请

WO2007032869A3 SELF-COMPENSATING BLOOD PRESSURE BLEED VALVE 审中-公开
公开(公告)号：WO2007032869A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/032814
申请日：2006-08-22
申请人： WELCH ALLYN, INC. , NEWMAN, Richard, W. , KRAUTER, Allan, I.
发明人： NEWMAN, Richard, W. , KRAUTER, Allan, I.
IPC分类号： A61B5/02 , F16K31/00 , F16K31/02 , F16K31/12 , F16K31/08 , F16K31/44 , F16K5/00
摘要： A bleed flow valve for venting air from a blood pressure cuff includes a valve body having an axially extending central bore. The central bore has a transition section, a fluid inlet port opening into the central bore upstream of the transition section and a fluid outlet port opening into the central bore downstream of the transition section. A piston is disposed within the central bore of the valve body and is axially translatable within the central bore of the valve body. An annular orifice is defined between an outer circumferential surface on the piston and the transition section of the central bore. The bleed valve is self-compensating as the pressure within the cuff decreases in that the piston self adjusts axially within the central bore to adjust the area of the annular orifice so as to maintain a relatively constant cuff pressure change rate throughout the deflation process.

3. 发明申请

WO2009064901A2 DIAGNOSTIC BIOMARKERS OF DIABETES 审中-公开
标题翻译：糖尿病诊断生物标志物
公开(公告)号：WO2009064901A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083424
申请日：2008-11-13
申请人： VERIDEX, LLC , PALMA, John, F. , BACKUS, John, W. , ZHANG, Yi , WANG, Yixin , YU, Jack, X. , VENER, Tatiana , DERECHO, Carlo , LEE, Dong, U.
发明人： PALMA, John, F. , BACKUS, John, W. , ZHANG, Yi , WANG, Yixin , YU, Jack, X. , VENER, Tatiana , DERECHO, Carlo , LEE, Dong, U.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.
摘要翻译：公开了用于鉴定在诊断患有糖尿病前状态和明显II型糖尿病的患者的PBMC中差异表达的基因组的方法，显示3个基因和10个基因特征以准确预测患者的糖尿病疾病状态。该应用还描述了在护理设施点的患者中快速诊断糖尿病疾病状态的试剂盒。

4. 发明申请

WO2009002334A1 MICROFLUIDIC DEVICE WITH ELASTOMERIC SEAL 审中-公开
标题翻译：具有弹性密封的微流体装置
公开(公告)号：WO2009002334A1
公开(公告)日：2008-12-31
申请号：PCT/US2007/066319
申请日：2007-06-26
申请人： WELCH ALLYN, INC. , DANNA, Dominick
发明人： DANNA, Dominick
IPC分类号： F16K31/00
CPC分类号： F16K15/188 , B01J19/0093 , B01J2219/00813 , B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0672 , B01L2300/0816
摘要： The invention comprises a low cost method of scaling and resealing a micro fluidic device before, during, and after communication of fluids into the microfluidic device. The invention includes a microfluidic device with fluid introduction ports substantially hermetically sealed with elastomeric plugs, wherein the plugs can be penetrated by hollow needles to introduce fluids such as air, water, ethanol, or other chemical or biological reagents into the device while maintaining a substantially hermetic seal. The invention includes a method for introducing fluids into a microfluidic device from an external source. The method comprises the steps of penetrating fluid introduction ports substantially hermetically sealed with elastomeric plugs with hollow needles connected to a fluid source, pumping fluid into the device, and removing the hollow needle from the plug, whereupon plug self-reseals to form a substantially hermetic seal.
摘要翻译：本发明包括在流体进入微流体装置之前，期间和之后将微流体装置缩放和重新密封的低成本方法。本发明包括具有基本上用弹性体塞密封的流体引入端口的微流体装置，其中塞子可被空心针穿透，以将诸如空气，水，乙醇或其他化学或生物试剂的流体引入装置中，同时保持基本上气密封。本发明包括从外部源将流体引入微流体装置的方法。该方法包括以下步骤：将具有弹性体塞的基本上气密密封的流体引入口穿过，所述弹性体塞具有连接到流体源的中空针，将流体泵送到所述装置中，以及从所述塞子中移出所述空心针，由此插头自发地形成基本上密封的密封。

5. 发明申请

WO2007033074A2 BLOOD PRESSURE BLEED VALVE ASSEMBLY 审中-公开
标题翻译：血压控制阀组件
公开(公告)号：WO2007033074A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/035302
申请日：2006-09-12
申请人： WELCH ALLYN, INC. , KRAUTER, Allan, I.
发明人： KRAUTER, Allan, I.
IPC分类号： A61B5/02
CPC分类号： A61B5/0235
摘要： A bleed flow valve assembly for venting air from a blood pressure cuff at relatively constant pressure decrease rate irrespective of cuff size includes a multiple chamber bleed valve and a multiple position control valve operatively associated therewith. A first end chamber is connected in pneumatic communication with the cuff and pneumatically sealed from a second central chamber by a first flexible diaphragm. A third end chamber is separated from the central chamber by a second flexible diaphragm. A variable flow area opening through the second diaphragm provides a flow path for controllably venting air from the second chamber to ambient pressure when the control valve is selectively positioned to connect the third chamber in pneumatic communication with ambient pressure. Air is vented from the cuff through the first chamber in regulated response to the pressure differential between the first chamber and the second chamber acting upon the first flexible diaphragm.
摘要翻译：用于以相对恒定的压力下降速率从血压套管排出空气的排出流量阀组件（不考虑套管尺寸）包括多腔室排出阀和与其可操作地相关联的多位置控制阀。第一端室与套囊气动连通地连接并且通过第一柔性隔膜与第二中心室气动密封。第三端室通过第二柔性隔膜与中央室隔开。当控制阀选择性地定位以将气动连通的第三腔室与环境压力连接时，通过第二隔膜开口的可变流动面积提供用于可控地将空气从第二腔室排放到环境压力的流动路径。响应于作用在第一柔性隔膜上的第一腔室和第二腔室之间的压差，空气从套管通过第一腔室排出。

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