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1. 发明申请

WO2016024914A1 A METHOD AND SYSTEM FOR ASSISTING IN IMPROVING SPEECH OF A USER IN A DESIGNATED LANGUAGE 审中-公开
标题翻译：一种用于帮助改进指定语言中的用户的演讲的方法和系统
公开(公告)号：WO2016024914A1
公开(公告)日：2016-02-18
申请号：PCT/SG2014/000385
申请日：2014-08-15
申请人： IQ-HUB PTE. LTD.
发明人： TOPOLEWSKI, David, L. , SCHOLZ, Karl, W.
IPC分类号： G10L25/51 , G10L15/06
CPC分类号： G10L25/51
摘要： A system and method of assisting in improving speech of a user in a designated language, the method including: receiving text in the designated language, or in another language, from the user to be spoken by the user in the designated language; processing the text to derive one or more expected properties of speech of the text in the designated language; receiving audio of the user speaking the text in the designated language; processing the audio to derive one or more properties of the user speaking the text; comparing said one or more properties of the user speaking the text to corresponding ones of said one or more expected properties of said speech of the text to determine an accuracy of the user speaking the text; and outputting feedback to the user indicative of the accuracy.
摘要翻译：一种辅助以指定语言改善用户语音的系统和方法，所述方法包括：以指定语言从用户接收用户以指定语言或另一种语言接收的语音; 处理文本以导出指定语言的文本的语音的一个或多个预期属性; 接收以指定语言说出文本的用户的音频; 处理音频以导出说出文本的用户的一个或多个属性; 将说出文本的用户的所述一个或多个属性与所述文本的所述语音的所述一个或多个预期属性中的相应的属性进行比较，以确定所述用户在说话时的准确性; 并向用户输出指示精度的反馈。

2. 发明申请

WO2015012762A1 FLYING BOAT 审中-公开
标题翻译：飞艇
公开(公告)号：WO2015012762A1
公开(公告)日：2015-01-29
申请号：PCT/SG2013/000307
申请日：2013-07-24
申请人： AHMAD BIN ABU BAKAR
发明人： AHMAD BIN ABU BAKAR
IPC分类号： B64C31/02 , B64C31/00 , B64C25/54 , B63B35/50 , B63B35/66 , B63B35/68 , B63B38/00
CPC分类号： B63B35/73 , B63B35/00 , B63B35/815 , B63B2035/008 , B64C37/02
摘要： A flying boat 10 comprises a flying part 1 1 adapted to float on a body of water 12 and fly through air, and a propulsion unit 13 which is separate from the flying part 1 1. The propulsion unit 13 being adapted to float on the body of water 12, propel itself along the body of water 12, and to be controlled remotely. The flying part 1 1 and the propulsion unit 13 being, connected to each other such that the propulsion unit 13 is able to tow the flying part 1 1 so that the flying part 11 is thereby able to be propelled along the body of water 12 and through the air.
摘要翻译：飞行艇10包括适于浮在水体12上并飞过空气的飞行部分11以及与飞行部分11分离的推进单元13.推进单元13适于在主体上浮动的水12，沿着水体12推进，并被远程控制。飞行部分11和推进单元13彼此连接，使得推进单元13能够拖动飞行部分11，使得飞行部分11因此能够沿着水体12推进，并且通过空气

3. 发明申请

WO2011008172A1 9E-15-(2-PYRROLIDIN-1-YL-ETHOXY)-7,12,25-TRIOXA-19,21,24-TRIAZA- TETRACYCLO[18.3.1.1(2,5).1(14)18)]HEXACOSA-1(24),2,4,9,14,16,18(26),20,22-NONAENE CITRATE SALT 审中-公开
标题翻译： 9E-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-二氧代-19,21,24-三唑-1-基] [18.3.1.1（2,5）.1（14）18）] HEXACOSA-1（24），2,4,9,14,16,18（26），20,22-NONAENE CITRATE SALT
公开(公告)号：WO2011008172A1
公开(公告)日：2011-01-20
申请号：PCT/SG2010/000265
申请日：2010-07-14
申请人： S*BIO PTE LTD , DYMOCK, Brian , LEE, Cheng Hsia, Angeline , WILLIAM, Anthony, Deodaunia
发明人： DYMOCK, Brian , LEE, Cheng Hsia, Angeline , WILLIAM, Anthony, Deodaunia
IPC分类号： C07D498/12 , A61K31/519 , A61P35/00
CPC分类号： C07D498/18
摘要： The present invention relates to certain salts of a 9E-15-(2-pyrrolidin-1-yl-ethoxy)- 7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1 (2,5).1(14,18)]hexacosa-1 (24),2,4,9,14,16,18(26),20,22-nonaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.
摘要翻译：本发明涉及9E-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-三氧杂-9,21,24-三氮杂 - 四环[18.3.1.1（2,5 ）（II）（14,18）]二十六碳-1（24），2,4,9,14,16,18（26），20,22-非烯（化合物I）。特别地，本发明涉及该化合物的柠檬酸盐。本发明还涉及含有柠檬酸盐的药物组合物和柠檬酸盐在使用某些医疗条件下的使用方法。

4. 发明申请

WO2009045174A1 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K 审中-公开
标题翻译：作为PI3K的抑制剂的2-吗啉基
公开(公告)号：WO2009045174A1
公开(公告)日：2009-04-09
申请号：PCT/SG2008/000378
申请日：2008-10-03
申请人： S*BIO PTE LTD , NAGARAJ, Harish, Kumar, Mysore , CHEN, Dizhong , POULSEN, Anders , WILLIAMS, Meredith
发明人： NAGARAJ, Harish, Kumar, Mysore , CHEN, Dizhong , POULSEN, Anders , WILLIAMS, Meredith
IPC分类号： C07D473/32 , A61K31/52 , A61P35/00
CPC分类号： C07D473/32
摘要： The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.
摘要翻译：本发明涉及可用作激酶抑制剂的嘌呤化合物。更具体地，本发明涉及嘌呤化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在增殖性疾病的治疗中的用途。这些化合物可用作治疗许多增殖性疾病的药物，包括肿瘤和癌症以及与mTOR激酶相关或与之相关的其它病症或病症。

5. 发明申请

WO2007058628A1 HETEROALKYL LINKED PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：异环醇连接的吡嗪衍生物
公开(公告)号：WO2007058628A1
公开(公告)日：2007-05-24
申请号：PCT/SG2006/000353
申请日：2006-11-15
申请人： S*BIO PTE LTD , BLANCHARD, Stéphanie , ETHIRAJULU, Kantharaj , LEE, Cheng Hsia, Angeline , NAGARAJ, Harish, Kumar, Mysore , POULSEN, Anders , SUN, Eric, T. , TAN, Yee Ling, Evelyn , TEO, Ee Ling , WILLIAM, Anthony, Deodaunia
发明人： BLANCHARD, Stéphanie , ETHIRAJULU, Kantharaj , LEE, Cheng Hsia, Angeline , NAGARAJ, Harish, Kumar, Mysore , POULSEN, Anders , SUN, Eric, T. , TAN, Yee Ling, Evelyn , TEO, Ee Ling , WILLIAM, Anthony, Deodaunia
IPC分类号： C07D498/02 , A61P35/00 , C07D495/12 , A61K31/505 , A61P35/02 , C07D498/12
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.
摘要翻译：本发明涉及可用作抗增殖剂的嘧啶化合物。更具体地，本发明涉及杂烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关的其它病症或病症的药物。

6. 发明申请

WO2007030080A1 HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：杂环化合物
公开(公告)号：WO2007030080A1
公开(公告)日：2007-03-15
申请号：PCT/SG2006/000217
申请日：2006-08-01
申请人： S*BIO PTE LTD , CHEN, Dizhong , DENG, Weiping , LEE, Ken, Chi, Lik , LYE, Pek Ling , SUN, Eric, T , WANG, Haishan , YU, Niefang
发明人： CHEN, Dizhong , DENG, Weiping , LEE, Ken, Chi, Lik , LYE, Pek Ling , SUN, Eric, T , WANG, Haishan , YU, Niefang
IPC分类号： C07D235/04 , A61K31/4184 , A61P25/00 , A61P29/00 , A61P35/00 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/16 , C07D235/22 , C07D401/04 , C07D403/04
CPC分类号： C07D235/08 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D401/04 , C07D403/04
摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。更具体地说，本发明涉及杂环化合物及其制备方法。这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。

7. 发明申请

WO2006101456A1 BICYCLIC HETEROCYCLES HYDROXAMATE COMPOUNDS USEFUL AS HISTONE DEACETYLASE (HDAC) INHIBITORS 审中-公开
标题翻译：双相异源杂环化合物可用作HISTONE脱乙酰壳多糖（HDAC）抑制剂
公开(公告)号：WO2006101456A1
公开(公告)日：2006-09-28
申请号：PCT/SG2006/000065
申请日：2006-03-20
申请人： S*BIO PTE LTD , YU, Niefang , DENG, Weiping , CHEN, Dizhong , ZHOU, Yifa
发明人： DENG, Weiping , CHEN, Dizhong , ZHOU, Yifa
IPC分类号： C07D403/06 , A61P27/02 , C07D231/56 , A61K31/404 , A61P35/00 , C07D403/12 , A61K31/4188 , C07D209/14 , C07D471/04 , A61P3/10 , C07D209/18 , A61P25/28 , C07D209/20
CPC分类号： C07D231/56 , C07D209/08 , C07D209/14 , C07D209/86 , C07D471/04
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。更具体地说，本发明涉及含杂环化合物及其制备方法。这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。

8. 发明申请

WO2006101455A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：咪唑并[1,2-A]吡啶衍生物：制备和药物应用
公开(公告)号：WO2006101455A1
公开(公告)日：2006-09-28
申请号：PCT/SG2006/000064
申请日：2006-03-20
申请人： S*BIO PTE LTD , LEE, Ken, Chi, Lik , SUN, Eric, T
发明人： LEE, Ken, Chi, Lik , SUN, Eric, T
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

9. 发明申请

WO2016148637A1 ELECTROLYSIS SYSTEM 审中-公开
标题翻译：电解系统
公开(公告)号：WO2016148637A1
公开(公告)日：2016-09-22
申请号：PCT/SG2015/000077
申请日：2015-03-13
申请人： H2SG ENERGY PTE LTD
发明人： IZGORODIN, Ivan , IZGORODIN, Alexey
IPC分类号： C25B1/04 , C25C7/00 , C25B9/00 , C25B15/00
CPC分类号： C25B15/02 , C25B1/10 , C25B9/00 , C25B9/10 , C25B15/08 , Y02E60/366
摘要： An electrolysis cell system (100) for producing hydrogen and oxygen from water comprising: at least ope electrolysis cell (101) including a membrane electrode assembly (102) which comprises at least one pair of gas permeable electrodes (107, 109) comprising an anode (107) and a cathode (109), and an ion conductive electrolyte (108) arranged between each pair of anode (107) and cathode (109); an electrode gas space (104, 106) on the non-electrolyte side of each electrode (107, 109) comprising an anode gas space (104) and a cathode gas space (106), at least one electrode gas space (104) including an inlet (130) and an outlet (132); a recirculating loop (143) for recirculating at least a portion of produced oxygen product gas from the outlet (132) of at least one electrode gas space (104) to the inlet (130) of the respective electrode gas space (104) and through the respective electrode gas space (104); a water supply vessel (142) in fluid communication with the recirculating loop (143), the water supply vessel (142) vaporising water from a water supply (144) utilising heat of vaporisation provided by the respective product gas in the recirculating loop (143) and feeding said water vapour into the recirculating loop (143); and a heat transfer arrangement (105) for transferring heat between the membrane electrode assembly (102) and gas in the anode gas space (104) located in the electrode gas space (104) fluidly connected to the recirculating loop through the inlet and outlet thereof, wherein the heat transfer arrangement (105) is in contact with the membrane electrode assembly (102) and also allows for gas circulation between the membrane electrode assembly (102) and the respective gas space (104).
摘要翻译：一种用于从水中生成氢和氧的电解池系统（100），包括：至少包含膜电极组件（102）的电解电解池（101），所述膜电极组件包括至少一对气体可渗透电极（107,109），其包括阳极（107）和阴极（109）以及布置在每对阳极（107）和阴极（109）之间的离子传导性电解质（108）。包括阳极气体空间（104）和阴极气体空间（106）的每个电极（107,109）的非电解质侧的电极气体空间（104,106），至少一个电极气体空间（104）入口（130）和出口（132）; 用于将至少一部分产生的产物气体从至少一个电极气体空间（104）的出口（132）再循环到相应电极气体空间（104）的入口（130）并通过各个电极气体空间（104）; 与所述循环回路（143）流体连通的供水容器（142），所述供水容器（142）利用由所述再循环回路（143）中的各个产物气体提供的蒸发热来蒸发来自供水（144）的水）并将所述水蒸气进料到所述再循环回路（143）中; 以及传热装置（105），用于在膜电极组件（102）和位于通过其入口和出口流体连接到再循环回路的电极气体空间（104）中的阳极气体空间（104）中的热量之间传递热量，其中所述传热装置（105）与所述膜电极组件（102）接触并且还允许所述膜电极组件（102）和所述相应气体空间（104）之间的气体循环。

10. 发明申请

WO2011078795A1 BRIDGED MORPHOLINO SUBSTITUTED PURINES 审中-公开
标题翻译： BRIDGED MORPHOLINO取代的皮革
公开(公告)号：WO2011078795A1
公开(公告)日：2011-06-30
申请号：PCT/SG2010/000474
申请日：2010-12-16
申请人： S*BIO PTE LTD , BLANCHARD, Stéphanie , DIZHONG, Chen , HARISH, Kumar, Mysore, Nagaraj , MEREDITH, Williams
发明人： BLANCHARD, Stéphanie , DIZHONG, Chen , HARISH, Kumar, Mysore, Nagaraj , MEREDITH, Williams
IPC分类号： C07D519/00 , A61K31/5386 , A61P35/00 , A61P35/02 , A61P35/04 , A61P29/00 , A61P25/28 , A61P25/16 , A61P17/06 , A61P19/02 , A61P37/08 , A61P9/00 , A61P9/10 , A61P3/10
CPC分类号： C07D519/00
摘要： The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative conditions or disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative conditions or disorders including tumours and cancers as well as other disorders or conditions related to or associated with PI3K and/or mTOR kinases.
摘要翻译：本发明涉及可用作激酶抑制剂的嘌呤化合物。更具体地，本发明涉及嘌呤化合物，其制备方法，含有这些化合物的药物组合物以及这些化合物在治疗增殖性疾病或病症中的用途。这些化合物可用作治疗多种增殖性病症或病症的药物，包括肿瘤和癌症以及与PI3K和/或mTOR激酶相关或相关的其它病症或病症。

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