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1. 发明申请

WO2003008057A1 A GAME DEVICE 审中-公开
标题翻译：游戏设备
公开(公告)号：WO2003008057A1
公开(公告)日：2003-01-30
申请号：PCT/GB2002/003053
申请日：2002-07-03
申请人： MCNALLY EGC LIMITED , MCNALLY, Gordon , BENTLEY, John, Ransome
发明人： MCNALLY, Gordon , BENTLEY, John, Ransome
IPC分类号： A63F3/06
CPC分类号： G07C15/006 , A63F3/0645
摘要： A card-like game device (2) includes a play push-button (4), a hold push-button (6) and a lock push-button (8). Five display windows (10) and five corresponding display windows (12) are spaced along the device in two parallel straight lines. The device is powered by batteries or solar cells (14) and the window (16) displays relevant information. To play the game the player chooses five numbers which are displayed in the windows (12). The lock button (8) is pressed to unlock the device, and the play button (4) is then pressed to start the game. Numbers move across the display windows (10) until numbers come to rest in sequence in all the windows (10). If a number in a display window (10) matches a number in the corresponding window (12) this is classed as a win. Any winning number in the windows (10) can be held and rolled over into the next game by pressing the hold button (6). Alternatively the lock button (8) can be pressed to retain any winning number in the windows (10) and to prevent any further games being played.
摘要翻译：卡式游戏装置（2）包括播放按钮（4），保持按钮（6）和锁定按钮（8）。五个显示窗口（10）和五个对应的显示窗口（12）沿着设备以两条平行的直线间隔开。该设备由电池或太阳能电池（14）供电，窗口（16）显示相关信息。播放游戏时，播放器选择窗口中显示的五个数字（12）。按下锁定按钮（8）以解锁设备，然后按下播放按钮（4）开始游戏。数字在显示窗口中移动（10），直到数字在所有窗口中依次休息（10）。如果显示窗口（10）中的数字与相应窗口（12）中的数字相匹配，则将其归为一个赢。通过按住按钮（6），可以将窗口（10）中的任何获胜号码保持并滚动到下一个游戏中。或者，可以按下锁定按钮（8）以将任何获胜号码保留在窗口（10）中，并且防止进行任何进一步的游戏。

2. 发明公开

EP1297007A2 MAMMALIAN PROTEIN PHOSPHATASES 审中-公开
标题翻译：哺乳动物蛋白磷酸酶
公开(公告)号：EP1297007A2
公开(公告)日：2003-04-02
申请号：EP01939611.8
申请日：2001-05-30
申请人： Sugen, Inc.
发明人： PLOWMAN, Gregory, D. , WHYTE, David , SUDARSANAM, Sucha , MANNING, Gerard , CAENEPEEL, Sean , MARTINEZ, Ricardo , HILL, Ronald, J. , FLANAGAN, Peter
IPC分类号： C07K14/47
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.

3. 发明公开

EP1261636A2 HUMAN PROTEIN KINASES AND PROTEIN KINASE-LIKE ENZYMES 审中-公开
标题翻译：新的人类蛋白激酶和蛋白激酶相关酶
公开(公告)号：EP1261636A2
公开(公告)日：2002-12-04
申请号：EP01913283.6
申请日：2001-03-02
申请人： Sugen, Inc.
发明人： PLOWMAN, Gregory, D. , WHYTE, David , MANNING, Gerard , SUDARSANAM, Sucha , MARTINEZ, Ricardo
IPC分类号： C07K14/47 , C12N9/12 , A61K38/45 , C07K16/46
CPC分类号： C07K16/40 , C12N9/1205 , C12Q1/485 , G01N2500/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.

4. 发明公开

EP1247803A2 Indolinone compounds suitable for modulation of protein kinases 失效
标题翻译：吲哚满酮化合物和它们作为蛋白激酶调节剂的用途
公开(公告)号：EP1247803A2
公开(公告)日：2002-10-09
申请号：EP02077564.9
申请日：1997-08-20
申请人： Sugen, Inc.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C07D209/34 , C07D409/06 , C07D403/06 , A61K31/40
CPC分类号： C07D401/06 , C07D209/34 , C07D403/06 , C07D405/06 , C07D409/06 , C07D455/06 , C07D495/04
摘要： The invention relates to indolinone compounds capable of modulating, regulating and/or inhibiting protein kinases. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction.

5. 发明公开

EP1173189A1 ASIALOCYTOKINES AND TREATMENT OF LIVER DISEASE 审中-公开
标题翻译： ASIALOZYTOKINE和肝脏疾病治疗
公开(公告)号：EP1173189A1
公开(公告)日：2002-01-23
申请号：EP00926393.0
申请日：2000-04-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TAKAHASHI, Hiroshi
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A01K67/0271 , A61K38/215 , C07K14/52 , C07K14/555 , C12Q1/6804 , C12Q1/706
摘要： The invention features methods for treating liver disease (e.g., viral hepatitis) by administering an asialocytokine (e.g., asialointerferon). The invention also includes methods of targeting a glycoprotein to a hepatocyte and a composition containing an asialocytokine.

6. 发明授权

EP0874854B1 CEPHALOSPORIN ANTIBIOTICS 失效
标题翻译：头孢菌素类抗生素
公开(公告)号：EP0874854B1
公开(公告)日：2001-12-12
申请号：EP96936406.6
申请日：1996-10-11
申请人： Microcide Pharmaceuticals, Inc.
发明人： CHO, In-Seop , HECKER, Scott , GLINKA, Tomasz , LEE, Ving, J. , ZHANG, Zhijia, J.
IPC分类号： C07D501/59 , A61K31/545
CPC分类号： C07D501/00
摘要： The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to β-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.

7. 发明公开

EP1048765A3 A multi-axial yarn structure forming machine 有权
标题翻译：用于制造多轴向纱结构的装置
公开(公告)号：EP1048765A3
公开(公告)日：2001-09-19
申请号：EP00302965.9
申请日：2000-04-07
申请人： SHORT BROTHERS PLC
发明人： Wilson, Robert Samuel
IPC分类号： D03D41/00
CPC分类号： D03D41/004 , Y10S139/01
摘要： In forming a multi-axial yarn structure (10) a bias yarn assembly forming device (18) makes use of cooperating yarn guide and yarn transfer members (21,22) having yarn guide elements (26,28) defining guide and transfer openings (27,29) which hold warp yarns (11,12) spaced apart in the weft direction. Warp yarn transfer from an opening in one member to an opening in the other member is facilitated by providing the guide elements (26,28) of the two members (21,22) with cooperating complementary salient and re-entrant inclined end portions (263,283). Furthermore, a yarn diverter blade (292) extends from the end portion (263,283) of each guide element (26,28) of one of the members (21,22) to hold the transferring yarns (11,12) away from the junctions (290,291) between the cooperating end portions (263,283) of the guide elements (26,28). To facilitate insertion of binding warp yarns (13) two sets (18A,18B) of yarn guide and yarn transfer members are provided to hold the yarns (11,12) spaced apart to form binding warp yarn insertion zones (301) between the two sets (18A,18B). A yarn beat-up member (305) carries out successive beat-up cycles in cooperation with a yarn engagement transfer member (306) which assists the beat-up member (305) during the beat-up cycle.

8. 发明授权

EP0861430B1 METHOD FOR QUANTIFICATION OF BIOLOGICAL MATERIAL IN A SAMPLE 失效
标题翻译：方法生物材料在样本数量化
公开(公告)号：EP0861430B1
公开(公告)日：2001-08-16
申请号：EP96939667.0
申请日：1996-11-12
申请人： BioControl Systems, Inc.
发明人： CROTEAU, Andrew, J. , PIERSON, Mark, W. , TOWNSEND, David, E. , NAQUI, Ali
IPC分类号： G01N1/00 , B01L3/00 , C12M1/20
CPC分类号： B01L3/5088 , B01L3/5085 , C12M23/10 , C12M23/12 , C12M23/20 , C12M23/38 , C12M41/36
摘要： Method for detection of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquefied sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.

9. 发明公开

EP1100941A2 ANTI-ANGIOGENESIS PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：抗血管生成PLASMIDE和应用系统及方法生产和使用
公开(公告)号：EP1100941A2
公开(公告)日：2001-05-23
申请号：EP99938769.9
申请日：1999-07-20
申请人： Valentis Inc.
发明人： MIN, Wang , SZYMANSKI, Paul , MEHRENS, Dorothy , RALSTON, Robert , SULLIVAN, Sean
IPC分类号： C12N15/85 , C12N15/55 , C12N15/12 , C12N15/88 , A61K48/00
CPC分类号： C12N9/6435 , A61K38/00 , A61K48/00 , C07K14/78 , C12N15/85 , C12N15/88 , C12N2830/007 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/85 , C12N2840/203 , C12Y304/21007
摘要： The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of anti-angiogenic agents in a mammal, formualtions for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic anti-angiogenic encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.

10. 发明公开

EP1059293A1 Novel amino chlorothiazole compounds 失效
标题翻译：新型氨基氯噻唑化合物
公开(公告)号：EP1059293A1
公开(公告)日：2000-12-13
申请号：EP00202566.6
申请日：1996-10-11
申请人： Microcide Pharmaceuticals, Inc.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C07D277/593
CPC分类号： C07D277/587
摘要： The invention relates to novel amino chlorothiazole compounds and to novel methods for producing the novel compounds. The compounds are useful in the production of cephalosporin antiobiotics.
摘要翻译：本发明涉及新的氨基氯噻唑化合物以及制备该新化合物的新方法。这些化合物可用于生产头孢菌素类抗生素。

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