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1. 发明申请

WO2021165424A1 AGENTS FOR USE IN THE TREATMENT OF TISSUE DAMAGE 2 审中-公开
公开(公告)号：WO2021165424A1
公开(公告)日：2021-08-26
申请号：PCT/EP2021/054072
申请日：2021-02-18
申请人： UCL BUSINESS PLC
发明人： PEPYS, Mark Brian , SWAIN, Christopher , TAYLOR, Graham Walter , WOOD, Stephen Paul , GLOSSOP, Melanie Susanne , LANE, Charlotte Alice Louise
IPC分类号： A61K31/438 , A61K45/06
摘要： An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

2. 发明申请

WO2019243313A1 PEPTIDE LIGANDS FOR BINDING TO EphA2 审中-公开
公开(公告)号：WO2019243313A1
公开(公告)日：2019-12-26
申请号：PCT/EP2019/065993
申请日：2019-06-18
申请人： BICYCLERD LIMITED
发明人： TEUFEL, Daniel , MUDD, Gemma , PAVAN, Sylvia
IPC分类号： C07K7/08 , A61P35/00 , A61K47/64 , C07K14/00
摘要： A peptide ligand specific for EphA2 comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3- diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N- HAlkDap), with the proviso that at least one of said three residues is selected from Dap, N- AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold.

3. 发明申请

WO2019064205A1 ALKALINE BATTERY SEPARATORS HAVING CONTROLLED PORE SIZE 审中-公开
公开(公告)号：WO2019064205A1
公开(公告)日：2019-04-04
申请号：PCT/IB2018/057465
申请日：2018-09-26
申请人： SWM INTL
发明人： DERRIEN, Stéphane
IPC分类号： H01M2/16 , C08L1/02 , D01F2/00
CPC分类号： H01M2/1626 , C08L1/02 , H01M2/162
摘要： An alkaline battery separator comprising a blend of polyvinyl alcohol and a cellulose derivative having a controlled pore size including highly fibrillating a cellulose derivative, and, optionally, cellulose and combining with PVA. A method of making an alkaline battery separator comprising a blend of polyvinyl alcohol and a cellulose derivative having a controlled pore size is further included.

4. 发明申请

WO2015169927A1 REDUCTION OF NICOTINE TO NORNICOTINE CONVERSION IN PLANTS 审中-公开
标题翻译：在植物中减少非诺贝宁转化率
公开(公告)号：WO2015169927A1
公开(公告)日：2015-11-12
申请号：PCT/EP2015/060124
申请日：2015-05-07
申请人： PHILIP MORRIS PRODUCTS S.A.
发明人： LIEDSCHULTE, Verena , GOEPFERT, Simon , BOVET, Lucien , SIERRO, Nicolas
IPC分类号： C12N15/82 , C12N9/02 , A01H5/00
CPC分类号： C12N15/8243 , C12N9/0073 , C12N15/8218 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Y114/13
摘要： The present invention relates to a mutant, non-naturally occurring or transgenic tobacco plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a functional nicotine N-demethylase and having at least 95% sequence identity to SEQ ID NO:2; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence encoding a nicotine N-demethylase and having at least 95% sequence identity to SEQ ID NO:3; or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i), and wherein the expression or activity of said nicotine demethylase is reduced as compared to a control tobacco plant cell in which the expression or activity of said nicotine demethylase has not been reduced.
摘要翻译：本发明涉及一种突变体，非天然存在或转基因烟草植物细胞，其包含：（i）多核苷酸，其包含，组成或者基本上由编码功能性尼古丁N-脱甲基酶的序列组成，并且与SEQ ID不得少于95％的序列同一性编号：2; （ii）由（i）中列出的多核苷酸编码的多肽; （iii）包含编码尼古丁N-脱甲基酶并且与SEQ ID NO：3具有至少95％序列同一性的序列的基本上由或由其组成的多肽; 或（iv）包含（i）所述的分离的多核苷酸的构建体，载体或表达载体，并且其中所述尼古丁脱甲基酶的表达或活性与对照烟草植物细胞相比，其中所述烟碱脱甲基酶的表达或活性尼古丁脱甲基酶尚未减少。

5. 发明申请

WO2013037484A2 ANTI-APLHABETATCR ANTIBODY 审中-公开
标题翻译：抗APLHABETATCR抗体
公开(公告)号：WO2013037484A2
公开(公告)日：2013-03-21
申请号：PCT/EP2012/003819
申请日：2012-09-12
申请人： GENZYME CORPORATION , SNELL, Daniel , MENRAD, Andreas , LACORCIA, Gina , SHANKARA, Shrinivas , QIU, Huawei , PAN, Clark
发明人： SNELL, Daniel , MENRAD, Andreas , LACORCIA, Gina , SHANKARA, Shrinivas , QIU, Huawei , PAN, Clark
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2893 , C07K2317/24 , C07K2317/31 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized monoclonal antibodies comprising the CDRs of murine antibody BMA031, which bind to the apTCR.CD3 complex and possess improved biological properties.
摘要翻译：本发明涉及包含鼠抗体BMA031的CDR的人源化单克隆抗体，其与apTCR.CD3复合物结合并具有改善的生物学性质。

6. 发明申请

WO2013034300A2 SYSTEMS AND METHODS FOR NETWORK-BASED BIOLOGICAL ACTIVITY ASSESSMENT 审中-公开
标题翻译：用于基于网络的生物活性评估的系统和方法
公开(公告)号：WO2013034300A2
公开(公告)日：2013-03-14
申请号：PCT/EP2012/003760
申请日：2012-09-07
申请人： PHILIP MORRIS PRODUCTS S.A , MARTIN, Florian
发明人： MARTIN, Florian
IPC分类号： G06F19/00
CPC分类号： G06F19/36 , G06F19/12
摘要： Systems and methods are disclosed herein for quantifying the response of a biological system to one or more perturbations based on measured activity data from a subset of the entities in the biological system. Based on the activity data and a network model of the biological system that describes the relationships between measured and non-measured entities, activities of entities that are not measured are inferred. The inferred activities are used for deriving a score quantifying the response of the biological system to a perturbation such as a response to a treatment condition. The score may be representative of the magnitude and topological distribution of the response of the network to the perturbation.
摘要翻译：本文公开了用于基于来自生物系统中的实体的子集的测量的活动数据来量化生物系统对一个或多个扰动的响应的系统和方法。基于描述测量和未测量实体之间关系的生物系统的活动数据和网络模型，推断未测量实体的活动。推断的活动被用于导出量化生物系统对干扰的响应的评分，例如对治疗状况的响应。得分可能代表网络对扰动响应的幅度和拓扑分布。

7. 发明申请

WO2012010855A1 INTRACELLULAR IMMUNITY 审中-公开
标题翻译：细胞免疫
公开(公告)号：WO2012010855A1
公开(公告)日：2012-01-26
申请号：PCT/GB2011/001116
申请日：2011-07-25
申请人： MEDICAL RESEARCH COUNCIL , JAMES, Leo, C. , MALLERY, Donna, L. , MCEWAN, William, A. , BIDGOOD, Susanna, R.
发明人： JAMES, Leo, C. , MALLERY, Donna, L. , MCEWAN, William, A. , BIDGOOD, Susanna, R.
IPC分类号： C07K16/08 , C07K14/435
CPC分类号： C07K16/00 , A61K2039/505 , C07K14/47 , C07K16/08 , C07K2317/77 , C07K2319/00 , C12N15/1137 , C12N2310/14
摘要： A compound comprising a ligand which binds, directly or indirectly, specifically to an antigen of a pathogen, provided that said ligand is not the PRYSPRY domain of TRIM21; and a RING domain and/or an inducer of TRIM21 expression.
摘要翻译：包含与病原体的抗原直接或间接结合的配体的化合物，条件是所述配体不是TRIM21的PRYSPRY结构域; 和RING结构域和/或TRIM21表达的诱导物。

8. 发明申请

WO2010089115A1 MULTISPECIFIC PEPTIDES 审中-公开
标题翻译：多功能肽
公开(公告)号：WO2010089115A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/000689
申请日：2010-02-04
申请人： MEDICAL RESEARCH COUNCIL , WINTER, Gregory Paul , HEINIS, Christian , BERNARD, Elise , LOAKES, David , TITE, John Paul , VAYSBURD, Marina , TEUFEL, Daniel Paul
发明人： WINTER, Gregory Paul , HEINIS, Christian , BERNARD, Elise , LOAKES, David , TITE, John Paul , VAYSBURD, Marina , TEUFEL, Daniel Paul
IPC分类号： A61K47/48 , G01N33/68
CPC分类号： C12N15/1037 , A61K47/55 , A61K47/64 , A61K47/643 , C07K14/001 , C12N15/1044 , C12N15/1058 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/531
摘要： The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
摘要翻译：本发明涉及一种提供多特异性肽配体的方法，所述多特异性肽配体包含在三个或更多个氨基酸残基处共价连接到分子支架并能够结合两个或更多个单独靶标的多肽，包括以下步骤：（a）提供第一多肽的所有组成部分，每个多肽包含两个或更多个能够与分子支架共价连接的反应性基团，以及至少一个环，其包含两个或更多个氨基酸的序列，对应于两个所述反应性基团; （b）提供如（a）所述的第二组多肽; （c）将第一组合物中的一个或多个成员的至少一个环连接到第二组合物的一个或多个成员的至少一个环，以形成至少一个包含两个环的多肽，和（d）将复合多肽（ s）至少在三个氨基酸位置分子支架。

9. 发明申请

WO2009155962A1 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2009155962A1
公开(公告)日：2009-12-30
申请号：PCT/EP2008/011135
申请日：2008-12-30
申请人： PENTRAXIN THERAPEUTICS LIMITED , PEPYS, Mark Brian
发明人： PEPYS, Mark Brian
IPC分类号： A61K31/401 , A61K39/395 , A61K45/06 , A61P25/28
CPC分类号： C07K16/18 , A61K31/401 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K2317/72 , C07K2317/92 , A61K2300/00
摘要： The invention describes the use of an antibody specific for serum amyloid P component, for the treatment or prophylaxis of amyloidosis, and the use of a compound which depletes serum amyloid P component from the circulation in combination with an antibody specific for serum amyloid P component.
摘要翻译：本发明描述了对血清淀粉样蛋白P成分特异性抗体的用途，用于治疗或预防淀粉样变性，以及使用从循环中消耗血清淀粉样蛋白P成分的化合物与对血清淀粉样蛋白P成分特异的抗体的组合。

10. 发明申请

WO2008050104A1 POLYMERASE 审中-公开
标题翻译：聚合酶
公开(公告)号：WO2008050104A1
公开(公告)日：2008-05-02
申请号：PCT/GB2007/004031
申请日：2007-10-23
申请人： MEDICAL RESEARCH COUNCIL , HOLLIGER, Philipp , D'ABBADIE, Marc , BAAR, Claudia
发明人： HOLLIGER, Philipp , D'ABBADIE, Marc , BAAR, Claudia
IPC分类号： C12N9/12 , C12Q1/68
CPC分类号： C12N9/1241 , C12N9/1252
摘要： An engineered DNA polymerase characterised in that the polymerase exhibits an enhanced ability to process nucleic acid in the presence of environmental and biological inhibitors compared to wild type DNA polymerase.
摘要翻译：工程改造的DNA聚合酶，其特征在于与野生型DNA聚合酶相比，聚合酶在环境和生物抑制剂存在下具有增强的处理核酸的能力。

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