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1. 发明申请

WO2022207652A1 METHODS OF TREATMENT USING PROTEIN BINDERS TO IRHOM2 EPITOPES 审中-公开
公开(公告)号：WO2022207652A1
公开(公告)日：2022-10-06
申请号：PCT/EP2022/058301
申请日：2022-03-29
申请人： SCIRHOM GMBH , NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
发明人： SCHNEIDER, Matthias , SELLE, Kerstin , RUHE, Jens , WESKAMP, Gisela , BLOBEL, Carl
IPC分类号： C07K16/28 , A61P35/00 , A61P37/06 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present disclosure relates to a method for inhibiting or reducing TACE/ADAM17 activity in a human or animal subject. The method comprises administering to the human or animal subject an effective amount for reducing or inhibiting TACE/ADAM 17 activity of a protein binder which, when bound to human iRhom2, binds at least within a region of Loop 1 thereof, or of a nucleic acid that encodes for at least one chain of a protein binder which, when bound to human iRhom2, binds at least within a region of Loop 1 thereof.

2. 发明申请

WO2021209452A1 DOSAGE UNITS AND REGIMEN, USES, METHODS OR FORMULATIONS OF COMPOSITIONS COMPRISING A RECOMBINANT PROTEIN COMPRISING INTERLEUKIN-12 AND AN ANTIBODY BINDING THE EXTRA-DOMAIN B OF FIBRONECTIN 审中-公开
公开(公告)号：WO2021209452A1
公开(公告)日：2021-10-21
申请号：PCT/EP2021/059570
申请日：2021-04-13
申请人： PHILOGEN S.P.A.
发明人： BACCI, Camilla , HEMMERLE, Theresa
IPC分类号： A61K38/20 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/68 , C07K14/54 , A61P35/00 , C07K14/78 , C07K16/18
摘要： The present invention relates to a dosage unit or regimen, recombinant protein for use, method or formulation of a recombinant protein comprising interleukin-12 (IL-12) and an antibody binding the extra-domain B (ED-B) of fibronectin, or a target binding fragment or derivative thereof.

3. 发明申请

WO2021028503A8 METHOD FOR THE CHARACTERIZATION OF PEPTIDE:MHC BINDING POLYPEPTIDES 审中-公开
公开(公告)号：WO2021028503A8
公开(公告)日：2021-02-18
申请号：PCT/EP2020/072674
申请日：2020-08-12
申请人： IMMATICS BIOTECHNOLOGIES GMBH
发明人： SCHUSTER, Heiko , HUTT, Meike , WEINSCHENK, Toni , BUNK, Sebastian , SCHOOR, Oliver , BACKERT, Linus , HOFMANN, Martin , FRITSCHE, Jens , UNVERDORBEN, Felix , SCHIMMACK, Gisela , SCHWÖRER, Florian
IPC分类号： G01N33/569 , G01N2333/70539 , G01N2570/00 , G01N33/56977 , G01N33/6848 , G01N33/6878
摘要： The present invention relates to a method for the characterization of peptide:MHC binding polypeptides, e.g. by mass spectrometry and an analysis of the recognized peptide space, i.e. in order to identify peptides that can be bound in the context of their presentation by MHC, and those who can not be bound.

4. 发明申请

WO2019016381A1 MULTISPECIFIC ANTIBODY PRODUCT THAT BINDS TO DIFFERENT ROR1 EPITOPES 审中-公开
公开(公告)号：WO2019016381A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069798
申请日：2018-07-20
申请人： NBE-THERAPEUTICS AG
发明人： GRAWUNDER, Ulf , BEERLI, Roger , WALDMEIER, Lorenz
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00
摘要： The present invention relates to a multi-specific product comprising a first entity comprising an antigen-binding domain that binds to the same RORl epitope as and/or competes for RORl binding with an antibody comprising a heavy chain variable region sequence shown in SEQ ID NO. 2 and a light chain variable region sequence shown in SEQ ID NO. 3; and a second entity comprising an antigen-binding domain that binds to a different target or RORl epitope than, and/or does not compete for binding with the antibody comprising a heavy chain variable region sequence shown in SEQ ID NO. 2 and a light chain variable region sequence shown in SEQ ID NO. 3.

5. 发明申请

WO2018115533A1 SCREENABLE LIVER DISEASE MODELS AND METHODS 审中-公开
公开(公告)号：WO2018115533A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084665
申请日：2017-12-27
申请人： INSPHERO AG
发明人： MESSNER, Simon , KELM, Jens M. , KOSTADINOVA-ANGELOVA, Radina , MORITZ, Wolfgang
IPC分类号： C12N5/071 , C12N5/0786 , G01N33/50
摘要： The present invention relates to an in vitro testing platform for the study of metabolic liver disease and related therapeutic strategies, composed of an artificial spheroidal microtissue comprising at least hepatocytes and hepatic stellate cells, and at least one type of hepatic inflammatory cells and further medium and reagents capable to establish and simulate different stages of metabolic liver disease and their progression and testing preventive and therapeutic strategies by pharmacological and/or dietary interventions.

6. 发明申请

WO2018115377A9 IMMUNOCYTOKINES WITH PROGRESSIVE ACTIVATION MECHANISM 审中-公开
公开(公告)号：WO2018115377A9
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084256
申请日：2017-12-21
申请人： PHILOGEN S.P.A.
发明人： NERI, Giovanni , VILLA, Alessandra , SAMAIN, Florent , BIGATTI, Martina
IPC分类号： A61K39/395 , A61K38/20 , A61K31/40 , C07K16/24 , A61P39/02 , A61P35/00 , A61P37/04
摘要： The present invention relates to a combination comprising at least an immunocytokine comprising at least a primary binding protein or peptide and a cytokine, fused or conjugated to one another, and a secondary binding molecule capable of binding to at least a section of at least one cytokine comprised in the immunocytokine.

7. 发明申请

WO2017085136A1 MISCHVORRICHTUNG ZUM DURCHMISCHEN EINES BIOREAKTORS AUFWEISEND EINE SYNCHRONISIERUNGSEINRICHTUNG 审中-公开
标题翻译：用于混合包含同步装置的生物反应器的混合装置
公开(公告)号：WO2017085136A1
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077880
申请日：2016-11-16
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： BRÜTSCH, Simon , SCHOLZ, Jochen
IPC分类号： C12M1/34
CPC分类号： C12M41/48 , C12M27/16 , C12M41/00
摘要： Die vorliegende Erfindung betrifft ein System aufweisend eine Mischvorrichtung zum Durchmischen eines Bioreaktors. Das System weist mindestens eine Bewegungseinrichtung zur Einleitung einer Durchmischungs-Bewegung in den Bioreaktor oder in eine Halterung zur Aufnahme eines Bioreaktors und mindestens einen in oder an dem Bioreaktor anordenbaren Sensor zur Aufnahme mindestens einer physiologischen oder physikalischen Messgröße. Die Mischvorrichtung oder der Bioreaktor weist ferner einen Sensor oder Geber zur Erzeugung einer Synchronisierungs-Messgröße auf.
摘要翻译：本发明涉及一种包括用于混合生物反应器的混合装置的系统。该系统包括至少一个移动设备，用于在生物反应器中或在夹持器中引入一个搅拌运动，用于接收一个生物反应器和至少一个可以被布置在或上记录至少一个生理或物理被测量＆OUML所述生物反应器传感器;道路。混合装置或生物反应器还包括用于生成同步测量的传感器或编码器。

8. 发明申请

WO2017081260A1 THREE-DIMENSIONAL MULTI-CELL TYPE SPHEROID BASED MULTI-PARAMETRIC COMPOUND CLASSIFICATION METHOD 审中-公开
标题翻译：三维多细胞球形多参数复合分类方法
公开(公告)号：WO2017081260A1
公开(公告)日：2017-05-18
申请号：PCT/EP2016/077445
申请日：2016-11-11
申请人： INSPHERO AG
发明人： WEYDERT, Zoe , KELM, Jens M.
IPC分类号： C12N5/00 , G01N33/50 , C12N5/09
CPC分类号： C12N5/0062 , C12N5/0693 , C12N2503/02 , C12N2510/00 , C12N2513/00 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N2500/10
摘要： The present invention relates to a method using three-dimensional spheroid comprising at least one type of cells, preferably comprising at least one type of tumor cells and at least one type of non-tumor cells, for compound classification. Cells of at least one type of said non-tumor cells have been subjected to transfection with a heterologous gene and act as an internal sensor to discriminate specific from un-specific drug effects. This enables multi-parametric compound classification and selection incorporating not only efficacy and potency bit also an in vitro generated therapeutic index and impact on tumor growth. The present invention also relates to methods for production of said three-dimensional spheroid and for screening compound libraries in the context of drug development or diagnostic assays.
摘要翻译：本发明涉及使用包含至少一种细胞的三维球状体的方法，所述细胞优选包含至少一种类型的肿瘤细胞和至少一种类型的非肿瘤细胞，用于化合物分类。至少一种所述非肿瘤细胞的细胞已经用异源基因进行转染，并作为内部传感器来区分特异性和非特异性药物作用。这使得多参数化合物分类和选择不仅可以结合疗效和效能，还可以体外产生治疗指数和对肿瘤生长的影响。本发明还涉及在药物开发或诊断测定中生产所述三维球状体和筛选化合物文库的方法。

9. 发明申请

WO2015110474A1 SCREENING FOR TARGET-SPECIFIC AFFINITY BINDERS 审中-公开
标题翻译：筛选目标特异性亲属关系
公开(公告)号：WO2015110474A1
公开(公告)日：2015-07-30
申请号：PCT/EP2015/051146
申请日：2015-01-21
申请人： KLOEHN, Peter Christian
发明人： KLOEHN, Peter Christian
IPC分类号： G01N33/50 , C07K16/00 , C12N15/113
CPC分类号： G01N33/6854 , C07K16/00 , C07K16/1063 , C07K16/18 , C07K2317/30 , C07K2317/33 , C07K2317/92 , C12N15/113 , C12N2310/10 , C12N2310/14 , C12N2310/20 , C12N2320/10 , G01N33/502 , G01N2500/10
摘要： The present invention is related to a method for determining the specificity of one or more antibodies, or one or more alternative affinity binders, for a target antigen. Said method comprises the following steps: (i) analyzing binding of the antibody, or the alternative affinity binder, to a target antigen expressed by an antigen-expressing cell; (ii) analyzing binding of the antibody, or the alternative affinity binder, to a target antigen expressed by an equivalent antigen-expressing cell, in which cell expression of the target antigen has been silenced and /or the gene of the target antigen has been deleted; and (iii) comparing the binding reactions of the antibody, or the alternative affinity binder, in steps (i) and (ii) The method further features that a reduction or loss of binding in step (ii), compared to step (i), indicates that the antibody, or the alternative affinity binder, has affinity and/or specificity for the target antigen.
摘要翻译：本发明涉及用于确定靶抗原的一种或多种抗体或一种或多种替代性亲和性结合物的特异性的方法。所述方法包括以下步骤：（i）分析抗体或替代亲和性结合剂与由抗原表达细胞表达的靶抗原的结合; （ii）分析抗体或替代的亲和性结合剂与目标抗原的细胞表达已经沉默和/或靶抗原的基因已经被表达的等同抗原表达细胞表达的靶抗原的结合删除; 与步骤（i）相比，该方法的特征还在于步骤（ii）中的结合减少或丧失，所述方法还包括：（iii）比较步骤（i）和（ii）中抗体或替代亲和性结合剂的结合反应。表明抗体或替代亲和性粘合剂对靶抗原具有亲和性和/或特异性。

10. 发明申请

WO2014202791A1 METHOD FOR DETECTING SMALL MOLECULES IN A SAMPLE 审中-公开
标题翻译：检测样品中小分子的方法
公开(公告)号：WO2014202791A1
公开(公告)日：2014-12-24
申请号：PCT/EP2014/063178
申请日：2014-06-23
申请人： IMMUSMOL SAS
发明人： BESSÈDE, Alban
IPC分类号： G01N33/94
CPC分类号： G01N33/94 , G01N33/577
摘要： The present invention telates to a method for detecting small molecular analytes in a sample, which method comprises derivatizing at least one small molecular analyte or at least one carrier molecule, in such way that one can bind to the other, thus forming at least one analyte-carrier complex, adding a detection immunoligand that s binds to the analyte-carrier complex, and detecting the small molecular analyte.
摘要翻译：本发明涉及一种用于检测样品中的小分子分析物的方法，该方法包括使至少一种小分子分析物或至少一种载体分子衍生化，使得可以结合另一种，从而形成至少一种分析物载体复合物，添加与分析物 - 载体复合物结合的检测免疫组织，以及检测小分子分析物。

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