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1. 发明申请

WO2014152269A1 PHARMACEUTICAL SOFT GELATIN CAPSULE DOSAGE FORM WITH MODIFIED GUAR GUM 审中-公开
标题翻译：药用软胶囊剂量形式与改良眼镜
公开(公告)号：WO2014152269A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027145
申请日：2014-03-14
申请人： WARNER CHILCOTT COMPANY, LLC
发明人： MULDOON, Brendan , LOUGHLIN, Ryan, Gerald , SWEENEY, Gerarde , BOYD, Emma, Karen
IPC分类号： A61K9/00 , A61K47/10 , A61K47/22 , A61K9/06 , A61K47/36 , A61K9/48 , A61K31/565
CPC分类号： A61K9/4825 , A61K9/0034 , A61K9/06 , A61K9/4866 , A61K31/565 , A61K47/10 , A61K47/22 , A61K47/36
摘要： A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin; and (b) a fill that includes at least one active ingredient, one or more polyethylene glycol, and a modified guar gum. The pharmaceutical soft gelatin capsule dosage form maintains its shell integrity (hardness) and fill viscosity after storage.
摘要翻译：一种药用软明胶胶囊剂型，其包含（a）包含明胶的壳; 和（b）包含至少一种活性成分，一种或多种聚乙二醇和改性瓜尔胶的填充物。药物软明胶胶囊剂型保存其外壳完整性（硬度）和储存后的填充粘度。

2. 发明申请

WO2009055489A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR 审中-公开
标题翻译：头发护理组合物和治疗头发的方法
公开(公告)号：WO2009055489A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/080819
申请日：2008-10-22
申请人： LIVING PROOF, INC. , ANDERSON, Daniel, Griffith , NASHAT, Amir , DEROSA, Mitchell, John , PUERTA, David, Thomas , MCLAUGHLIN, Ronald, P. , AKCASU, Bryan, Scott , WILLIAMS, Susan, Alice , RAMIREZ, Richard, Matthew
发明人： ANDERSON, Daniel, Griffith , NASHAT, Amir , DEROSA, Mitchell, John , PUERTA, David, Thomas , MCLAUGHLIN, Ronald, P. , AKCASU, Bryan, Scott , WILLIAMS, Susan, Alice , RAMIREZ, Richard, Matthew
IPC分类号： A61K8/00 , A61K8/18 , A61Q5/00
CPC分类号： A61K8/37 , A61K8/8152 , A61Q5/06 , A61Q5/12 , A61Q9/02
摘要： The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non- polymeric compounds in a suitable excipient to provide beneficial effects on hair.
摘要翻译：本发明提供用于治疗头皮头发的组合物，试剂盒和方法。组合物包括氟化（但不是全氟化的）非合适赋形剂中的非聚合物，以提供对头发的有益作用。

3. 发明申请

WO2007146805A3 METHODS TO ADMINISTER SOLID DOSAGE FORMS OF ETHINYL ESTRADIOL AND PRODRUGS THEREOF WITH IMPROVED BIOAVAILABILTY 审中-公开
公开(公告)号：WO2007146805A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/070761
申请日：2007-06-08
申请人： WARNER CHILCOTT COMPANY, INC. , DEVRIES, Tina , McNAMEE, Brian
发明人： DEVRIES, Tina , McNAMEE, Brian
IPC分类号： A61K31/565 , A61K9/00
摘要： Methods of improving the bioavailability of ethinyl estradiol by orally administering to a patient a solid dosage form containing ethinyl estradiol or prodrug thereof where that dosage form releases at least some of the ethinyl estradiol or prodrug thereof in the oral cavity for absorption through the oral mucosa to treat the patient for a predetermined indication such as, for example, hormone replacement therapy or contraception. The solid dosage forms may be selected from, among others, chewable tablets, fast melt tablets, films, dissolving films, mucoadhesive tablets, lozenges, and chewing gum.

4. 发明申请

WO2007001839A2 4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的4-苯胺三喹诺酮
公开(公告)号：WO2007001839A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/023063
申请日：2006-06-13
申请人： WYETH , BOSCHELLI, Frank, Charles
发明人： BOSCHELLI, Frank, Charles
CPC分类号： A61K31/4709 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to a method of preventing treating and/or inhibiting cancer using compounds of formula (I): or a pharmaceutically acceptable salt thereof. This invention is also directed to pharmaceutical compositions containing compounds of formula (I).
摘要翻译：本发明涉及使用式（I）的化合物或其药学上可接受的盐来预防治疗和/或抑制癌症的方法。本发明还涉及含有式（I）化合物的药物组合物。

5. 发明申请

WO2006127207A1 METHODS OF SYNTHESIZING SUBSTITUTED 3-CYANOQUINOLINES AND INTERMEDIATES THEREOF 审中-公开
标题翻译：合成取代的3-氰基喹啉的方法及其中间体
公开(公告)号：WO2006127207A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/016215
申请日：2006-04-28
申请人： WYETH , CHEW, Warren , CHEAL, Gloria, Karen , LUNETTA, Jacqueline, Francesca
发明人： CHEW, Warren , CHEAL, Gloria, Karen , LUNETTA, Jacqueline, Francesca
IPC分类号： C07D215/56 , C07D401/12 , A61K31/47 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/12 , C07D215/56 , C07D403/02 , C07D413/02
摘要： The invention is directed to methods of making substituted 3- cyanoquinolines, including compounds according to the following formula: (IV) The methods are amenable to large scale manufacture, avoid the use of chromatographic separations, and provide stable, high purity product more efficiently than in the prior art.
摘要翻译：本发明涉及制备取代的3-氰基喹啉的方法，包括根据下式的化合物：（Ⅳ）该方法适于大规模生产，避免使用色谱分离，并提供比在现有技术中。

6. 发明申请

WO2005111246A1 OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：寡核苷酸阵列监测基因表达及其制备和使用方法
公开(公告)号：WO2005111246A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/016880
申请日：2005-05-11
申请人： WYETH , MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
发明人： MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.
摘要翻译：本发明提供了能够鉴定涉及通过细胞系诱导特定表型的基因和相关途径的寡核苷酸阵列，例如涉及通过细胞系诱导转基因表达的基因和相关途径。当关于正在研究的细胞系的基因组的信息很少或没有信息时，本发明是特别有用的，因为它提供了用于鉴定已知和先前未被发现的基因的共有序列的方法，以及为所识别的共有序列设计寡核苷酸探针。另外，当该阵列用于确定由细胞系表达转基因的最佳条件时，本发明教导了将寡核苷酸探针包括在阵列中的转基因序列的方法。本发明还提供了使用该阵列鉴定涉及诱导特定细胞系表型的基因和相关途径的方法。本发明还提供未被发现的基因的新型多核苷酸（即，未被测序和/或显示由CHO细胞表达的基因）和参与诱导特定细胞表型的新型多核苷酸，例如当在下面生长时增加的存活压力培养条件，转基因表达增加，抗原产生减少等。这些新型多核苷酸分别被称为新的CHO序列和差异CHO序列。本发明还提供基因工程表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供使用本发明的多核苷酸的方法。

7. 发明申请

WO2005070949A1 DI-STEROIDAL PRODRUGS OF ESTRADIOL 审中-公开
标题翻译：雌雄异体抗原
公开(公告)号：WO2005070949A1
公开(公告)日：2005-08-04
申请号：PCT/US2004/041464
申请日：2004-12-10
申请人： WARNER CHILCOTT COMPANY, INC. , KING, John, Alexander , KEOWN, James , MCILROY, James, William , ARMSTRONG, William, Paul , MCKERVEY, Anthony , MCMORDIE, Austin
发明人： KING, John, Alexander , KEOWN, James , MCILROY, James, William , ARMSTRONG, William, Paul , MCKERVEY, Anthony , MCMORDIE, Austin
IPC分类号： C07J1/00
CPC分类号： C07J9/00
摘要： The present invention is a di-steroidal prodrug of estradiol having formula (I).
摘要翻译：本发明是具有式（I）的雌二醇的二甾体前药。

8. 发明申请

WO2005049142A3 GRADUATED ESTROGEN CONTRACEPTIVE 审中-公开
公开(公告)号：WO2005049142A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/037975
申请日：2004-11-12
申请人： WARNER CHILCOTT COMPANY, INC. , BOISSONNEAULT, Roger, M.
发明人： BOISSONNEAULT, Roger, M.
IPC分类号： A61K31/565
摘要： A multiphasic estrogenic/progestogenic contraceptive regimen that provides for the reduction or elimination of estrogen in the initial phase is disclosed. Also described is a contraceptive kit that may be used to practice the method of the invention.

9. 发明申请

WO2004107618A3 GITR LIGAND AND GITR LIGAND-RELATED MOLECULES AND ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2004107618A3
公开(公告)日：2004-12-09
申请号：PCT/US2004/016381
申请日：2004-05-24
申请人： WYETH , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , COLLINS, Mary , SHEVACH, Ethan, Menahem , McHUGH, Rebecca, Suzanne , WHITTERS, James, Matthew , YOUNG, Deborah, Ann , BYRNE, Michael, Chapman , REDDY, Padmalatha, F. , STEPHENS, Geoffrey, Laurence , CARRENO, Beatriz, M.
发明人： COLLINS, Mary , SHEVACH, Ethan, Menahem , McHUGH, Rebecca, Suzanne , WHITTERS, James, Matthew , YOUNG, Deborah, Ann , BYRNE, Michael, Chapman , REDDY, Padmalatha, F. , STEPHENS, Geoffrey, Laurence , CARRENO, Beatriz, M.
IPC分类号： C07K14/715
摘要： The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoidinduced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.

10. 发明申请

WO2004012518A1 INK-JET PRINTING ON SURFACE MODIFIED CONFECTIONERY AND RESPECTIVE PRODUCTS 审中-公开
标题翻译：喷墨打印面修改的CONFECTIONERY和相关产品
公开(公告)号：WO2004012518A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/024167
申请日：2003-08-05
申请人： MARS, INCORPORATED
发明人： SHASTRY, Arun , BEN-JOSEPH, Eyal
IPC分类号： A23G3/00
CPC分类号： A23G1/54 , A23G3/0089 , A23G3/0097 , A23G3/54 , A23P20/10 , A23P20/105 , A23P30/10 , B41M3/00 , B41M5/0047
摘要： Modifying the surface of an edible with a high polarity water-based glaze or polishing gum improves the printing of images on the edibles with low viscosity inks typically used in ink jet printing. The methods described herein are suited to printing high resolution ink jet images on edible substrate, such as a hard panned sugar shell confectionery.
摘要翻译：用高极性水性釉料或抛光胶改性可食用的表面可以改善通常用于喷墨印刷的低粘度油墨在食品上印刷图像。本文所述的方法适用于在可食用的基底上打印高分辨率喷墨图像，例如硬的平底糖壳糖食。

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