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1. 发明申请

WO2017189499A1 RESIDUAL STRESS FEATURES IN ORGAN MODELS 审中-公开
标题翻译：器官模型中的残余应力特征
公开(公告)号：WO2017189499A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/029281
申请日：2017-04-25
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： HOFSTETTER, Gregory, K.
IPC分类号： G09B23/30
摘要： Simulated tissue structures and methods of making them are disclosed. An elastic first material is placed in tension. An elastic second material is adhered to the first material while the first material is in tension. The adhered second material and the first material in tension forms a first shape of the simulated tissue structure. Tension on the first material is released. In releasing the tension of the first material, a force is exerted on the adhered second material bring the combination of the first material and the second material into a second shape. The first shape is maintained by a mold or mandrel and the second shape is the desired shape of the simulated tissue structure.
摘要翻译：公开了模拟组织结构及其制造方法。弹性第一材料处于张紧状态。当第一材料处于拉伸状态时，弹性第二材料粘附到第一材料上。粘附的第二材料和处于拉伸状态的第一材料形成模拟组织结构的第一形状。第一种材料的张力被释放。在释放第一材料的张力时，对粘附的第二材料施加力，使得第一材料和第二材料的组合成为第二形状。第一种形状由模具或心轴维持，第二种形状是模拟组织结构的所需形状。

2. 发明申请

WO2016183412A1 SYNTHETIC TISSUE STRUCTURES FOR ELECTROSURGICAL TRAINING AND SIMULATION 审中-公开
标题翻译：用于静电训练和模拟的合成组织结构
公开(公告)号：WO2016183412A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032292
申请日：2016-05-13
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： FELSINGER, Natasha , CHEHAYEB, Sam , BOLANOS, Eduardo
IPC分类号： A61B18/12 , G09B23/28
CPC分类号： C08L33/26 , A61B18/12 , B29C39/003 , B29K2005/00 , B29K2033/26 , C08J5/122 , C08J2333/26 , C08J2405/04 , G09B23/30
摘要： A surgical simulator for electrosurgical training and simulation is provided. The surgical simulator includes one or more simulated tissue structures made substantially of a hydrogel comprising a dual interpenetrating network of ionically cross-linked alginate and covalently cross-linked acrylamide. Combinations of different simulated tissue structures define procedural-based models for the practice of various electrosurgical procedures including laparoscopic total mesorectal excision, transanal total mesorectal excision, cholecystectomy and transanal minimally invasive surgery. Methods of making the simulated tissue structures are also provided.
摘要翻译：提供了一种用于电外科训练和模拟的手术模拟器。手术模拟器包括基本由水凝胶制成的一个或多个模拟组织结构，其包含离子交联的藻酸盐和共价交联的丙烯酰胺的双互穿网络。不同模拟组织结构的组合定义了用于各种电外科手术操作的基于程序的模型，包括腹腔镜全直肠切除术，经肛门全直肠切除术，胆囊切除术和经肛门微创手术。还提供了制作模拟组织结构的方法。

3. 发明申请

WO2016134269A1 SIMULATED TISSUE STRUCTURES AND METHODS 审中-公开
标题翻译：模拟组织结构和方法
公开(公告)号：WO2016134269A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018697
申请日：2016-02-19
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： HOFSTETTER, Gregory, K
IPC分类号： B29C41/20 , G09B23/34 , G09B23/28 , B29L31/00
CPC分类号： G09B23/281 , B29C41/20 , B29L2031/753 , B29L2031/7532 , G09B23/28 , G09B23/30 , G09B23/34
摘要： Simulated tissue structures (10) and methods of manufacturing are provided. The simulated tissue structures (10) are particularly useful for placement inside abdominal simulators for practicing laparoscopic surgical techniques. One simulated tissue structure (10) includes a combination of two materials that are attached together wherein one of the materials forms a hollow anatomical structure configured to contain the other material. The two materials are attached in an anatomically advantageous manner such that the inner surface of the outer material closely conforms to the outer surface of the inner material. Another simulated tissue structure includes a plurality of layers wherein at least one layer is applied by printing the layer with at least one stencil to impart one or more functional characteristic to the simulated tissue structure.
摘要翻译：提供模拟组织结构（10）和制造方法。模拟的组织结构（10）对于放置在腹部模拟器中用于实践腹腔镜手术技术特别有用。一个模拟组织结构（10）包括连接在一起的两种材料的组合，其中一种材料形成构造成容纳其它材料的中空解剖结构。两种材料以解剖学有利的方式附接，使得外部材料的内表面与内部材料的外表面紧密地一致。另一个模拟组织结构包括多个层，其中通过用至少一个模板印刷该层来施加至少一个层，以赋予模拟组织结构一个或多个功能特征。

4. 发明申请

WO2016077195A1 SIMULATED TISSUE MODELS AND METHODS 审中-公开
标题翻译：模拟组织模型和方法
公开(公告)号：WO2016077195A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059668
申请日：2015-11-09
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： HOFSTETTER, Gregory, K. , BRESLIN, Tracy , POULSEN, Nikolai , SALEH, Kodr
IPC分类号： G09B23/28
CPC分类号： G09B23/34 , B29C41/085 , B29C41/20 , B29C41/22 , B29K2083/00 , B29L2031/753 , G09B23/28 , G09B23/285 , G09B23/30
摘要： Simulated tissue structures for practicing surgical techniques and methods of manufacturing those structures are provided. In particular, a realistic organ model or simulated tissue portion for practicing the removal of a tumor or other undesired tissue followed by suturing a remnant defect as part of the same surgical procedure is provided. The simulated tissue structures include a polyp simulation having a suturable mesh layer that is separable from a defect layer. A simulated colon model with interchangeable and suturable tissue pods is also provided as is a fully suturable rectum model and a rectum model with integrative suturable and removable polyp zones.
摘要翻译：提供了用于实践手术技术的模拟组织结构和制造这些结构的方法。特别地，提供了用于实践去除肿瘤或其它不需要的组织的实际器官模型或模拟组织部分，随后缝合残余缺损作为相同外科手术的一部分。模拟的组织结构包括具有可与缺陷层分离的可固定网格层的息肉模拟。还提供具有可互换和可切除的组织荚的模拟结肠模型，其是完全可缝合的直肠模型和具有整合的可切除和可除去的息肉区的直肠模型。

5. 发明申请

WO2014152912A1 SURGICAL STAPLER WITH PARTIAL POCKETS 审中-公开
标题翻译：外科手术器与部分口袋
公开(公告)号：WO2014152912A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/028211
申请日：2014-03-14
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： HOPKINS, Timothy , GADBERRY, Donald, L. , BECERRA, Matthew, A. , JASEMIAN, Babek , JOHNSON, Gary, M. , DECKER, Steven, E.
IPC分类号： A61B17/072 , A61B17/064
CPC分类号： A61B17/07207 , A61B17/0644 , A61B2017/0641 , A61B2017/07221 , A61B2017/07228 , A61B2017/07264 , A61B2017/07278 , A61B2017/07285
摘要： A surgical stapler includes a jaw assembly at a distal end connected to a handle assembly that is configured to control the stapler and actuate the deployment of staples. The surgical stapler successfully eliminates intermediate caming portions commonly known as pushers that are located between the staples and a translating slider. The staples are located in pockets at an angle such that the base of the staple is parallel to an angled caming surface of the slider. The translating slider comes into direct contact with staples during deployment as the slider moves through each staple pocket where staples are partially supported by recesses along the slider pathway. The staples are deployed at an angle against the anvil surface. Because there are no pushers, a great deal of space is saved resulting in a much smaller diameter surgical stapler that is particularly suitable for laparoscopic stapling applications.
摘要翻译：手术吻合器包括在与手柄组件相连的远端处的钳口组件，所述手柄组件被构造成控制缝合器并致动缝钉的展开。外科缝合器成功地消除了通常被称为推动器的中间凸轮部分，其位于钉和平移滑块之间。订书针以一定角度位于口袋中，使得订书钉的底部平行于滑块的倾斜的凸轮表面。当滑块移动通过每个订书钉仓时，平移滑块在装配期间与订书钉直接接触，其中订书针沿着滑块通道由凹部部分地支撑。订书针以与砧座表面成一定角度展开。因为没有推动器，所以节省了大量的空间，导致更小直径的外科缝合器特别适用于腹腔镜缝合应用。

6. 发明申请

WO2014134597A1 ADVANCED SURGICAL SIMULATION CONSTRUCTIONS AND METHODS 审中-公开
标题翻译：高级手术模拟结构与方法
公开(公告)号：WO2014134597A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/019840
申请日：2014-03-03
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： HART, Charles, C. , BOLANOS, Eduardo , CHEHAYEB, Sam
IPC分类号： G09B23/28
CPC分类号： G09B23/30 , G09B23/28 , G09B23/285
摘要： A surgical simulation system is provided. The system includes at least one simulated body organ placed upon the base of an organ tray and at least one covering layer placed over the simulated body organ. At least one of the simulated body organ and covering layer includes electro-conductive gel that is operably severable under application of electrical current to simulate electrosurgery in a training environment. The training environment comprises a top cover connected to and spaced apart from a base to define an internal cavity that is partially obstructed from direct observation by a practitioner. The tray, simulated body organs and covering layer are placed inside the internal cavity for the practice of laparoscopic surgical procedures.
摘要翻译：提供了一种手术模拟系统。该系统包括放置在器官托盘的基部上的至少一个模拟身体器官和放置在模拟身体器官上的至少一个覆盖层。模拟的身体器官和覆盖层中的至少一个包括在施加电流下可操作地分离以在训练环境中模拟电外科手术的导电凝胶。训练环境包括连接到基座并与基座间隔开的顶盖，以限定被从业者直接观察部分阻碍的内部空腔。托盘，模拟的身体器官和覆盖层放置在内腔内用于腹腔镜手术的实践。

7. 发明申请

WO2014052808A1 SURGICAL TRAINING MODEL FOR TRANSLUMINAL LAPAROSCOPIC PROCEDURES 审中-公开
标题翻译：腰椎间盘手术手术训练模型
公开(公告)号：WO2014052808A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/062269
申请日：2013-09-27
申请人： APPLIED MEDICAL RESOURCES CORPORATION
发明人： POULSEN, Nikolai , BRESLIN, Tracy , DEMARCHI, Jacqueline
IPC分类号： G09B23/28 , G09B23/30
CPC分类号： G09B23/285 , G09B23/30
摘要： A model for practicing laparoscopic surgical skills is provided. The model comprises a body having an elongate lumen and a plurality of eyelets connected to an inner surface of the lumen. The plurality of eyelets defines at least one pathway for practicing the passing of at least one needle and suture through the eyelets. The model further includes a staging area with removable objects having apertures configured to be placed onto hook-like eyelets. The model provides a platform for practicing hand-to- hand transfer, depth perception among other skills required in laparoscopic procedures within a confined tubular space. The model may be placed inside a laparoscopic trainer in which the practice is performed in a simulated laparoscopic environment and observed on a video display.
摘要翻译：提供了一种实践腹腔镜手术技巧的模型。该模型包括具有细长内腔和连接到内腔内表面的多个孔眼的主体。多个孔眼限定了用于实践至少一个针的通过并缝合穿过孔眼的至少一个通路。该模型还包括具有可拆卸物体的分段区域，其具有被配置成放置在钩状孔眼上的孔。该模型提供了一个平台，用于在密闭的管状空间内进行手动传递，深度感知以及腹腔镜手术所需的其他技能。该模型可以放置在腹腔镜训练器中，其中练习在模拟的腹腔镜环境中进行并在视频显示器上观察。

8. 发明申请

WO2006031574A2 LASER MICRODISSECTION APPARATUS AND METHOD 审中-公开
标题翻译：激光显微镜装置及方法
公开(公告)号：WO2006031574A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/031897
申请日：2005-09-08
申请人： ARCTURUS BIOSCIENCE, INC. , DONOVAN, Brian, W. , BAER, Thomas, M.
发明人： DONOVAN, Brian, W. , BAER, Thomas, M.
IPC分类号： G01N1/00
CPC分类号： G01N1/28 , G01N1/2813 , G01N1/286 , G01N1/30 , G01N1/44 , G01N2001/2826 , G01N2001/2833 , G01N2001/284 , G01N2001/2886 , Y10T156/10 , Y10T156/1054
摘要： Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane. Then, an UV laser cuts along a cut path around the targeted portions of biological material in a closed cut path or a substantially closed cut path defining an interior and an exterior portion of the tissue sample. In a substantially closed cut path, bridges are left spanning the interior of the cut path and the exterior of the cut path. An IR laser activates at least a portion of the transfer film such that the transfer film in the vicinity of targeted portion adheres to the biological material interior to the cut path. The transfer film is then removed separating the targeted portions of biological material which are adhered to the transfer film from the remaining portion of the tissue sample.
摘要翻译：公开了用于自动激光显微切割的系统和方法。在一个变型中，手动或自动选择目标生物材料，并且将转移膜并排放置在切割路径的内部的位置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其放置在基底上。手动或自动选择靶向生物材料，并将转移膜与生物材料侧面上的靶向生物材料并置放置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其反转到基底上。手动或自动选择目标生物材料，并将转移膜与聚合物膜侧面上的目标生物材料并置放置。然后，UV激光沿着围绕生物材料的目标部分的切割路径切割成闭合切割路径或限定组织样本的内部和外部部分的基本封闭的切割路径。在基本封闭的切割路径中，跨越切割路径的内部和切割路径的外部。红外激光激活转印膜的至少一部分，使得目标部分附近的转印膜附着在生物材料内部至切割路径。然后除去转移膜，从生物材料的目标部分分离出粘附到转移膜上的剩余部分的组织样品。

9. 发明申请

WO2004025569A2 INTERACTIVE AND AUTOMATED TISSUE IMAGE ANALYSIS WITH GLOBAL TRAINING DATABASE AND VARIABLE-ABSTRACTION PROCESSING IN CYTOLOGICAL SPECIMEN CLASSIFICATION AND LASER CAPTURE MICRODISSECTION APPLICATIONS 审中-公开
标题翻译：利用全球训练数据库和变量提取处理细胞学标本分类和激光捕获微分应用的交互式和自动化组织图像分析
公开(公告)号：WO2004025569A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/029060
申请日：2003-09-15
申请人： ARCTURUS ENGINEERING, INC. , KIL, David, H.
发明人： KIL, David, H.
IPC分类号： G06T7/00
CPC分类号： G06K9/00147 , G01N1/06 , G01N1/30 , G01N15/1475 , G01N2001/284 , G02B21/365 , G06K9/00127 , G06K9/0014 , G06K9/6228 , G06K9/6253 , G06T7/00 , G06T7/0012 , G06T7/11 , G06T7/143 , G06T2207/10056 , G06T2207/20132 , G06T2207/30024
摘要： A system and method for performing tissue image analysis and region of interest identification for further processing applications such as laser capture microdissection is provided. The invention provides three-stage processing with flexible state transition that allows image recognition to be performed at an appropriate level of abstraction. The three stages include processing at one or more than one of the pixel, subimage and object levels of processing. Also, the invention provides both an interactive mode and a high-throughput batch mode which employs training files generated automatically.
摘要翻译：提供了用于执行组织图像分析和感兴趣区域识别以用于进一步处理应用的系统和方法，例如激光捕获显微切割。本发明提供具有灵活状态转换的三阶段处理，其允许以适当的抽象水平执行图像识别。三个阶段包括处理一个或多个像素，子图像和对象级别的处理。而且，本发明提供了交互式模式和高通量批量模式，其使用自动生成的训练文件。

10. 发明申请

WO2004011122A2 LOW VOLUME FILTRATION COLUMN DEVICES AND METHODS OF FILTERING THEREWITH 审中-公开
标题翻译：低体积过滤柱装置及其过滤方法
公开(公告)号：WO2004011122A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023680
申请日：2003-07-28
申请人： ARCTURUS ENGINEERING, INC. , PAI, Derek, S. , KUNITAKE, Steven, T. , RICHARDSON, Derrick, A. , MONTEON, Jorge
发明人： PAI, Derek, S. , KUNITAKE, Steven, T. , RICHARDSON, Derrick, A. , MONTEON, Jorge
IPC分类号： B01D35/00
CPC分类号： B01L3/5021 , B01L3/5082 , B01L2300/042 , B01L2300/043 , B01L2300/046 , B01L2300/048 , B01L2300/0681 , G01N1/40 , G01N1/405
摘要： This relates to filter columns for isolating nucleic acids, particularly at small elution volumes. The filter column is adapted for stable placement within the upper portion of standard plastic collection tubes of various sizes. The body of the filter column has a number of surfaces to accommodate placement within variously sized collection tubes. The filter column contains nucleic acis-specific filter which can be located at alternate regions within the filter column, providing different filter surface areas and loading volume capacities using the same column body. The filter column has an opening on an upper end adapted to be sealed by a cap. A method for recovering nucleic acids using such filter column is also provided.
摘要翻译：这涉及用于分离核酸的过滤柱，特别是在小洗脱体积下。过滤柱适用于稳定放置在各种尺寸的标准塑料收集管的上部。过滤柱的主体具有多个表面，以适应放置在不同尺寸的收集管内。过滤柱包含核酸特异性过滤器，其可以位于过滤器柱内的交替区域，使用相同的柱体提供不同的过滤器表面积和负载体积容量。过滤柱在上端具有适于被帽密封的开口。还提供了使用这种过滤柱回收核酸的方法。

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