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1. 发明申请

WO2016007767A3 ASSIGNMENT OF QUALITATIVE IMPORTANCE OF GENETIC PHENOTYPES TO THE USE OF DRUGS BASED ON GENETIC TEST RESULTS 审中-公开
标题翻译：遗传性表型对基于遗传检验结果的药物使用的定性重要性的分配
公开(公告)号：WO2016007767A3
公开(公告)日：2016-01-14
申请号：PCT/US2015/039778
申请日：2015-07-09
申请人： ELEVATED CAPITAL GROUP LLC
发明人： MASSEY, Bill, W. , ZIMMER, Richard , MONEY, Jason , ST. PIERRE, Christopher
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/12
摘要： The present invention is a method for assigning a qualitative importance of relevant genetic phenotypes to the use of specific drugs for individual patients based on genetic test results. The invention provides a drug-centric integration of pharmacogenetic test information across multiple genes relevant to an individual drug. The invention then assigns a color designation for each drug reported and groups the drugs together on a report according to drug class/therapeutic area, thus allowing the physician to easily and quickly identify a drug from a specific drug class that would be best for that patient according to their entire pharmacogenetic test results. The outputs of the method can be added to existing pharmacogenetic test reports as a quick guide for the physician. Such integration of pharmacogenetic information from multiple genes and drug-centric organization of the outputs should allow physicians to more easily utilize and incorporate pharmacogenetic testing into their practice.
摘要翻译：本发明是一种基于遗传测试结果将相关遗传表型的定性重要性分配给个体患者使用特定药物的方法。本发明提供跨多个与单独药物相关的基因的药物遗传学测试信息的以药物为中心的整合。然后，本发明为报告的每种药物指定一种颜色名称，并根据药物类别/治疗区域在报告上将药物分组在一起，从而允许医师容易且快速地从对该患者最适合的特定药物类别中识别药物根据他们的整个药物遗传学测试结果。该方法的输出可作为医生的快速指南添加到现有的药物遗传学检测报告中。这种将来自多个基因的药物遗传学信息和产品以药物为中心的组织结合起来应该能够让医生更容易地将药物遗传学检测应用到他们的实践中。

2. 发明申请

WO2014116463A1 COILING CONTINUOUS PIPELINES FOR TRANSPORT AND INSTALLATION 审中-公开
标题翻译：用于运输和安装的连续连续管道
公开(公告)号：WO2014116463A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/011508
申请日：2014-01-14
申请人： SMART PIPE COMPANY, INC.
发明人： CHARBONEAU, Kenneth, R. , CATHA, Stephen, C. , EKELUND, Aron, R. , LITTLESTAR, Gary , MANDICH, Ivan, G. , REED, Justin, M.
IPC分类号： B21F3/04 , B65H55/04 , B65H75/14
CPC分类号： B65H55/04 , B65H49/08 , B65H54/28 , B65H75/362 , B65H2701/33
摘要： A method and structural inventive system-construction or mechanism for the figure eight coiling for non-metallic pipelines and conduits, preferred to be of the composite structure and instrumented with detection inventive systems, the coiling which was not previously available and specifically indicated for the means of the long lengths, up to 10 miles, continuous pipelines coiling, transportation and installation at the site. The figure eight inventive system provides for a natural assumption of the bending repose for the pipeline and relaxation of the stresses and preservation of the pipeline's properties from the manufacturing, through the transportation and installation all the way to the site.
摘要翻译：用于非金属管道和导管的图8绕组的方法和结构性发明系统构造或机构，优选为复合结构并且与检测本发明的系统一起装配，该卷绕不是先前可获得的并且具体指示用于该装置长达10英里，连续管道卷取，运输和现场安装。图8创造性系统为管道的弯曲休息提供了一个自然的假设，并且通过运输和安装一直到现场，放松了应力和保护管道的性能。

3. 发明申请

WO2014100729A2 IN LINE INSPECTION METHOD AND APPARATUS FOR PERFORMING IN LINE INSPECTIONS 审中-公开
标题翻译：在线检查方法和在线检测中执行的装置
公开(公告)号：WO2014100729A2
公开(公告)日：2014-06-26
申请号：PCT/US2013/077249
申请日：2013-12-20
申请人： SMART PIPE COMPANY, INC.
发明人： LITTLESTAR, Gary , LITTLESTAR, Chris
IPC分类号： F16L55/26 , G08C19/00
CPC分类号： F16L55/26 , F16L55/1656 , F16L55/46 , F16L2101/30 , G08C19/00
摘要： An apparatus and method for performing inline inspections of pipelines of composite structure installed in a host pipeline or standing alone comprising a multiplicity of sensor/transducers located on or within the pipe structure to measure and record various pipeline properties, an activation/reading/storage device to activate read and collect measurement results from the sensor transducers, an automatic launch and recovery system for the activation/reading/storage device, and a database/storage/analytical device to receive, analyze and interpret results from collected data and transmit appropriate instructions to a pipeline operator or remotely activated system for action. The remote reading of sensor/transducers may be accomplished by a device running through the pipeline or passing over or near the pipeline, where ground-level handheld or wheeled vehicle mounted, fixed wing or rotary aircraft, hovercraft watercraft or satellite based instrumentation can record the location and condition of a pipeline.
摘要翻译：一种用于执行安装在主机管道中或独立地站立的复合结构的管道的在线检查的装置和方法，包括位于管结构上或管道结构内的多个传感器/换能器，以测量和记录各种管道特性，激活/读取/存储装置激活读取和收集传感器传感器的测量结果，用于激活/读取/存储设备的自动启动和恢复系统，以及数据库/存储/分析设备，用于从收集的数据接收，分析和解释结果，并传送适当的指令管道操作员或远程激活的系统用于动作。传感器/换能器的远程读取可以通过流经管道的设备或管道上或附近进行，其中安装有地面级手持式或轮式车辆，固定翼型或旋转式飞机，气垫船或卫星仪器可记录管道的位置和状况。

4. 发明申请

WO2014074707A1 FREQUENCY TRANSLATION COMPRESSION AND SELECTABLE RESPONSE TIME 审中-公开
标题翻译：频率翻译压缩和可选择的响应时间
公开(公告)号：WO2014074707A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068933
申请日：2013-11-07
申请人： LANNES, Kenneth, John
发明人： LANNES, Kenneth, John
IPC分类号： H03F3/68 , G06F17/10 , G06F17/15
CPC分类号： G10L19/00 , G10H7/02 , G10H2250/571 , G10L21/003
摘要： A method and system has been developed and demonstrated which provides real-time frequency translation, frequency compression, and user selectable response time for non- deterministic signals. This method and system provides for the real-time separation and isolation of theoretically an infinite amount of frequencies present in an incoming non-deterministic signal. The bandwidth of the filter for the separated frequencies is user selectable and provides varying rise times for the individual frequencies. The linear frequency shifting property of the algorithm creates bandwidth compression opportunities while signals are present in a channel for transmission.
摘要翻译：已经开发和演示了一种方法和系统，其为非确定性信号提供实时频率转换，频率压缩和用户可选择的响应时间。该方法和系统在理论上提供实时分离和隔离输入非确定性信号中存在的无限量的频率。用于分离频率的滤波器的带宽是用户可选择的，并且为各个频率提供变化的上升时间。该算法的线性频移特性产生带宽压缩机会，同时信号存在于用于传输的信道中。

5. 发明申请

WO2015164398A1 INVENTIVE SYSTEM AND METHODS FOR MAKING COMPOSITE REINFORCED PIPE BY ECCENTRIC APPLICATION WITH THE PORTABLE AND MOVABLE FACTORY, AND INSTALLING THE PIPE IN A PIPELINE 审中-公开
标题翻译：用便携式和可移动工厂通过偏心应用制造复合增强管的安全系统和方法，以及在管道中安装管道
公开(公告)号：WO2015164398A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/026911
申请日：2015-04-21
申请人： SMART PIPE COMPANY, INC
发明人： CHARBONEAU, Kenneth, R. , EKELUND, Aron, R. , LITTLESTAR, Gary , MANDICH, Ivan, C. , CATHA, Stephen, C. , REED, Justin, M.
IPC分类号： B29C63/10
CPC分类号： B29C53/68 , B29C53/086 , B29C53/582 , B29C53/70 , F16L11/12
摘要： A transportable system and method for the in situ eccentric manufacturing of reinforced thermoplastic pipelines in continuous lengths up to 10 miles and from 8 to 60 inches in diameter having a rotating frame assembly with a eccentric spools for application of reinforcing tapes and other components to a polyolefin core pipe, and further having a forming machine for cross sectional shape reduction of the reinforced thermoplastic pipelines to facilitate pulling the reinforced thermoplastic pipelines inside a host pipeline. Also provided are continuous monitoring and marking with application of tape in the hoop stress direction and the axial stress direction as well as saturated tape feeding stations for impregnation of the reinforcing tape for in situ curing.
摘要翻译：用于现场偏心制造直径达10英里和8至60英寸直径的连续长度的增强热塑性管道的可移动系统和方法，其具有带有用于将加强带和其它部件应用于聚烯烃的偏心线轴的旋转框架组件并且还具有用于增强热塑性管道的横截面形状减小的成形机，以便于将主体管道内的加强的热塑性管道拉动。还提供了连续监测和标记，其中在环向应力方向和轴向应力方向上施加带，以及用于浸渍增强带用于原位固化的饱和带馈送站。

6. 发明申请

WO2006004612A2 EPITROCHOIDAL CRANKSHAFT MECHANISM AND METHOD 审中-公开
标题翻译： EPITROCHOIDAL CRANKSHAFT机制和方法
公开(公告)号：WO2006004612A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022625
申请日：2005-06-27
申请人： VENETTOZZI, Thomas, Mark
发明人： VENETTOZZI, Thomas, Mark
IPC分类号： F16H55/18
CPC分类号： F16H21/28 , F02B25/24 , F02B75/048 , F02B75/32 , F16C3/28 , F16C23/10 , Y10T74/2173 , Y10T74/2181
摘要： This invention relates to a mechanism and method for enhancing the performance of both two stroke and four stroke cycle reciprocating piston internal combustion engines, reciprocating piston pumps and compressors by generating an Epitrochoidal path of travel for the lower end of the piston connecting rod. The piston, attached to the upper end of the connecting rod, will be made to dwell at the lower part of its travel, enhancing the output of the engine, pump or compressor through better utilization of the available cylinder pressure.
摘要翻译：本发明涉及通过为活塞连杆的下端产生外行波行进路径来提高两冲程和四冲程循环往复活塞内燃机，往复活塞泵和压缩机的性能的机构和方法。安装在连杆上端的活塞将在其行程的下部停留，通过更好地利用可用的气缸压力来增强发动机，泵或压缩机的输出。

7. 发明申请

WO2005115483A1 ASSAY FOR TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES 审中-公开
标题翻译：测量可传播的声音识别
公开(公告)号：WO2005115483A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/017904
申请日：2005-05-23
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BASTIAN, Frank, O.
发明人： BASTIAN, Frank, O.
IPC分类号： A61K49/00
CPC分类号： G01N33/56911 , C07H21/02 , C07H21/04 , C07K16/1253 , G01N33/6896 , G01N2333/195 , G01N2800/2828
摘要： Provided is a novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a sera sample from a subject to determine whether the subject has transmissible spongiform encephalopathy; and detecting antibodies that immune react with Spiroplasma proteins in the sample. The method detects antibodies in the individual sera samples that react with recombinant Spiroplasma-specific Hsp60 by standard ELISA methodology. This method provides for rapid detection of TSE by determination of presence of antibodies in test sera showing associated Spiroplasma infection that has become consistent with presence of TSE. The method provides a mechanism to detect presence of TSE without invasive techniques currently needed to make diagnosis using brain tissues for prion detection. This method provides means of detection of TSE in the live patient without need for using necropsy tissues. This method provides the first method discovered that detects antibodies against TSE infection-specific proteins in sera or cerebrospinal fluid samples.
摘要翻译：提供了一种检测传染性海绵状脑病（TSE）的新方法。该方法包括：从受试者中选择血清样品以确定受试者是否具有传染性海绵状脑病; 并检测与样品中的螺旋体蛋白免疫反应的抗体。该方法通过标准ELISA方法检测与重组Spiroplasma特异性Hsp60反应的各个血清样品中的抗体。该方法通过测定显示相关螺旋体感染的测试血清中存在与存在TSE一致的TSE的快速检测。该方法提供了一种检测TSE存在的机制，而无需使用脑组织进行朊病毒检测诊断的目前需要的侵入性技术。该方法提供在活体患者中检测TSE的手段，而不需要使用尸检组织。该方法提供了发现在血清或脑脊液样品中检测针对TSE感染特异性蛋白质的抗体的第一种方法。

8. 发明申请

WO2021016470A1 SYSTEM AND METHOD FOR TRANSIENT MITIGATION DEVICE IN CONTINUOUS PIPELINES FOR SURGE IMPACT CONTROL 审中-公开
公开(公告)号：WO2021016470A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/043302
申请日：2020-07-23
申请人： SMART PIPE COMPANY, INC.
发明人： LITTLESTAR, Gary, Dean , LITTLESTAR, Chris, Dean , EKELUND, Aron, Robert , MANDICH, Ivan, Capistran
IPC分类号： F16L55/04 , F16L55/054 , G01M3/00 , B29C48/00 , B29C53/08 , B29C65/00 , B29C66/00
摘要： A device and method to mitigate transient events in a transported medium of fluids and gases subjected to surges, and over pressure events caused by the transient state of a transported medium in a continuous pipeline, where the device has one or more concentrically positioned multilayered composite pipes encased in an outer spool pipe with an annulus space between the spool pipe and the multilayered composite pipes, with flanged adaptors at each end of the device for inline installation in a pipeline, with a management system for receiving, processing and transmitting information gathered in combination with existing pipeline monitoring, and acoustical detection system for receiving and processing of acoustic transmission due to an acoustical wave. Mitigation of pressure events is achieved by energy dissipation and expansion of the multilayered composite pipes and reduction of amplification of pressure waves is achieved by initiation of active counter waves by expansion of the multilayered composite pipes to sinusoidal shape.

9. 发明申请

WO2011142823A3 DETACHABLE EARS ROPE THIMBLE 审中-公开
公开(公告)号：WO2011142823A3
公开(公告)日：2011-11-17
申请号：PCT/US2011/000839
申请日：2011-05-12
申请人： DCL ENGINEERED SOLUTIONS L.L.C , HAUN, Richard, D. , HALL, Richard, E. , KAZUNAS, Peter, L.
发明人： HAUN, Richard, D. , HALL, Richard, E. , KAZUNAS, Peter, L.
IPC分类号： F16G11/00
摘要： The detachable ears rope thimble comprised of thimble body, detachable ears and having the optional features of bale, main load pin sub assembly, and a restraning load sub assembly. The inventive thimble provides very high load capacity ability for wire or synthetic ropes. Furthermore the thimble assembly enables eye splicing on new ropes yet allows for the thimble addition to previously formed eyes without resplicing the eyes. The invention provides a thimble that fully contains even the oversize found in fresh synthetic ropes protecting them within an array of detachable ears from abrasion. The outer body has smooth form with embedded detachable ears and rounded edges preventing synthetic fiber damage.

10. 发明申请

WO2010002439A1 LCAC LANDER, LAUNCHER AND LIFTER 审中-公开
标题翻译： LCAC土地，发起人和租客
公开(公告)号：WO2010002439A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/003788
申请日：2009-06-25
申请人： COLANGELO, Vladislav, Francis
发明人： COLANGELO, Vladislav, Francis
IPC分类号： B63B35/44
CPC分类号： B63B35/40 , B63B27/36
摘要： Presented is an advance naval ship's stern appendage called an LCAC (Landing Craft Air Cushion) Lander, Launcher and Lifter (L4 system) to provide for landing and launching of amphibious hovercraft and increase the delivery capacity of amphibious hovercraft by naval vessels. The stern appendage which may be retrofitted on existing vessels or fully designed into new hull forms of new ships. Included in the stern appendage are longitudinally extending cantilever wingwalls, at least one hoistable platform with a backstop fold up gate, a med-moor ramp, drainage ducts, a resistance reduction leading edge, locking pins and a transfer conveyor system for amphibious hovercraft to gain access to and from the ship's decks above the waterline, and a hoisting system for raising and lowering the hoistable platform between said cantilever wingwalls.
摘要翻译：提出的是一艘先进的海军船尾船，称为LCAC（落地工具气垫）落地机，起重机和升降机（L4系统），用于着陆和发射两栖气垫船，并增加海军舰艇两栖气垫船的运输能力。可在现有船舶上进行改装或完全设计成新船体形式的新船的船尾附件。包括在船尾附件中的是纵向延伸的悬臂翼壁，至少一个具有后挡板折叠门的悬挂平台，药液斜坡，排水管，阻力减小前缘，锁定销和用于两栖气垫船的传送输送系统以获得进出水线以上的船甲板，以及用于升高和降低悬臂翼壁之间的可升降平台的起升系统。

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