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1. 发明申请

WO2019212211A1 ANTIANGIOGENIC CHROMANE DERIVATIVE AND USES THEREOF 审中-公开
公开(公告)号：WO2019212211A1
公开(公告)日：2019-11-07
申请号：PCT/KR2019/005143
申请日：2019-04-29
申请人： GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION , INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , KINGSTON UNIVERSITY , UNIVERSITY OF SURREY
发明人： CORSON, Timothy W. , SEO, Seung-Yong , LEE, Bit , SCHWIKKARD, Sianne , MULHOLLAND, Dulcie , WHITMORE, Hannah
IPC分类号： C07D311/04 , C12N5/071
摘要： A novel chromane derivative, (3'-hydroxy-4'-ethoxybenzyl)-5,6,7-trimethoxy-2H-1-benzopyran (SH-17059 (1)) is disclosed herein. This chromane derivative has been found to inhibit blood vessel cell growth and proliferation, providing a promising treatment for ocular angiogenesis-mediated diseases.

2. 发明申请

WO2016153262A2 PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF PLATYCODON GRANDIFLORUM ENHANCED EFFECTIVE SAPONIN CONTENTS FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：包含高效液相色谱法提取有效柚苷含量的药物组合物，用于治疗恶病质
公开(公告)号：WO2016153262A2
公开(公告)日：2016-09-29
申请号：PCT/KR2016/002906
申请日：2016-03-23
申请人： B&C BIOPHARM CO., LTD.
发明人： RYU, Dong Seoung , LEE, Sang Wook , SOHN, Wee Yong
IPC分类号： A61K36/34 , A23L1/30 , A61K9/20
CPC分类号： A61K36/346 , A23L33/105 , A61K9/0056 , A61K9/5047 , A61K9/5073 , A61K2236/00
摘要： The present invention relates to a pharmaceutical composition comprising the Platycodon grandiflorum extract containing the enhanced effective saponin content as an active ingredient for the treatment of rheumatoid arthritis. The Platycodon grandiflorum extract of the present invention displays a significant therapeutic effect on rheumatoid arthritis. In particular, when the extract was administered as being coated specifically with the enteric coating agent that can be released in the intestines, in order for the extract to show the maximum effect with the minimum dose with minimum damage and side effects in the stomach by not being released in the stomach but being released and absorbed in the intestines, a significant therapeutic effect on rheumatoid arthritis was observed. Therefore, the Platycodon grandiflorum extract of the present invention can be effectively used for the treatment of rheumatoid arthritis.
摘要翻译：本发明涉及一种药物组合物，其包含含有增强的有效皂苷含量的桔梗提取物作为治疗类风湿性关节炎的活性成分。本发明的桔梗提取物对类风湿性关节炎显示出显着的治疗作用。特别是当将提取物特异性地涂敷于能够在肠中释放的肠溶衣时，为了提取物以最小的剂量显示出最大的效果，而不是在胃中具有最小的损伤和副作用在胃中释放并释放并吸收肠道，观察到对类风湿性关节炎的显着治疗作用。因此，本发明的桔梗提取物可以有效地用于治疗类风湿性关节炎。

3. 发明申请

WO2016013738A1 A METHOD FOR MANUFACTURING CARBON ELECTRODE BY RADIATION 审中-公开
标题翻译：通过辐射制造碳电极的方法
公开(公告)号：WO2016013738A1
公开(公告)日：2016-01-28
申请号：PCT/KR2015/000248
申请日：2015-01-09
申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE
发明人： KANG, Phil-Hyun , OH, Seung-Hwan , KIM, Kyu Ri , KIM, Hyun Bin
IPC分类号： H01B13/00 , H01B5/14 , H01B1/04
CPC分类号： H01B1/04 , H01M4/88 , H01M4/96
摘要： The present invention relates to a method for manufacturing carbon electrode comprising the following steps: drawing carbon electrode pattern on the upper substrate (step 1); and irradiating the carbon electrode pattern drawn in step 1 (step 2). In the method for manufacturing carbon electrode of the present invention, the carbon electrode is fixed on the substrate by irradiation, by which the conductivity of the carbon electrode can be also increased. The carbon electrode pattern can be fabricated by drawing with a carbon material such as pencil lead, suggesting that the preparation process is very simple.
摘要翻译：碳电极制造方法技术领域本发明涉及碳电极的制造方法，其特征在于，包括以下步骤：在上基板上拉制碳电极图案（工序1）。并照射步骤1中绘制的碳电极图案（步骤2）。在本发明的碳电极的制造方法中，通过照射将碳电极固定在基板上，由此碳电极的导电性也可以增加。碳电极图案可以通过用诸如铅笔等碳材料的拉伸来制造，这表明制备过程非常简单。

4. 发明申请

WO2015102159A1 PET-MRI DEVICE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译： PET-MRI装置及其制造方法
公开(公告)号：WO2015102159A1
公开(公告)日：2015-07-09
申请号：PCT/KR2014/002602
申请日：2014-03-27
申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE
发明人： HA, Jang Ho , KIM, Han Soo , KIM, Young Soo , JEONG, Man Hee , YEO, Sun Mog
IPC分类号： A61B5/055
CPC分类号： G01T1/2985 , A61B5/0035 , A61B5/055 , A61B6/037 , G01R33/28 , G01R33/381
摘要： A PET-MRI device and a manufacturing method thereof are disclosed. The PET device includes a magnetic resonance imaging (MRI) machine comprising a solenoid coil and a magnetic-field correction coil, wherein the MRI machine has a cylindrical structure or a dipole structure; and a positron emission tomography (PET) machine comprising a PET image sensor, wherein PET image sensor electrodes are formed on one and the other ends of the PET image sensor that have a doughnut shape, and the PET machine has a cylindrical structure or a lattice structure, wherein the PET machine is formed in the MRI machine to allow a direction of an electric field of the PET machine to be parallel to a direction of a magnetic field of the MRI machine.
摘要翻译：公开了一种PET-MRI装置及其制造方法。 PET装置包括磁共振成像（MRI）机，其包括螺线管线圈和磁场校正线圈，其中所述MRI机器具有圆柱形结构或偶极结构; 以及包括PET图像传感器的正电子发射断层摄影（PET）机器，其中PET图像传感器电极形成在具有环形形状的PET图像传感器的一端和另一端上，并且PET机器具有圆柱形结构或晶格结构，其中PET机器形成在MRI机器中以允许PET机器的电场的方向平行于MRI机器的磁场的方向。

5. 发明申请

WO2014168429A1 PHARMACEUTICAL COMPOSITION AND HEALTH FOOD FOR PREVENTING OR IMPROVING LIPID RELATED METABOLIC DISEASE OR THE LOSS OF WEIGHT AND BODY FAT, WHICH COMPRISE THE BLACK TEA AQUEOUS ETHANOL ENFLEURAGE EXTRACT 审中-公开
标题翻译：药物组合物和健康食品，用于预防或改善脂质相关代谢疾病或重量和身体脂肪的损失，包括黑茶水分乙醇提取物
公开(公告)号：WO2014168429A1
公开(公告)日：2014-10-16
申请号：PCT/KR2014/003114
申请日：2014-04-10
申请人： DONG-A ST CO. LTD
发明人： SON, Mi Won , LEE, Tae Ho , BAEK, Nam Joon , LEE, Sang Jin , LEE, Hyang Hwa , PARK, Hyun Sung
IPC分类号： A61K36/82 , A61P3/04 , A61P3/00
CPC分类号： A61K36/82 , A23L33/105 , A23V2002/00 , A61K2236/00 , A23V2200/332 , A23V2250/214
摘要： The present invention relates to a composition comprising black tea extracts. More particularly, the herb extract extracted by enfleurage with aqueous ethanol solution of the present invention contains higher concentration of gallic acid which is an active ingredient and an index ingredient of black tea than the herb extract prepared by the conventional hot-water extraction and ethanol extraction, and has excellent effect of reducing body weight and body fat, improving fatty liver, regulating blood sugar, and reducing blood cholesterol in the high fat diet-induced obese mouse model, so that the extract of the present invention can be effectively used as an active ingredient of a pharmaceutical composition and health food for preventing and treating obesity, metabolic disease, diabetes, and hyperlipidemia.
摘要翻译：本发明涉及包含红茶提取物的组合物。更具体地说，通过本发明的乙醇水溶液浸泡提取的草本植物提取物含有比通过常规热水提取和乙醇提取制备的草药提取物更高浓度的没食子酸作为活性成分和红茶指数成分，并且在高脂肪饮食诱导的肥胖小鼠模型中具有降低体重和体脂肪，改善脂肪肝，调节血糖和降低血液胆固醇的优异效果，使得本发明的提取物可以有效地用作用于预防和治疗肥胖，代谢疾病，糖尿病和高脂血症的药物组合物和保健食品的活性成分。

6. 发明申请

WO2014065510A1 NOVEL ROTENONE DERIVATIVES AND A USE THEREOF 审中-公开
标题翻译：新型罗丹酮衍生物及其用途
公开(公告)号：WO2014065510A1
公开(公告)日：2014-05-01
申请号：PCT/KR2013/008487
申请日：2013-09-23
申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE
发明人： CHUNG, Byung Yeoup , KIM, Tae Hoon , LEE, Seung Sik , BAI, Hyoungwoo , LEE, Sungbeom , PARK, Chul Hong
IPC分类号： C07D493/14 , C07D493/20 , A61K31/537 , A61P3/04
CPC分类号： C07D493/22 , A61K31/537 , B01J19/08 , C07D493/14 , C07D493/20
摘要： The present invention relates to a novel rotenone derivative and a use of the same. Particularly, the present inventors identified the novel rotenoisin A and B which were the compounds with no toxicity and prepared by irradiation with gamma ray onto rotenone represented by the following formula 1 and further confirmed that the novel rotenone derivative significantly inhibited pancreatic lipase activity and preadipocyte differentiation. The novel rotenone derivative of the present invention can be effectively used as a composition for the prevention and treatment of obesity and as a composition for health functional food for the prevention and improvement of obesity: [Formula 1] (In formula 1, R1 and R2 are as defined in this description).
摘要翻译：本发明涉及一种新颖的鱼藤酮衍生物及其用途。特别地，本发明人鉴定了作为无毒性化合物的新型罗非鱼素A和B，其通过用γ射线照射到由下式1表示的鱼藤酮上制备，并进一步证实该新型鱼藤酮衍生物显着抑制胰脂肪酶活性和前脂肪细胞分化。本发明的新颖的鱼藤酮衍生物可以有效地用作预防和治疗肥胖的组合物，并且作为用于预防和改善肥胖症的健康功能性食品的组合物：[式1]（式1中R1和R2 如本说明书中所定义）。

7. 发明申请

WO2011030981A1 METHOD FOR PREPARING [18F]FALLYPRIDE WITH LOW BASE CONCENTRATION 审中-公开
标题翻译：用于制备具有低碱浓度的[18F] FALLYPRIDE的方法
公开(公告)号：WO2011030981A1
公开(公告)日：2011-03-17
申请号：PCT/KR2010/001351
申请日：2010-03-04
申请人： SNU R&DB FOUNDATION , KIM, Sang Eun , LEE, Byung Chul , MOON, Byung Seok , KIM, Yu Kyeong
发明人： KIM, Sang Eun , LEE, Byung Chul , MOON, Byung Seok , KIM, Yu Kyeong
IPC分类号： C07D207/14 , A61K31/40 , A61P21/00
CPC分类号： C07D207/09
摘要： A method for preparing [ 18 F]fallypride is disclosed, which comprises a first step for trapping a fluorine-18 to a polymer ion exchange cartridge; a second step for extraction of fluorine-18 by inputting low base concentrations: 5.0~25μL of 40% TBAHCO 3 or K2.2.2./K 2 CO 3 (5~25mg/0.5~3.0 mg) as a phase-transfer catalyst in a mixture of alcohol/water(1.0/0.2(v/v)) or alcohol as a solvent into the polymer ion exchange cartridge trapped by the fluorine-18; a third step for preparing a [ 18 F]fallypride product by removing the solvent from the trapped fluorine-18, by inputting tosylate precursor in CH 3 CN as a solvent into a reactor and by reacting the same for 5~35 minutes at 50~120°C; and a fourth step for preparing a pure [ 18 F]fallypride by purifying the prepared [ 18 F]fallypride product. The present invention makes it possible to improve the radiochemical yield of [ 18 F]fallypride, the improvement of which was a problem in the conventional automated method, by more than about 50% while reducing the preparation time by about 20 minutes. The present invention can be well applied to a clinical research by the positron emission tomography (PET).
摘要翻译：公开了一种制备[18 F]菲拉必利的方法，其包括将氟-18捕获到聚合物离子交换盒的第一步骤; 通过输入低碱浓度来提取氟-18的第二步：将5.0〜25μL40％TBAHCO 3或作为相转移催化剂的K2.2.2./K2CO3（5〜25mg / 0.5〜3.0mg）在醇的混合物中 /水（1.0 / 0.2（v / v））或醇作为溶剂进入被氟-18捕获的聚合物离子交换柱; 将通过在CH 3 CN中的甲苯磺酸酯前体作为溶剂输入反应器并通过在50〜120℃下反应5〜35分钟，通过从捕获的氟-18中除去溶剂来制备[18 F] fallypride产物的第三步骤 ; 以及通过纯化制备的[18 F] fallypride产物制备纯的[18 F] fallypride的第四步骤。通过本发明，可以提高常规自动化方法中的改善成为问题的[18F] fallypride的放射化学产率超过约50％，同时将制备时间缩短约20分钟。本发明可以很好地应用于正电子发射断层摄影（PET）的临床研究。

8. 发明申请

WO2011025179A2 METHOD OF INDUCING THE DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO MESENCHYMAL STEM CELLS 审中-公开
标题翻译：诱导人胚胎干细胞分化为间质干细胞的方法
公开(公告)号：WO2011025179A2
公开(公告)日：2011-03-03
申请号：PCT/KR2010/005471
申请日：2010-08-18
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , HAN, Yong-Mahn , TUNG, Tran-Ngoc , PARK, Sang-Wook , JANG, Mi-jin
发明人： HAN, Yong-Mahn , TUNG, Tran-Ngoc , PARK, Sang-Wook , JANG, Mi-jin
IPC分类号： C12N5/00 , C12N7/00
CPC分类号： C12N5/0606 , C12N5/0662 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2501/999 , C12N2506/02
摘要： Disclosed is a method for inducing human embryonic stem cells to differentiate into mesenchymal stem cells, using an optimal medium. Human embryonic stem cells are induced differentiate into mesodermal progenitors by activating TGF-β (Transforming growth factor-β), WNT and BMP (Bone morphogenic protein) signaling pathways and further into mesenchymal stem cells by treating with bFGF. The method is effective for producing mesenchymal stem cells, useful cell-based therapies, on a large scale.
摘要翻译：公开了使用最佳培养基诱导人胚胎干细胞分化为间充质干细胞的方法。通过激活TGF-β（转化生长因子-β），WNT和BMP（骨形态发生蛋白）信号传导途径并通过用bFGF处理进一步进入间充质干细胞，诱导人胚胎干细胞分化成中胚层祖细胞。该方法对于大规模生产间充质干细胞是有效的基于细胞的疗法是有效的。

9. 发明申请

WO2010061982A1 STENT INCLUDING ELASTIC PART USING FOR SURGICAL OPERATION OF IMPLANT 审中-公开
标题翻译：包括用于外科手术操作的弹性部件的步骤
公开(公告)号：WO2010061982A1
公开(公告)日：2010-06-03
申请号：PCT/KR2008/006466
申请日：2008-11-03
申请人： YI, Tae-Kyoung , JUNG, Je-Kyo
发明人： YI, Tae-Kyoung , JUNG, Je-Kyo
IPC分类号： A61C8/00
CPC分类号： A61C1/084 , A61B17/176
摘要： A stent for implant surgery is disclosed. The stent includes a support part surrounding a buccal side, lingual side and occlusal side of at least one tooth, and a treated part having a through hole through which a drill for drilling alveolar bone passes. The support part extends further from a height of a contour of at least one of the buccal side and the lingual side to surround part of an undercut of the tooth. Further, an elastic part which is elastically deformable is attached to the inner surface of each of the buccal side and the lingual side of the support part.
摘要翻译：公开了一种用于植入手术的支架。支架包括围绕至少一个牙齿的颊侧，舌侧和咬合侧的支撑部分，以及具有用于钻孔牙槽骨钻头通过的通孔的处理部分。支撑部分从颊侧和舌侧至少一个的轮廓的高度进一步延伸以围绕齿的底切部分。此外，可弹性变形的弹性部分附接到支撑部分的颊侧和舌侧的内表面。

10. 发明申请

WO2010053218A1 FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME 审中-公开
标题翻译：氟化苯并噻唑衍生物，其制备方法及使用其诊断阿尔茨海默病的成像剂
公开(公告)号：WO2010053218A1
公开(公告)日：2010-05-14
申请号：PCT/KR2008/006546
申请日：2008-11-06
申请人： SNU R&DB FOUNDATION , KIM, Sang Eun , LEE, Byung Chul , KIM, Ji Sun , CHUN, Young Sin
发明人： KIM, Sang Eun , LEE, Byung Chul , KIM, Ji Sun , CHUN, Young Sin
IPC分类号： C07D417/02 , A61K49/00 , C07D277/82 , A61K31/425
CPC分类号： C07D277/66 , A61K51/0453 , C07B59/002
摘要： The present invention relates to fluorinated benzothiazole derivatives, a preparation method thereof, and an imaging agent for diagnosing Alzheimer' s disease using the same, and more particularly to fluorinated benzothiazole derivatives represented by Chemical Formula 1, derivatives of Chemical Formula 2 as a starting material for preparation thereof, a preparation method thereof, and an imaging agent for diagnosing Alzheimer's disease using fluorinated benzothiazole derivatives with a strong binding force to beta-amyloid plaque, which is a kind of biomarker for Alzheimer's disease. According to the present invention, fluorine-labeled benzothiazole derivatives, which have been difficult to synthesize by conventional methods, may be obtained by simple processes and the thus-obtained benzothiazole derivatives may be useful in diagnosing the presence and severity of Alzheimer's disease.
摘要翻译：本发明涉及氟化苯并噻唑衍生物，其制备方法和用于诊断阿尔茨海默病的成像剂，更具体地说，涉及化学式1所示的氟化苯并噻唑衍生物，作为原料的化学式2的衍生物用于制备其制备方法和用于使用对β-淀粉样蛋白斑具有强结合力的氟化苯并噻唑衍生物来诊断阿尔茨海默病的成像剂，其是阿尔茨海默氏病的一种生物标志物。根据本发明，通过常规方法难以合成的氟标记的苯并噻唑衍生物可以通过简单的方法获得，因此得到的苯并噻唑衍生物可用于诊断阿尔茨海默氏病的存在和严重性。

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