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1. 发明申请

WO2005099716A2 METHOD FOR ANALYZING THE BIOLOGICAL AGE OF A SUBJECT 审中-公开
标题翻译：分析受试者生物学年龄的方法
公开(公告)号：WO2005099716A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012340
申请日：2005-04-12
申请人： SHALLENBERGER, Frank
发明人： SHALLENBERGER, Frank
IPC分类号： A61K31/56
CPC分类号： A61B5/083 , A61K31/56
摘要： The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subject's biological age and treat the factors associated with biological age.
摘要翻译：本发明是用于分析受试者的生物学年龄的方法。该方法分析生物学年龄，因为它涉及许多表明健康水平，能量生产和新陈代谢的因素。该方法也可用于计算受试者的生物年龄并治疗与生物年龄相关的因素。

2. 发明申请

WO2009014532A1 STABILIZED TOLTERODINE TARTRATE FORMULATIONS 审中-公开
标题翻译：稳定的妥尔妥膦酸盐配方
公开(公告)号：WO2009014532A1
公开(公告)日：2009-01-29
申请号：PCT/US2007/025970
申请日：2007-12-20
申请人： MYLAN PHARMACEUTICALS, INC. , ROSSI, David, T. , LI, Boyong , MCCALL, James, Paul
发明人： ROSSI, David, T. , LI, Boyong , MCCALL, James, Paul
IPC分类号： A61K31/205
CPC分类号： A61K31/137 , A61K9/1676 , A61K9/5078 , A61K9/5084 , A61K31/135 , A61K47/12
摘要： A pharmaceutical composition contains tolterodine L-tartrate stabilized against degradation with an acid. Acid-stabilized tolterodine L-tartrate may be used to make various types of immediate release and controlled release dosage forms.
摘要翻译：药物组合物含有稳定的抗酸降解的托特罗定L-酒石酸盐。酸稳定的托特罗定L-酒石酸盐可用于制备各种类型的即时释放和控释剂型。

3. 发明申请

WO2005060738A1 BEEHIVE FEEDER 审中-公开
公开(公告)号：WO2005060738A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/027334
申请日：2004-08-24
申请人： WILLS, Robert
发明人： WILLS, Robert
IPC分类号： A01K53/00
CPC分类号： A01K53/00
摘要： A device for feeding bees, comprising a rigid heat-absorptive housing having a chamber therein, said chamber having a bottom surface with a plurality of holes passing therethrough. The housing has an access port which allows a viscous syrup to be poured into the chamber. The port may be reversibly sealed. The device further includes a means for mounting said housing on top of a beehive. The plurality of holes in the bottom of the chamber are large enough to allow a bee to access the viscous syrup through the holes, but small enough to prevent the viscous syrup from dripping through the holes.
摘要翻译：一种用于喂食蜂的装置，包括其中具有室的刚性吸热壳体，所述室具有底表面，多个孔穿过其中。壳体具有允许将粘性糖浆倒入室中的进入口。港口可以可逆地密封。该装置还包括用于将所述壳体安装在蜂巢之上的装置。室底部的多个孔足够大以允许蜜蜂通过孔进入粘性糖浆，但足够小以防止粘性糖浆滴穿孔。

4. 发明申请

WO2004065505A1 WATER BASED PROTECTANT CONTAINING A REACTION PRODUCT OF TWO IONIC SURFACTANTS 审中-公开
标题翻译：含有两种离子表面活性剂的反应产物的水基保护剂
公开(公告)号：WO2004065505A1
公开(公告)日：2004-08-05
申请号：PCT/US2003/040818
申请日：2003-12-23
申请人： GHODOUSSI, Vahid
发明人： GHODOUSSI, Vahid
IPC分类号： C09G1/08
CPC分类号： C09G1/12 , C09G1/08
摘要： A composition for application to a surface and a method of making the same, said composition comprising at least one wax; at least one reaction product derived from a first surfactant and a second surfactant; and between 40% and 99.8% water by weight. The composition is made by: a) forming an emulsion by combining the water and the wax after heating both the water and the wax to a temperature greater than the melting point of the wax, where at least one of said water and said wax contains said first surfactant, said first surfactant being selected from the group consisting of a cationic surfactant and an anionic surfactant; andb) adding said second surfactant to the emulsion, said second surfactant having a charge which is opposite to that of said first surfactant.
摘要翻译：一种用于表面的组合物及其制备方法，所述组合物包含至少一种蜡; 至少一种衍生自第一表面活性剂和第二表面活性剂的反应产物; 和40％至99.8％之间的水。该组合物通过以下方法制备：a）在将水和蜡加热至大于蜡的熔点的温度下，通过组合水和蜡来形成乳液，其中所述水和所述蜡中的至少一种含有所述所述第一表面活性剂选自阳离子表面活性剂和阴离子表面活性剂; 和b）向所述乳液中加入所述第二表面活性剂，所述第二表面活性剂具有与所述第一表面活性剂相反的电荷。

5. 发明授权

US11975445B2 System for connecting end effectors to robot arms that operate under sterile conditions 有权
公开(公告)号：US11975445B2
公开(公告)日：2024-05-07
申请号：US17396189
申请日：2021-08-06
申请人： DePuy Synthes Products, Inc. , Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
发明人： Matias de la Fuente Klein , Lukas Theisgen , Manuel Vossel , Klaus Radermacher , Gerd Petasch
IPC分类号： B25J19/00 , A61B17/00 , A61B34/00 , A61B34/30 , A61B46/10 , B25J15/04
CPC分类号： B25J19/0075 , A61B34/30 , A61B34/70 , A61B46/10 , B25J15/0408 , A61B2017/00477 , A61B2034/305
摘要： An end effector is removably connected to a robot arm under sterile conditions with an arm mount module configured to be connected to the robot arm, and an arm drape module configured to be removably connected to the arm mount module by a first locking mechanism. A third module may be configured to be removably connected to the arm drape module by a second locking mechanism. A sterile hand drape module may be configured to be removably connected to the arm drape module by the second locking mechanism; and a hand mount module may be configured to be removably connected to the hand drape module by a third locking mechanism, and to be connected to the end effector or the hand mount module is the end effector itself. A transmission pathway for signals, electrical energy, or mechanical energy is provided between the robot arm and the end effector.

6. 发明授权

US11911048B2 Variable angle drill guide 有权
公开(公告)号：US11911048B2
公开(公告)日：2024-02-27
申请号：US17541676
申请日：2021-12-03
申请人： DEPUY SYNTHES PRODUCTS, INC.
发明人： Michael McGurk , Henri Défossez , Simon Wampfler , Gregor Spreiter , Frederic Gueissaz , Marcel Schweizer , Said Ghammar , Andreas Baeriswyl , Mirko Rocci , Steffan Daniel
IPC分类号： A61B17/17 , A61B17/00 , A61B90/00
CPC分类号： A61B17/1728 , A61B2017/0046 , A61B2017/00862 , A61B2090/034
摘要： A drill guide handle configured to engage a variable angle drill guide, including: a handle grip; a first cannula extending from a proximal end of the drill guide handle to a distal end of the drill guide handle, wherein the first cannula is configured to provide a zero degree insertion angle for a drill bit; and a body including: a first tab and a second tab wherein the first and second tabs include a first and second tab protrusion, respectively, wherein each of the first tab and the second is configured to flex so that the first and second tab protrusions engage a horizontal groove on a variable angle drill guide; and a body protrusion on an inner surface of the body, wherein the body protrusion is configured to engage a vertical grove on the variable angle drill guide.

7. 发明授权

US11781155B2 Potent and balanced bidirectional promoter 有权
公开(公告)号：US11781155B2
公开(公告)日：2023-10-10
申请号：US17204312
申请日：2021-03-17
申请人： Kerstin Wunderlich , Jort Vellinga
发明人： Kerstin Wunderlich , Jort Vellinga
IPC分类号： C12N15/86 , C12N15/85 , A61K39/00
CPC分类号： C12N15/86 , C12N15/85 , A61K2039/53 , A61K2039/70 , C12N2710/10321 , C12N2710/10343 , C12N2710/16122 , C12N2710/16143 , C12N2830/15 , C12N2830/205
摘要： The invention provides a bidirectional hCMV-rhCMV promoter and recombinant vectors and recombinant virus comprising the bidirectional hCMV-rhCMV promoter operably linked to a first transgene in one direction and to a second transgene in the opposite direction. The invention also provides methods of making and using such recombinant vectors and recombinant virus.

8. 发明授权

US11723723B2 Outcome-based splinting 有权
公开(公告)号：US11723723B2
公开(公告)日：2023-08-15
申请号：US17384319
申请日：2021-07-23
申请人： DEPUY SYNTHES PRODUCTS, INC.
发明人： Steffan Daniel , Andre Furrer , Simon Bosshard
IPC分类号： A61B17/64 , A61B34/10 , A61B17/56 , A61B17/66 , A61B17/72 , A61B17/00 , A61B17/68
CPC分类号： A61B34/10 , A61B17/56 , A61B17/64 , A61B17/66 , A61B17/72 , A61B2017/0092 , A61B2017/00862 , A61B2017/00964 , A61B2017/564 , A61B2017/681 , A61B2034/104 , A61B2034/105
摘要： A bone fracture fixation system including reference pins inserted into bone fragments of a patient in a first configuration and an image capture device configured to capture an image of the reference pins, and the bone fragments. The system includes a processor configured to receive and pre-process the captured image data. The processor pre-processes the image data by virtually re-positioning the reference pins in the first configuration into a second configuration, wherein the re-positioning virtually re-positions the bone fragments into normal alignment; and virtually generating a support device. The system includes a point-of-care production apparatus that produces a three-dimensional model of the virtually generated support device in a form that can be applied to the patient. The three-dimensional support device generated by the point-of-care production apparatus is configured to receive the reference pins in the first configuration; and simultaneously re-positions and fixes the bone fragments into normal alignment.

9. 发明授权

US11701132B2 Lateral cortex penetrator 有权
公开(公告)号：US11701132B2
公开(公告)日：2023-07-18
申请号：US17212600
申请日：2021-03-25
申请人： Depuy Synthes Products, Inc.
发明人： Stanley J. Kmiec, Jr.
IPC分类号： A61B17/17 , A61B17/16 , A61B17/34 , A61B17/56
CPC分类号： A61B17/1721 , A61B17/1604 , A61B17/1615 , A61B17/1633 , A61B17/1668 , A61B17/1697 , A61B17/1725 , A61B17/1753 , A61B17/3472 , A61B2017/564
摘要： A system for penetrating the lateral cortex of a long bone includes a tubular cortex penetrator having an inner surface and an outer surface, a proximal end, and a distal end comprising a beveled cutting edge configured to penetrate the lateral cortex. A guide wire is configured to pass over the tubular cortex penetrator, and a guide sleeve is configured to surround the outer surface of the tubular cortex penetrator. A hollow extraction screw with an axial bore, a proximal end, a distal end, and a threaded cutting edge is configured to pass through the axial bore of the hollow extraction screw; and the hollow extraction screw is configured to retract into a distal end of a bore through the tubular cortex penetrator.

10. 发明授权

US11565251B2 Microfluidic chip as a model for blood-tissue barriers 有权
公开(公告)号：US11565251B2
公开(公告)日：2023-01-31
申请号：US16786335
申请日：2020-02-10
申请人： WEST VIRGINIA UNIVERSITY
发明人： Paul Lockman
IPC分类号： B01L3/00 , C12M3/06
摘要： A microfluidic device is useful for modelling drug transmission across the vasculature and vascular barriers. The device includes a frame, a fluid-permeable lumen configured to carry a fluid through the frame in a first direction, a first chamber surrounding the lumen, and a second chamber surrounding the first fluid-permeable chamber. At least one surface of the first chamber is configured for deposition of a first population of endothelial cells. An outer surface of the second chamber is configured for deposition a second population of cells. The second chamber is configured to carry a fluid through the frame in a second direction. The fluid-permeable lumen is configured to allow the fluid to permeate through a wall of the lumen into the first chamber, and the first chamber and the second chamber are in fluid communication with each other.

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