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1. 发明申请

WO2018148209A1 METHOD OF USE FOR THERAPEUTIC BONE AGENTS 审中-公开
公开(公告)号：WO2018148209A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017082
申请日：2018-02-06
申请人： ISO THERAPEUTICS GROUP, LLC
发明人： SIMON, Jaime , FRANK, R. Keith
IPC分类号： A61K51/04 , A61K51/00 , G21G1/02
摘要： This invention relates to radioactive, bone-seeking, pharmaceutical compositions that are administered multiple times to a patient, have a lower impurity profile, a longer shelf life, and are less expensive to prepare.

2. 发明申请

WO2013096776A2 RADIOACTIVE COMPOSITIONS AND METHODS FOR THEIR THERAPEUTIC USE 审中-公开
标题翻译：放射性组合物及其治疗方法
公开(公告)号：WO2013096776A2
公开(公告)日：2013-06-27
申请号：PCT/US2012/071256
申请日：2012-12-21
申请人： ISO THERAPEUTICS GROUP LLC
发明人： WILSON, David, A. , FRANK, R., Keith , SIMON, Jaime , CRUMP, Druce, K.
IPC分类号： A61K51/12
CPC分类号： A61K51/1282 , A61K51/00 , A61K51/1244
摘要： This invention concerns a pharmaceutically-acceptable composition of radioactive metals, which are used for treating various diseases in animals or humans, such as cancer and arthritis.
摘要翻译：本发明涉及用于治疗动物或人类诸如癌症和关节炎的各种疾病的放射性金属的药学上可接受的组合物。

3. 发明申请

WO2011103529A1 CROSSLINKED POLYMER-CARBON SORBENT FOR REMOVAL OF HEAVY METALS, TOXIC MATERIALS AND CARBON DIOXIDE 审中-公开
标题翻译：用于去除重金属，有毒材料和二氧化碳的交联聚合物碳分子
公开(公告)号：WO2011103529A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025583
申请日：2011-02-21
申请人： CENTRAL MICHIGAN UNIVERSITY , MOHANTY, Dillip , MATTY, David, J.
发明人： MOHANTY, Dillip , MATTY, David, J.
IPC分类号： B01D53/02
CPC分类号： B01D53/64 , B01D53/02 , B01D53/83 , B01D2253/102 , B01D2253/202 , B01D2253/25 , B01D2257/504 , B01D2257/60 , B01D2257/602 , B01D2257/93 , B01D2258/0283 , B01J20/20 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/30 , B01J20/3078 , B01J2220/46 , B01J2220/56 , B01J2220/58 , Y02C10/04 , Y02C10/08
摘要： A polymer-carbon sorbent for removing carbon dioxide, heavy metals and toxic materials from a flue gas from a combustion process, such as coal-fired power plants, is described. The sorbent comprises a carbonaceous sorbent material and a cured amine- containing polymer, and sulfur. The polymer-carbon sorbents are formed by curing a curable amine-containing polymer in the presence of the carbonaceous sorbent material, a sulfur crosslinker, a cure accelerator and, optionally, a cure activator. A convenient carbonaceous sorbent material is an activated carbon, and a convenient curable amine- containing polymer is an allyl-containing poly(ethyleneimine), having a number average molecular weight between about 1,500 and about 10,000. The polymer-carbon sorbents may contain sulfur in excess of an amount needed to cure the curable amine-containing polymer. Such polymer-carbon sorbents are shown to capture more mercury, in both elemental an ionic forms, compared to activated carbon and adsorb carbon dioxide.
摘要翻译：描述了用于从诸如燃煤发电厂的燃烧过程的烟道气中去除二氧化碳，重金属和有毒物质的聚合物 - 碳吸附剂。吸附剂包括含碳吸附剂材料和固化的含胺聚合物和硫。聚合物 - 碳吸附剂通过在含碳吸附剂材料，硫交联剂，固化促进剂和任选的固化活化剂的存在下固化可固化的含胺聚合物而形成。方便的含碳吸附剂材料是活性炭，并且方便的可固化含胺聚合物是含烯丙基的聚（乙烯亚胺），其数均分子量为约1,500至约10,000。聚合物 - 碳吸附剂可以含有超过固化可固化含胺聚合物所需量的硫。与活性炭和吸附二氧化碳相比，这种聚合物 - 碳吸附剂显示出更多的汞以元素的离子形式捕获。

4. 发明申请

WO2011022588A1 SULFONATION OF POLYHYDROXYAROMATICS 审中-公开
标题翻译：聚羟基甲烷的降解
公开(公告)号：WO2011022588A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/046079
申请日：2010-08-20
申请人： DRATHS CORPORATION , FROST, John, W. , BUI, Vu
发明人： FROST, John, W. , BUI, Vu
IPC分类号： A01N57/00
CPC分类号： C07C309/60 , C07B2200/05 , C07C303/06 , Y02P20/582
摘要： The present invention provides improved process for the sulfonation of hydroxyaromatics amenable to direct isolation of the sulfonylated hydroxyaromatics in their free-acid forms. The process allows for the recyclization of sulfuric acid and minimizes waste. The starting materials are from a renewal resource, e.g., biomass, and contain detectable 14C up to a 14C content of 0.0000000001% (one part per trillion). The products made include sulfonated catechol, disulfonated pyrogallol and sulfonated protocatechuic acid.
摘要翻译：本发明提供改进的用于磺化羟基芳族化合物的方法，该方法适于直接分离其游离酸形式的磺酰化羟基芳族化合物。该方法允许硫酸的再循环，并最大限度地减少浪费。起始材料来自更新资源，例如生物质，并含有可检测的14C至14C含量为0.0000000001％（一兆份）。所制备的产品包括磺化儿茶酚，二磺化连连酚和磺化原儿茶酸。

5. 发明申请

WO2009120309A9 NETWORKS CONTAINING PERFLUOROCARBON ORGANOSILICON HYPERBRANCHED POLYMERS 审中-公开
公开(公告)号：WO2009120309A9
公开(公告)日：2009-10-01
申请号：PCT/US2009/001824
申请日：2009-03-24
申请人： MICHIGAN MOLECULAR INSTITUTE , HU, Jin , XU, Quiyun , SACHDEVA, Rakesh , MEIER, Dale, J. , NOWAK, Robert, M. , DVORNIC, Petar, R.
发明人： HU, Jin , XU, Quiyun , SACHDEVA, Rakesh , MEIER, Dale, J. , NOWAK, Robert, M. , DVORNIC, Petar, R.
IPC分类号： C08L83/08
摘要： The present invention relates to hyperbranched copolymer networks containing hyperbranched copolymers that have perfluorocarbon and organosilicon entities that have high hydrophobicity, or high oleophobicity, or high thermal stability, or good adhesion to substrates, or any combinations thereof. This invention provides a further desirable combination of properties that include solubility before crosslinking, chemical resistance, and easy processibility. The copolymers may be crosslinked with a variety of crosslinking agents to give either rigid or elastomeric networks.

6. 发明申请

WO2008118254A3 REMOTE LASER INTERROGATION OF THREAT CLOUDS AND SURFACES 审中-公开
标题翻译：远程激光干扰威胁云和表面
公开(公告)号：WO2008118254A3
公开(公告)日：2008-10-02
申请号：PCT/US2008/000994
申请日：2008-01-25
申请人： MICHIGAN MOLECULAR INSTITUTE , HARTMANN-THOMPSON, Claire
发明人： HARTMANN-THOMPSON, Claire
IPC分类号： C08K5/24 , A01N55/00 , A61K8/00
摘要： This invention concerns the remote detection of threat clouds and evaluation of their components. Also included is the remote detection and evaluation of contamination on surfaces or in air streams. To enable this detection, fluorophores that are attached to POSS are used with two-photon LIF imaging that provides enhanced background-free imaging even in the presence of scattering particles such as dust, sand and water droplets.
摘要翻译：本发明涉及威胁云的远程检测和它们的组件的评估。还包括远程检测和评估表面或气流中的污染物。为了实现这种检测，连接到POSS的荧光团与双光子LIF成像一起使用，即使在存在散射粒子（如灰尘，沙子和水滴）的情况下也可提供增强的无背景成像。

7. 发明申请

WO2008013618A1 PROCESS FOR PREPARING ALKYNE INTERMEDIATES FOR DENDRITIC POLYMERS 审中-公开
标题翻译：制备聚合物烯烃中间体的方法
公开(公告)号：WO2008013618A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/014404
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , TOMALIA, Donald, A. , SWANSON, Douglas, R.
发明人： TOMALIA, Donald, A. , SWANSON, Douglas, R.
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： C07D295/205 , C07D249/04
摘要： This invention provides a process for preparing alkyne intermediates used for making dendritic polymers. This process concerns alkyne compounds, useful as "clickable intermediates" to produce novel core reagents, branch cell reagents, surface group reagents, dendron reagents, oligomeric extender reagents, dendrimer core reagents, or dendrimer shell reagents suitable for preparing dendritic polymers, which comprises: 1) reacting acetylenic halides ( i.e. chlorides, bromides or iodides) or acetylenic mesylates/tosylates with 2-alkyl/aryl-2-oxazolines or oxazines to produce N-acetylenic-2-oxazolinium or 2-oxazinium cation salts; and 2) reacting N-acetylenic-2-oxazolinium or 2-oxazinium cation salts as catalytic reagents for the polymerization of 2-alkyl/aryl-2-oxazolines or 2-alkyl/aryl-2-oxazines; or 3) reacting propargyl tosylate or propargyl halides with 2-ethyl-2-oxazoline and then polymerizing to alkyne substituted poly(2-ethyl-2-oxazolines) with a degree of polymerization ( i.e. , dp=1-100); or 4) reacting propargyl tosylate with 2-ethyl-2-oxazoline (1:1) in the presence of sodium bromide or sodium iodide in acetonitrile to form N-propargyl-2-oxazolinium bromides/iodides, respectively; or 5) reacting 3-butyne-1,4-ditosylate in the presence of sodium iodide or sodium bromide in acetonitrile to form 3-butyne-1,4-dioxazolinium iodide or bromide, respectively.
摘要翻译：本发明提供了制备用于制备树枝状聚合物的炔烃中间体的方法。该方法涉及可用作“可点击中间体”的炔基化合物，用于制备适用于制备树枝状聚合物的新型核心试剂，支链细胞试剂，表面试剂，树枝状试剂，低聚延伸剂试剂，树枝状聚合物核试剂或树枝状大分子壳试剂，其包括： 1）使炔基卤化物（即氯化物，溴化物或碘化物）或炔丙基甲磺酸酯/甲苯磺酸酯与2-烷基/芳基-2-恶唑啉或恶嗪反应，生成N-炔属-2-恶唑啉鎓或2-恶嗪鎓阳离子盐; 和2）N-炔属-2-恶唑啉鎓或2-恶嗪鎓阳离子盐作为用于2-烷基/芳基-2-恶唑啉或2-烷基/芳基-2-恶嗪的聚合的催化剂; 或3）使炔丙基甲苯磺酸酯或炔丙基卤化物与2-乙基-2-恶唑啉反应，然后聚合成具有聚合度（即dp = 1-100）的炔取代的聚（2-乙基-2-恶唑啉）; 或4）在溴化钠或碘化钠存在下，在乙腈存在下，使甲磺酸炔丙酯与2-乙基-2-恶唑啉（1:1）反应，分别形成N-炔丙基-2-恶唑啉溴化物/碘化物; 或5）在碘化钠或溴化钠存在下在乙腈中的3-丁炔-1,4-二硫酸酯反应，分别形成3-丁炔-1,4-二氧杂环丁烷碘化物或溴化物。

8. 发明申请

WO2005019290A2 ULTRA HIGH MOLECULAR WEIGHT HYBRID DENDRIGRAFT ARCHITECTURES 审中-公开
标题翻译：超高分子量混合动力建筑
公开(公告)号：WO2005019290A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/025045
申请日：2004-08-03
申请人： DENDRITIC NANOTECHNOLOGIES, INC.
发明人： TOMALIA, Donald, A. , SWANSON, Douglas, R.
IPC分类号： C08G
CPC分类号： C08G83/002 , C08G83/005
摘要： Mono-reactive dendrigrafts prepared by convergent self-branching polymerization and their subsequent grafting to linear, dendritic, and dendrigraft, branched, and hyper-branched substrates to prepare ultra-high molecular weight dendrigraft architectures using alkyl halides and aryl halides as initiators.
摘要翻译：通过会聚自支化聚合制备的单反应性树枝状体，并且随后将其接枝到线性，树枝状和树枝状，支链和超分支底物，以制备使用烷基卤和芳基卤化物作为引发剂的超高分子量树枝状结构。

9. 发明申请

WO2020123894A1 CARBON BLACK FROM BIOMASS 审中-公开
公开(公告)号：WO2020123894A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/066129
申请日：2019-12-13
申请人： CHRISMAN, Ray W.
发明人： CHRISMAN, Ray W.
IPC分类号： C09C1/48 , C09C1/60
摘要： A process for making carbon black is described by pyrolizing unsulfonated lignin or by pyrolizing aromatic monomers formed by hydrolyzing a biomass comprising unsulfonated lignin.

10. 发明申请

WO2016191413A1 DOTMP KIT FORMULATIONS FOR RADIOISOTOPES 审中-公开
标题翻译：放射性物质的DOTMP工具包制剂
公开(公告)号：WO2016191413A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033900
申请日：2016-05-24
申请人： ISO THERAPEUTICS GROUP, LLC
发明人： FRANK, R., Keith , SIMON, Jaime , JAY, Kelli, R.
IPC分类号： A61K31/675 , A61K51/04 , A61P19/08
CPC分类号： A61K51/0482 , A61K51/121 , A61K51/1282 , A61K2121/00 , A61P19/08
摘要： This invention relates to a Kit formulation to prepare a radioactive, bone-seeking, pharmaceutical drug that has high radiochemical purity (RCP) in a fast, facile and reproducible process. The Kit has at least two vials and a two part buffer system with instructions on how to make the drug formulation in a radiopharmacy. The drug formulations of this invention can be conveniently and reproducibly prepared with better delivery of the drug to mammals, better radiochemical purity of the formulation for use in treating a mammal having bone pain, one or more calcific tumors or needing bone marrow suppression.
摘要翻译：本发明涉及一种用于制备放射性，寻骨的药物的Kit制剂，其具有高放射化学纯度（RCP），快速，简便且可再现的方法。该试剂盒至少有两个小瓶和两部分缓冲系统，其中包含如何在放射性药物中制备药物的说明。本发明的药物制剂可以以更好的药物递送到哺乳动物，更好的放射化学纯度用于治疗具有骨痛的哺乳动物，一种或多种钙化肿瘤或需要骨髓抑制的方法可重复地制备。

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