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1. 发明申请

WO2021239471A1 CANCER TREATMENT STRATEGIES USING ARENAVIRUS VECTORS 审中-公开
公开(公告)号：WO2021239471A1
公开(公告)日：2021-12-02
申请号：PCT/EP2021/062728
申请日：2021-05-12
申请人： HOOKIPA BIOTECH GMBH
发明人： MATUSHANSKY, Igor , HWANG, Andy , KATCHAR, Kianoosh , EDWARDS, Donna , LAUTERBACH, Henning , SCHWENDINGER, Michael , ORLINGER, Klaus , SCHMIDT, Sarah , BERKA, Ursula , IACOBUCCI, Corinne , SCHLIENGER, Katia
IPC分类号： A61K39/12 , A61P35/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/585 , A61K2039/70 , A61K2039/80 , A61K39/395 , C07K16/2818 , C07K2317/24 , C07K2317/76 , C12N2710/20034 , C12N2760/10023 , C12N2760/10034
摘要： The present application relates generally to cancer treatment strategies using arenavirus particles. The treatment strategies described herein are for treating cancer, including head and neck squamous cell carcinoma, using tri-segmented arenavirus particles encoding a human papillomavirus (HPV) antigen. The treatment strategies described herein can include administration of an immune checkpoint inhibitor.

2. 发明申请

WO2021140144A1 ENGINEERED LEISHMANIA CELLS 审中-公开
公开(公告)号：WO2021140144A1
公开(公告)日：2021-07-15
申请号：PCT/EP2021/050173
申请日：2021-01-07
申请人： LIMMATECH BIOLOGICS AG
发明人： MALLY, Manuela , FARIDMOAYER, Amirreza , SERVENTI, Fabio , FOLLADOR, Rainer , HARSMAN, Anke, Judith
IPC分类号： C12N1/10 , C12N15/64 , C12N15/79 , C12N15/87 , C12N15/90 , C12P21/00 , C12N15/902 , C12P21/005
摘要： The present application relates to a method of recombinantly engineering a Leishmania cell that involves homologous recombination of DNA fragments. Further provided herein are Leishmania cells recombinantly engineered using the method provided herein. Also provided herein are methods of making a polypeptide using a Leishmania cell described herein and polypeptides produced by the methods provided herein.

3. 发明申请

WO2021140143A1 GLYCOENGINEERING USING LEISHMANIA CELLS 审中-公开
公开(公告)号：WO2021140143A1
公开(公告)日：2021-07-15
申请号：PCT/EP2021/050172
申请日：2021-01-07
申请人： LIMMATECH BIOLOGICS AG
发明人： MALLY, Manuela , FARIDMOAYER, Amirreza , FOLLADOR, Rainer , HARSMAN, Anke, Judith
IPC分类号： C12N9/10 , C12N15/79 , C12R1/90 , C12P21/00 , A23L3/3463 , C12N9/1051 , C12P21/005
摘要： The present application relates to Leishmania cells genetically engineered such that the formation of an O-linked GlcNAc on a polypeptide in the Leishmania cell is reduced or eliminated. The formation of the O-linked GlcNAc may be catalyzed in the Leishmania cell prior to said genetic engineering by at least one N-acetylglucosamine (GlcNAc)-transferase. Also provided herein are methods of making a polypeptide using a Leishmania cell described herein and polypeptides produced by the methods provided herein.

4. 发明申请

WO2018167096A1 LIGHT EMITTING MIRROR BEZEL 审中-公开
公开(公告)号：WO2018167096A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056299
申请日：2018-03-13
申请人： MOTHERSON INNOVATIONS COMPANY LTD.
发明人： HERRMANN, Andreas , LETTIS, Andrew , SCOTT-COLLINS, Callum , SMITH, Gary , REHILL, Graham
IPC分类号： B60R1/12
摘要： A rearview device (100) including a housing, a bezel (130) and a rearview element (120) used for vehicles. In one embodiment the bezel includes a transparent or chrome-based coating as to allow one or more lighting assemblies positioned in or beneath the bezel to illuminate the surrounding and provide different functions to the driver or other persons. For example, different indicator functions can be provided. Different electronic means may be placed in or beneath the bezel to optimize the used space inside the rearview device.

5. 发明申请

WO2017093291A1 METHODS OF PRODUCING GLYCOSYLATED PROTEINS 审中-公开
标题翻译：生产糖基化蛋白质的方法
公开(公告)号：WO2017093291A1
公开(公告)日：2017-06-08
申请号：PCT/EP2016/079232
申请日：2016-11-30
申请人： LIMMATECH BIOLOGICS AG , EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH
发明人： WETTER, Michael L. , KOWARIK, Michael T. , FARIDMOAYER, Amirreza , MALLY, Manuela , LIZAK, Christian A. , AEBI, Markus , LIN, Chia-wei , HANG, Ivan , KEYS, Timothy
IPC分类号： C12N9/10 , C12N1/21 , C12P19/04 , A61K38/00 , A61K39/00
CPC分类号： C12P19/04 , A61K38/00 , A61K39/00 , C12N9/1051 , Y02A50/47
摘要： Described herein are methods of producing glycosylated proteins in vitro and in vivo. The methods include using host cells to produce glycosylated proteins. Also described herein are glycosylated proteins produced using such methods and uses thereof.
摘要翻译：本文描述了体外和体内生产糖基化蛋白质的方法。该方法包括使用宿主细胞产生糖基化蛋白质。本文还描述了使用这些方法产生的糖基化蛋白质及其用途。

6. 发明申请

WO2017060353A1 METHODS FOR TREATING INFLAMMATORY AND OTHER DISEASES AND THE USE OF BIOMARKERS AS PREDICTORS OF CLINICAL SENSITIVITY TO TREATMENT WITH APREMILAST 审中-公开
标题翻译：治疗炎症和其他疾病的方法和生物标志物作为临床敏感性预防剂治疗APREMILAST的方法
公开(公告)号：WO2017060353A1
公开(公告)日：2017-04-13
申请号：PCT/EP2016/073880
申请日：2016-10-06
申请人： CELGENE INTERNATIONAL II SARL
发明人： SCHAFER, Peter H. , TROTTER, Matthew William Burnell
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/10 , G01N2800/52
摘要： Provided herein are methods for predicting the clinical sensitivity of an inflammatory disease (e.g., ankylosing spondylitis) and a subject's response to treatment with apremilast using the level of a biomarker (e.g., MCP1). Also provided herein are methods for treating an inflammatory disease.
摘要翻译：本文提供了使用生物标志物（例如，MCP1）的水平来预测炎症性疾病（例如强直性脊柱炎）的临床敏感性和受试者对使用去甲雷司特治疗的反应的方法。本文还提供了治疗炎性疾病的方法。

7. 发明申请

WO2016055534A3 COMBINATION THERAPY OF HBV AND HDV INFECTION 审中-公开
公开(公告)号：WO2016055534A3
公开(公告)日：2016-04-14
申请号：PCT/EP2015/073173
申请日：2015-10-07
申请人： MYR GMBH
发明人： ALEXANDROV, Alexander
IPC分类号： A61K38/17 , A61K31/00 , A61K38/16 , C07K14/005 , A61K38/21 , A61K31/522 , C07K14/705
摘要： The invention provides a composition comprising an inhibitor of Na+-taurocholate cotransporting polypeptide (NTCP) and a active ingredient selected from the group consisting of a nucleoside analogue such as lamivudine, telbivudine, or entecavir, a nucleotide analogue such as tenofovir, adefovir and an immunomodulator such as interferon alpha. The NTCP inhibitor inhibits HBV/HDV entry into a cell and is preferably derived from an HBV pre-S1 peptide. Also provided are methods of treating HBV and HDV infection, hepatitis B and D, or chronic hepatitis B and D.

8. 发明申请

WO2015118115A1 DIAGNOSIS OF A NEUROLOGICAL DISEASE 审中-公开
标题翻译：诊断神经病
公开(公告)号：WO2015118115A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052529
申请日：2015-02-06
申请人： INSTITUT D'INVESTIGACIONES BIOMÈDIQUES AUGUST PI I SUNYER , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , UNIVERSITAT DE BARCELONA , HOSPITAL CLÍNIC DE BARCELONA
发明人： DALMAU, Josep , GRAUS, Francesc
IPC分类号： G01N33/68 , C07K16/00 , G01N33/564
CPC分类号： G01N33/6896 , C07K16/2803 , G01N33/564 , G01N33/6854 , G01N2800/2814 , G01N2800/2821 , G01N2800/2864
摘要： The present invention concerns subject matter connected to or making use of lgLON5, lgLON5 fragments and variants of lgLON5 and lgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an lgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of lgLON5, an lgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an lgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.
摘要翻译：本发明涉及与lgLON5，lgLON5片段和lgLON5和lgLON5片段的变体连接或利用的主题。具体地说，本发明涉及包含一种或多种IgLON5，其IgL5-片段或其变体序列用于诊断疾病的多肽的用途，用于诊断此类疾病的体外方法，包含一种或多种 lgLON5，lgLON5片段或其变体的序列或编码用于治疗疾病的所述多肽的核酸，包含该多肽的药物组合物，治疗这种疾病的方法，与IgLON5结合的自身抗体， lgLON5片段或其变体，分离此类自身抗体的方法，包含此类自身抗体或此类多肽的医学或诊断装置以及用于诊断疾病的测试试剂盒，该测试试剂盒包含该自身抗体和/或该多肽。

9. 发明申请

WO2014106667A2 VERFAHREN ZUR SOLVOLYSE VON WÄSSRIGEN ORGANISCHEN SUSPENSIONEN UND LÖSUNGEN ZU KONZENTRIERTEN, WÄSSRIGEN, SCHWARZLAUGENÄHNLICHEN UND/ODER SALZARTIGEN LÖSUNGEN ORGANISCHER VERBINDUNGEN 审中-公开
标题翻译：水性有机悬浮液和浓缩溶液，水性，SCHWARZL EYES LIKE和/或有机化合物的盐状解决方案的方法溶剂分解
公开(公告)号：WO2014106667A2
公开(公告)日：2014-07-10
申请号：PCT/EP2014/050172
申请日：2014-01-07
申请人： PATRICK VON HERTZBERG, STEFAN BOTHUR UND THOMAS MÜLLER RECHTEVERWERTUNG GBR
发明人： MÜLLER, Thomas , VON HERTZBERG, Patrick , BOTHUR, Stefan
IPC分类号： B09B3/00
CPC分类号： B09B3/0016 , B09B3/0083 , C05F3/00 , C05F7/00 , C10G1/10 , Y02A40/205 , Y02A40/213 , Y02P20/145
摘要： Verfahren zum Aufbereiten von wasserhaltigen Abfall- und Rohstoffen, aufweisend folgende Schritte: Zusammenführen der aufzubereitenden Abfälle mit einer wässrigen, alkalischen Lösung zu einer Reaktionsmischung, um den Umlaufstrom zu erzeugen; Erwärmen der Reaktionsmischung auf einen Temperaturbereich zwischen 140°C bis 250°C und einem Druck zwischen 2 bar und 12 bar zur Erzeugung von mindestens einer wässrigen, gegebenenfalls einer organischen Phase, einer Gasphase und ggf. einer Festphase; Abführen der Gasphase aus dem Reaktor; gegebenenfalls Trennung der organischen und wässrigen Bestandteile der Gasphase, insbesondere durch eine Rektifikationskolonne, insbesondere bei Einsatz organischer Hilfsmittel; Verdichtung der wässrigen Phase; Entfernung von Ammoniak und von anderen unerwünschten Bestandteile aus dem Dampf; Abkühlen des entstehenden Dampfes im Wärmetauscher (6) oder im Doppelmantel-Reaktor, so dass ein Kondensat entsteht, und gleichzeitig die Wärme an den Produktumlauf (35) abgegeben wird, wobei Wasser aus dem Produkt verdampft wird; Entfernung des Kondensates aus dem Prozess, nachdem die physikalische Wärme des Kondensates über den Wärmetauscher (33) an die zufließenden Ausgangsstoffe (1 und 2) abgegeben wurde.
摘要翻译：处理含水废物和原料，其包括以下步骤的方法：合并所述废物到用含水碱性溶液中的反应混合物，以产生循环流进行处理; 将反应混合物加热至140℃至的温度范围内，以250℃和2巴和至少一种水，任选的有机相，气相和任选的固相的产生12巴之间的压力; 排出来自反应器的蒸气相; 任选地被一精馏塔中分离气相的有机相和水组件，特别是，特别是在使用有机助剂时; 水相的致密化; 氨和从蒸汽其它不希望的组分的去除; 冷却在热交换器（6）得到的蒸汽或在双夹套反应器中，以使冷凝物形成的，并同时热到产品循环（35）被排出，由此水从产物中蒸发; 来自过程的冷凝液通过热交换器（33）进入的原料（1和2）的物理热后的冷凝物的去除已经作出。

10. 发明申请

WO2014057109A1 METHODS OF HOST CELL MODIFICATION 审中-公开
标题翻译：宿主细胞修饰方法
公开(公告)号：WO2014057109A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/071328
申请日：2013-10-11
申请人： GLYCOVAXYN AG
发明人： WACKER, Michael , KOWARIK, Michael , FERNANDEZ, Fabiana
IPC分类号： C12N1/00
CPC分类号： C12N15/64 , C12N9/1048 , C12N9/1051 , C12N15/52 , C12N15/70 , C12N2800/30 , C12N2800/40 , C12P19/28 , C12Y204/99
摘要： Described herein are novel methods of inserting nucleic acid sequences into host cells. Also described herein are genetically stable host cells comprising inserted nucleic acid sequences and methods of using such host cells in the generation of proteins.
摘要翻译：本文描述的是将核酸序列插入宿主细胞的新方法。本文还描述了包含插入的核酸序列的遗传稳定的宿主细胞和在产生蛋白质中使用这种宿主细胞的方法。

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