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    • 1. 发明申请
    • CAPILLARY MULTI-CHANNEL OPTICAL FLOW CELL
    • 毛细管多通道光学细胞
    • WO2005116614A1
    • 2005-12-08
    • PCT/US2005/012083
    • 2005-04-08
    • NANOSTREAM, INC.HOBBS, Steven, E.
    • HOBBS, Steven, E.
    • G01N21/05
    • G01N21/05G01N30/74G01N2021/0346G01N2021/056G01N2030/746G01N30/466
    • A first multi-channel optical flow cell (10, 100, 200, 540) includes a two end blocks (14, 114, 214, 16, 116, 216) disposed around a channel-defining flow layer (12, 112, 212, 292, 400, 410, 420, 430, 440, 450, 1212, 2212), with a first end block (14, 114, 214) having multiple inlet ports (20A-20X, 120X, 220A-220X) each containing an associated optical fiber (26A-26X, 126X, 535A-535X) and fluid conduit (24A-24X, 124X, 528A-528X) terminated substantially flush against an inner surface (40, 140) of the first end block (14, 114, 214). The second end block (16, 116, 216) may have multiple outlet ports (22A-22X, 122X, 222A-222X) each containing at least one of an additional optical fiber (30A-30X, 130X, 537A-537X) and additional fluid conduit (28A-28X, 128X, 529A-529X). A method for fabricating a multi-channel flow cell (10, 100, 200, 540) includes inserting a first plurality of optical fibers (26A-26X, 126X, 535A-535X) and a first plurality of fluid conduits (24A-24X, 124X, 528A-528X) through a plurality of inlet ports (20A-20X, 120X, 220A-220X) defined in a first end block (14, 114, 214), sealing the optical fibers (26A-26X, 126X, 535A-535X) and conduits (24A-24X, 124X, 528A-528X), polishing the optical fibers (26A-26X, 126X, 535A-535X), and then positioning and joining a channel-defining flow layer (12, 112, 212, 292, 400, 410, 420, 430, 440, 450, 1212, 2212) between the first end block (14, 114, 214) and a second end block (16, 116, 216).
    • 第一多通道光学流通池(10,100,200,540)包括设置在通道限定流动层(12,112,212和216)周围的两个端部块(14,114,214,16,116,216) 具有多个入口端口(20A-20X,120X,220A-220X)的第一端块(14,114,214),每个入口端口(20A-20X,120X,220A-220X) 光纤(26A-26X,126X,535A-535X)和流体导管(24A-24X,124X,528A-528X)基本上与第一端块(14,114,214)的内表面(40,140)齐平 )。 第二端块(16,116,216)可以具有多个出口端口(22A-22X,122X,222A-222X),每个出口端口包含附加光纤(30A-30X,130X,537A-537X)中的至少一个和附加的 流体导管(28A-28X,128X,529A-529X)。 一种制造多通道流动池(10,100,200,540)的方法包括:将第一组多个光纤(26A-26X,126X,535A-535X)和第一组多个流体导管(24A-24X, 124A,528A-528X)通过限定在第一端块(14,114,214)中的多个入口端口(20A-20X,120X,220A-220X),将光纤(26A-26X,126X, 532X,535X)和导管(24A-24X,124X,528A-528X),抛光光纤(26A-26X,126X,535A-535X),然后定位和连接通道限定流动层(12,112,212, 在第一端块(14,114,214)和第二端块(16,116,216)之间的第二端块(292,114,216)上。
    • 6. 发明授权
    • System and method for the establishment of a connection between a contact requester and a communications center
    • 用于建立联系人请求者和通信中心之间的连接的系统和方法
    • US07831032B2
    • 2010-11-09
    • US10549392
    • 2004-03-12
    • Davide Antilli
    • Davide Antilli
    • H04M3/00
    • H04M3/51H04M3/42382H04M3/5231H04M2203/652
    • A system for establishing a connection between a contact requester (i.e. a potential customer) and a communications center is disclosed. The system has a message receiver which accepts a message from a communications device, such as a mobile telephone or a PDA, and a contact number. The contact number is usually the number of the mobile telephone or PDA. The system has furthermore a parser for parsing the message and identifying one or more identifiers in the message, including a destination identifier. The destination identifier indicates the number of a communications center, such as a call center, to which the message should be sent. A connector in the system uses the destination identifier and the contact number to establish a connection between a requested one of the communications centers and the contact requester.
    • 公开了一种用于在联系人请求者(即,潜在客户)和通信中心之间建立连接的系统。 该系统具有接收来自诸如移动电话或PDA的通信设备的消息的消息接收器以及联系号码。 联系电话通常是移动电话或PDA的号码。 该系统还具有用于解析消息并识别消息中的一个或多个标识符的解析器,包括目的地标识符。 目的地标识符表示应该发送消息的通信中心(例如呼叫中心)的号码。 系统中的连接器使用目的地标识符和联系人号码建立所请求的一个通信中心和联系请求者之间的连接。
    • 7. 发明授权
    • Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
    • 衍生自人类脂肪组织的多能干细胞和包含其的细胞治疗剂
    • US07807461B2
    • 2010-10-05
    • US11313083
    • 2005-12-20
    • Kyung Sun KangJeong Chan RaJung Ran Park
    • Kyung Sun KangJeong Chan RaJung Ran Park
    • C12N5/071C12N5/00C12N5/02A01N1/00A01N1/02
    • C12N5/0667C12N2500/14C12N2500/20C12N2500/32C12N2500/44C12N2500/84C12N2501/11C12N2501/115C12N2501/33C12N2501/39
    • This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells and insulin-releasing pancreatic beta-cells. Also, the invention relates to cellular therapeutic agents for treating osteoarthritis, osteoporosis and diabetes and for forming breast tissue, which contain the differentiated cells or the adult stem cells. Although the multipotent stem cells are adult stem cells, they have the ability to differentiate into osteogenic cells, nerve cells, astrocytes, fat cells, chrondrogenic cells or insulin-releasing pancreatic beta-cells, and so are effective in treating osteoporosis, osteoarthritis, nerve disease, diabetes, etc. Also, the stem cells form spheres in a serum-free medium containing CORM-2, and thus can be maintained in an undifferentiated state for a long period of time. Also, the stem cells have very high proliferation rates. Accordingly, the stem cells are useful as cellular therapeutic agents.
    • 本发明涉及人脂肪组织衍生的多潜能成体干细胞。 更具体地说,本发明涉及人类脂肪组织衍生的多潜能干细胞,其可以通过形成球体并且具有高增殖率而长时间维持在未分化状态,以及分离和维持成体干细胞的方法 细胞和用于将多能成体干细胞分化成神经细胞,脂肪细胞,软骨细胞,成骨细胞和胰岛素释放胰腺β-细胞的方法。 此外,本发明涉及用于治疗骨关节炎,骨质疏松症和糖尿病以及形成含有分化细胞​​或成体干细胞的乳腺组织的细胞治疗剂。 虽然多能干细胞是成体干细胞,但它们具有分化成成骨细胞,神经细胞,星形胶质细胞,脂肪细胞,成纤维细胞或胰岛素释放胰腺β-细胞的能力,因此有效治疗骨质疏松症,骨关节炎,神经 疾病,糖尿病等。此外,干细胞在含有CORM-2的无血清培养基中形成球,因此可以长时间维持在未分化状态。 此外,干细胞具有非常高的增殖率。 因此,干细胞可用作细胞治疗剂。