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1. 发明授权

EP1107746B1 METHODS OF USING AND COMPOSITIONS COMPRISING DOPAMINE REUPTAKE INHIBITORS 有权
标题翻译：使用方法及套DOPAMINEWIEDERAUFNAHMEINHIBITOR CONTAIN
公开(公告)号：EP1107746B1
公开(公告)日：2004-10-13
申请号：EP99945137.0
申请日：1999-08-23
申请人： Sepracor Inc.
发明人： JERUSSI, Thomas, P. , SENANAYAKE, Chrisantha, H. , FANG, Qun, K.
IPC分类号： A61K31/13 , A61K31/135 , A61P25/28
CPC分类号： A61K45/06 , A61K31/11 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional disorders, pain, obsessive-compulsive disorder, substance abuse, chronic disorders, anxiety, eating disorders, migraines, incontinence, depresson, attention deficit disorder, attention deficit disorder with hyperactivity, bipolar and manic conditions, dysthymic disorder, and cyclothymic disorder, senile dementia, Alzheimer's type dementia, memory loss, amnesia/amnestic syndrome, disturbance of consciousness, coma, lowering of attention, speech disorders, Parkinson's disease, Lennox syndrome, autism, epilepsy, hyperkinetic syndrome and schizophrenia. The methods comprise the administration of a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Pharmaceutical compositions and dosage forms are also disclosed that comprise a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Preferred dopamine reuptake inhibitors are racemic or optionally pure sibutramine metabolites, wherein the sibutramine metabolite is selected from the group consisting of (+)-desmethylsibutramine, (-)-desmethylsibutramine, (±)-desmethylsibutramine, (+)-didesmethylsibutramine, (-)-didesmethylsibutramine, and (±)-didesmethylsibutramine.

2. 发明公开

EP1400530A1 Suppression of immune response via inhibition of cathepsin S 失效
标题翻译： Unterdrückungeiner Immunantwort durch Inhibierung von组织蛋白酶S
公开(公告)号：EP1400530A1
公开(公告)日：2004-03-24
申请号：EP03027094.6
申请日：1997-04-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BRIGHAM & WOMEN'S HOSPITAL, INC.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C07K5/06 , A61P37/00
CPC分类号： C07K5/0819 , A61K38/05 , A61K38/55 , C07K5/06043 , C07K5/06095 , C07K5/06113
摘要： Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. New pharmaceutical and therapeutic compositions which are peptide-based inhibitors of cathepsin S are also described
摘要翻译：描述了用于抑制哺乳动物或哺乳动物细胞中II类MHC限制性免疫应答的方法和产品。该方法取决于来自II类MHC /不变链复合物的组织蛋白酶S的不变链蛋白酶解，从而降低II类MHC分子与抗原肽结合的能力，减少由II类MHC分子呈递抗原肽，并抑制免疫应答。该方法可用于治疗自身免疫性疾病，过敏反应和器官或组织移植排斥。还描述了作为组织蛋白酶S的基于肽的抑制剂的新的药物和治疗组合物

3. 发明授权

EP1124800B1 COMPOUNDS COMPRISING POLYENE CHAIN STRUCTURE AND PROCESSES FOR PREPARING THE SAME 有权
标题翻译：随着对生产的多烯链的结构和方法链接
公开(公告)号：EP1124800B1
公开(公告)日：2004-01-07
申请号：EP99951244.5
申请日：1999-10-28
申请人： Koo, Sangho
发明人： KOO, Sangho , CHOI, Hojin , JI, Minkoo; , PARK, Minsoo
IPC分类号： C07C323/05 , C07C323/14 , C07C323/22 , C07C47/21 , C07C403/24
CPC分类号： C07C403/24 , C07C45/60 , C07C315/02 , C07C319/20 , C07C323/05 , C07C323/14 , C07C323/22 , C07C2601/16 , C07C47/21 , C07C317/14 , C07C323/65
摘要： The present invention provides valuable intermediates which can be used in the synthesis of a compound having polyene chain structure, processes for preparing the same, and a process for preparing β-carotene by using said intermediates. The process for preparing β-carotene (Chemical Formula 3) or a compound having polyene chain structure, is characterized in that the polyene chain structure is formed by applying Ramberg-Bäcklund reaction to a diallylic sulfone obtained by the oxidation of diallylic sulfide. Further, the present invention provides retinyl sulfide which was synthesized by the coupling of diallylic sulfide with the corresponding Wittig salt.

4. 发明公开

EP1355919A2 MOLECULES WITH EXTENDED HALF-LIVES, COMPOSITIONS AND USES THEREOF 有权
标题翻译：具有延长半小时，组成及其用途分子
公开(公告)号：EP1355919A2
公开(公告)日：2003-10-29
申请号：EP01997063.1
申请日：2001-12-12
申请人： MEDIMMUNE, INC.
发明人： DALL'ACQUA, William , JOHNSON, Leslie, S. , WARD, Elizabeth, Sally
IPC分类号： C07H21/04 , A61K48/00
CPC分类号： C07K16/283 , A61K38/00 , A61K39/00 , A61K47/48507 , A61K47/6835 , A61K49/0002 , A61K49/0004 , A61K2039/505 , C07K2/00 , C07K14/70503 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.

5. 发明授权

EP1066235B1 SYNTHETIC ENDOGENOUS CANNABINOID ANALOGUES AND USES THEREOF 有权
标题翻译：合成内源性大麻素模拟和用途
公开(公告)号：EP1066235B1
公开(公告)日：2003-10-01
申请号：EP99913555.1
申请日：1999-03-30
申请人： Yissum Research And Development Company Of The Hebrew University Of Jerusalem
发明人： MECHOULAM, Raphael , FRIDE, Esther , BEN SHABAT, Shimon , SHESKIN, Tzviel , BREUER, Aviva
IPC分类号： C07C43/15 , C07C43/178 , C07B59/00 , A61K31/08
CPC分类号： C07C43/178 , C07B59/001 , C07B2200/07 , C07C43/15

6. 发明公开

EP1208838A3 Pure S(+)isomer fluoxetine 失效
标题翻译：雷诺素（+）氟西汀异构体
公开(公告)号：EP1208838A3
公开(公告)日：2003-07-09
申请号：EP02003532.5
申请日：1992-02-05
申请人： Sepracor Inc.
发明人： Young, James , Barberich, Timothy
IPC分类号： A61P25/24 , A61K31/135
CPC分类号： A61K31/135
摘要： Methods and compositions are disclosed utilizing the pure S(+) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of unwanted, adverse toxic or psychological effects, for the treatment of human depression. In addition, methods and compositions are disclosed utilizing the pure S(+) isomer of fluoxetine which is useful in treating migraine headaches, pain, in particular chronic pain, and obsessive-compulsive disorders. Further, methods and compositions for treating a condition alleviated or improved by inhibition of serotonin uptake in serotonergic neurons and platelets in a human using optically pure S(+) fluoxetine are disclosed.

7. 发明公开

EP1281082A1 METHOD AND COMPOSITION FOR ANALYZING A CARBOHYDRATE POLYMER 审中-公开
标题翻译：方法和组合物糖类聚合物分析
公开(公告)号：EP1281082A1
公开(公告)日：2003-02-05
申请号：EP00980286.9
申请日：2000-11-03
申请人： Procognia, Ltd.
发明人： MARKMAN, Ofer , ORON, Assaf, Peretz , ROTHMAN, Chana
IPC分类号： G01N33/53 , C12Q1/34
CPC分类号： C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02 , G01N2400/10
摘要： Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.

8. 发明公开

EP1208838A2 Pure S(+)isomer fluoxetine 失效
标题翻译：雷诺素（+）氟西汀异构体
公开(公告)号：EP1208838A2
公开(公告)日：2002-05-29
申请号：EP02003532.5
申请日：1992-02-05
申请人： Sepracor Inc.
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K31/135
CPC分类号： A61K31/135
摘要： Methods and compositions are disclosed utilizing the pure S(+) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of unwanted, adverse toxic or psychological effects, for the treatment of human depression. In addition, methods and compositions are disclosed utilizing the pure S(+) isomer of fluoxetine which is useful in treating migraine headaches, pain, in particular chronic pain, and obsessive-compulsive disorders. Further, methods and compositions for treating a condition alleviated or improved by inhibition of serotonin uptake in serotonergic neurons and platelets in a human using optically pure S(+) fluoxetine are disclosed.
摘要翻译：公开了使用氟西汀的纯S（+）异构体的方法和组合物，其是对于治疗人类抑郁症基本上没有不希望的，不利的毒性或心理作用的有效的抗抑郁药和食欲抑制剂。此外，利用氟西汀的纯S（+）异构体可用于治疗偏头痛，疼痛，特别是慢性疼痛和强迫症的方法和组合物被公开。此外，公开了通过使用光学纯的S（+）氟西汀抑制人血清素能神经元和血小板中5-羟色胺摄取而减轻或改善的病症的方法和组合物。

9. 发明公开

EP1166774A1 Pharmaceutical aerosol compositions comprising a flavouring oil 审中-公开
标题翻译： Pharmazeutische Aerosol-Zusammensetzungen，die einAromaölenthalten
公开(公告)号：EP1166774A1
公开(公告)日：2002-01-02
申请号：EP01202415.4
申请日：2001-06-22
申请人： Pharmasol Limited
发明人： Ross, Calvin
IPC分类号： A61K9/12
CPC分类号： A61K9/006
摘要： The present invention relates to the use of a flavouring oil in a pharmaceutical aerosol formulation, preferably for sublingual delivery. The flavouring oil acts as a lubricant of the valve of the dispensing device used to administer said formulation. Preferably, the flavouring oil is a volatile oil and therefore also acts as a penetration enhancer.
摘要翻译：本发明涉及调味油在药物气雾剂中的用途，优选用于舌下递送。调味油用作用于施用所述制剂的分配装置的阀的润滑剂。优选地，调味油是挥发性油，因此也用作渗透促进剂。

10. 发明公开

EP1145712A1 Sustained release excipient 失效
标题翻译： TrägerstoffzurverzögertenFreisetzung
公开(公告)号：EP1145712A1
公开(公告)日：2001-10-17
申请号：EP01112778.4
申请日：1995-03-21
申请人： EDWARD MENDELL CO., INC.
发明人： Baichwal, Anand R. , McCall, Troy W.
IPC分类号： A61K9/20
CPC分类号： A61K9/2009 , A61K9/2018 , A61K9/205
摘要： A sustained-release excipient for use in oral solid dosage forms includes from about 15 to about 30 percent or more by weight heteropolysaccharide gum; an effective amount of a cationic cross-linking agent capable of cross-linking the heteropolysaccharide in an environment of use; and an inert pharmaceutical filler.
摘要翻译：用于口服固体剂型的持续释放赋形剂包括约15至约30重量％或更多的杂多糖胶; 能够在使用环境中交联杂多糖的有效量的阳离子交联剂; 和惰性药物填料。

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