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1. 发明申请

WO2004018434A1 PYRIMIDINE COMPOUNDS 审中-公开
标题翻译：吡嗪化合物
公开(公告)号：WO2004018434A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009221
申请日：2003-08-19
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
IPC分类号： C07D239/42
CPC分类号： C07D239/42 , C07D401/12
摘要： The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译：本发明涉及新颖的嘧啶衍生物，含有这些化合物的药物组合物及其用于治疗由大麻素受体的活性增加或减少而直接或间接引起的疾病，特别是疼痛的疾病。

2. 发明申请

WO2004012741A1 SUSTAINED RELEASE FORMULATIONS COMPRISING LAMOTRIGINE 审中-公开
标题翻译：包含LAMOTRIGINE的持续释放配方
公开(公告)号：WO2004012741A1
公开(公告)日：2004-02-12
申请号：PCT/EP2003/008368
申请日：2003-07-28
申请人： GLAXO GROUP LIMITED , BUXTON, Ian, Richard , CURRIE, Robin , DELA-CRUZ, Myrna, A. , GOODSON, Gary, Wayne , KAROLAK, Wlodzimierz , MALEKI, Mehran , IYER, Vijay, Mohan , MUPPIRALA, Gopal , PARR, Alan, Frank , SIDHU, Jagdev, Singh , STAGNER, Robert, Allen , VIJAY-KUMAR, Akunuri, Venkata
发明人： BUXTON, Ian, Richard , CURRIE, Robin , DELA-CRUZ, Myrna, A. , GOODSON, Gary, Wayne , KAROLAK, Wlodzimierz , MALEKI, Mehran , IYER, Vijay, Mohan , MUPPIRALA, Gopal , PARR, Alan, Frank , SIDHU, Jagdev, Singh , STAGNER, Robert, Allen , VIJAY-KUMAR, Akunuri, Venkata
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , A61K9/2031 , A61K9/2054 , A61K9/2846 , A61K9/2866
摘要： A sustained release formulation of lamotrigine or a pharmaceutically acceptable derivative thereof and methods of treatment and uses thereof.
摘要翻译：拉莫三嗪或其药学上可接受的衍生物的缓释制剂及其治疗方法及其用途。

3. 发明申请

WO2003080608A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2003080608A2
公开(公告)日：2003-10-02
申请号：PCT/EP2003/003195
申请日：2003-03-25
申请人： GLAXO GROUP LIMITED , JOHNSON, Christopher, Norbert , MACDONALD, Gregor, James , MITCHELL, Darren, Jason , MOSS, Stephen, Frederick , THOMPSON, Mervyn , WITTY, David
发明人： JOHNSON, Christopher, Norbert , MACDONALD, Gregor, James , MITCHELL, Darren, Jason , MOSS, Stephen, Frederick , THOMPSON, Mervyn , WITTY, David
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D215/40 , C07D215/46
摘要： The present invention relates to novel quinoline and aza indole compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译：本发明涉及具有药理活性的新型喹啉和氮杂吲哚化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。

4. 发明申请

WO2003032991A1 N-AROYL PIPERAZINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为OREXIN受体拮抗剂的N-硝基苯哌酮衍生物
公开(公告)号：WO2003032991A1
公开(公告)日：2003-04-24
申请号：PCT/EP2002/011316
申请日：2002-10-09
申请人： SMITHKLINE BEECHAM PLC , BRANCH, Clive, Leslie , JOHSON, Christopher, Norbert , NASH, David, John , STEMP, Geoffrey
发明人： BRANCH, Clive, Leslie , JOHSON, Christopher, Norbert , NASH, David, John , STEMP, Geoffrey
IPC分类号： A61K31/495
CPC分类号： C07D413/10 , C07D241/04 , C07D417/06
摘要： This invention relates to N-aroyl piperazine derivatives of formula (I), wherein: Y represents NR 2 ; m represents 1, 2 or 3; p represents 0 or 1; X is O, S, C=O, SO 2 , or CH=CH-; Ar 1 is aryl, or a mono or bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; any of which may be optionally substituted; Ar 2 represents phenyl or a 5- or 6-membered heterocyclyl group containing 1 to 3 heteroatoms selected from N, O and S, wherein the phenyl heterocyclyl group is substituted by R 1 and further optional substituents; or Ar 2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing 1 to 4 heteroatoms selected from N, O and S; R 1 represents optionally substituted (C 1-4 )alkoxy, halo, optionally substituted (C 1-6 )alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S; R?2 ¿represents hydrogen, optionally substituted (C 1-4 )alkyl, optionally substituted (C 1-6 )alkanoyl, optionally subtituted (C 1-6 )alkanoxycarbonyl or optionally substituted aryl(C 1-6 )alkyloxycarbonyl; and their use as orexin receptor-antagonists.
摘要翻译：本发明涉及式（I）的N-芳酰基哌嗪衍生物，其中：Y表示NR 2; m表示1,2或3; p表示0或1; X是O，S，C = O，SO 2或CH = CH-; Ar 1是芳基或含有至多4个选自N，O和S的杂原子的单或双环杂芳基; 任何一个可以任选地被取代; Ar 2表示苯基或含有1至3个选自N，O和S的杂原子的5或6元杂环基，其中苯基杂环基被R 1取代，另外任选的取代基; 或Ar 2表示含有1至4个选自N，O和S的杂原子的任选取代的双环芳族或双环杂芳族基团; R 1表示任选取代的（C 1-4）烷氧基，卤素，任选取代的（C 1-6）烷基，任选取代的苯基，或任选取代的含有1至4个选自N， O和S; 任选取代的（C 1-6）烷酰基，任选取代的（C 1-6）烷氧基羰基或任选取代的芳基（C 1-6）烷氧基羰基; 以及它们作为食欲肽受体拮抗剂的用途。

5. 发明申请

WO2004029027A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS 审中-公开
标题翻译：吡啶衍生物作为CB2受体调节剂
公开(公告)号：WO2004029027A1
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010935
申请日：2003-09-25
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , JANDU, Karamjit, Singh , MITCHELL, William, Leonard , NAYLOR, Alan , PALOMBI, Giovanni , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , JANDU, Karamjit, Singh , MITCHELL, William, Leonard , NAYLOR, Alan , PALOMBI, Giovanni , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
IPC分类号： C07D213/82
CPC分类号： C07D213/82 , C07D401/12 , C07D413/12
摘要： The present invention relates to novel pyridine derivatives of formula (I) pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译：本发明涉及式（I）的新型吡啶衍生物，其含有这些化合物的药物组合物及其用于治疗由大麻素受体的活性的增加或减少直接或间接引起的疾病，特别是疼痛的疾病。

6. 发明申请

WO2004014425A1 ACTIVATORS OF SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNELS AND USE THEREOF 审中-公开
标题翻译：小肠钙激活钾通道的激活剂及其用途
公开(公告)号：WO2004014425A1
公开(公告)日：2004-02-19
申请号：PCT/EP2003/008752
申请日：2003-08-05
申请人： GLAXO GROUP LIMITED , DALE, Timothy, James , DAVIES, David, John , TREZISE, Derek, John
发明人： DALE, Timothy, James , DAVIES, David, John , TREZISE, Derek, John
IPC分类号： A61K45/00
CPC分类号： C07D207/08 , C07D211/22 , C07D211/26 , C07D211/34 , C07D409/12
摘要： The invention relates to activators of small conductance calcium potassium channels of formula (I) and their use in the treatment of disorders responsive to enhanced calcium activated potassium channel activity.
摘要翻译：本发明涉及式（I）的小电导钙钾通道的活化剂及其在治疗对增强的钙活化钾通道活性有反应作用的病症中的用途。

7. 发明申请

WO2003051871A1 N-AROYL CYCLIC AMINE DERIVATIVES AND THEIR USE AS ORXIN RECEPTOR ANTAGONIST 审中-公开
标题翻译： N-芳基环胺衍生物及其作为ORXIN受体拮抗剂的用途
公开(公告)号：WO2003051871A1
公开(公告)日：2003-06-26
申请号：PCT/GB2002/005675
申请日：2002-12-13
申请人： SMITHKLINE BEECHAM PLC , BRANCH, Clive, Leslie , JOHNS, Amanda , JOHNSON, Christopher, Norbert , NOVELLI, Riccardo , PORTER, Roderick, Alan , STEAD, Rachel, Elizabeth, Anne , STEMP, Geoffrey , THEWLIS, Kevin
发明人： BRANCH, Clive, Leslie , JOHNS, Amanda , JOHNSON, Christopher, Norbert , NOVELLI, Riccardo , PORTER, Roderick, Alan , STEAD, Rachel, Elizabeth, Anne , STEMP, Geoffrey , THEWLIS, Kevin
IPC分类号： C07D417/06
CPC分类号： C07D417/06 , C07D211/34 , C07D417/14
摘要： This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals.
摘要翻译：本发明涉及N-芳酰基环胺衍生物及其作为药物的用途。

8. 发明申请

WO2004029026A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS 审中-公开
标题翻译：吡啶衍生物作为CB2受体调节剂
公开(公告)号：WO2004029026A1
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010930
申请日：2003-09-25
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , JANDU, Karamjit, Singh , MITCHELL, William, Leonard , NAYLOR, Alan , PALOMBI, Giovanni , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , JANDU, Karamjit, Singh , MITCHELL, William, Leonard , NAYLOR, Alan , PALOMBI, Giovanni , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
IPC分类号： C07D213/82
CPC分类号： C07D213/82 , C07D401/06 , C07D403/06 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel pyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译：本发明涉及新颖的吡啶衍生物，含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途，该疾病通过大麻素受体的活性的增加或减少直接或间接引起。

9. 发明申请

WO2004026890A1 ACETYLENE COMPOUNDS 审中-公开
标题翻译：乙烯化合物
公开(公告)号：WO2004026890A1
公开(公告)日：2004-04-01
申请号：PCT/EP2003/010350
申请日：2003-09-16
申请人： GLAXO GROUP LIMITED , ELLIS, Frank , FULTON, Heather, Elizabeth , HALL, Adrian , JAXA-CHAMIEC, Albert, Andrzej , SWANSON, Stephen , VILE, Sadie
发明人： ELLIS, Frank , FULTON, Heather, Elizabeth , HALL, Adrian , JAXA-CHAMIEC, Albert, Andrzej , SWANSON, Stephen , VILE, Sadie
IPC分类号： C07H19/167
CPC分类号： C07H19/16 , C07H19/167
摘要： The present invention is concerned with certain adenosine derivatives having an acetylene group attached in the 5' position by a linker, which are adenosine A1 agonists, and to their use in therapy.
摘要翻译：本发明涉及具有乙炔基的腺苷衍生物，其通过连接体（其为腺苷A1激动剂）在5'位上连接，并且用于治疗。

10. 发明申请

WO2003106475A3 PROCESS FOR THE PREPARATION OF HETEROCYCLYL SUBSTITUTED ADENOSINE DERIVATIVES 审中-公开
公开(公告)号：WO2003106475A3
公开(公告)日：2003-12-24
申请号：PCT/EP2003/006412
申请日：2003-06-16
申请人： GLAXO GROUP LIMITED , SHIPTON, Mark, Ralph , SMITH, Neil, Michael , WHITEHEAD, Andrew, Jonathan , WOOD-KACZMAR, Marian, Wladyslaw
发明人： SHIPTON, Mark, Ralph , SMITH, Neil, Michael , WHITEHEAD, Andrew, Jonathan , WOOD-KACZMAR, Marian, Wladyslaw
IPC分类号： C07H19/16
摘要： The present invention relates to an improved process for the preparation of heterocyclyl substituted adenosine derivatives. More particularly the invention is concerned with preparation of particular physical forms of (2S, 3S, 4R, 5R)-2-(5 tert-butyl-[1,3,4]oxadiazol-2-yl)-5-[6-(4-chloro-2-fluoro-phenylamino)-9H-purin-9-yl]-tetrahydro-furan-3,4-diol.

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