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1. 发明申请

WO2017027062A1 PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA 审中-公开
标题翻译：快速检测MYCOBACTERIA的探索
公开(公告)号：WO2017027062A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/014058
申请日：2016-01-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： RAO, Jianghong , CHENG, Yunfeng , XIE, Jinghang
IPC分类号： C12Q1/34 , C07D501/57
CPC分类号： C12Q1/689 , C07D501/32 , C07D501/36
摘要： The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β- lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.
摘要翻译：本公开的组合物提供用于特异性成像和检测分枝杆菌物种，特别是β-内酰胺抗生素抗性的新型荧光探针。通过引入特异性靶向分枝杆菌中发现的DprE1的独特诱捕机制的部分，赋予这些探针的特异性。因此，只有表达β-内酰胺酶和DprE1的分枝杆菌物种才能使得笼养的荧光探针的活化，以及通过功能还原 - 共价结合机制将释放的荧光探针附着到细菌细胞。有利地，这种探针能够在其最敏感的情况下允许单次分枝杆菌检测。

2. 发明申请

WO2016210054A1 NOVEL RHODOL FLUOROPHORES FOR NEAR-INFRARED IMAGING 审中-公开
标题翻译：用于近红外成像的新型RHODOL荧光粉
公开(公告)号：WO2016210054A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038899
申请日：2016-06-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , THE CURATORS OF THE UNIVERSITY OF MISSOURI
发明人： CHIN, Frederick, T. , KLOCKOW, Jessica , HETTIE, Kenneth , GLASS, Timothy
IPC分类号： C07D407/02 , C07D493/02
CPC分类号： A61K49/0043 , A61K49/0058 , C07D491/052 , G01N33/582 , G01N2458/00
摘要： The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from "off" to "on." This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
摘要翻译：本公开涵盖了新型近红外发射分子荧光团和掺入所述荧光团的探针的实施方案，其有利于体外和体内研究研究。荧光团是稳定的，光稳定的，并且具有容易的生物正交结合的功能（例如，点击化学，腙形成，狄尔斯·阿德尔，施陶丁格结扎等）。它是生物相容的，在水性条件下以711nm发射。这些荧光团可用于荧光标记感兴趣的生物分子或结构，或用作特定生物标志物/分析物的光学记录器（即可激活的分子探针，荧光染料），因为它们可以从“关闭”切换到“开”。该荧光团对于细胞测定和临床前小动物成像是有用的，因为近红外发射是高度穿透的，并且光物理性质是突出的。因此，这种类型的荧光团的性质可以容易地被翻译用于临床应用。

3. 发明申请

WO2015142713A1 COMPOSITIONS AND METHODS FOR REDUCING C/EBP HOMOLOGOUS PROTEIN ACTIVITY IN MYELOID-DERIVED SUPPRESSOR CELLS 审中-公开
标题翻译：用于降低MYELOID衍生的抑制细胞中C / EBP同源蛋白活性的组合物和方法
公开(公告)号：WO2015142713A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/020692
申请日：2015-03-16
申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人： RODRIGUEZ, Paulo, Cesar , OCHOA, Augusto, C.
IPC分类号： A61K9/127 , C07H21/02
CPC分类号： C12N15/113 , A61K9/1271 , C12N2310/14
摘要： Provided are compositions and methods of use thereof that modulate C/EBP homologous stress-related protein (Chop) activity in Myeloid-derived Suppressor Cells (MDSCs). Chop is a key point in the response of MDSCs to tumor-generated stress factors. In turn, the MDSCs release cytokines and other factors that function as immune suppressors, thereby allowing the tumors to thrive and expand. By inhibiting the level of Chop activity, the immunosuppressive function of MDSCs is disrupted. It has also been unexpectedly found that there is a concomitant increase in the ability of MDSCs to act as antigen-presenting and cytokine producing cells so as to act in increasing the efficacy of anti-tumor immune-based therapies.
摘要翻译：提供其调节骨髓衍生抑制细胞（MDSC）中的C / EBP同源应激相关蛋白（Chop）活性的组合物和使用方法。斩波是MDSCs对肿瘤生成应激因子反应的关键点。反过来，MDSC释放细胞因子和其他作为免疫抑制因子的因子，从而使肿瘤茁壮成长。通过抑制Chop活性的水平，MDSC的免疫抑制功能被破坏。也意外地发现，MDSC作为抗原呈递和细胞因子产生细胞的能力伴随增加，以便提高抗肿瘤免疫基疗法的功效。

4. 发明申请

WO2015021143A1 METAL ION SENSORS AND METHODS OF DETECTING METAL IONS 审中-公开
标题翻译：金属离子传感器和检测金属离子的方法
公开(公告)号：WO2015021143A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049927
申请日：2014-08-06
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： YANG, Jenny, Jie , TANG, Shen , ZHUO, You (Joy)
IPC分类号： G01N33/20 , G01N33/52 , G01N33/58 , G01N33/68 , C07K16/18 , C12Q1/68 , C12N5/06 , C12N15/09
CPC分类号： G01N33/84 , C07K14/43595 , C07K14/4728 , C07K2319/04 , C07K2319/60 , G01N21/6428 , G01N33/582 , G01N2021/6441
摘要： A method for constructing an metal ion binding motif by identifying an metal ion binding peptide that binds an metal ion with specificity, ascertaining at least a portion of a nucleic acid sequence encoding the metal ion binding peptide, tailoring the nucleic acid sequence encoding the metal ion binding peptide into an metal ion binding site, identifying a host protein and a relevant portion of the nucleic acid sequence of the host protein, operatively linking the tailored nucleic acid sequence encoding the metal ion binding peptide and the host protein nucleic acid sequence into an metal ion binding motif sequence, and expressing metal ion binding motif sequence, in which the nucleic acid sequence encoding the metal ion binding peptide is tailored so as to achieve the metal ion binding motif with a desired specificity for the metal ion. Also, the proteins encoded by the metal ion binding motif sequence as constructed by the method.
摘要翻译：一种金属离子结合基序的构建方法，该方法通过鉴定金属离子结合肽，其特异性结合金属离子，确定至少一部分编码金属离子结合肽的核酸序列，调节编码金属离子的核酸序列将结合肽结合到金属离子结合位点中，鉴定宿主蛋白和宿主蛋白的核酸序列的相关部分，将编码金属离子结合肽的定制核酸序列与宿主蛋白核酸序列可操作地连接成金属离子结合基序序列和表达金属离子结合基序序列，其中编码金属离子结合肽的核酸序列被定制以达到具有金属离子所需特异性的金属离子结合基序。此外，由该方法构建的由金属离子结合基序序列编码的蛋白质。

5. 发明申请

WO2011050052A2 PROTEIN AGENT FOR DIABETES TREATMENT AND BETA CELL IMAGING 审中-公开
标题翻译：用于糖尿病治疗和细胞成像的蛋白剂
公开(公告)号：WO2011050052A2
公开(公告)日：2011-04-28
申请号：PCT/US2010/053361
申请日：2010-10-20
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , LIU, Zhi-Ren , YANG, Jie , XU, Bing , ZHOU, Wangda , XUE, Shengui
发明人： LIU, Zhi-Ren , YANG, Jie , XU, Bing , ZHOU, Wangda , XUE, Shengui
IPC分类号： C07K19/00 , A61K38/26 , A61K49/14 , G01N33/52 , A61P3/10
CPC分类号： A61K38/26 , A61K38/00 , A61K47/60 , A61K49/085 , C07K14/605 , C07K2319/00
摘要： Glucagon-like peptide-1 (GLP-1 ) is a member of a large family of incretin hormones secreted in nutrient-dependent response. GLP-1 acts on GLP-1 receptor (GLP-1 R) that is highly expressed on pancreatic β-cells. The peptide has great potential for development of diabetes treatment and diagnosis. However, the pharmaceutical effects of the peptide suffer from in vivo instability and short life due to degradation by Dipeptidylpeptidase-1 (DPP-4). The 30 amino acid peptide GLP-1 has been integrated into a stable host protein human calbindin D9k. The fusion protein binds to GLP-1 R as demonstrated by immunostaining analyses of GLP-1 R expressing cells. The fusion protein agents can be useful for both diabetes treatment and GLP-1 R receptor targeting MR imaging. The fusion protein has a size about 14 kDa, which enables efficient tissue penetration and retention, and an extended circulation time, is stable, remaining intact and retaining activity after 48 hours incubation with 75% human serum. The protein retains its native folded structure after boiling for ten minutes forming the basis of an experimental protocol for large scale production of the fusion protein (>30 mg/l bacterial culture). No toxicity has been observed with tests on mice. One aspect of the disclosure, therefore, provides a fusion protein comprising a first peptide characterized by selectively binding to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone. In embodiments of this aspect of the disclosure, the fusion protein may further comprise a detectable label attached thereto. In some embodiments of this aspect of the disclosure, the first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1 ), glucagon-like peptide-1 (GLP-1 )(7-36), or glucagon-like peptide-1 (GLP-1 ) (9-36), or a conservative variant thereof.
摘要翻译：胰高血糖素样肽-1（GLP-1）是营养依赖性反应中分泌的大肠激素的成员之一。 GLP-1作用于在胰腺β细胞上高表达的GLP-1受体（GLP-1R）。该肽具有发展糖尿病治疗和诊断的巨大潜力。然而，由于二肽基肽酶-1（DPP-4）的降解，肽的药物作用遭受体内不稳定性和短寿命。 30个氨基酸的肽GLP-1已经被整合到稳定的宿主蛋白人类calbindin D9k中。如通过GLP-1R表达细胞的免疫染色分析所证明的，融合蛋白与GLP-1R结合。融合蛋白剂可用于糖尿病治疗和靶向MR-1的受体受体。融合蛋白具有约14kDa的大小，其能够有效的组织穿透和保留，并且延长的循环时间是稳定的，在75％人血清孵育48小时后保持完整和保留活性。蛋白质在煮沸10分钟后保持其天然折叠结构，形成大规模生产融合蛋白（> 30mg / l细菌培养物）的实验方案的基础。在小鼠试验中没有观察到毒性。因此，本公开的一个方面提供了包含第一肽的融合蛋白，其特征在于选择性结合靶细胞的位点并连接到第二个肽，其中融合蛋白比单独的第一个肽更稳定。在本公开的该方面的实施方案中，融合蛋白还可包含附着于其上的可检测标记。在本公开的该方面的一些实施方案中，融合蛋白的第一肽可以是胰高血糖素样肽-1（GLP-1），胰高血糖素样肽-1（GLP-1）（7-36）或胰高血糖素样肽-1（GLP-1）（9-36）或其保守变体。

6. 发明申请

WO2017075395A1 TUMOR-SPECIFIC ADENOVIRUS VECTORS AND THERAPEUTIC USES 审中-公开
标题翻译：肿瘤特异性腺病毒载体和治疗用途
公开(公告)号：WO2017075395A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059382
申请日：2016-10-28
申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人： LAN, Michael , BRESLIN, Mary
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： C12N15/86 , A61K49/0097 , C07K14/005 , G01N33/50
摘要： A conditionally replicating adenovirus were generated that can specifically replicate and express therapeutic genes in neuroendocrine tumors. The promoter-specific expression of the adenoviruses is regulated upstream by an INSM1 (insulinoma-associated-1) promoter that is silent in normal adult tissues but active in developing neuroendocrine cells and neuroendocrine tumors. By placing the I NSM 1 -promoter with an insulator and two copies of neuronal restrictive silencer elements in an adenoviral vector, the construct can retain tumor specificity and drive expression of a mutated adenovirus E1A gene (Δ24Ε1Α) and the herpes simplex virus thymidine kinase gene. The I NSM1 -promoter-driven viruses could replicate specifically in the I NSM1 -positive cells and I NSM1 -specific HSV-tk expression in combination with ganciclovir treatment displayed dose-dependent tumor cell-specific killing in insulinomas. When the I NSM1 -promoter driven HSV-tk was combined with Δ24Ε1Α and I NSM 1 p- HSV-tk viruses, the co-infected insulinoma expressed higher levels of HSV-tk and more efficient tumor suppression as compared to the I NSM1 p- HSV-tk virus alone.
摘要翻译：产生可在神经内分泌肿瘤中特异性复制和表达治疗基因的条件性复制型腺病毒。 INSM1（胰岛瘤相关-1）启动子在上游调节腺病毒的启动子特异性表达，所述启动子在正常成人组织中沉默，但在发育中神经内分泌细胞和神经内分泌肿瘤中有活性。通过将I NSM1启动子与绝缘子和神经元限制性沉默子元件的两个拷贝置于腺病毒载体中，该构建体可保留肿瘤特异性并驱动突变的腺病毒E1A基因（Δ24E1A）的表达和驱动单纯疱疹病毒胸苷激酶基因。 I NSM1启动子驱动的病毒可以特异性地在I NSM1阳性细胞中复制，并且I NSM1特异性HSV-tk表达与更昔洛韦治疗组合在胰岛瘤中显示剂量依赖性肿瘤细胞特异性杀伤。当I NSM1启动子驱动的HSV-tk与Δ24E1A和I NSM1p-HSV-tk病毒组合时，与I NSM1对照相比，共感染的胰岛瘤表达更高水平的HSV-tk和更有效的肿瘤抑制，仅HSV-tk病毒。

7. 发明申请

WO2016196604A1 ELECTROACTIVE SUPRAMOLECULAR POLYMERIC ASSEMBLIES, METHODS OF MAKING ELECTROACTIVE SUPRAMOLECULAR POLYMERIC ASSEMBLIES, AND METHODS OF USING ELECTROACTIVE SUPRAMOLECULAR POLYMERIC ASSEMBLIES 审中-公开
标题翻译：电动式分子式聚合物组合物，制备电解性SUPRAM分子聚合物组合物的方法，以及使用电化学分散聚合物组合物的方法
公开(公告)号：WO2016196604A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035227
申请日：2016-06-01
申请人： THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： HARDY, John , SCHMIDT, Christine, E.
IPC分类号： A61F2/84 , A61N1/30 , C08G61/12 , G02F1/155
CPC分类号： A61K47/6935 , A61N1/30 , A61N1/325 , C08G69/10 , C08G73/0266 , C08G73/028
摘要： Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
摘要翻译：本公开的实施方案提供电活性超分子聚合物组合物，制备电活性超分子聚合物组合物的方法，使用电活性超分子聚合物组合物的方法等。

8. 发明申请

WO2009102864A1 HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE 审中-公开
公开(公告)号：WO2009102864A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033913
申请日：2009-02-12
申请人： STANFORD UNIVERSITY , CHEN, James, K. , HYMAN, Joel, M. , OCASIO, Cory, A.
发明人： CHEN, James, K. , HYMAN, Joel, M. , OCASIO, Cory, A.
IPC分类号： A61K31/00
CPC分类号： C07D215/54 , A61K31/47 , A61K31/4709 , C07C257/14 , C07C311/16 , C07C311/21 , C07D215/42 , C07D231/14 , C07D237/28 , C07D239/90 , C07D239/95 , C07D285/135 , C07D333/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D455/02 , C07D471/14 , C07D513/04
摘要： The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated with the Hh pathway.
摘要翻译：本公开提供了用于抑制Hh途径的化合物，药物制剂，试剂盒和方法以及与Hh途径相关的癌症和发育障碍的缓解。

9. 发明申请

WO2016178968A1 METHOD OF ENHANCING SOMATIC CELL REPROGRAMMING WITH THE ACETYLLYSINE READER BRD3R 审中-公开
标题翻译：用乙酰胆碱读取器BRD3R增强肌细胞表达的方法
公开(公告)号：WO2016178968A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/030014
申请日：2016-04-29
申请人： THE UAB RESEARCH FOUNDATION, INC.
发明人： HU, Kejin , SHAO, Zhicheng
IPC分类号： C12N5/07 , C12N5/071 , C12N5/00
CPC分类号： C12N5/0696 , C07K14/4702 , C12N15/86 , C12N2501/115 , C12N2501/40 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/1307 , C12N2510/00 , C12N2740/15043
摘要： A method of generating an induced pluripotent stem cell (iPSC) comprises introducing to an animal somatic cell at least one nuclear reprogramming inducing factor and a BRD3R polypeptide or at least one nucleic acid expressing the at least one nuclear reprogramming factor and the BRD3R-related polypeptide in the recipient somatic cell, and culturing said cell to generate an induced pluripotent stem cell (iPSC). The introduction of the BRD3R-related polypeptide into the recipient somatic cell can increase the efficiency of inducing the generation of an iPSC by the at least one nuclear reprogramming inducing factor.
摘要翻译：产生诱导多能干细胞（iPSC）的方法包括向动物体细胞引入至少一种核重编程诱导因子和BRD3R多肽或表达至少一种核重编程因子和BRD3R相关多肽的至少一种核酸在受体体细胞中，并培养所述细胞以产生诱导多能干细胞（iPSC）。将BRD3R相关多肽引入受体体细胞可以通过至少一种核重编程诱导因子增加诱导iPSC产生的效率。

10. 发明申请

WO2016144995A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GLIOBLASTOMA 审中-公开
标题翻译：组合物和治疗GLIOBLASTOMA的方法
公开(公告)号：WO2016144995A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021429
申请日：2016-03-09
申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSIDAD DE ALCALA
发明人： BAZAN, Nicolas G. , MUSTO, Alberto E. , ALVAREZ-BUILLA, Julio
IPC分类号： A61P7/02 , A61K31/44 , C07D211/90
CPC分类号： A61K31/5377 , A61K45/06 , A61P25/00 , A61P25/08 , A61P35/00 , C07D211/90 , A61K2300/00
摘要： Provided are compositions that include a platelet-activating factor antagonist, pharmaceutical compositions including the platelet-activating factor antagonist, methods of treating a modulating the proliferation of a glioma or a pathological condition resulting from patient having a glioma.
摘要翻译：提供了包括血小板活化因子拮抗剂，包含血小板活化因子拮抗剂的药物组合物，治疗调节胶质瘤增生的方法或由患有神经胶质瘤的患者引起的病理状况的组合物。

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