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1. 发明申请

WO2019173376A1 IPSC-DERIVED CELL COMPOSITIONS, AND RELATED SYSTEMS AND METHODS FOR CARTILAGE REPAIR 审中-公开
公开(公告)号：WO2019173376A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020804
申请日：2019-03-05
申请人： ORIG3N, INC.
发明人： SMITH, Robin Y. , GLICKSMAN, Marcie A. , CORNIVELLI, Lizbeth
IPC分类号： A61K35/12 , A61L27/00 , A61L27/38 , A61P19/00 , C12N5/00 , C12N5/06 , C12N5/077
摘要： Presented herein are personalized compositions comprising iPSCs and/or iPSC-derived cells (cells) and methods of producing personalized compositions suitable for various therapies, including chondrogenesis therapies, to be administered to an individual or a group of individuals. The cells and/or cell lines, and any compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match. The compatible cells are then used to derive "personalized" compositions, wherein the "personalized" compositions comprise one or more cell-secreted molecules suitable for therapy. It is found herein that a composition comprising one or more iPSC-derived MSCs, iPSC-derived chondrocytes, and iPSC-derived chondrons may provide improved treatment efficacy than would be offered by bone marrow-MSCs (BM-MSCs) or compositions comprising BM-MSCs.

2. 发明申请

WO2019045775A1 IPSC-DERIVED SECRETOME COMPOSITIONS, AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2019045775A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/022325
申请日：2018-03-14
申请人： ORIG3N, INC.
发明人： SMITH, Robin Y. , GLICKSMAN, Marcie A.
IPC分类号： A61K9/00 , A61K9/10 , A61K35/12 , A61K35/30 , A61K38/17 , A61K39/395 , A61K47/36
摘要： Presented herein are methods of producing "personalized" secretome compositions suitable for secretome based therapy to be administered to a specific individual and/or specific group of individuals. The iPSCs and/or iPSC-derived cells, and any iPSC-derived compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match and/or ABO blood match and/or RHD blood group match. The identified compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a suitable donor. The retrieved compatible cells are then used to derive the "personalized" iPSC-derived secretome compositions, that comprise the complete secretome or a subset of the secretome suitable for treatment of a specific individual and/or specific group of individuals.

3. 发明申请

WO2015168475A1 MELT-PROCESSED POLYMERIC CELLULAR DOSAGE FORM 审中-公开
标题翻译：金属加工聚合物细胞剂量形式
公开(公告)号：WO2015168475A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028655
申请日：2015-04-30
申请人： BLAESI, Aron H.
发明人： BLAESI, Aron H. , SAKA, Nannaji
IPC分类号： A61K47/32 , A61K47/36
CPC分类号： A61K9/1641 , A61K9/2095 , A61K31/167 , A61K31/616
摘要： Presented herein are polymeric cellular dosage forms exhibiting improved immediate release properties, while maintaining high uniformity and satisfactory mechanical properties (e.g., to permit necessary handling). An exfoliating polymeric cellular dosage form is described herein that can be cost-effectively manufactured via batch or even non-batch (continuous or semi-continuous) melt processing. The solid dosage forms have a unique cellular microstructure featuring a number of open, interconnected cells. The cell walls contain the active ingredient(s) as well as an excipient that swells in the presence of a physiological fluid such as gastrointestinal fluid and/or saliva under physiological conditions.
摘要翻译：这里呈现的是表现出改善的立即释放性能，同时保持高均匀性和令人满意的机械性能（例如，以允许必要的处理）的聚合物细胞剂型。本文描述的剥离性聚合物细胞剂型可以通过批次或甚至非批次（连续或半连续）熔融加工成本有效地制造。固体剂型具有独特的细胞微结构，其具有多个开放的互连细胞。细胞壁含有活性成分以及在生理条件下在诸如胃肠液和/或唾液之类的生理液体存在下溶胀的赋形剂。

4. 发明申请

WO2014144478A2 SYSTEM AND METHOD FOR INTEGRATING A MEDICAL SEQUENCING APPARATUS AND LABORATORY SYSTEM INTO A MEDICAL FACILITY 审中-公开
标题翻译：将医疗测序装置和实验室系统整合到医疗设施中的系统和方法
公开(公告)号：WO2014144478A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028902
申请日：2014-03-14
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER
发明人： ARTZ, David R.
IPC分类号： G03F7/20
CPC分类号： G06Q50/22 , G06F19/00 , G06Q10/06314
摘要： A method may include accessing an order including a request for analysis by high throughput sequencer apparatus, where the order is associated with a biological sample identifier and a patient identifier, and scheduling, for processing with the sequencer apparatus, the request. The method may include determining availability of result information, including raw data generated by the sequencer apparatus, and assembling the raw data into aligned data, where assembling includes aligning the raw data against one or more references. The method may include analyzing the aligned data with respect to information identified by the request, and providing the raw data and/or the aligned data for long term storage. The method may include formatting a report for review by a medical professional, including information derived through analyzing the aligned data, and providing information associated with the report to a separate medical facility computing device for association with the patient identifier.
摘要翻译：一种方法可以包括：访问命令，该命令包括高吞吐量定序器装置的分析请求，其中该命令与生物样本标识符和患者标识符相关联;以及调度，用于利用定序器装置进行处理，请求。该方法可以包括确定结果信息的可用性，所述结果信息包括由定序器装置生成的原始数据，并将原始数据组装成对齐的数据，其中汇编包括将原始数据与一个或多个参考对齐。该方法可以包括针对由请求识别的信息分析对齐的数据，并且提供用于长期存储的原始数据和/或对齐的数据。该方法可以包括格式化报告以由医疗专业人员评论，包括通过分析对齐的数据而得到的信息，并且将与报告相关联的信息提供给单独的医疗设施计算设备用于与患者标识符关联。

5. 发明申请

WO2014046646A1 APPARATUS AND METHODS FOR STORAGE AND TRANSFER OF PATIENT INFORMATION USING BIOLOGICAL SAMPLE CARDS WITH SHORT RANGE COMMUNICATIONS 审中-公开
标题翻译：使用生物样本卡存储和转移患者信息的方法与短距离通信
公开(公告)号：WO2014046646A1
公开(公告)日：2014-03-27
申请号：PCT/US2012/055950
申请日：2012-09-18
申请人： WALLAC OY , PERKINELMER HEALTH SCIENCES, INC.
发明人： NEUVONEN, Teppo , RANTALA, Sami , GAILLARD, Grant , PAULETTE, Curt
IPC分类号： G06F19/00
CPC分类号： G16H10/40 , G06F19/00 , G16H10/65
摘要： Described herein are methods and apparatus for storing and transferring patient information related to biological sample testing using biological sample cards and short range communications. In certain embodiments, the disclosed technology provides for the localized data transfer with biological sample cards equipped with a transmission and storage device that is capable of storing data such as patient information so that errors associated with manually entering handwritten patient information are reduced. The transmission and storage device may include a radio frequency identification (RFID) tag/chip such as a near field communication (NFC) tag/chip.
摘要翻译：本文描述了使用生物样本卡和短程通信来存储和传送与生物样品测试相关的患者信息的方法和装置。在某些实施例中，所公开的技术提供了配备有传输和存储设备的生物样本卡的本地化数据传输，该传输和存储设备能够存储诸如患者信息之类的数据，从而减少与手动输入手写病人信息相关的错误。传输和存储设备可以包括诸如近场通信（NFC）标签/芯片的射频识别（RFID）标签/芯片。

6. 发明申请

WO2013141953A2 LIQUID-ENCAPSULATED RARE-EARTH BASED CERAMIC SURFACES 审中-公开
标题翻译：基于液体的基于稀土的陶瓷表面
公开(公告)号：WO2013141953A2
公开(公告)日：2013-09-26
申请号：PCT/US2013/021558
申请日：2013-01-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： AZIMI, Gisele , PAXSON, Adam, T. , SMITH, J., David , VARANASI, Kripa, K.
IPC分类号： B05D5/00
CPC分类号： C04B41/81 , B05D5/00 , Y10T428/24364 , Y10T428/3154 , Y10T428/31544 , Y10T428/31663 , Y10T428/31678 , Y10T428/31844
摘要： Described herein are non-wetting surfaces comprising rare-earth containing ceramics. Furthermore, the surfaces include liquid impregnated within a matrix of micro- or nano- engineered features on the surface. The surfaces are non-wetting and can resist liquid impalement, ice formation, scale formation, hydrate formation, and/or have antifouling properties.
摘要翻译：这里描述的是包含含稀土陶瓷的非润湿表面。此外，表面包括浸渍在表面上的微米或纳米工程特征的基体内的液体。表面不润湿并且可以抵抗液体冲击，冰形成，结垢形成，水合物形成和/或具有防污性能。

7. 发明申请

WO2013130893A2 HIERARCHICAL POROUS MEMBRANE FOR EMULSION SEPARATION 审中-公开
标题翻译：用于乳化分离的分层多孔膜
公开(公告)号：WO2013130893A2
公开(公告)日：2013-09-06
申请号：PCT/US2013/028439
申请日：2013-02-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SOLOMON, Brian, Richmond , VARANASI, Kripa, K. , HYDER, Md, Nasim
IPC分类号： B01D69/02
CPC分类号： C02F1/44 , B01D17/085 , B01D67/0034 , B01D67/0093 , B01D69/02 , B01D69/10 , B01D71/42 , B01D71/50 , B01D71/68 , B01D2325/022 , B01D2325/04 , B01D2325/38 , C02F1/40 , C02F1/444 , C02F2101/32 , C02F2101/325 , C10G33/06
摘要： Hierarchical porous membranes suitable for use in oil/water separation processes are provided. The membranes described herein are particularly well suited for separating trace amounts of water (e.g., no greater than 3 wt% water content, no greater than 1 wt% water content, or 50-1000 ppm water) from oil. The membranes have a wide range of applications, including deep seep oil exploration, oil purification, and oil spill cleanup.
摘要翻译：提供了适用于油/水分离过程的分层多孔膜。本文所述的膜特别适合于从油中分离痕量的水（例如，不大于3重量％的水含量，不大于1重量％的水含量或50-1000ppm的水）。膜具有广泛的应用范围，包括深渗油勘探，油净化和溢油清理。

8. 发明申请

WO2007123736A3 PROCESSES FOR SHAPING MACROCYCLIC OLIGOESTERS 审中-公开
公开(公告)号：WO2007123736A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/007982
申请日：2007-03-30
申请人： CYCLICS CORPORATION , THOMPSON, Timothy, A. , PHELPS, Peter, D. , WINCKLER, Steven, J.
发明人： THOMPSON, Timothy, A. , PHELPS, Peter, D. , WINCKLER, Steven, J.
IPC分类号： C08G63/78 , C07D321/00 , C08J3/12
摘要： In one aspect, the invention relates to processes for producing substantially free-flowing shapes of macrocyclic oligoester, wherein the freshly-shaped macrocyclic oligoester is maintained at elevated temperature for a sufficient time. In certain embodiments, the shapes are heated in water, thereby avoiding agglomeration during the heating process itself. In another aspect, the invention relates to processes for removing solvent from a solution of macrocyclic oligoester using elevated temperature, reduced pressure, or both, thereby obviating the need for an anti-solvent to precipitate the macrocyclic oligoester from the solution. Other aspects of the invention related to shaping of macrocyclic oligoesters are presented as well.

9. 发明申请

WO2007117338A3 METHODS FOR POLYMERIZING MACROCYCLIC POLYESTER OLIGOMERS USING CATALYST PROMOTERS 审中-公开
公开(公告)号：WO2007117338A3
公开(公告)日：2007-10-18
申请号：PCT/US2007/000606
申请日：2007-01-10
申请人： CYCLICS CORPORATION , TAKEKOSHI, Tohru , PHELPS, Peter, D. , WANG, Yi-Feng , WINCKLER, Steven, J.
发明人： TAKEKOSHI, Tohru , PHELPS, Peter, D. , WANG, Yi-Feng , WINCKLER, Steven, J.
IPC分类号： C08G63/00 , C08G63/85 , C08K5/05 , C08K5/1515 , C08K5/00 , C08L67/02 , C08K5/10 , C08L71/02 , C08K5/57
摘要： The invention provides methods and formulations involving the use of promoters that accelerate the polymerization of macrocyclic polyester oligomers (MPOs). For example, in certain embodiments, the invention provides blends of macrocyclic polyester oligomer (MPO), catalyst, and promoter that are substantially stable at ambient temperature for a period of time. The blend material may be stored without premature polymerization of MPO or deactivation of catalyst. The invention also provides processes employing one-part, ready-to-polymerize blends that contain MPO, catalyst, and promoter, as well as processes in which the catalyst and promoter are used in separate streams and are contacted when it is desired to accelerate polymerization of MPO. Methods of the invention offer advantages in the manufacture of thermoplastic parts and composites, due at least in part to the unique properties of MPO.

10. 发明申请

WO2007021731A2 DYE-ATTACHED AND/OR SURFACE-MODIFIED PIGMENTS 审中-公开
标题翻译：染料附着和/或表面改性的颜料
公开(公告)号：WO2007021731A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031018
申请日：2006-08-09
申请人： SOANE LABORATORIES, LLC. , SOANE, David , BERG, Michael, C. , MOWERS, William, A.
发明人： SOANE, David , BERG, Michael, C. , MOWERS, William, A.
CPC分类号： C09C1/3676 , A61K8/0241 , A61K8/736 , A61K2800/412 , A61K2800/43 , A61K2800/57 , A61K2800/612 , A61Q1/06 , A61Q3/02 , A61Q5/02 , A61Q5/065 , C01P2002/88 , C01P2004/51 , C01P2004/61 , C01P2004/62 , C01P2006/62 , C01P2006/63 , C01P2006/64 , C01P2006/65 , C01P2006/66 , C08K3/22 , C08K5/0041 , C09B67/0097 , C09C1/0015 , C09C1/24 , C09C1/3072 , C09C1/3081 , C09C1/309 , C09C1/3684 , C09C1/3692 , C09C1/407 , C09C1/42 , C09C3/006 , C09C3/10 , C09C3/12 , C09C2200/407 , C09C2200/408
摘要： This invention relates generally to dye-attached and/or surface-modified (e.g. functionalized) pigments. Certain embodiments include pigments formed by attaching a dye to the surface of a metal oxide or semi-metal oxide particle. Other embodiments include surface- modified pigments formed by attaching polymers having amine groups to the surface of a pigment. The surface functionalization of pigment particles with polymers having amine groups may provide the pigment with enhanced water resistance, color-fastness, smudge resistance, and/or compatibility with other materials in a composite or matrix material(s). For example, such functionalized pigments may be used in inks, paints, paper, fabrics, coatings, cosmetics, food, or other composites to provide or adjust hydrophobicity, softness, smoothness, and/or oleophobicity.
摘要翻译：本发明一般涉及染料附着和/或表面改性（例如官能化）的颜料。某些实施方案包括通过将染料附着到金属氧化物或半金属氧化物颗粒的表面而形成的颜料。其他实施方案包括通过将具有胺基的聚合物附着到颜料表面而形成的表面改性颜料。具有胺基团的聚合物的颜料颗粒的表面官能化可以提供具有增强的耐水性，色牢度，抗污迹性和/或与复合材料或基质材料中的其他材料的相容性的颜料。例如，这种官能化颜料可用于提供或调节疏水性，柔软性，光滑性和/或疏油性的油墨，油漆，纸张，织物，涂料，化妆品，食品或其它复合材料中。

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