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1. 发明申请

WO2022082178A2 METHODS FOR TREATING AND MONITORING FRONTOTEMPORAL DEMENTIA 审中-公开
公开(公告)号：WO2022082178A2
公开(公告)日：2022-04-21
申请号：PCT/US2021/071835
申请日：2021-10-13
申请人： DENALI THERAPEUTICS INC.
发明人： ASTARITA, Giuseppe , DEVOS, Sarah L. , DI PAOLO, Gilbert , FANG, Meng , HUANG, Fen , LOGAN, Todd P. , SIMON, Matthew J.
IPC分类号： G01N33/68
摘要： The present disclosure provides methods and materials for screening a compound or monitoring a subject's response to a compound or dosing regimen for treating frontotemporal dementia (FTD). Methods and materials for identifying and treating a subject having FTD are also provided.

2. 发明申请

WO2019217803A1 GENE THERAPY METHODS AND COMPOSITIONS USING AUXOTROPHIC REGULATABLE CELLS 审中-公开
公开(公告)号：WO2019217803A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031699
申请日：2019-05-10
申请人： AUXOLYTIC LTD. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： PATTERSON, James , PORTEUS, Matthew , WIEBKING, Volker
IPC分类号： C12N15/113 , C12N15/90
摘要： The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved gene therapy involving administration of an auxotrophic factor.

3. 发明申请

WO2019018534A8 SCARLESS GENOME EDITING THROUGH TWO-STEP HOMOLOGY DIRECTED REPAIR 审中-公开
公开(公告)号：WO2019018534A8
公开(公告)日：2019-01-24
申请号：PCT/US2018/042702
申请日：2018-07-18
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： IKEDA, Kazuya , PORTEUS, Matthew, H.
IPC分类号： C12N15/113 , C12N15/63 , C12N15/09
摘要： A method for scarless genome editing is disclosed. In particular, the method provides scarless genome modification by using homology directed repair (HDR) steps to genetically modify cells and remove unwanted sequences. This method can be used for genome editing, including introducing mutations, deletions, or insertions at any position in the genome without leaving silent mutations, selection marker sequences, or other additional undesired sequences in the genome.

4. 发明申请

WO2017152044A1 COMPOSITIONS AND METHODS FOR MUSCLE REGENERATION USING PROSTAGLANDIN E2 审中-公开
标题翻译：前列腺素E2用于肌肉再生的组合物和方法
公开(公告)号：WO2017152044A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020650
申请日：2017-03-03
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： BLAU, Helen, M. , HO, Andrew, Tri, Van , PALLA, Adelaida, R.
IPC分类号： A61K31/7088 , A61K35/12 , A61K35/28 , A61K39/395 , A61K45/06
摘要： Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.
摘要翻译：本文提供了用于通过将肌细胞暴露于前列腺素E2（PGE2）化合物或激活PGE2信号传导的化合物而增殖肌肉细胞的组合物，方法和试剂盒。还提供了通过单独或与分离的肌肉细胞组合施用PGE 2化合物来使患有肌萎缩，营养不良和/或损伤的受试者中的肌肉再生的方法。 PGE2化合物与分离的肌肉细胞组合可预防性施用以预防肌肉疾病或病症。

5. 发明申请

WO2017127442A1 METHODS FOR TREATING CANCER WITH RORGAMMA INHIBITORS 审中-公开
标题翻译：用RORGAMMA抑制剂治疗癌症的方法
公开(公告)号：WO2017127442A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/013966
申请日：2017-01-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH
发明人： CHEN, Hongwu , ZOU, June X. , WANG, Junjian , CAI, Demin , XU, Yong , XUE, Xiaoqian , ZHANG, Yan
IPC分类号： C07D401/02 , C07D401/10
CPC分类号： C07C205/11 , A61K31/138 , A61K31/167 , A61K31/277 , A61K31/337 , A61K31/4166 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions, methods, and kits comprising one or more compounds of Formula I, such as XY018, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, gastric cancer, lymphoma, and glioma.
摘要翻译：本发明提供单独或与一种或多种抗癌药物如抗雄激素药物组合的一种或多种式I化合物如XY018的组合物，方法和试剂盒，其可用于治疗癌症，例如前列腺癌，诸如去势抵抗性前列腺癌（CRPC），以及许多其他类型的癌症，包括肺癌，乳腺癌，肝癌，卵巢癌，子宫内膜癌，膀胱癌，结肠癌，胃癌，淋巴瘤和神经胶质瘤。

6. 发明申请

WO2017039694A1 PREPARATION OF COFFEE-BASED EXTRACTS AND POWDERS 审中-公开
标题翻译：基于咖啡的提取物和粉末的制备
公开(公告)号：WO2017039694A1
公开(公告)日：2017-03-09
申请号：PCT/US2015/048608
申请日：2015-09-04
申请人： KOFFEEFRUIT PTE. LTD.
发明人： MULLER, Mark L.
IPC分类号： A23F5/16
CPC分类号： A23F5/26 , A23F5/00 , A23L33/105
摘要： Processes for preparing antioxidant-rich compositions, for example from coffee cherries, arc disclosed. These processes can involve promptly contacting de-beaned coffee cherries with a preservative coating, and optionally storing under refrigerated conditions, prior to the preparation of an extract or powder. A process for preparing an antioxidant-rich powder, comprising the steps of: providing de-beaned coffee cherries; promptly contacting the de-beaned coffee cherries with a coating comprising citric acid and ascorbic acid to product a coated de-beaned coffee cherry and dehydrating the coated de-beaned coffee cherries under substantially oxygen-free conditions.
摘要翻译：公开了制备富含氧化剂的组合物，例如咖啡樱桃的方法。这些方法可以包括在制备提取物或粉末之前迅速地将脱脂咖啡樱桃与防腐剂涂层接触，并任选地在冷藏条件下储存。一种制备富含抗氧化剂的粉末的方法，包括以下步骤：提供脱脂咖啡樱桃; 及时将脱脂咖啡樱桃与包含柠檬酸和抗坏血酸的涂层接触，以产生涂覆的脱脂咖啡樱桃，并在基本上无氧条件下脱水涂覆的脱脂咖啡樱桃。

7. 发明申请

WO2016154020A1 METHODS FOR REDUCING SEBUM PRODUCTION AND/OR EXCRETION 审中-公开
标题翻译：减少生产和/或排泄的方法
公开(公告)号：WO2016154020A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023180
申请日：2016-03-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： SIVAMANI, Raja , SHI, Vivian
IPC分类号： A61K38/48 , A61K39/08 , A61P17/10
CPC分类号： A61K38/08
摘要： Provided herein are methods, compositions and kits for reducing or preventing excessive sebum production and/or excretion by a subject. The method includes administering a composition comprising a peptide that can modulate neurotransmitter release such as acetyl hexapeptide-8 RT001, Vialox ® , Leuphasyl ® , Syn ® -Ake, and any combination thereof. The method can include topical administration of the composition. Also provided herein are methods, compositions and kits for treating or preventing a condition associated with sebum overproduction or excessive excretion, including seborrhea and acne.
摘要翻译：本文提供了用于减少或预防受试者过度皮脂产生和/或排泄的方法，组合物和试剂盒。该方法包括施用包含可以调节神经递质释放的肽的组合物，例如乙酰六肽-8 RT001，Vialox，Leuphasyl，A-Ake及其任何组合。该方法可以包括组合物的局部施用。本文还提供了用于治疗或预防与皮脂过度产生或过度排泄相关的病症（包括皮脂溢和痤疮）的方法，组合物和试剂盒。

8. 发明申请

WO2016073737A1 METHODS OF SELECTING AND ISOLATING CANCER STEM CELLS 审中-公开
标题翻译：选择和分离癌细胞的方法
公开(公告)号：WO2016073737A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059269
申请日：2015-11-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： SATAKE, Noriko , NITIN, Nitin
IPC分类号： C12N5/09 , C12N5/095 , G01N33/52
CPC分类号： G01N33/57426 , G01N33/5005 , G01N33/574 , G01N33/57407 , G01N33/582
摘要： Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.
摘要翻译：本文提供了使用荧光葡萄糖类似物从生物样品或细胞培养样品中选择/鉴定和/或分离癌症干细胞的方法。本文还提供了用于选择/鉴定和/或分离白血病干细胞及其亚群的方法。本发明部分地基于以下发现：基于与非癌症干细胞相比荧光葡萄糖类似物的较低荧光水平可以选择/鉴定癌症干细胞，并且该特定基因在白血病干细胞中差异表达细胞与非白血病干细胞相比。

9. 发明申请

WO2015171720A1 METHODS FOR DIAGNOSING AND TREATING NEUROIMMUNE-BASED PSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于诊断和治疗基于神经缺陷的心理障碍的方法
公开(公告)号：WO2015171720A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/029407
申请日：2015-05-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MCALLISTER, A. Kimberley , ESTES, Myka E. , BAUMAN, Melissa , CARTER, Cameron
IPC分类号： A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： C12Q1/6883 , A61K31/7088 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/6863 , G01N2800/28
摘要： The methods of the present invention are useful for determining whether an individual has or is at risk of developing a neuroimmune-based psychiatric disorder by detecting the expression level of one or more cytokine receptors in a biological sample. The methods of the present invention are also useful for the in vivo imaging of brain tissue by detecting one or more imaging agents such as ligands (e.g. , cytokines) that bind to one or more cytokine receptors. In addition, the methods of the present invention are useful for identifying compounds that modulate ( e.g. , increase) the expression level or activity of one or more cytokine receptors. The present invention further provides therapeutic methods that target one or more cytokine receptors for the treatment of a neuroimmune-based psychiatric disorder.
摘要翻译：本发明的方法可用于通过检测生物样品中一种或多种细胞因子受体的表达水平来确定个体是否具有发展基于神经免疫的精神障碍的风险。本发明的方法还可用于通过检测一种或多种显像剂（例如结合一种或多种细胞因子受体的配体（例如细胞因子））来体内成像脑组织。此外，本发明的方法可用于鉴定调节（例如，增加）一种或多种细胞因子受体的表达水平或活性的化合物。本发明还提供靶向一种或多种细胞因子受体以治疗基于神经免疫的精神障碍的治疗方法。

10. 发明申请

WO2014205366A1 METHOD AND APPARATUS FOR MEDICAL ACCESSORIES DISINFECTION 审中-公开
标题翻译：医疗配件消毒的方法和装置
公开(公告)号：WO2014205366A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/043442
申请日：2014-06-20
申请人： NOSOCOM SOLUTIONS, INC.
发明人： SUNKARA, Naresh , GARCIA, Ricardo, R. , NAIKAL, Nikhil, Santosh , SUNKARA, Jaya
IPC分类号： A61L2/24
CPC分类号： A61L2/10 , A61B90/98 , A61L2/24 , A61L2202/14 , A61L2202/24
摘要： The present invention provides an apparatus for disinfecting and/or sterilizing medical or laboratory apparel or accessories, comprising: a cabinet, a disinfecting system housed within the cabinet, wherein the disinfecting system comprises at least one disinfecting agent, and an embedded computer or a programmable logic controller (PLC) housed within the cabinet, wherein the embedded computer or the PLC controls one or more systems of the apparatus. The cabinet has advanced tracking features (e.g., RFID readers) that can track the apparel or accessories being disinfected. The embedded computer or PLC has the capabilities to send electronic messages to users or additional computers for further transmission of information at regular intervals. Methods for disinfecting and/or sterilizing medical or laboratory apparel or accessories are also provided.
摘要翻译：本发明提供了一种用于对医疗或实验室服装或附件进行消毒和/或消毒的设备，包括：机柜，容纳在机柜内的消毒系统，其中所述消毒系统包括至少一种消毒剂，以及嵌入式计算机或可编程逻辑控制器（PLC），其中嵌入式计算机或PLC控制设备的一个或多个系统。机柜具有先进的跟踪功能（例如，RFID读取器），其可以跟踪被消毒的服装或附件。嵌入式计算机或PLC具有向用户或附加计算机发送电子消息以便定期进一步传输信息的能力。还提供了对医疗或实验室服装或附件进行消毒和/或灭菌的方法。

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