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1. 发明授权

US07842850B2 Methods for producing fertile crosses between wild and domestic soybean species 有权
标题翻译：在野生和国内大豆品种之间生产肥沃杂交的方法
公开(公告)号：US07842850B2
公开(公告)日：2010-11-30
申请号：US11417369
申请日：2006-05-04
申请人： Ram J. Singh
发明人： Ram J. Singh
IPC分类号： A01H1/00 , A01H1/02
CPC分类号： A01H5/10 , A01H1/00
摘要： Methods for producing hybrids between domestic and wild soybean that are fertile and can be further bred with other soybean plants are provided, thus allowing transfer of desirable traits and genes from the wild soybean into the domestic soybean. This invention also provides novel media for producing callus and multiple somatic embryos, as well as novel media for producing multiple shoots from the embryos. The hybrid plants are made fertile by colchicine treatment to double their chromosome number so that they can be backcrossed into domestic soybean. These methods and media allow the production of elite soybean lines containing traits or genes from wild soybean as well as a minimum amount of additional wild soybean DNA. Backcrosses containing only one wild soybean chromosome can be produced, as well as sets of such backcrossed lines that each contain one chromosome from the wild ancestor, but collectively all the wild chromosomes from the hybrid ancestor. Plants and plant progeny and plant tissue (tissue including seeds) of plants produced by the foregoing methods are also provided. The methods do not require genetic modification, and thus this invention allows production of domestic soybean plants that are not genetically-modified organisms (non-GMO) but that express desirable traits derived from wild soybean.
摘要翻译：提供了能够生育并可与其他大豆植物进一步育种的家庭和野生大豆之间的杂交种的方法，从而使所需的性状和基因从野生大豆转移到国内大豆中。本发明还提供用于产生愈伤组织和多个体细胞胚的新型培养基，以及用于从胚胎产生多个芽的新型培养基。通过秋水仙素处理使杂交植物变得肥沃，使其染色体数量增加一倍，使其可以回交到国内大豆中。这些方法和培养基允许生产含有来自野生大豆的性状或基因的精英大豆品系以及最少量的额外的野生大豆DNA。可以产生仅含有一个野生大豆染色体的回交，以及各自含有来自野生祖先的一条染色体的这种回交系的集合，但是共同地来自混合祖先的所有野生染色体。还提供了通过前述方法生产的植物和植物后代和植物组织（包括种子的组织）。这些方法不需要遗传修饰，因此本发明允许生产不是转基因生物（非转基因）的国内大豆植物，但表达来自野生大豆的理想性状。

2. 发明授权

US07785825B2 Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics 有权
标题翻译：肽，合成化合物和羊毛硫抗生素的脱水和环化的组合物和方法
公开(公告)号：US07785825B2
公开(公告)日：2010-08-31
申请号：US11034275
申请日：2005-01-12
申请人： Willem A. van der Donk , Lili Xie , Champak Chatterjee , Moushumi Paul
发明人： Willem A. van der Donk , Lili Xie , Champak Chatterjee , Moushumi Paul
IPC分类号： C12P21/06 , C12N9/00 , C12N9/14
CPC分类号： C12P21/02 , A61K38/164 , C12N9/52
摘要： Lantibiotics are synthesized on ribosomes as prepeptides and post-translationally modified to a mature form. These modifications include dehydrations and cyclizations. Compounds and related methods of generating compounds, modified by dehydration, cyclization, or dehydration and cyclization, are disclosed. The disclosure includes in vitro approaches to effecting dehydration and cyclization leading to production of biologically active compounds such as lantibiotics and variants thereof. Synthetic variants and methods including combinatorial approaches for generating diverse lantibiotics and other compounds are disclosed. The invention has broad potential for applications including food, agricultural, and medical industries.
摘要翻译：蓝霉素在核糖体上合成为前肽，并经翻译后修饰成成熟形式。这些修饰包括脱水和环化。公开了通过脱水，环化或脱水和环化改性产生化合物的化合物和相关方法。本公开内容包括进行脱水和环化的体外方法，从而导致生物活性化合物例如兰蒂生物及其变体。公开了合成变体和方法，包括用于产生不同的羊毛硫抗生素和其它化合物的组合方法。本发明具有广泛的应用前景，包括食品，农业和医疗行业。

3. 发明授权

US07707302B2 Method for transmitting a data stream from a producer to a plurality of viewers 失效
标题翻译：用于从生产者向多个观看者发送数据流的方法
公开(公告)号：US07707302B2
公开(公告)日：2010-04-27
申请号：US10490098
申请日：2002-09-20
申请人： Johannes Welck , Martin Miller , Kurt Kirchhübel , Ulrich Margull
发明人： Johannes Welck , Martin Miller , Kurt Kirchhübel , Ulrich Margull
IPC分类号： G06F15/16
CPC分类号： H04L65/4076 , H04L12/185 , H04L12/1854 , H04L12/189 , H04L29/06027
摘要： In a method for transmitting a data stream, especially a reducible data stream, from a producer to a plurality of viewers, wherein producer and viewers are subscribers in a network having point-to-point connections, the producer transmits the data stream over a point-to-point network connection to at least one viewer, at least one viewer receives the data stream over a point-to-point network connection and promptly transmits it in identical or reduced form to at least one additional viewer, and every viewer is promptly supplied with the data stream in identical or reduced form by either the producer or another viewer over a point-to-point network connection.
摘要翻译：在用于从生产者到多个观看者的数据流特别是可还原数据流的传输方法中，其中生产者和观看者是具有点对点连接的网络中的用户，生产者通过点发送数据流至少一个观众通过点对点网络连接接收数据流，并以相同或简化的形式及时将其发送到至少一个附加的观众，并且每个观众都迅速地将其连接到至少一个观众，由生产者或其他观众通过点对点网络连接以相同或简化的形式提供数据流。

4. 发明授权

US07704684B2 Methods and devices for fabricating three-dimensional nanoscale structures 有权
标题翻译：制造三维纳米尺度结构的方法和装置
公开(公告)号：US07704684B2
公开(公告)日：2010-04-27
申请号：US11001689
申请日：2004-12-01
申请人： John A. Rogers , Seokwoo Jeon , Jangung Park
发明人： John A. Rogers , Seokwoo Jeon , Jangung Park
IPC分类号： G03F7/00
CPC分类号： B81C99/00 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/50 , G03F7/70283 , G03F7/703 , G03F7/7035 , G03F7/70408 , Y10S430/146
摘要： The present invention provides methods and devices for fabricating 3D structures and patterns of 3D structures on substrate surfaces, including symmetrical and asymmetrical patterns of 3D structures. Methods of the present invention provide a means of fabricating 3D structures having accurately selected physical dimensions, including lateral and vertical dimensions ranging from 10s of nanometers to 1000s of nanometers. In one aspect, methods are provided using a mask element comprising a conformable, elastomeric phase mask capable of establishing conformal contact with a radiation sensitive material undergoing photoprocessing. In another aspect, the temporal and/or spatial coherence of electromagnetic radiation using for photoprocessing is selected to fabricate complex structures having nanoscale features that do not extend entirely through the thickness of the structure fabricated.
摘要翻译：本发明提供了用于在衬底表面上制造3D结构的3D结构和图案的方法和装置，包括3D结构的对称和非对称图案。本发明的方法提供了一种制造具有精确选择的物理尺寸的3D结构的方法，包括从10纳米到1000纳米的横向和垂直尺寸。在一个方面，使用掩模元件提供方法，所述掩模元件包括能够与正在进行光刻处理的辐射敏感材料形成保形接触的适形的弹性体相位掩模。在另一方面，选择用于光处理的电磁辐射的时间和/或空间相干性来制造具有纳米尺度特征的复杂结构，其不完全延伸通过制造的结构的厚度。

5. 发明授权

US07696116B2 Implementing a pressure-induced phase transformation in beta-eucryptite to impart toughening 失效
标题翻译：在β-eucryptite中实施压力相变以赋予韧性
公开(公告)号：US07696116B2
公开(公告)日：2010-04-13
申请号：US11689366
申请日：2007-03-21
申请人： Ivar Reimanis , Chris Seick , Kyle Fitzpatrick
发明人： Ivar Reimanis , Chris Seick , Kyle Fitzpatrick
IPC分类号： C04B35/00
CPC分类号： C04B35/117 , C04B35/19 , C04B35/488 , C04B35/645 , C04B2235/3203 , C04B2235/3217 , C04B2235/3225 , C04B2235/3244 , C04B2235/3246 , C04B2235/3472 , C04B2235/5427 , C04B2235/5436 , C04B2235/5445 , C04B2235/6562 , C04B2235/6565 , C04B2235/77 , C04B2235/80 , C04B2235/96
摘要： The invention provides composite materials comprising eucryptite particles distributed in a matrix material other than eucryptite. The matrix material may be a ceramic material such as an oxide ceramic. In an embodiment, the eucryptite particles are transformed from the β-phase to the ε-phase during fabrication of the composite. This phase transformation can enable a eucryptite-based transformation toughening mechanism.
摘要翻译：本发明提供了包含分布在除了锂辉石之外的基质材料中的堇青石颗粒的复合材料。基质材料可以是陶瓷材料，例如氧化物陶瓷。在一个实施方案中，在复合材料的制造期间，堇青石颗粒从“相”转变为“相”。这种相变可以实现基于eucryptite的转化增韧机理。

6. 发明授权

US07687582B1 Methods of production, purification, and processing of poly(heteroaromatic) block copolymers with improved solubility or dispersability 失效
标题翻译：具有改进的溶解度或分散性的聚（杂芳族）嵌段共聚物的生产，纯化和加工方法
公开(公告)号：US07687582B1
公开(公告)日：2010-03-30
申请号：US10954621
申请日：2004-09-30
申请人： Silvia D. Luebben , Shawn A. Sapp
发明人： Silvia D. Luebben , Shawn A. Sapp
IPC分类号： C08F234/00 , C08F234/04 , C08F293/00 , C08G61/12
CPC分类号： C08F297/04 , C08F6/00 , C08F295/00 , C08F297/00
摘要： This invention relates to improved methods for the preparation, purification, and processing of poly(heteroaromatic) block copolymers, as well as compositions prepared by these methods. Methods relate to preparation of multiblock and triblock copolymers of intrinsically conducting polymers (ICPs) containing at least one block of a poly(heteroaromatic) polymer and at least two blocks of a non-conducting polymer. This invention provides polymer solutions or dispersions of improved stability and better film-forming properties. The poly(heteroaromatic) block copolymers are obtained in their conducting or doped form, and are retained in a solvated, wet form throughout the production and purification processes. Stable solutions or dispersions of the purified copolymers in organic solvents, water, or mixtures thereof are provided. Stable solutions or dispersions of ICPs are useful in the preparation of semiconducting and conducting films, blends, and coatings on a variety of substrates using standard processing and coating techniques.
摘要翻译：本发明涉及用于制备，纯化和加工聚（杂芳族）嵌段共聚物的改进方法，以及通过这些方法制备的组合物。方法涉及制备含有至少一个聚（杂芳族）聚合物嵌段和至少两个非导电聚合物嵌段的固有导电聚合物（ICP）的多嵌段和三嵌段共聚物。本发明提供了具有改进的稳定性和更好的成膜性能的聚合物溶液或分散体。聚（杂芳族）嵌段共聚物以其导电或掺杂形式获得，并且在整个生产和纯化过程中以溶剂化，湿的形式保留。提供了纯化的共聚物在有机溶剂，水或其混合物中的稳定溶液或分散体。 ICP的稳定溶液或分散体可用于使用标准加工和涂覆技术在各种基材上制备半导体和导电膜，共混物和涂层。

7. 发明授权

US07662410B2 Membrane scaffold proteins and embedded membrane proteins 有权
标题翻译：膜支架蛋白和嵌入膜蛋白
公开(公告)号：US07662410B2
公开(公告)日：2010-02-16
申请号：US11439466
申请日：2006-05-23
申请人： Stephen G. Sligar , Timothy H. Bayburt
发明人： Stephen G. Sligar , Timothy H. Bayburt
IPC分类号： A61K9/14 , C07K14/00 , C07K14/435
CPC分类号： C07K14/47
摘要： Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.
摘要翻译：膜蛋白难以以重组形式表达，纯化和表征，至少部分是由于其疏水性或部分疏水性质。膜支架蛋白（MSP）与靶膜或其他疏水或部分疏水的蛋白质或膜片段组装形成可溶性纳米级颗粒，保留其天然结构和功能; 它们比脂质体和洗涤剂胶束改进。在磷脂的存在下，MSP形成纳米视磷脂双层盘，MSP在双层结构域的周边稳定颗粒。颗粒双层结构允许在溶液中或固体载体上操作掺入的蛋白质，包括用于诸如扫描探针显微镜或表面等离子体共振的表面敏感技术。纳米级颗粒促进药物和生物学研究，结构/功能相关性，结构测定，生物分离和药物发现。

8. 发明授权

US07642285B2 Compounds and methods for modulating communication and virulence in quorum sensing bacteria 有权
标题翻译：用于调节群体感染细菌中的通讯和毒力的化合物和方法
公开(公告)号：US07642285B2
公开(公告)日：2010-01-05
申请号：US11275896
申请日：2006-02-02
申请人： Helen E. Blackwell , Grant D. Geske , Rachel W. Wezeman
发明人： Helen E. Blackwell , Grant D. Geske , Rachel W. Wezeman
IPC分类号： A01N43/08 , C07D309/30
CPC分类号： C07D307/33
摘要： The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.
摘要翻译：本发明提供用于调节群体感应细菌的通讯和毒力的组合物和方法。在各种示例性实施方案中，本发明提供了包括天然存在和非天然存在的酰基 - 高丝氨酸内酯（AHL）类似物的合成类似物的群体感应化合物的组合文库，以及合成和使用这些化合物的方法。

9. 发明授权

US07632972B2 Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells 失效
标题翻译：用于治疗癌症的化合物和方法以及黑色素瘤和其他癌细胞程序性细胞死亡的调节
公开(公告)号：US07632972B2
公开(公告)日：2009-12-15
申请号：US10976186
申请日：2004-10-27
申请人： Paul J. Hergenrother , Vitaliy Nesterenko , Karson Putt , Brittany Joy Allen , Robin Shane Dothager , Benjamin James Leslie
发明人： Paul J. Hergenrother , Vitaliy Nesterenko , Karson Putt , Brittany Joy Allen , Robin Shane Dothager , Benjamin James Leslie
IPC分类号： C07C233/05 , A61K31/165
CPC分类号： C07C233/22 , C07B2200/07 , C07C233/11 , C07C233/18 , C07C233/31 , C07C233/40 , C07C233/44 , C07C233/51 , C07C235/34 , C07C235/36 , C07C235/38 , C07C271/16 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C40B30/06 , C40B40/04 , C40B50/08
摘要： Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.
摘要翻译：公开了合成的化合物和相关方法，以及化合物和组合疗法在细胞治疗中的应用和细胞凋亡的调节。公开了合成组合文库的产生以及关于在癌细胞中选择性诱导凋亡的文库成员化合物的评估。描述了化合物，制备化合物的方法以及应用于乳腺癌细胞，黑素瘤癌细胞，结肠癌细胞和其它癌细胞的治疗方法。

10. 外观设计

USD605313S1 Landscape edging cover 有权
标题翻译：风景边缘罩
公开(公告)号：USD605313S1
公开(公告)日：2009-12-01
申请号：US29284897
申请日：2007-09-18
申请人： Scott A. Wilson , Dennis R. Long , Scot E. Sullivan
设计人： Scott A. Wilson , Dennis R. Long , Scot E. Sullivan

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