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1. 发明申请

WO2018112595A1 POWERED CONCRETE FINISHING APPARATUS HAVING ANNULAR WORKING SURFACE 审中-公开
公开(公告)号：WO2018112595A1
公开(公告)日：2018-06-28
申请号：PCT/CA2016/051514
申请日：2016-12-20
申请人： 2544-9455 QUEBEC INC.
发明人： ROUILLARD, Benoit
IPC分类号： E04F21/24 , E01C19/22
CPC分类号： E04F21/248 , E04F21/247
摘要： Powered concrete finishing apparatus including a working head for working the concrete. The working head has a rotatable working surface having a ring shape in contact with the concrete during a finishing operation. The concrete finishing apparatus further includes a motor for driving the working head to perform a rotational working movement on the concrete during the finishing operation. The working surface comprises a clearance for allowing concrete to aggregate within said clearance. The clearance is free of additional working surfaces contacting the concrete during the finishing operation, such as blades, pans, floats or arms, thereby providing an improved finishing of the concrete.

2. 发明申请

WO2018098585A1 OPENLY POROUS ACOUSTIC FOAM, PROCESS FOR MANUFACTURE AND USES THEREOF 审中-公开
公开(公告)号：WO2018098585A1
公开(公告)日：2018-06-07
申请号：PCT/CA2017/051446
申请日：2017-12-01
申请人： POLYVALOR, LIMITED PARTNERSHIP
发明人： FOTSING, Edith Roland , DUBOURG, Arnaud , ROSS, Annie
IPC分类号： C08J9/26
摘要： There is provided a method of manufacturing an openly and highly porous thermoset foam, the method comprising the steps of mixing a thermosetting resin and crystals to form a mixture; applying pressure to the mixture to expel excess thermosetting resin, thereby producing a network of crystals touching each other with the thermosetting resin filling the interstices between the crystals of said network; curing the thermosetting resin in the mixture under pressure to produce a cured material; and contacting the cured material with a solvent for the crystals, thereby leaching the crystals out of the cured material, thereby obtaining said openly and highly porous thermoset foam. There is also provided a thermoset foam made of a thermoset and having a porosity of at least about 70%, wherein more than about 75% of the pores in the foam are connected to a neighboring pore.

3. 发明申请

WO2018094504A1 METHOD AND SYSTEM OF LASER-DRIVEN IMPACT ACCELERATION 审中-公开
公开(公告)号：WO2018094504A1
公开(公告)日：2018-05-31
申请号：PCT/CA2017/050991
申请日：2017-08-22
申请人： INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： KIEFFER, Jean-Claude
IPC分类号： F03H1/00 , B24C5/08 , B64G1/40 , F03H3/00 , H05H1/24 , C21D7/06 , C23C24/04
摘要： A system and a method for laser-driven propulsion, comprising transferring momentum to a projectile through a low-density material at laser fluences below plasma ablation threshold, the method comprising providing a metal layer having a first surface and a second opposite surface; providing a low density layer having a first surface and a second opposite surface; positioning the low density layer with the first surface thereof in direct contact with the second surface of the metal layer; positioning a projectile on the second surface of the low density layer; and heating the metal layer with laser pulses to temperatures below the liquefaction and ionization thresholds of the metal.

4. 发明申请

WO2018049534A1 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT 审中-公开
标题翻译：在2'位置处带有第四个全碳上样活性中心的核苷和核苷类似物以及用作心脏防护剂的方法
公开(公告)号：WO2018049534A1
公开(公告)日：2018-03-22
申请号：PCT/CA2017/051095
申请日：2017-09-18
申请人： LCB PHARMA INC. , UNIVERSITÉ D'OTTAWA
发明人： GUINDON, Yvan , MOCHIRIAN, Philippe , NEMER, Mona
IPC分类号： C07H19/20 , A61K31/7076 , A61P9/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/16
摘要： Nucleoside and nucleotide analogues that can be used as cardioprotective agents are provided. The nucleosides and nucleotide analogues comprise tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary stereogenic all-carbon centers at the 2' position and a phosphonate ester at the 5' position.
摘要翻译：提供了可用作心脏保护剂的核苷和核苷酸类似物。核苷和核苷酸类似物包括四氢呋喃基或四氢噻吩基部分，在2'位具有四价立体异构全碳中心和在5'位具有膦酸酯。

5. 发明申请

WO2018039783A1 SELECTION SYSTEMS AND METHODS FOR GENOME EDITING 审中-公开
标题翻译：用于基因组编辑的选择系统和方法
公开(公告)号：WO2018039783A1
公开(公告)日：2018-03-08
申请号：PCT/CA2017/051011
申请日：2017-08-29
申请人： UNIVERSITÉ LAVAL
发明人： DOYON, Yannick
IPC分类号： C12N15/11 , C07K14/705 , C12N15/09 , C12N15/55 , C12N15/63 , C12N15/85 , C12N15/90 , C12N9/14 , C12N9/22 , C12Q1/02 , C12Q1/68
CPC分类号： C12N15/85 , C12N9/22 , C12N15/09 , C12N15/102 , C12N15/63 , C12N15/90 , C12Q1/02
摘要： Described herein are methods and products for modification (e.g., deletion, insertion or substitution) of a target gene in a cell. In an aspect, the method entails introduction of a modification into an endogenous gene (e.g., ATP1A) locus thereby to confer resistance to a drug (e.g., ouabain or a derivative thereof), and co-introduction of a modification in a target gene of interest. Drug-based selection may be used to enrich cells comprising said modified genes within a population of cells, thereby to select for such modified genes. Novel polypeptides, including novel ATP1A1 polypeptides, are also described, which confer drug (e.g., ouabain) resistance, as well as corresponding nucleic acids encoding same, and vectors and host cells comprising same.
摘要翻译：本文描述了用于在细胞中修饰（例如缺失，插入或取代）靶基因的方法和产物。在一个方面，该方法需要向内源基因（例如ATP1A）基因座引入修饰，从而赋予对药物（例如，哇巴因或其衍生物）的抗性，以及将修饰物共同导入利益。基于药物的选择可用于富集在细胞群体内包含所述修饰的基因的细胞，从而选择这些修饰的基因。还描述了赋予药物（例如哇巴因）抗性的新多肽，包括新型ATP1A1多肽，以及编码它们的相应核酸，以及包含它们的载体和宿主细胞。

6. 发明申请

WO2018035606A1 DETERMINING THE RISK OF SCOLIOSIS COMPRISING DETERMINING CELLULAR RESPONSE TO MECHANOSTIMULATION 审中-公开
标题翻译：确定包括确定细胞对机械刺激的反应的风险
公开(公告)号：WO2018035606A1
公开(公告)日：2018-03-01
申请号：PCT/CA2017/050992
申请日：2017-08-23
申请人： CHU SAINTE-JUSTINE
发明人： MOREAU, Alain , OLIAZADEH, Niaz , GORMAN, Kristen Fay , EVELEIGH, Robert , BOURQUE, Guillaume
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/02 , C40B30/04 , C40B40/06 , G01N33/48
摘要： Disclosed herein are novel molecular markers associated with idiopathic scoliosis (IS). Accordingly, the present invention concerns novel methods of identifying subjects at risk of developing IS or suffering from IS and of genotyping and classifying IS subjects into genetic and functional groups. Also provided are compositions, DNA chips and kits for applying the methods.
摘要翻译：本文公开了与特发性脊柱侧凸（IS）相关的新型分子标志物。因此，本发明涉及鉴定处于发展为IS或患有IS的风险的受试者以及将IS受试者基因分型和分类为遗传和功能组的受试者的新方法。还提供了用于应用这些方法的组合物，DNA芯片和试剂盒。

7. 发明申请

WO2018014106A1 METHOD FOR VITRIFICATION OF ARSENIC AND ANTIMONY 审中-公开
标题翻译：一种砷和锑的蒸馏方法
公开(公告)号：WO2018014106A1
公开(公告)日：2018-01-25
申请号：PCT/CA2016/050854
申请日：2016-07-21
申请人： DUNDEE SUSTAINABLE TECHNOLOGIES INC.
发明人： LALANCETTE, Jean-Marc , LEMIEUX, David , NASRALLAH, Khalil , GARCIA CURIEL, Gabriel , BARBAROUX, Romain
IPC分类号： A62D3/30 , B09B3/00
CPC分类号： B09B3/0025 , C03C1/002 , C03C3/087
摘要： A method for vitrification of arsenic and antimony, comprising substituting oxygen to sulfur on thiosalts, incorporating resulting sodium arsenate and sodium antimonate into a sodium silicate glass-forming mixture and vitrifying the sodium silicate glass-forming mixture into a resulting glass sequestering the arsenic and antimony.
摘要翻译：一种用于玻璃化砷和锑的方法，包括在硫代盐上将氧替换成硫，将所得的砷酸钠和锑酸钠掺入形成硅酸钠玻璃的混合物中，并将形成硅酸钠玻璃的混合物玻璃化成所产生的玻璃隔离了砷和锑。

8. 发明申请

WO2017205974A1 BATHTUB WITH DOOR AND DRAIN 审中-公开
标题翻译：带门和漏的浴缸
公开(公告)号：WO2017205974A1
公开(公告)日：2017-12-07
申请号：PCT/CA2017/050658
申请日：2017-05-30
申请人： LES PRODUITS NEPTUNE INC.
发明人： ROCHETTE, Jean , MARCHAND, Alexandre , VEILLEUX, Marc , BEAUPRÉ, Luc , DESLAURIERS, Alain , CHARBONNEAU, Patrick
IPC分类号： A47K3/00 , A47K3/022
摘要： A bathtub comprising a tub having an enclosure defined by at least one sidewall for holding a water capacity, a doorway on the sidewall for providing access to the tub, a door mountable onto the doorway for holding at least two water levels in the tub; an actuator allowing a user to move the door between at least three positions; a mechanical drain for emptying the tub, a double reservoir for receiving water from the tub through the drain and the door drip, a control interface, door position sensors, water level detection sensors, a pressure sensor, and a controller configured to receive input controls signals from the control interface, receive input door lock position signals, receive input water detection signals, receive input pressure signals, send control signals to control a sealing valve of the door, and send control signals for operating a drain valve.
摘要翻译：一种浴缸，其包括：桶，其具有由至少一个侧壁限定的用于保持水容量的外壳;侧壁上的用于提供进入桶的入口;门，其可安装到门口上以用于至少保持浴缸中有两个水位; 允许使用者在至少三个位置之间移动门的致动器; 用于清空桶的机械排水口，用于通过排水口和门滴水接收来自桶的水的双储存器，控制接口，门位置传感器，水位检测传感器，压力传感器以及配置成接收输入控制来自控制接口的信号，接收输入门锁定位置信号，接收输入水检测信号，接收输入压力信号，发送控制信号以控制门的密封阀，并发送用于操作排水阀的控制信号。

9. 发明申请

WO2017205957A1 REMOTE ACCESS SYSTEM AND METHOD FOR PLANT PATHOGEN MANAGEMENT 审中-公开
标题翻译：用于植物病原体管理的远程访问系统和方法
公开(公告)号：WO2017205957A1
公开(公告)日：2017-12-07
申请号：PCT/CA2016/051326
申请日：2016-11-15
申请人： 9087-4405 QUEBEC INC.
发明人： CHAMPAGNE, Michel , LEBEAU JACOB, Christian , DESJARDINS, Sonia
IPC分类号： C12Q1/00 , A01N25/00 , A01P3/00 , C12M1/34 , C12Q1/04 , C12Q1/68
CPC分类号： C12R1/645 , A01N25/00 , A01N63/04 , C12N1/00 , C12N1/14
摘要： Remote access methods and systems for plant pathogen (e.g., fungi or fungus-like organisms) assessment and management, and uses thereof, in particular for real-time agricultural applications, are described herein. In embodiments, the method and systems combine the capture of pathogenic spores (e.g., by impaction on an adhesive surface), laboratory analysis to identify the spores (e.g., by microscopy and/or PCR), collecting weather data, determining the level of risk for each pathogen, and providing an output to a user, who may for example access such risk data remotely as a risk report. A weather station is installed in proximity to the field/area where the spore sampling/collection occurs, and allows the constant transfer of weather data to effect the risk assessment. The risk assessment may be used to direct and optimize pesticide (e.g., fungicide) application in accordance with the pathogen identification and assessed risk level.
摘要翻译：本文描述了用于植物病原体（例如真菌或真菌样生物体）评估和管理的远程访问方法和系统及其用于特别是用于实时农业应用的系统。在实施方案中，所述方法和系统组合病原孢子的捕获（例如，通过在粘合剂表面上的撞击），实验室分析以鉴定孢子（例如通过显微镜和/或PCR），收集天气数据，确定风险水平针对每种病原体，并向用户提供输出，例如可以将风险数据作为风险报告远程访问。气象站安装在发生孢子采样/采集的田地/地区附近，并允许持续传输天气数据以进行风险评估。根据病原体鉴定和评估的风险水平，可以使用风险评估来指导和优化杀虫剂（例如杀真菌剂）应用。

10. 发明申请

WO2017181274A1 BOTTLEBRUSH POLYMER COMPOSITIONS, LUBRICATING FLUID, POROUS MATERIALS COMPRISING SAID COMPOSITIONS, AND SURFACE BEARING SAID COMPOSITIONS 审中-公开
标题翻译：瓶装聚合物组合物，润滑流体，包含所述组合物的多孔材料和表面轴承组合物
公开(公告)号：WO2017181274A1
公开(公告)日：2017-10-26
申请号：PCT/CA2017/050461
申请日：2017-04-13
申请人： VALORISATION-RECHERCHE, LIMITED PARTNERSHIP , VALORISATION HSJ, LIMITED PARTNERSHIP , CARNEGIE MELLON UNIVERSITY
发明人： BANQUY, Xavier , FAIVRE, Jimmy , SHRESTHA, Buddha Ratna , MATYJASZEWSKI, Krzysztof , BURDYNSKA, Joanna , MOLDOVAN, Florina
IPC分类号： C08L51/06 , A61K8/73 , A61K8/91 , A61L31/10 , A61Q19/00 , C08L5/08
摘要： A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
摘要翻译：提供具有润滑性能的聚合物的混合物。该聚合物可用于生产润滑液。它们也可以出现在表面或嵌入多孔材料中。该聚合物混合物包含（a）包含具有聚合侧链的主链的药学上可接受的瓶刷聚合物，和（b）药学上可接受的线性聚合物。在润滑液中，瓶刷聚合物和线性聚合物一起溶解在药学上可接受的溶剂中。

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