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1. 发明申请

WO2023006841A1 USE OF THYROID HORMONE T4 IN A HIGH VERSATILITY TREATMENT IN PATIENTS TAKING PROTON PUMP INHIBITORS 审中-公开
公开(公告)号：WO2023006841A1
公开(公告)日：2023-02-02
申请号：PCT/EP2022/071125
申请日：2022-07-27
申请人： ALTERGON S.A.
发明人： SCARSI PERLER, Claudia , BETTAZZI, Elisa
IPC分类号： A61K9/00 , A61K47/10 , A61K9/08
摘要： The present document describes the medical use of an ethanol-free glycerol solution of thyroid hormone T4 in the treatment or prevention of a pathological condition related to an abnormal functioning of the thyroid hormone in patients under treatment with a proton pump inhibitor, wherein both treatments with hormone T4 and with proton pump inhibitor are performed orally. Unexpectedly with respect to what was previously known, the oral absorption of T4 from the present solution is not affected by the administration of proton pump inhibitor, therefore the two medicaments can be administered independently of one another, without any limitation regarding the mutual administration schedules.

2. 发明申请

WO2023285591A1 LIPOSOMES CONTAINING SYNERGISTIC ANTIMICROBIAL COMPOSITIONS BASED ON SELECTED PEPTIDES AND FATTY ACIDS 审中-公开
公开(公告)号：WO2023285591A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/069723
申请日：2022-07-14
申请人： CLEVER BIOSCIENCE S.R.L.
发明人： MAZZEI, Emma , BREVIARIO, Elisa , ZUCCHINALI, Stefano , FRESCHI, Giorgio , DE SIMEIS, Davide
IPC分类号： A01H1/00 , A01N33/00 , A61K8/92 , A61K38/16
摘要： Novel synergistic combinations based on antimicrobial peptides and fatty acids and formulated in liposomes are described. Antimicrobial peptides may be selected from the classes of defensins, thionins, heveins, snakins/GASA, knottins. Fatty acids may contain 4 to 22 carbon atoms and may be saturated, monounsaturated or polyunsaturated. The present peptides and fatty acids synergize, thereby providing a strong antifungal and antibacterial activity, with important applications, especially in the agronomic field.

3. 发明申请

WO2022118207A1 METHOD OF PREPARATION OF A CHEESE PRODUCT WITH INCREASED SHELF LIFE AND PRODUCT OBTAINED THEREBY 审中-公开
公开(公告)号：WO2022118207A1
公开(公告)日：2022-06-09
申请号：PCT/IB2021/061164
申请日：2021-12-01
申请人： PARMITAL S.R.L.
发明人： FERRARI, Davide
IPC分类号： A23C19/068 , A23C19/076 , A23C19/14 , A23C19/08
摘要： A method of preparation of a dairy product or compound is illustrated, said method comprising the following steps: providing a quantity of fresh and/or soft cheese, said fresh and/or soft cheese having a standard shelf life between 15 days and 60 days, and being close to expiry of said conservation period; providing a quantity of acid coagulum; mixing said quantities of fresh and/or soft cheese and acid coagulum, thereby obtaining a quantity of a re-processed dairy product; eliminating an excess moisture from said quantity of fresh and/or soft cheese and/or from said quantity of acid coagulum and/or from said quantity of re-processed dairy product. Each of said fresh and/or soft cheese, acid coagulum and re-processed dairy product has a composite average fat content between 15% and 32% by weight and the respective composite average fat contents differ from each other by maximum 5%. Moreover, the acid coagulum is added to the fresh and/or soft cheese in a weight ratio lower than or equal to 2:1.

4. 发明申请

WO2020128932A1 BIOMATERIAL AND USE THEREOF IN THE TREATMENT OF LUNG PATHOLOGIES 审中-公开
公开(公告)号：WO2020128932A1
公开(公告)日：2020-06-25
申请号：PCT/IB2019/061072
申请日：2019-12-19
申请人： BORZACCHIELLO, Assunta , MESSINA, Francesco
发明人： BORZACCHIELLO, Assunta , MESSINA, Francesco , DELLA SALA, Francesca
IPC分类号： A61L27/20 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/52 , A61L26/00
摘要： The present invention relates to a new biomaterial comprising: (a) hyaluronic acid having a molecular weight between 100 and 500 KDa; (b) optional collagen; (c) human mesenchymal cells and/or their secretome, and the use thereof in the treatment of lung pathologies, in particular chronic obstructive pulmonary disease (COPD), asthma, pulmonary idiopathic fibrosis (IPF) and pulmonary bronchodysplasia (BPD) of the premature infant.

5. 发明申请

WO2020083983A1 NEW PROBIOTICS USEFUL FOR ERADICATING HELICOBACTER PYLORI INFECTION 审中-公开
公开(公告)号：WO2020083983A1
公开(公告)日：2020-04-30
申请号：PCT/EP2019/078872
申请日：2019-10-23
申请人： VAIRA, Berardino
发明人： VAIRA, Berardino
IPC分类号： A61K35/745 , A61K35/747 , C12N1/20
摘要： New probiotic clones have been obtained having enhanced activity against Helicobacter pylori infection. The new clones are derived from selected strains of Lactobacillus acidophilus and Bifidobacterium animalis lactis sp. They are advantageously non-susceptible to antibiotics currently used in the treatment of Helicobacter pylori infection, which makes them ideal for co-treatment with said antibiotics in the eradication of Helicobacter pylori infection. Synergistic effects of combinations among the present probiotics and their strong adjuvant effect on the activity of antibiotics on Helicobacter pylori are herein reported.

6. 发明申请

WO2018146237A1 SOFT GELATIN CAPSULES CONTAINING H YD ROXYP RO PYL BETA CYCLODEXTRIN WITH HIGH STABILITY 审中-公开
公开(公告)号：WO2018146237A1
公开(公告)日：2018-08-16
申请号：PCT/EP2018/053244
申请日：2018-02-09
申请人： ALTERGON S.A.
发明人： CARUCCI, Simone , MARCHIORRI, Maurizio , PONTIGGIA, Marco , FOSSATI, Tiziano
IPC分类号： A61K47/40 , A61K9/48 , A61K31/196 , A61K31/4985
摘要： New soft gelatin capsules highly protected against the degradation of the active ingredient contained therein and highly resistant to hydration are described. The capsular wall is characterized by containing hydroxypropyl beta cyclodextrin in low quantity with respect to the weight of the wall and sub-stoichiometric with respect to that necessary for complexing the drug contained within the capsule. The new capsules are storage-stable, avoid the development of active ingredient by-products and maintain a high weight constancy, i.e. low hygroscopy.

7. 发明申请

WO2014180527A1 SHEET FOR CUTANEOUS APPLICATION CONTAINING VITAMIN E OR AN ESTER THEREOF 审中-公开
标题翻译：包含维生素E或其中的芹菜的应用表
公开(公告)号：WO2014180527A1
公开(公告)日：2014-11-13
申请号：PCT/EP2014/000979
申请日：2014-04-11
申请人： BIO.LO.GA. S.R.L.
发明人： PANIN, Giorgio
IPC分类号： A61L15/44 , A61K9/00 , A61K47/34 , A61K9/70 , A61K31/355 , A61L15/26
CPC分类号： A61K31/355 , A61L15/26 , A61L15/44 , A61L2300/428 , A61L2300/606 , A61L2420/02 , A61L2420/06 , C08L83/04
摘要： Sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein the layer of silicone elastomer has a thickness less than or equal to 2.0 mm and the silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C 8 -C 18 fatty acids.
摘要翻译：用于皮肤应用的片材包括由松散编织织物制成的支撑层，所述支撑层嵌入在包含维生素E或其酯的硅氧烷弹性体层中，其中硅氧烷弹性体层的厚度小于或等于2.0mm，并且硅氧烷弹性体含有弹性调节剂由饱和C8-C18脂肪酸的甘油三酯组成。

8. 发明申请

WO2014102596A2 NEW CYCLIC CATIONIC PEPTIDES WITH ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：具有抗微生物活性的新型循环阳离子肽
公开(公告)号：WO2014102596A2
公开(公告)日：2014-07-03
申请号：PCT/IB2013/002893
申请日：2013-12-30
申请人： UNIVERSITA' DEGLI STUDI DI PARMA , AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
发明人： BARONI, Maria Cristina , CABASSI, Clotilde Silvia , ROMANI, Antonello
IPC分类号： A61K38/04
CPC分类号： C07K7/08 , A61K38/00 , A61K38/04 , A61K38/10 , A61K38/16 , C07K7/50 , C07K14/00 , Y02A50/401 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： A series of cationic cyclic peptides, useful for the treatment of infectious diseases in both human and veterinary clinical/surgical environment are described herein. The peptides of the invention have a length of 15 to 21 amino acids, and are cyclizable via formation of a disulfide bridge between two amino acids containing sulfur, suitably located in proximity to -NH 2 terminal and -COOH terminal regions of the peptide. Additionally, the central portion of the peptide is characterized by the presence of a number of charged amino acids, partly or totally alternate with neutral amino acids. More specifically, the peptides show a sequence A-B-C-D C'-B'-A', where units A and A' correspond to -NH 2 terminal and -COOH terminal regions; units B and B' correspond to amino acids containing sulfur; units C and C are sequences of 5 or 6 amino acids selected among hydrophobic amino acids and basic amino acids and amino acids forming hydrogen bonds; unit D corresponds to the amino acid glycine. Said peptides show significant antibacterial activity, associated with high stability and resistance to the action of bacterial endopeptidases, and weak or null toxicity against eukaryotic cells. In particular, the disposition of hydrophobic amino acids in discrete regions, separate from charged amino acids, gives the peptides high activity, also associated with significant salt-insensitivity. The invention also relates to the synthesis of said peptides, relative pharmaceutical compositions, and the use of said peptides in the treatment of infections caused by bacteria, fungi and /or yeasts.
摘要翻译：本文描述了一系列用于治疗人和兽医临床/手术环境中的感染性疾病的阳离子环肽。本发明的肽具有15至21个氨基酸的长度，并且可通过在两个含硫氨基酸之间形成二硫键在适当位于肽的-NH 2末端和-COOH末端区域附近环化。此外，肽的中心部分的特征在于存在多个带电荷的氨基酸，部分或完全与中性氨基酸交替。更具体地，肽显示序列A-B-C-D C'-B'-A'，其中单元A和A'对应于-NH 2末端和-COOH末端区; 单元B和B'对应于含硫的氨基酸; 单元C和C是选自疏水性氨基酸和碱性氨基酸中的5或6个氨基酸和形成氢键的氨基酸的序列; 单元D对应于氨基酸甘氨酸。所述肽显示出显着的抗菌活性，与细菌内肽酶的作用具有高稳定性和抗性，对真核细胞具有弱或无毒性。特别地，在离开带电氨基酸的离散区域中疏水性氨基酸的配置给出了肽高活性，也与显着的盐不敏感性有关。本发明还涉及所述肽的合成，相对药物组合物以及所述肽在治疗由细菌，真菌和/或酵母引起的感染中的用途。

9. 发明申请

WO2008058988A1 PYRROLO[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：治疗由化疗药物引起的外周神经毒性的PYRROLO [1,2-A]咪达拉灭有效
公开(公告)号：WO2008058988A1
公开(公告)日：2008-05-22
申请号：PCT/EP2007/062323
申请日：2007-11-14
申请人： BRANE DISCOVERY S.R.L. , FARINA, Carlo , GHELARDINI, Carla , PETRILLO, Paola
发明人： FARINA, Carlo , GHELARDINI, Carla , PETRILLO, Paola
IPC分类号： A61K31/4188 , A61P39/00 , A61P25/02
CPC分类号： A61K31/4188 , C07D487/04
摘要： The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
摘要翻译：公开了式（I）化合物在治疗和/或预防5化疗诱发的周围神经毒性（CIPN）中的应用。本发明包括其中式（I）化合物与抗癌剂混合存在的药物组合物。还提供了具有减少的CIPN相关副作用的改进的抗癌治疗。

10. 发明申请

WO2004046423A1 AN APPARATUS AND PROCESS FOR THE DRY REMOVAL OF THE SCALE FOUND ON THE SURFACE OF METAL PRODUCTS 审中-公开
标题翻译：干燥除去金属产品表面的尺寸的装置和工艺
公开(公告)号：WO2004046423A1
公开(公告)日：2004-06-03
申请号：PCT/EP2003/012781
申请日：2003-11-14
申请人： DANIELI & C. OFFICINE MECCANICHE S.P.A. , PAVLICEVIC, Milorad , POLONI, Alfredo , PRIMAVERA, Alessandra , GUASTINI, Fabio , SANZ LARA, Alejandro , VECCHIET, Fabio
发明人： PAVLICEVIC, Milorad , POLONI, Alfredo , PRIMAVERA, Alessandra , GUASTINI, Fabio , SANZ LARA, Alejandro , VECCHIET, Fabio
IPC分类号： C23G5/00
CPC分类号： C23G5/00 , B08B7/00 , B21B45/004 , B21B45/04 , B21B2045/006
摘要： An apparatus and process for the dry removal of the scale from the surface of a metal product comprising at least one heating area that does not reduce the specific surface of the material to be treated and does not cause oxidation, at least one reducing area for performing the reaction between a specific reducing gas (normally hydrogen) and at least the scale, at least one cooling area for cooling the metal product, means for heating the metal product, means for heating the reducing gas, means for controlling the fluid dynamics of the boundary layer produced by the flow of said reducing gas over the surface of the metal product, means for removing the reaction products from the reducing gas after the reaction, means for cooling the metal product, and means for removing the reaction products from the treated surface of the metal product.
摘要翻译：一种用于从金属制品的表面干燥除垢的装置和方法，包括至少一个加热区域，其不减少待处理材料的比表面并且不引起氧化，至少一个还原区域用于执行特定的还原气体（通常为氢）和至少氧化皮之间的反应，用于冷却金属产品的至少一个冷却区域，用于加热金属产品的装置，用于加热还原气体的装置，用于控制所述还原气体的流体动力学的装置通过在金属制品的表面上的所述还原气体的流动产生的边界层，用于从反应后的还原气体中除去反应产物的装置，用于冷却金属产物的装置，以及用于从经处理的表面除去反应产物的装置的金属制品。

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