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1. 发明申请

WO2014191364A1 THERAPIES FOR CARDIOMYOPATHY 审中-公开
标题翻译：心脏病的治疗方法
公开(公告)号：WO2014191364A1
公开(公告)日：2014-12-04
申请号：PCT/EP2014/060853
申请日：2014-05-26
申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND
发明人： WATSON, Chris , BAUGH, John , LEDWIDGE, Mark , MCDONALD, Ken
IPC分类号： A61K45/00 , A61P9/00
CPC分类号： A61K31/7064 , A61K31/706 , A61K31/713 , C12Q1/6883 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5023 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2800/325
摘要： The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.
摘要翻译：本发明涉及用于治疗心肌病的疗法和治疗剂。特别地，本发明涉及但不限于用于治疗肥厚型心肌病的疗法和治疗剂。这样的治疗剂包括低甲基化剂。

2. 发明申请

WO2014114799A1 WETSUIT/DRYSUIT REMOVAL TOOL 审中-公开
标题翻译：湿巾/液体清除工具
公开(公告)号：WO2014114799A1
公开(公告)日：2014-07-31
申请号：PCT/EP2014/051545
申请日：2014-01-27
申请人： ADVENTURE SPORTS INNOVATION LIMITED
发明人： TAYLOR, Laura
IPC分类号： A47G25/90 , A47G25/32 , A47G25/14
CPC分类号： A47G25/90 , A47G25/32 , A47G25/902 , A47G2025/1485
摘要： The wetsuit removal tool is a product that helps surfers and other wetsuit users, to remove their wetsuit with ease. The rounded tips help guide rollers into heel position while the fins work in harmony to push the wetsuit off the user's legs. It is also a hanger that the wetsuit will be hung on after use. The hanger also has air vents which will allow the air to filter around the wetsuit to help it dry quicker. Another feature is a hook that will help the user zip up and down their wetsuit.
摘要翻译：潜水衣去除工具是一种可以帮助冲浪者和其他潜水衣用户轻松移除潜水服的产品。圆形尖端有助于将滚轮导向脚跟位置，同时翅片协调工作，将潜水器推出使用者的腿部。使用后潜水衣也将挂在衣架上。衣架还具有通风口，这样可以让空气过滤掉潜水衣，帮助它更快地干燥。另一个功能是一个钩子，可以帮助用户上下拉下潜水衣。

3. 发明申请

WO2014096090A1 NOVEL TRH BINDING SITE IN HUMAN CNS 审中-公开
标题翻译：人类中枢神经系统新型TRH结合位点
公开(公告)号：WO2014096090A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/077221
申请日：2013-12-18
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN
发明人： KELLY, Julie
IPC分类号： C07K7/06 , C07K5/117
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1024 , C07K14/723 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/473
摘要： The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterise the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.
摘要翻译：本发明涉及在人类中枢神经系统（CNS）中与人垂体TRH受体亚型药理学上不同的新型促甲状腺激素释放激素（TRH）受体亚型。本发明提供了一种了解TRH的中枢作用如何介导并分离和表征新型受体的方法，以及适用于研究和开发人类CNS疾病的诊断和治疗应用的方法。

4. 发明申请

WO2014057108A1 SERUM AMYLOID P-COMPONENT AS A THERAPEUTIC AGENT OR BIOMARKER 审中-公开
标题翻译：作为治疗剂或生物标志物的血清淀粉样蛋白组分
公开(公告)号：WO2014057108A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/071327
申请日：2013-10-11
申请人： THE HEARTBEAT TRUST LIMITED , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND
发明人： WATSON, Chris , LEDWIDGE, Mark , McDONALD, Kenneth , HORGAN, Stephen , BAUGH, John
IPC分类号： A61K38/17
CPC分类号： A61K38/1716
摘要： The present invention relates to the treatment of inflammatory diseases and in particular to the provision of therapeutic agents which may halt or slow the progression of inflammatory diseases or disorders. Such diseases include fibrosis, hypertrophy and cardiovascular inflammatory conditions. In particular the agent may be used to halt or slow the progression of hypertensive heart disease into heart failure with preserved ejection fraction. A suitable therapeutic agent is Serum Amyloid P-component. The invention also relates to the use of Serum Amyloid P-component as a biomarker in diagnosing or monitoring the progression of such diseases.
摘要翻译：本发明涉及炎性疾病的治疗，特别涉及提供可阻止或减慢炎性疾病或病症进展的治疗剂。这些疾病包括纤维化，肥大和心血管炎症状况。特别地，该药剂可用于以保持的射血分数来停止或减慢高血压心脏病进入心力衰竭的进展。合适的治疗剂是血清淀粉样蛋白P-组分。本发明还涉及血清淀粉样蛋白P-组分作为诊断或监测这些疾病进展的生物标志物的用途。

5. 发明申请

WO2013091720A1 A BREAST PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：一种乳制品及其制造方法
公开(公告)号：WO2013091720A1
公开(公告)日：2013-06-27
申请号：PCT/EP2011/073895
申请日：2011-12-22
申请人： TRULIFE LIMITED , MURPHY, Noel , GUNNING, Olive
发明人： MURPHY, Noel , GUNNING, Olive
IPC分类号： B29C67/20 , B29C39/02 , A61F2/52
CPC分类号： B29C67/202 , A61F2/52
摘要： A method of manufacturing a prosthesis comprising a distal wall, a proximal wall, and a core, the method comprising applying a layer of silicone-based curable composition to a prosthesis mould; curing the layer of curable composition to form the distal wall defining a cavity; applying a mixture to the cavity, the mixture comprising a dispersed phase of dissolvable granular bodies suspended in a suspension medium comprising the curable composition; moulding the curable mixture so that it is adapted to fill the cavity curing the curable mixture to form the core, such that the surface of the curable mixture not in contact with the distal wall forms the proximal wall; and dissolving the granular bodies from the suspension medium to form a cellular structure.
摘要翻译：一种制造假体的方法，其包括远端壁，近侧壁和芯部，所述方法包括将一层硅氧烷基可固化组合物施加到假体模具上; 固化可固化组合物层以形成限定空腔的远侧壁; 将混合物施加到空腔，所述混合物包含悬浮在包含可固化组合物的悬浮介质中的可溶性颗粒体的分散相; 模制可固化混合物，使得其适于填充固化可固化混合物以形成芯的空腔，使得不与远侧壁接触的可固化混合物的表面形成近壁; 并从悬浮介质中溶解颗粒体以形成多孔结构。

6. 发明申请

WO2011138454A1 NOVEL FACTORS THAT PROMOTE TRIPLET REPEAT EXPANSIONS 审中-公开
标题翻译：促进TRIPLET REPEAT扩张的新因素
公开(公告)号：WO2011138454A1
公开(公告)日：2011-11-10
申请号：PCT/EP2011/057357
申请日：2011-05-06
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY , LAHUE, Robert , DEBACKER, Kim , KIRKHAM-McCARTHY, Lucy , GLEESON, Olive , FRIZZELL, Aisling , CONCANNON, Claire
发明人： LAHUE, Robert , DEBACKER, Kim , KIRKHAM-McCARTHY, Lucy , GLEESON, Olive , FRIZZELL, Aisling , CONCANNON, Claire
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： G01N33/5008 , G01N2500/10 , G01N2800/2835 , G01N2800/2878 , G01N2800/2892
摘要： A pharmaceutical composition comprising an agent that inhibits the protein target of the human genes listed in Figure 4. A method of identifying a therapeutic agent for the treatment of a disease(s) caused by expansions of DNA trinucleotide repeats and a method of identifying a gene involved in DNA trinucleotide expansion.
摘要翻译：一种药物组合物，其包含抑制图4中所列的人基因的蛋白质靶标的试剂。鉴定用于治疗由DNA三核苷酸重复序列扩增引起的疾病的治疗剂的方法和鉴定基因的方法涉及DNA三核苷酸扩增。

7. 发明申请

WO2011076903A1 MUTANT NISIN SER 29 DERIVATIVES AND THE USE THEREOF 审中-公开
标题翻译：突变NISIN SER 29衍生物及其用途
公开(公告)号：WO2011076903A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070597
申请日：2010-12-22
申请人： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY , UNIVERSITY COLLEGE CORK-NATIONAL UNIVERSITY OF IRELAND, CORK , HILL, Colin , COTTER, Paul , ROSS, Paul, R. , FIELD, Desmond
发明人： HILL, Colin , COTTER, Paul , ROSS, Paul, R. , FIELD, Desmond
IPC分类号： C07K14/315 , A61K38/16
CPC分类号： C07K14/315 , A61K38/00
摘要： A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when compared to wild type Nisin. The Nisin derivative has an application as a natural food additive and as a therapeutic agent.
摘要翻译： Nisin衍生物或变体，其包含氨基酸序列中氨基酸位置29处的氨基酸取代。与野生型乳酸链球菌肽相比，乳酸链球菌肽衍生物表现出增强的抗微生物活性。 Nisin衍生物可用作天然食品添加剂和治疗剂。

8. 发明申请

WO2010004041A1 DIAGNOSTIC KIT FOR ASPERGILLUS FUMIGATUS SPECIES 审中-公开
标题翻译：。US US US。。。。。。。。。。。。。
公开(公告)号：WO2010004041A1
公开(公告)日：2010-01-14
申请号：PCT/EP2009/058858
申请日：2009-07-10
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY , O CONNOR, Louise , MAHER, Majella
发明人： O CONNOR, Louise , MAHER, Majella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895
摘要： The use of the Aygl gene or an RNA transcript of the Aygl gene or fragments thereof as target regions in a diagnostic assay for the eukaryotic organism Aspergillus fumigatus species is described. The unique sequence of the Aygl gene in Aspergillus fumigatus provides the basis of nucleic acid diagnostic test for the identification of the pathogen at a the molecular level.
摘要翻译：描述了用于真菌生物烟曲霉菌种的诊断测定中Aygl基因或其作为其片段的RNA转录物作为靶区域的用途。烟曲霉中Aygl基因的独特序列为分子水平鉴定病原体提供了核酸诊断试验的基础。

9. 发明申请

WO2009141427A2 INCREASING THE SHELF LIFE OF BAKERY AND PATISSERIE PRODUCTS BY USING THE ANTIFUNGAL LACTOBACILLUS AMYLOVORUS DSM 19280 审中-公开
标题翻译：通过使用反义乳酸杆菌AMYLOVORUS DSM 19280增加面包和食品产品的寿命
公开(公告)号：WO2009141427A2
公开(公告)日：2009-11-26
申请号：PCT/EP2009/056229
申请日：2009-05-22
申请人： UNIVERSITY COLLEGE CORK-NATIONAL UNIVERSITY OF IRELAND, CORK , ARENDT, Elke K , DAL BELLO, Fabio , RYAN, Liam
发明人： ARENDT, Elke K , DAL BELLO, Fabio , RYAN, Liam
IPC分类号： C12N1/00
CPC分类号： C12R1/225 , A01N63/00 , A23L29/065 , C12N1/20
摘要： The current inventions relates to a strain of Lactobacillus amylovorus designated FST 2.11 as deposited under the accession no DSM 19280 on 13 th April 2007 in the DSMZ depository, and strains substantially similar thereto also encoding antifungal and bread antistaling properties and applications thereof.
摘要翻译：本发明涉及一种称为FST 2.11的乳酸乳杆菌菌株，其保藏于2007年4月13日在DSMZ保藏处的DSM 19280登记号，以及基本相似的菌株也编码抗真菌和面包抗变性及其应用。

10. 发明申请

WO2007129288A2 ELECTRONIC DOCUMENT REFORMATTING 审中-公开
标题翻译：电子文件重组
公开(公告)号：WO2007129288A2
公开(公告)日：2007-11-15
申请号：PCT/IE2007/000030
申请日：2007-03-06
申请人： BIG RIVER LIMITED , MCGRENERY, Seamus , MCGRATH, Brian , CLARKE Kevin
发明人： MCGRENERY, Seamus , MCGRATH, Brian , CLARKE Kevin
IPC分类号： G06F17/21
CPC分类号： G06F17/2264 , G06F17/24 , G06K9/00442
摘要： An apparatus and methods are provided for converting electronic documents formatted for printing into corresponding electronic documents formatted for display. The conversion involves the comparison the document layout defined by the print format against at least one document layout template, the mapping of alphanumerical data in the electronic document to corresponding ASCII character data, the optical recognition of alphanumerical data in the electronic document, the comparison of the optically-recognized alphanumerical data against the mapped alphanumerical data, the identification of image data in the electronic document, the optional rescaling of the image data if the image data exceeds an image data parameter, and the output of a converted electronic document including the optionally rescaled image data and compared ASCII character data, the output electronic document being formatted for display according to the document layout template.
摘要翻译：提供了一种将格式化用于打印的电子文档转换为格式化以显示的相应电子文档的装置和方法。该转换包括将由打印格式定义的文档布局与至少一个文档布局模板，电子文档中的字母数字数据映射到相应的ASCII字符数据，电子文档中的字母数字数据的光学识别，比较针对映射的字母数字数据的光学识别的字母数字数据，电子文档中的图像数据的识别，如果图像数据超过图像数据参数，则可选地重新缩放图像数据，以及包括任选地转换的电子文档的输出重新缩放图像数据并比较ASCII字符数据，输出电子文档根据文档布局模板进行格式化显示。

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