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1. 发明申请

WO2017060840A1 USE OF HTRA1 FOR EARLY DETECTION OF COLORECTAL CANCER 审中-公开
标题翻译：使用HTRA1早期检测彩色癌
公开(公告)号：WO2017060840A1
公开(公告)日：2017-04-13
申请号：PCT/IB2016/055979
申请日：2016-10-06
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： ALTOBELLI, Emma
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/96425
摘要： The invention relates to a novel test for the early diagnosis of colorectal cancer (CRC),. The test measures the expression decrease of HtrA1 protein in plasma samples. Its application implies either the use of HtrA1 alone or in combination with the immunochemical fecal occult blood test (iFOBT). The latter application is called "combined test". The new test offers the advantage of affording greater sensitivity than the most reliable available fecal occult blood test (FOBT). It may be hypothesized that the test could be used for routine population-based CRC screening, either alone or combined, before patients who are positive for fecal occult blood are referred for colonoscopy.
摘要翻译：本发明涉及一种用于结直肠癌（CRC）早期诊断的新型检测方法。该测试测量血浆样品中HtrA1蛋白的表达降低。其应用意味着单独使用HtrA1或与免疫化学粪便潜血试验（iFOBT）组合使用。后一种应用被称为“组合测试”。新测试提供了比最可靠的可靠的粪便潜血试验（FOBT）提供更大的灵敏度的优点。可以假设，在将粪便潜血阳性的患者称为结肠镜检查之前，该检测可以单独使用或组合用于常规基于人群的CRC筛查。

2. 发明申请

WO2017021759A1 METHODS AND PROBES FOR DETERMINING THE CONCENTRATION OF COPPER 审中-公开
标题翻译：确定铜浓度的方法和探针
公开(公告)号：WO2017021759A1
公开(公告)日：2017-02-09
申请号：PCT/IB2015/055958
申请日：2015-08-06
申请人： CANOX4DRUG S.P.A.
发明人： COLABUFO, Nicola Antonio
IPC分类号： G01N33/84 , G01N33/68
CPC分类号： G01N33/84 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to new probes and methods for determining the concentration of copper. In particular the present invention refers to a method for determining the concentration of "free" copper in a serum or blood sample with a high degree of sensitivity and accuracy.
摘要翻译：本发明涉及用于测定铜浓度的新探针和方法。特别地，本发明涉及一种以高灵敏度和准确度测定血清或血液样品中“游离”铜浓度的方法。

3. 发明申请

WO2015177743A1 SMALL INTERFERING RNA (SIRNA) FOR THE THERAPY OF TYPE 2 (ADO2) AUTOSOMAL DOMINANT OSTEOPETROSIS CAUSED BY CLCN7 (ADO2 CLCN7-DEPENDENT) GENE MUTATION 审中-公开
标题翻译：用于由CLCN7（ADO2 CLCN7依赖）基因突变引起的类型2（ADO2）自体主导性OSTEOPETROSIS治疗的小干扰RNA（SIRNA）
公开(公告)号：WO2015177743A1
公开(公告)日：2015-11-26
申请号：PCT/IB2015/053730
申请日：2015-05-21
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： TETI, Anna Maria , RUCCI, Nadia , CAPULLI, Mattia , MAURIZI, Antonio
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2320/34
摘要： The present invention lies in the field of molecules known as "small interfering RNA" with therapeutic applications. siRNAs have the ability to reduce gene expression in an extremely specific way (1). These are small sequences of double-strand RNA, normally used in laboratory to modify cell function, which revolutionized cell biology by allowing previously precluded molecular manipulations.
摘要翻译：本发明在于具有治疗应用的称为“小干扰RNA”的分子领域。 siRNA具有以非常特异的方式降低基因表达的能力（1）。这些是双链RNA的小序列，通常用于实验室来修饰细胞功能，其通过允许先前排除的分子操作来改变细胞生物学。

4. 发明申请

WO2012172505A1 SOLAR SELECTIVE ABSORBER BASED ON DOUBLE NITRIDE COMPOSITE MATERIAL AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：基于双硝酸盐复合材料的太阳能选择性吸收剂及其制备方法
公开(公告)号：WO2012172505A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/053008
申请日：2012-06-14
申请人： AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE (ENEA) , ANTONAIA, Alessandro , ESPOSITO, Salvatore , ADDONIZIO, Maria Luisa , GUGLIELMO, Antonio
发明人： ANTONAIA, Alessandro , ESPOSITO, Salvatore , ADDONIZIO, Maria Luisa , GUGLIELMO, Antonio
IPC分类号： F24J2/48 , C23C14/06 , C23C14/34 , C04B35/58 , C23C16/455
CPC分类号： G02B1/10 , C04B35/581 , C04B35/584 , C04B2235/3886 , C04B2235/75 , C04B2235/79 , C04B2235/80 , C23C14/0042 , C23C14/0617 , C23C14/0641 , C23C14/0652 , C23C14/14 , C23C14/34 , C23C14/3464 , F24S70/20 , F24S70/30 , G02B5/085 , Y02E10/40
摘要： A thin-film spectrally selective coating for receiver tube of vacuumed type for use in thermodynamic solar installations and operating both at medium temperature (up to 400 °C) and at high temperature (up to 550 °C), coating where the optically absorbing layer is a multilayer of cermet material of type: W y N-AIN x or Mo y N-AIN x , material prepared with reactive co-sputtering technique from an Al target and a W or Mo target, process conducted under a transition regimen, under PEM (Plasma Emission Monitoring) or CVM (Cathode Voltage Monitoring) monitoring for the sole Al target, with inletting near the Al target of a N 2 amount adequate for obtainment of a high-transparency, high growth rate sub-stoichiometric ceramic AIN and with inletting near the W or Mo target of a N 2 amount adequate for obtainment of the sole W 2 N or Mo 2 N phase, phase very stable at high temperature, such as to make the cermet material as close as possible to the formulation W 2 N-AIN x or Mo 2 N-AIN x (with x comprised between 0.90 and 1.00, preferably 0.95) and, therefore, cermet material employable at least up to the temperature of 550 °C.
摘要翻译：用于热力学太阳能装置的真空接收管的薄膜光谱选择性涂层，并且在中等温度（高达400℃）和高温（高达550℃））下操作，其中光学吸收层是一种多层金属陶瓷材料，其类型为：WyN-AINx或MoyN-AINx，由Al靶和W或Mo靶的反应共溅射技术制备的材料，在转化方案下进行的PEM（等离子体发射监测）或对于唯一Al靶的CVM（阴极电压监测）监测，其入口附近的Al靶的N2量足以获得高透明度，高生长速率的亚化学计量陶瓷AIN，并且在W或Mo靶附近进入的N2量足以获得唯一的W2N或Mo2N相，在高温下非常稳定的相，例如使金属陶瓷材料尽可能接近制剂W2N-AINx或Mo2N-AINx（x包含在 en 0.90和1.00，优选为0.95），因此，金属陶瓷材料至少可以在550℃的温度下使用。

5. 发明申请

WO2012159674A1 METHOD OF SCREENING FOR THERAPEUTIC COMPOUNDS USEFUL IN DETOXIFYING CENTRAL NERVOUS SYSTEM FROM B-AMYLOID PEPTIDE 审中-公开
标题翻译：用于从B-淀粉样肽中分离中枢神经系统的治疗化合物的筛选方法
公开(公告)号：WO2012159674A1
公开(公告)日：2012-11-29
申请号：PCT/EP2011/058631
申请日：2011-05-26
申请人： UNIVERSITA' DEGLI STUDI DI BARI , COLABUFO, Nicola Antonio , BERARDI, Francesco , INGLESE, Carmela , LEOPOLDO, Marcello , PERRONE, Maria Grazia , PERRONE, Roberto
发明人： COLABUFO, Nicola Antonio , BERARDI, Francesco , INGLESE, Carmela , LEOPOLDO, Marcello , PERRONE, Maria Grazia , PERRONE, Roberto
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5082 , G01N33/6896 , G01N2333/4709
摘要： The present invention refers to a method and a kit of screening for therapeutic compounds useful in detoxifying central nervous system from β-amyloid peptide. The method and kit involve the use of the beta amyloid peptide in the everted gut sac assay and allow assessing the inducing activity of the test compounds on the P-gp-mediated β-amyloid peptide transport.
摘要翻译：本发明涉及一种筛选用于从β-淀粉样肽解毒中枢神经系统的治疗化合物的方法和试剂盒。该方法和试剂盒涉及在直肠肠囊测定中使用β-淀粉样肽，并且允许评估测试化合物对P-gp介导的β-淀粉样蛋白肽转运的诱导活性。

6. 发明申请

WO2011098968A2 METHOD FOR PREPARING A GREEN COLOURING MIXTURE FROM PLANTS BELONGING TO THE MYRTUS GENUS 审中-公开
标题翻译：从绿叶植物中提取绿色混合物的方法
公开(公告)号：WO2011098968A2
公开(公告)日：2011-08-18
申请号：PCT/IB2011/050565
申请日：2011-02-10
申请人： UNIVERSITÀ DEGLI STUDI DI SALERNO , DE FALCO, Enrica , ROSCIGNO, Graziana
发明人： DE FALCO, Enrica , ROSCIGNO, Graziana
IPC分类号： C09B61/00 , D06P3/20 , D06P1/34 , D06P1/36
CPC分类号： C09B61/00 , D06P1/34 , D06P1/67375
摘要： The present invention relates to a method for preparing a green colouring mixture from plant material of plants belonging to the Myrtus genus, the green colouring mixture obtainable by said method and its use in colouring processes. The method and the products of the invention are used in the dyeing of animal fibres, leather, paper and other products.
摘要翻译：本发明涉及一种由属于芒果属植物的植物的植物材料制备绿色着色混合物的方法，可通过所述方法获得的绿色着色混合物及其在着色过程中的用途。本发明的方法和产品用于动物纤维，皮革，纸张和其他产品的染色。

7. 发明申请

WO2010046458A3 COMPOSITIONS COMPRISING VITAMINS 审中-公开
公开(公告)号：WO2010046458A3
公开(公告)日：2010-04-29
申请号：PCT/EP2009/063943
申请日：2009-10-22
申请人： TUTINO, Matteo
发明人： TUTINO, Matteo
IPC分类号： A61K36/87 , A61K31/4045 , A61K31/375 , A61K31/05 , A61P17/02 , A61P17/00
摘要： Compositions according to the invention comprise one or more vitamins and/or hormones and/or alpha arbutine and/or their derivatives in association with an Vitis Vinifera extract, preferably an aqueous extract, and/or one or more of its components, such as resveratrol, polyphenols and anthocyanidine, and/orionene polimers, along with one or more adjuvants and/or excipients pharmaceutically or cosmetically acceptable.

8. 发明申请

WO2009125341A3 METHOD AND APPARATUS FOR THE MICROBIOLOGICAL REMOVAL OF MERCURY FROM CONTAMINATED MATERIALS 审中-公开
公开(公告)号：WO2009125341A3
公开(公告)日：2009-10-15
申请号：PCT/IB2009/051457
申请日：2009-04-07
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA , BESTETTI, Giuseppina , GANDOLFI, Isabella , FRANZETTI, Andrea
发明人： BESTETTI, Giuseppina , GANDOLFI, Isabella , FRANZETTI, Andrea
IPC分类号： C22B43/00 , C22B3/18 , C22B3/46 , C22B7/00 , C22B5/00 , A62D3/02 , C02F1/28 , C02F1/70 , C12N1/00 , C12R1/01
摘要： The present invention relates to microorganisms able to reduce mercury ion to metallic mercury; in particular, it refers to systems, apparatuses such as a stirred bioreactor and methods for microbiological mercury removal from contaminated materials, such as, e.g., contaminated environmental matrices, like soil and sediments. The contaminated material is mixed with selected microrganisms capable to enable enzymatic reduction of mercury in ionic form to elemental mercury.

9. 发明申请

WO2008049887A1 STABILIZING ADDITIVE FOR FUEL OIL 审中-公开
标题翻译：稳定燃油添加剂
公开(公告)号：WO2008049887A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061478
申请日：2007-10-25
申请人： CHIMEC S.p.A. , ZANOTTI, Andrea , MANTARRO, Milena , BUCCOLINI, Marco
发明人： ZANOTTI, Andrea , MANTARRO, Milena , BUCCOLINI, Marco
IPC分类号： C10L1/23 , C10L1/232 , C10L1/10 , C10L10/00 , C10G9/00
CPC分类号： C10L1/232 , C10G9/007 , C10L1/04 , C10L1/10 , C10L1/1608 , C10L1/1824 , C10L1/1826 , C10L1/1852 , C10L1/23 , C10L10/00
摘要： The present invention relates to additives for the stabilization of fuel oil, compositions containing them and use processes thereof, in particular in the stabilization of fuel oil exiting Visbreaking (VSB) plants.
摘要翻译：本发明涉及用于稳定燃料油的添加剂，含有它们的组合物及其使用方法，特别是在稳定脱乙烯（VSB）设备中的燃料油时。

10. 发明申请

WO2008044213A1 AMIOTROPIC LATERAL SCLEROSIS (ALS) BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：生物标志物及其用途
公开(公告)号：WO2008044213A1
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054127
申请日：2007-10-10
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , CAVALLARO, Sebastiano
发明人： CAVALLARO, Sebastiano
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention consists in the use of a group of genes and correlated pathways for the diagnosis, prognosis and therapeutic treatment of Amyotrophic Lateral Sclerosis.
摘要翻译：本发明在于使用一组基因和相关途径用于肌萎缩性侧索硬化症的诊断，预后和治疗性治疗。

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