专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07053219B2 Isoxazolopyridone derivatives and their use 失效
标题翻译：异恶唑吡啶酮衍生物及其用途
公开(公告)号：US07053219B2
公开(公告)日：2006-05-30
申请号：US10732988
申请日：2003-12-10
申请人： Masayuki Nakamura , Hideki Kurihara , Mitsuru Ohkubo , Naohiro Tsukamoto
发明人： Masayuki Nakamura , Hideki Kurihara , Mitsuru Ohkubo , Naohiro Tsukamoto
IPC分类号： C07D471/22 , A61K31/44
CPC分类号： C07D498/04
摘要： The invention relates to isoxazolopyridone derivatives of a formula (I-a): wherein R1a represents an optionally-substituted heteroaryl or phenyl group, R2a represents an optionally-substituted phenyl or heteroaryl group, and R3a represents a methyl group, provided that, (1) when R1a is an unsubstituted phenyl group, then R2a must not be a para-substituted phenyl group of which the substituent is any of a methoxy group, a chloro group, a methyl group, a trifluoromethyl group, a fluoro group, a bromomethyl group or a dimethylaminomethyl group, and R2a must not be an unsubstituted heteroaryl group, and (2) when R1a is a 4-tolyl group or a 4-fluorophenyl group, then R2a must not be an unsubstituted phenyl group, a 4-methoxyphenyl group or a 4-fluorophenyl group, or their pharmaceutically-acceptable salts. The isoxazolopyridone derivatives or their pharmaceutically-acceptable salts of the invention have a metabotropic glutamic acid receptor-antagonistic effect, and are useful for remedy of, for example, anxiety disorders, psychosomatic disorders, obsessive-compulsive neurosis, bipolar disorders, melancholia, eating disorders, schizophrenia, multi-infarct dementia, Alzheimer disease, epilepsy, Parkinson disease, Huntington's chorea, pain or retrograde neurosis.
摘要翻译：本发明涉及式（Ia）的异恶唑吡啶酮衍生物：其中R 1a表示任选取代的杂芳基或苯基，R 2a表示任选取代的苯基或杂芳基基团，且R 3a表示甲基，条件是（1）当R 1a为未取代的苯基时，R 2a必须不是取代基是甲氧基，氯基，甲基，三氟甲基，氟基，溴甲基或二甲基氨基甲基中的任何一个的对位取代的苯基，R 2a， / SUP>不能是未取代的杂芳基，和（2）当R 1a是4-甲苯基或4-氟苯基时，R 2a不能为未取代的苯基，4-甲氧基苯基或4-氟苯基，或其药学上可接受的盐。本发明的异恶唑吡啶酮衍生物或其药学上可接受的盐具有代谢型谷氨酸受体拮抗作用，并且可用于治疗例如焦虑症，心理障碍，强迫性神经症，双相情感障碍，忧郁症，进食障碍，精神分裂症，多发性梗塞性痴呆，阿尔茨海默病，癫痫，帕金森病，亨廷顿舞蹈病，疼痛或逆行神经症。

2. 发明授权

US06950102B2 Graphics drawing apparatus and method 失效
标题翻译：图形绘图装置及方法
公开(公告)号：US06950102B2
公开(公告)日：2005-09-27
申请号：US10330952
申请日：2002-12-27
申请人： Hideaki Tomikawa , Junichi Fujita
发明人： Hideaki Tomikawa , Junichi Fujita
IPC分类号： G06F12/06 , G06F13/00 , G06F13/36 , G06T1/00 , G06T11/00 , G06T15/00 , G09G5/36
CPC分类号： G06T15/04
摘要： A graphics drawing apparatus able to reduce the amount of data transferred, able to realize a lower power consumption, and consequently able to achieve an improvement of performance of the system as a whole, provided with address generator for automatically generating addresses of drawing parameter registers required for the drawing in a defined sequence of drawing parameters according to address data and a specified drawing type; a register address selector for selecting either of the address data for specifying the register addresses of the address generator transferred through a general purpose bus or the address data for specifying the register address of the address generator by a former engine and inputting the same to the address generator; and a drawing data selector for selecting either of the drawing parameter data transferred through the general purpose bus or the drawing parameter data from the former engine and inputting the same to the drawing engine, and a method of the same.
摘要翻译：一种图形绘图装置，能够减少传送的数据量，能够实现更低的功耗，并且因此能够实现整个系统的性能的提高，并且具有地址发生器，用于自动产生所需的绘图参数寄存器的地址用于根据地址数据和指定的图纸类型以规定的绘图参数顺序绘制; 寄存器地址选择器，用于选择用于指定通过通用总线传送的地址生成器的寄存器地址的地址数据中的任一个或用于指定由前引擎指定地址生成器的寄存器地址的地址数据，并将其输入到地址发电机; 以及用于选择通过通用总线传送的绘制参数数据或来自前一个引擎的绘图参数数据并将其输入到绘图引擎的绘图数据选择器及其方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式