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    • 1. 发明申请
    • SURFACTANT PEPTIDE NANOSTRUCTURES, AND USES THEREOF
    • 表面活性剂纳米结构及其用途
    • WO2003006043A1
    • 2003-01-23
    • PCT/US2002/021757
    • 2002-07-10
    • MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    • ZHANG, ShuguangVAUTHEY, Sylvain
    • A61K38/00
    • B82Y30/00A61K48/00C07K7/06C07K7/08C07K14/001Y10S977/705
    • This work describes a new class of short polypeptides that can self-assemble to form regular nanotubes with an average diameters of about 50 nm. These peptides (7 to 8 amino acids) have a structure very similar to those observed in surfactant molecules with a defined hydrophilic head group constituting of charged amino acids and a lipophilic tail made out of hydrophobic amino acids such as alanine, valine or leucine. Cryo-TM micrographs show numerous three-fold junctions connecting the self-assembling nanostructures and thus leading to the formation of a rather dense network of entangled nanotubes. Additionally, the observation of clear openings at the end of the supramolecular structures confirms the presence of tubular organization.
    • 这项工作描述了一类新的能够自组装形成平均直径为约50nm的纳米管的短多肽。 这些肽(7至8个氨基酸)具有与表面活性剂分子中观察到的结构非常相似的结构,其具有构成带电氨基酸的限定的亲水性头基和由疏水性氨基酸如丙氨酸,缬氨酸或亮氨酸形成的亲脂性尾巴。 Cryo-TM显微照片显示了连接自组装纳米结构的许多三重结,从而导致形成相当密集的缠结纳米管网络。 另外,在超分子结构末端的透明开口的观察证实了管状组织的存在。