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1. 发明申请

WO2004096160A2 VESICLE-ASSOCIATED PROTEINS 审中-公开
标题翻译： VESICLE相关蛋白
公开(公告)号：WO2004096160A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/008521
申请日：2004-03-19
申请人： INCYTE CORPORATION , RICHARDSON, Thomas, W. , BHATIA, Umesh, G. , BURRILL, John, D. , LEE, Sally , BLAKE, Julie, J. , HO, Anne , ZHENG, Wenjin , YUE, Henry , BANDMAN, Olga , HAFALIA, April, J.A. , RECIPON, Shirley, A. , GRIFFIN, Jennifer, A. , LEE, Soo Yeun
发明人： RICHARDSON, Thomas, W. , BHATIA, Umesh, G. , BURRILL, John, D. , LEE, Sally , BLAKE, Julie, J. , HO, Anne , ZHENG, Wenjin , YUE, Henry , BANDMAN, Olga , HAFALIA, April, J.A. , RECIPON, Shirley, A. , GRIFFIN, Jennifer, A. , LEE, Soo Yeun
IPC分类号： A61K
CPC分类号： C07K14/47
摘要： Various embodiments of the invention provide human vesicle-associated proteins (VAP) and polynucleotides which identify and encode VAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists,and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of VAP.
摘要翻译：本发明的各种实施方案提供鉴定和编码VAP的人囊泡相关蛋白（VAP）和多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其他实施方案提供用于诊断，治疗或预防与VAP异常表达相关的紊乱的方法。

2. 发明申请

WO2004085625A2 PROTEINS ASSOCIATED WITH CELL GROWTH, DIFFERENTIATION, AND DEATH 审中-公开
标题翻译：与细胞生长，分化和死亡有关的蛋白质
公开(公告)号：WO2004085625A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/009388
申请日：2004-03-23
申请人： INCYTE CORPORATION , MARQUIS, Joseph, P. , TRAN, Uyen, K. , YANG, Yonghong, G. , TANG, Tom, Y. , CHAWLA, Narinder, K. , MURAGE, Jagi , WANG, Jonathan, T. , ELLIOTT, Vicki, S. , CHIEN, David , YUE, Henry , AZIMZAI, Yalda , ISON, Craig, H. , KHARE, Reena , JIN, Pei , RAMKUMAR, Jayalaxmi , FAVERO, Kristin, D. , RICHARDSON, Thomas, W. , HAFALIA, April, J.A. , BAUGHN, Mariah, R. , BECHA, Shanya, D. , WILSON, Amy, D.
发明人： MARQUIS, Joseph, P. , TRAN, Uyen, K. , YANG, Yonghong, G. , TANG, Tom, Y. , CHAWLA, Narinder, K. , MURAGE, Jagi , WANG, Jonathan, T. , ELLIOTT, Vicki, S. , CHIEN, David , YUE, Henry , AZIMZAI, Yalda , ISON, Craig, H. , KHARE, Reena , JIN, Pei , RAMKUMAR, Jayalaxmi , FAVERO, Kristin, D. , RICHARDSON, Thomas, W. , HAFALIA, April, J.A. , BAUGHN, Mariah, R. , BECHA, Shanya, D. , WILSON, Amy, D.
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： Various embodiments of the invention provide human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.
摘要翻译：本发明的各种实施方案提供与细胞生长，分化和死亡（CGDD）相关的人类蛋白质和鉴定和编码CGDD的多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其他实施方案提供用于诊断，治疗或预防与CGDD异常表达相关的紊乱的方法。

3. 发明申请

WO2004072267A2 ENZYMES 审中-公开
公开(公告)号：WO2004072267A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004280
申请日：2004-02-12
申请人： INCYTE CORPORATION , KABLE, Amy, E. , YUE, Henry , BAUGHN, Mariah, R. , TRIBOULEY, Catherine, M. , RING, Huijun, Z. , TRAN, Uyen, K. , EMERLING, Brooke, M. , RAMKUMAR, Jayalaxmi , HAFALIA, April, J.A. , SWARNAKAR, Anita , LEE, Soo Yeun , CHAWLA, Narinder, K. , GIETZEN, Kimberly, J. , MARQUIS, Joseph, P. , ELLIOTT, Vicki, S. , BECHA, Shanya, D. , FAVERO, Kristin, D. , WANG, Jonathan, T. , NAIDU, Sangeeta , HAWKINS, Phillip, R. , JIN, Pei , CHIEN, David
发明人： KABLE, Amy, E. , YUE, Henry , BAUGHN, Mariah, R. , TRIBOULEY, Catherine, M. , RING, Huijun, Z. , TRAN, Uyen, K. , EMERLING, Brooke, M. , RAMKUMAR, Jayalaxmi , HAFALIA, April, J.A. , SWARNAKAR, Anita , LEE, Soo Yeun , CHAWLA, Narinder, K. , GIETZEN, Kimberly, J. , MARQUIS, Joseph, P. , ELLIOTT, Vicki, S. , BECHA, Shanya, D. , FAVERO, Kristin, D. , WANG, Jonathan, T. , NAIDU, Sangeeta , HAWKINS, Phillip, R. , JIN, Pei , CHIEN, David
IPC分类号： C12N
CPC分类号： C07K14/4713 , C12N9/00
摘要： Various embodiments of the invention provide human enzymes (ENZM) and polynucleotides which identify and encode ENZM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ENZM.

5. 发明申请

WO2004094658A2 FLUORESCENT SUBSTRATES FOR DETECTING ORGANOPHOSPHATASE ENZYME ACTIVITY 审中-公开
标题翻译：用于检测有机磷酸酶酶活性的荧光底物
公开(公告)号：WO2004094658A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/007897
申请日：2004-03-16
申请人： AMERICAN RED CROSS , SOUKHAREV, Serguei , HAMMOND, David
发明人： SOUKHAREV, Serguei , HAMMOND, David
IPC分类号： C12Q1/42
CPC分类号： C07F9/65522 , C07F9/6561 , C12Q1/42
摘要： Disclosed are compounds of the formula (I): wherein R 3 , R 4 , R 5 , R 9 , and R 10 are selected from the group consisting of H and groups or atoms other than H, and R 6 and R 8 are halo or hydrogen; X 1 , X 2 , and X 3 are independently O or S; provided that R 9 and R 10 are not simultaneously H, when all of X 1 , X 2 , and X 3 are O; and of the formula (II) wherein R 11 -R 14 are selected from the group consisting of H and groups or atoms other than H; X 4 - X 9 are independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R 15 - R 24 can be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.
摘要翻译：公开了式（I）的化合物：其中R 3，R 4，R 5，R 9和R 10选自H和除 H和R 6和R 8是卤素或氢; X 1，X 2和X 3独立地为O或S; 条件是当R 1和X 3都全部为O时，R 9和R 10不同时为H; 和式（II）的化合物，其中R 11 -R 14选自H和H以外的基团或原子; X 4 - X 9独立地为O或S; n和m是0或1，但m和n不能同时为0; R 15 -R 24可以是H或任何取代基，只要在水解时式II化合物提供荧光化合物即可。这些化合物可用作对有机磷酸酶特别是人类对氧磷酶和细菌有机磷水解酶具有高特异性的底物。还公开了一种用于检测和/或测量流体中对氧磷酶活性的方法，包括使流体与荧光底物接触并测量形成的荧光产物的荧光。

6. 发明申请

WO2004094589A3 SECRETED PROTEINS 审中-公开
公开(公告)号：WO2004094589A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/010077
申请日：2004-04-01
申请人： INCYTE CORPORATION , SWARNAKAR, Anita , RICHARDSON, Thomas, W. , RAMKUMAR, Jayalaxmi , LEE, Soo Yeun , BECHA, Shanya, D. , ELLIOTT, Vicki, S. , CHAWLA, Narinder, K. , FAVERO, Kristin, D. , WANG, Jonathan, T. , BAUGHN, Mariah, R. , CHIEN, David , JIN, Pei , WILSON, Amy, D.
发明人： SWARNAKAR, Anita , RICHARDSON, Thomas, W. , RAMKUMAR, Jayalaxmi , LEE, Soo Yeun , BECHA, Shanya, D. , ELLIOTT, Vicki, S. , CHAWLA, Narinder, K. , FAVERO, Kristin, D. , WANG, Jonathan, T. , BAUGHN, Mariah, R. , CHIEN, David , JIN, Pei , WILSON, Amy, D.
IPC分类号： C07K14/47
摘要： Various embodiments of the invention provide human secreted proteins (SECP) and polynucleotides which identify and encode SECP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

7. 发明申请

WO2004092350A2 G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译： G蛋白偶联受体
公开(公告)号：WO2004092350A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/009049
申请日：2004-03-24
申请人： INCYTE CORPORATION , BAUGHN, Mariah, R. , KABLE, Amy, E. , EMERLING, Brooke, M. , CHAWLA, Narinder, K. , LEE, Ernestine, A. , ISON, Craig, H. , BLAKE, Julie, J. , TRAN, Uyen, K. , JIN, Pei , ELLIOTT, Vicki, S. , KHARE, Reena , CHIEN, David , RAMKUMAR, Jayalaxmi , HAFALIA, April, J.A.
发明人： BAUGHN, Mariah, R. , KABLE, Amy, E. , EMERLING, Brooke, M. , CHAWLA, Narinder, K. , LEE, Ernestine, A. , ISON, Craig, H. , BLAKE, Julie, J. , TRAN, Uyen, K. , JIN, Pei , ELLIOTT, Vicki, S. , KHARE, Reena , CHIEN, David , RAMKUMAR, Jayalaxmi , HAFALIA, April, J.A.
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： Various embodiments of the invention provide human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Otherembodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.
摘要翻译：本发明的各种实施方案提供了人G-蛋白偶联受体（GCREC）和识别和编码GCREC的多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。实施方案提供诊断，治疗或预防与GCREC异常表达相关的疾病的方法。

8. 发明申请

WO2004083395A2 TRANSPORTERS AND ION CHANNELS 审中-公开
标题翻译：运输和离子通道
公开(公告)号：WO2004083395A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/007967
申请日：2004-03-15
申请人： INCYTE CORPORATION , TANG, Y. , Tom , LEE, Ernestine, A. , RICHARDSON, Thomas, W. , ELLIOTT, Vicki, S. , GRIFFIN, Jennifer, A. , HAFALIA, April, J.A. , DING, Li , CHAWLA, Narinder, K. , YANG, Junming , BAUGHN, Mariah, R. , THORNTON, Michael, B. , GIETZEN, Kimberly, J. , MARQUIS, Joseph, P. , TRIBOULEY, Catherine, M. , ISON, Craig, H. , RAMKUMAR, Jayalaxmi , JIN, Pei , CHIEN, David , BECHA, Shanya, D. , WILSON, Amy, D. , HAWKINS, Phillip, R. , KHARE, Reena , BHATIA, Umesh, G. , BLAKE, Julie, J. , BURRILL, John, D. , HO, Anne , LEE, Sally , ZHENG, Wenjin
发明人： TANG, Y. , Tom , LEE, Ernestine, A. , RICHARDSON, Thomas, W. , ELLIOTT, Vicki, S. , GRIFFIN, Jennifer, A. , HAFALIA, April, J.A. , DING, Li , CHAWLA, Narinder, K. , YANG, Junming , BAUGHN, Mariah, R. , THORNTON, Michael, B. , GIETZEN, Kimberly, J. , MARQUIS, Joseph, P. , TRIBOULEY, Catherine, M. , ISON, Craig, H. , RAMKUMAR, Jayalaxmi , JIN, Pei , CHIEN, David , BECHA, Shanya, D. , WILSON, Amy, D. , HAWKINS, Phillip, R. , KHARE, Reena , BHATIA, Umesh, G. , BLAKE, Julie, J. , BURRILL, John, D. , HO, Anne , LEE, Sally , ZHENG, Wenjin
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： Various embodiments of the invention provide human transporters and ionchannels (TRICH) and polynucleotides which identify and encode TRICH. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
摘要翻译：本发明的各种实施方案提供了识别和编码TRICH的人转运体和离子通道（TRICH）和多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其它实施方案提供用于诊断，治疗或预防与TRICH异常表达相关的紊乱的方法。

9. 发明申请

WO2003093444A3 TRANSPORTERS AND ION CHANNELS 审中-公开
公开(公告)号：WO2003093444A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/014026
申请日：2003-05-02
申请人： INCYTE CORPORATION , BAUGHN, Mariah, R. , BECHA, Shanya, D. , BULLOCH, Sean, A. , CHANG, Hsin-Ru , ELLIOTT, Vicki, S. , EMERLING, Brooke, M. , GRIFFIN, Jennifer, A. , HAFALIA, April, J., A. , ISON, Craig, H. , JACKSON, Alan, A. , JIANG, Xin , JIN, Pei , KABLE, Amy, E. , KHARE, Reena , LEE, Soo, Y. , LEE, Sally , MASON, Patricia, M. , MARQUIS, Joseph, P. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SWARNAKAR, Anita , TRAN, Uyen, K. , CHAWLA, Narinder, K. , WILSON, Amy, D.
发明人： BAUGHN, Mariah, R. , BECHA, Shanya, D. , BULLOCH, Sean, A. , CHANG, Hsin-Ru , ELLIOTT, Vicki, S. , EMERLING, Brooke, M. , GRIFFIN, Jennifer, A. , HAFALIA, April, J., A. , ISON, Craig, H. , JACKSON, Alan, A. , JIANG, Xin , JIN, Pei , KABLE, Amy, E. , KHARE, Reena , LEE, Soo, Y. , LEE, Sally , MASON, Patricia, M. , MARQUIS, Joseph, P. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SWARNAKAR, Anita , TRAN, Uyen, K. , CHAWLA, Narinder, K. , WILSON, Amy, D.
IPC分类号： C12N15/12 , C12N15/00 , C12Q1/68 , C12P21/04 , C12P21/06
摘要： Various embodiments of the invention provide human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.

10. 发明申请

WO2003093427A3 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
公开(公告)号：WO2003093427A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/013629
申请日：2003-04-30
申请人： INCYTE CORPORATION , SWARNAKAR, Anita , TRAN, Uyen, K. , KHARE, Reena , MARQUIS, Joseph, P. , HAFALIA, April, J.A. , ELLIOTT, Vicki, S. , BECHA, Shanya, D. , RAMKUMAR, Jayalaxmi , KABLE, Amy, E. , WILSON, Amy, D. , YUE, Henry , FORSYTHE, Ian, J. , GRIFFIN, Jennifer, A. , BULLOCH, Sean, A. , JIN, Pei , JIANG, Xin , JACKSON, Alan, A. , MASON, Patricia, M. , CHAWLA, Narinder, K. , CHANG, Hsin-Ru , RICHARDSON, Thomas, W. , TANG, Y., Tom , LEE, Soo, Y. , GIETZEN, Kimberly, J. , FU, Glenn, K.
发明人： SWARNAKAR, Anita , TRAN, Uyen, K. , KHARE, Reena , MARQUIS, Joseph, P. , HAFALIA, April, J.A. , ELLIOTT, Vicki, S. , BECHA, Shanya, D. , RAMKUMAR, Jayalaxmi , KABLE, Amy, E. , WILSON, Amy, D. , YUE, Henry , FORSYTHE, Ian, J. , GRIFFIN, Jennifer, A. , BULLOCH, Sean, A. , JIN, Pei , JIANG, Xin , JACKSON, Alan, A. , MASON, Patricia, M. , CHAWLA, Narinder, K. , CHANG, Hsin-Ru , RICHARDSON, Thomas, W. , TANG, Y., Tom , LEE, Soo, Y. , GIETZEN, Kimberly, J. , FU, Glenn, K.
IPC分类号： C12P21/06
摘要： Various embodiments of the invention provide human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.

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