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1. 发明授权

EP1637788B1 Improved pipe seal element 有权转让
标题翻译：对于管的改进的密封元件
公开(公告)号：EP1637788B1
公开(公告)日：2013-11-06
申请号：EP05108698.1
申请日：2005-09-21
申请人： Krausz Metal Industries Ltd.
发明人： Krausz, Eliezer , Chiproot, Avi
IPC分类号： F16L21/02 , F16L25/14 , F16L21/06
CPC分类号： F16L21/065 , F16L17/04 , F16L21/022 , F16L25/14

2. 发明授权

EP2294918B8 Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting tumor angiogenesis 有权
标题翻译：使用T2家族的核糖核酸酶的具有用于抑制肿瘤血管生成的肌动蛋白的结合活性
公开(公告)号：EP2294918B8
公开(公告)日：2012-11-14
申请号：EP10183935.5
申请日：2000-08-29
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： Roiz, Levava , Shoseyov, Oded , Schwartz, Betty , Smirnoff, Patricia
IPC分类号： C12N9/22 , A61K38/46
CPC分类号： C12Y301/27001 , A61K38/00 , C12N9/22 , Y02A50/473
摘要： The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5.

3. 发明公开

EP2324812A3 Composition exhibiting enhanced formulation stability and delivery of topical active ingredients 审中-公开
标题翻译：组合物与吊舱用于局部剂的更高的制剂稳定性和给药
公开(公告)号：EP2324812A3
公开(公告)日：2012-09-19
申请号：EP10182378.9
申请日：2001-04-20
申请人： Sol-Gel Technologies Ltd.
发明人： Lapidot, Noa , Magdassi, Shlomo , Avnir, David , Rottman, Claudio , Ben Zazon, Orit , Seri-Levy, Alon
IPC分类号： A61K8/11 , A61Q17/04
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/56 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00
摘要： The present invention concerns a process for the preparation of microcapsules having a core-shell structure, wherein said microcapsules have a diameter of approximately 0.1 to 100 micron, wherein each core includes at least one active ingredient, said core is encapsulated within a microcapsular shell, and wherein said shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and said microcapsular shell protects the active ingredient prior to topical application and releases said active ingredient after topical application, said process comprises the steps of; (a) preparing a hydrophobic solution or a hydrophobic dispersion comprising sol-gel precursors and an ingredient to be encapsulated; (b) emulsifying the hydrophobic solution or dispersion of step (a) in an aqueous solution under high shear forces to obtain an emulsion; (c) mixing and stirring the emulsion obtained, with a second aqueous solution, at a selected pH to obtain the sol-gel microcapsules.

4. 发明授权

EP2051735B1 CONJUGATES COMPRISING A PSYCHOTROPIC DRUG OR A GABA AGONIST AND AN ORGANIC ACID AND THEIR USE TREATING PAIN AND OTHER CNS DISORDERS 有权
标题翻译： WITH A PSYCHO热带医学或任何GABA激动剂和有机酸及其治疗疼痛和中枢神经系统等疾病结合物
公开(公告)号：EP2051735B1
公开(公告)日：2012-08-29
申请号：EP07789958.1
申请日：2007-07-17
申请人： Ramot, at Tel Aviv University Ltd. , Bar-Ilan University
发明人： NUDELMAN, Abraham , REPHAELI, Ada , GIL-AD, Irit , WEIZMAN, Abraham
IPC分类号： A61K45/06 , A61K47/48 , A61P25/18 , A61P25/28 , A61K31/138 , A61K31/137 , A61K31/197
CPC分类号： A61K45/06 , A61K47/55

5. 发明公开

EP2481593A2 Method and apparatus for safe use of a wet on wet textile printer 有权
标题翻译：方法和设备的安全使用湿纺织打印机
公开(公告)号：EP2481593A2
公开(公告)日：2012-08-01
申请号：EP11157603.9
申请日：2011-03-10
申请人： Kornit Digital Technologies Ltd.
发明人： Ben-Zur, Ofer
IPC分类号： B41J2/175 , B41J3/407 , B41J11/00
CPC分类号： B41J11/0015 , B41J2/175 , B41J2/17546 , B41J3/4078 , B41J11/06 , D06P5/30
摘要： A wet on wet garment printing device for printing on a textile surface comprises: an ink holder (2); a printing head (4) mounted for printing onto the textile surface using ink from the ink holder (2); a wetting applicator (6) for wetting the locations prior to printing using a wetting composition (8); and an ink regulator (14) configured to identify compatibility of ink in the holding unit (2) with the wetting composition (8) and to operate the wetting applicator (6) only upon successful identification of compatibility.

6. 发明公开

EP2457078A1 NANOFLUIDIC CELL 审中-公开
标题翻译：纳米流体CELL
公开(公告)号：EP2457078A1
公开(公告)日：2012-05-30
申请号：EP10801830.0
申请日：2010-07-23
申请人： Insight Nanofluidics Inc.
发明人： HARB, Maher , PAARMANN, Alex , DWYER, Jason , MILLER, Dwayne, R., J.
IPC分类号： G01N1/00 , G01N21/05 , G01N23/00 , G01N29/22 , G01Q30/20 , H01J37/20 , H01J37/26 , G01N23/20
CPC分类号： G01N21/05 , B82Y35/00 , G01N29/032 , G01N29/222 , G01N2021/0346 , G01N2223/637 , G01N2291/02466 , G01N2291/048 , H01J37/20 , H01J2237/2003 , H01J2237/2004
摘要： A flow cell is provided for the analysis and/or microscopy of liquid or gas samples on the nanometer to micron scale. The flow cell preferably includes a thin membrane that is transparent to electrons and/or photons, thereby enabling the penetration of electrons or photons into a liquid flowing through the cell. Trenches are provided on either side of the membrane, which advantageously minimize fluidic resistance outside of the window area of the cell and also enable a faster response time in response to changes in external fluidic pressure. This feature enables active feedback using pathlength sensitive probes to stabilize the fluid flow to thin streams from nanometer to micron scale thicknesses with nanometer precision.

7. 发明公开

EP2360261A1 Collagen producing plants and methods of generating and using same 审中-公开
标题翻译：胶原产生植物和产生和使用它们的方法
公开(公告)号：EP2360261A1
公开(公告)日：2011-08-24
申请号：EP10181115.6
申请日：2005-09-28
申请人： CollPlant Ltd.
发明人： Shoseyov, Oded , Stein, Hanan
IPC分类号： C12N15/82 , C07K14/78 , A01H5/00
CPC分类号： C07K14/78 , C12N15/8257
摘要： The present invention concerns a recombinant collagen, having been produced in a plant or isolated plant cells generated by targeting at least one type of a collagen chain and an exogenous mammalian prolyl 4 hydroxylase (P4H) to a vacuole of the plant or the isolated plant cells so as to allow hydroxylation of said at least one type of said collagen chain by said P4H and not by an endogenous P4H of the plant or isolated plant cells.
摘要翻译：本发明涉及在植物中产生的重组胶原或通过将至少一种类型的胶原链和外源哺乳动物脯氨酰4羟化酶（P4H）靶向植物或分离的植物细胞的液泡而产生的分离的植物细胞从而允许所述P4H而不是植物或分离的植物细胞的内源性P4H对所述至少一种类型的所述胶原蛋白链进行羟基化。

8. 发明公开

EP2332651A2 Interactive transparent individual cells biochip processor 审中-公开
标题翻译： Interaktiver transparenter Biochip-Prozessorfüreinzeln adressierbare Zellen
公开(公告)号：EP2332651A2
公开(公告)日：2011-06-15
申请号：EP10183774.8
申请日：2001-10-25
申请人： BAR ILAN UNIVERSITY
发明人： Deutsch, Mordechai
IPC分类号： B01L3/00 , C12M1/34 , G02B21/34 , G01N15/14
CPC分类号： C12M41/46 , B01J2219/00317 , B01J2219/00702 , B01L3/5027 , B01L2300/0681 , B01L2300/0877 , C12M23/12 , C12M25/08 , C40B60/14 , G01N15/1475 , G01N15/1484 , G01N33/5005 , G01N2015/1006 , G01N2015/1472 , G01N2015/1497 , G01N2035/00158 , G01N2035/0429 , G02B21/34
摘要： The present invention concerns a device for holding a plurality of living cells, comprising:
a transparent element defining a multiplicity of optically transparent wells, wherein the size of said wells is configured to hold a single cell, any defined number of cells, or other defined particles; and characterized by a plurality of said wells including an integral biosensor component.
摘要翻译：本发明涉及一种用于保持多个活细胞的装置，包括：限定多个光学透明孔的透明元件，其中所述孔的大小被配置为保持单个细胞，任何限定数量的细胞或其它限定的细胞粒子; 并且其特征在于包括整体生物传感器部件的多个所述孔。

9. 发明公开

EP2324812A2 Composition exhibiting enhanced formulation stability and delivery of topical active ingredients 审中-公开
标题翻译： Zusammensetzung miterhöterFormulationsstabilitätund Verabreichung von topischen Wirkstoffen
公开(公告)号：EP2324812A2
公开(公告)日：2011-05-25
申请号：EP10182378.9
申请日：2001-04-20
申请人： Sol-Gel Technologies Ltd.
发明人： Lapidot, Noa , Magdassi, Shlomo , Avnir, David , Rottman, Claudio , Ben Zazon, Orit , Seri-Levy, Alon
IPC分类号： A61K8/11
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/56 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00
摘要： The present invention concerns a process for the preparation of microcapsules having a core-shell structure, wherein said microcapsules have a diameter of approximately 0.1 to 100 micron, wherein each core includes at least one active ingredient, said core is encapsulated within a microcapsular shell, and wherein said shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and said microcapsular shell protects the active ingredient prior to topical application and releases said active ingredient after topical application, said process comprises the steps of; (a) preparing a hydrophobic solution or a hydrophobic dispersion comprising sol-gel precursors and an ingredient to be encapsulated; (b) emulsifying the hydrophobic solution or dispersion of step (a) in an aqueous solution under high shear forces to obtain an emulsion; (c) mixing and stirring the emulsion obtained, with a second aqueous solution, at a selected pH to obtain the sol-gel microcapsules.
摘要翻译：本发明涉及一种制备具有核 - 壳结构的微胶囊的方法，其中所述微胶囊具有约0.1至100微米的直径，其中每个核心包括至少一种活性成分，所述核心包封在微胶囊壳内，并且其中所述壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且所述微囊壳在局部施用之前保护活性成分，并在局部施用后释放所述活性成分，所述方法包括以下步骤：（a）制备包含溶胶 - 凝胶前体和待包封的成分的疏水性溶液或疏水性分散体; （b）在高剪切力下将步骤（a）的疏水性溶液或分散体乳化在水溶液中以获得乳液; （c）将所得乳液与第二水溶液在选定的pH下混合并搅拌，得到溶胶 - 凝胶微胶囊。

10. 发明公开

EP2308994A1 Methods for determining a risk to develop cancer 审中-公开
标题翻译：维尔法赫恩zur Bestimmung eines Risikos，Krebs zu erkranken
公开(公告)号：EP2308994A1
公开(公告)日：2011-04-13
申请号：EP10181096.8
申请日：2002-03-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD.
发明人： Livneh, Zvi , Paz-Elizur, Tamar , Blumenstein, Sara
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , G01N33/574 , G01N2333/924 , G01N2333/988 , G01N2800/52
摘要： The present invention concerns a method of determining a risk of a subject to develop cancer, the method comprising determining a level of catalytic activity of a DNA repair enzyme in a biological sample of the subject, wherein said DNA repair enzyme is selected from the group consisting of 8-oxoguanine DNA glycosylase (OGG1), AP endonuclease1 (APE1), methylpurine DNA glycosylase (MFG), uracil DNA glycosylase1 (UNG1), uracil DNA glycosylase2 (UNG2), SMUG1, MBD4, mismatch-specific thymine/uracil glycosylase (TDG), enodonuclease III (NTH1), adenine-specific mismatch DNA glycosylase (MYH), 8-oxo-GTPase/8-oxodGTPase (MTH1), dUTPase (DUT), AP endonuclease2 (APE2), deoxyribose phosphate lyase (POLB) and wherein a level of said activity below a predetermined value is indicative of an increased risk of the subject to develop said cancer.
摘要翻译：本发明涉及确定受试者发展癌症的风险的方法，所述方法包括测定受试者生物样品中DNA修复酶的催化活性水平，其中所述DNA修复酶选自（OGG1），AP内切核酸酶1（APE1），甲基嘌呤DNA糖基化酶（MFG），尿嘧啶DNA糖基化酶1（UNG1），尿嘧啶DNA糖基化酶2（UNG2），SMUG1，MBD4，错配特异性胸腺嘧啶/尿嘧啶糖基化酶），核酸核酸酶III（NTH1），腺嘌呤特异性错配DNA糖基化酶（MYH），8-氧代-GTP酶/ 8-氧化GTP酶（MTH1），dUTPase（DUT），AP内切核酸酶2（APE2），脱氧核糖磷酸裂解酶（POLB）所述活性低于预定值的水平表示受试者发展所述癌症的风险增加。

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