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1. 发明申请

WO2012048271A1 PHOSPHORAMIDATE DERIVATIZATION OF INORGANIC POLYPHOSPHATES AND METHODS 审中-公开
标题翻译：无机磷酸酯的磷酸酯衍生物及方法
公开(公告)号：WO2012048271A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/055447
申请日：2011-10-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , MORRISSEY, James H. , CHOI, Sharon H.
发明人： MORRISSEY, James H. , CHOI, Sharon H.
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07F9/6561 , C07F9/2458 , G01N33/86
摘要： Provided are methods for making phosphoramidate-modified polyphosphate molecules using a reactant with a primary amine group and polyphosphate (optionally in the presence of divalent cations), in the presence of a zero-length linking group, where the modifying moiety is linked via the nitrogen of a primary amine group to a terminal phosphorus of a polyphosphate moiety. The phosphoramidate derivatized polyphosphate molecules are useful in methods to stimulate or accelerate coagulation in a human or animal subject where there is coagulation deficiency due to medication or genetic deficiency and/or where there is trauma, surgery or other event or risk of bleeding, and to inhibit tumor growth, survival or angiogenesis in a patient in need thereof.
摘要翻译：提供了在零长度连接基团的存在下，使用具有伯胺基和多磷酸酯（任选在二价阳离子存在下）的反应物制备氨基磷酸酯改性的多磷酸盐分子的方法，其中改性部分经由氮的伯胺基团连接到聚磷酸酯部分的末端磷。氨基磷酸衍生的多磷酸盐分子可用于刺激或加速由于药物或遗传缺陷导致凝血不足和/或存在创伤，手术或其他事件或出血风险的人或动物受试者的凝血的方法，并且在有需要的患者中抑制肿瘤生长，存活或血管发生。

2. 发明申请

WO2008058035A1 ALPHAVIRUS AND ALPHAVIRUS REPLICON PARTICLE FORMULATIONS AND METHODS 审中-公开
标题翻译： ALPHAVIRUS和ALPHAVIRUS REPLICON颗粒制剂和方法
公开(公告)号：WO2008058035A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/083537
申请日：2007-11-02
申请人： AlphaVax, Inc. , DEPAZ, Roberto A. , TALARICO, Todd L.
发明人： DEPAZ, Roberto A. , TALARICO, Todd L.
IPC分类号： A61K39/12 , A61K9/19 , C12N15/86
CPC分类号： C12N7/00 , A61K9/19 , A61K39/12 , A61K2039/525 , A61K2039/5256 , C12N2770/36134 , C12N2770/36151
摘要： Disclosed are methods for preparing dried (preferably lyophilized) preparations comprising a population of alphaviruses or alphavirus replicon particles, a sugar or polyol, a surfactant and a salt and preparations made by said methods, both in the dried form but also as liquids prior to drying or after reconstituting dried preparations. These preparations may further comprise a plasticizer and/or a bulking agent. These preparations are readily reconstituted, with little or no loss in infectivity of the viruses or replicon particles.
摘要翻译：公开了用于制备干燥（优选冻干）制剂的方法，其包含一群甲病毒或甲病毒复制子颗粒，糖或多元醇，表面活性剂和盐以及通过所述方法制备的制剂，干燥形式，但在干燥之前也为液体或在重构干燥制剂后。这些制剂还可以包含增塑剂和/或填充剂。这些制剂易于重构，病毒或复制子颗粒的感染性很少或没有损失。

3. 发明申请

WO2008008092A2 CAMPYLOBACTER PILUS PROTEIN, COMPOSITIONS AND METHODS 审中-公开
标题翻译： CAMPYLOBACTER PILUS蛋白，组合物和方法
公开(公告)号：WO2008008092A2
公开(公告)日：2008-01-17
申请号：PCT/US2006/061470
申请日：2006-12-01
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , JOENS, Lynn A. , THEORET, James R. , REESER, Ryan J. , LAW, Bibiana
发明人： JOENS, Lynn A. , THEORET, James R. , REESER, Ryan J. , LAW, Bibiana
IPC分类号： B01L11/02
CPC分类号： G01N33/56922 , G01N2333/205 , G01N2469/10 , G01N2469/20
摘要： The present disclosure provides coding and amino acid sequences for a Campylobacter jejuni pilus protein (and from other species as well). This protein, when administered to a human or animal, elicits the expression of an immune response to Campylobacter jejuni, with the result that colonization and/or infection by this organism is reduced. Recombinant protein or biofilm material comprising the pilus protein is formulated into immunogenic compositions, especially for mucosal administration. Thus, the present invention provides methods for improvement of the microbial quality of food products including poultry, eggs, meat and dairy products, and indirectly of plant foods that may come in contact with agricultural waste, either from fertilization or from irrigation water.
摘要翻译：本公开提供了空肠弯曲杆菌（以及来自其他物种）的编码和氨基酸序列。当向人或动物施用时，该蛋白质引起对空肠弯曲杆菌的免疫应答的表达，结果是该生物体的定居和/或感染减少。将包含菌毛蛋白的重组蛋白质或生物膜材料配制成免疫原性组合物，特别是用于粘膜给药。因此，本发明提供了改善包括家禽，鸡蛋，肉类和乳制品在内的食品的微生物质量的方法，以及间接地可能与受精或来自灌溉水的农业废物接触的植物性食品的方法。

4. 发明申请

WO2004055166A2 MULTI-ANTIGENIC ALPHAVIRUS REPLICON PARTICLES AND METHODS 审中-公开
标题翻译：多发性阿尔茨海默病复制颗粒和方法
公开(公告)号：WO2004055166A2
公开(公告)日：2004-07-01
申请号：PCT/US2003/039723
申请日：2003-12-12
申请人： ALPHAVAX, INC.
发明人： SMITH, Jonathan, F. , KAMRUD, Kurt , DRYGA, Sergey , CALEY, Ian
IPC分类号： C12N
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/5256 , A61K2039/70 , C12N15/86 , C12N2740/16222 , C12N2770/36134 , C12N2770/36143 , C12N2770/36152
摘要： Viral replicon selected nucleic acid expression libraries are useful for analyzing multiple antigens associated with a parasite, pathogen or neoplasia or for preparing immunogenic compositions for generating immune responses specific for the parasite pathogen or neoplasia. Alphavirus replicon particles representative of the nucleic acid expression library are preferred. The nucleic acid library can be a random library, or it can be prepared after a selection step, for example, by differential hybridization prior to cloning into the replicon vector.
摘要翻译：病毒复制子选择的核酸表达文库可用于分析与寄生虫，病原体或瘤形成相关的多种抗原或用于制备用于产生对寄生虫病原体或瘤形成特异性的免疫应答的免疫原性组合物。代表核酸表达文库的甲病毒复制子颗粒是优选的。核酸文库可以是随机文库，或者可以在选择步骤后进行制备，例如在克隆到复制子载体之前通过差异杂交。

5. 发明申请

WO2004034992A2 ENCAPSULATION AND DEAGGREGATION OF POLYENE ANTIBIOTICS USING POLY(ETHYLENE GLYCOL)-PHOSPHOLIPID MICELLES 审中-公开
标题翻译：聚（乙二醇） - 磷脂酰胆碱对聚烯烃抗菌剂的包封和脱胶
公开(公告)号：WO2004034992A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032726
申请日：2003-10-15
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , KWON, Glen, S.
发明人： KWON, Glen, S.
IPC分类号： A61K
CPC分类号： A61K9/1075
摘要： Amphotericin B (or other hydrophobic compound) is encapsulated in a deaggregated form in micelles of monomethoxy poly(ethylene glycol)-phospholipid (as specifically exemplified, the phospholipid is 1,2 di-stearoyl-sn-glycero-3-phosphatidyl ethanolamine) formed by solvent evaporation. Advantageously, the hydration of the dried drug-polymer film is carried at between about 25 °C and about 80 °C. The micelles can be reconstituted with the Amphotericin B (or other hydrophobic compound) in a deaggregated state and safely used in therapy for fungal infections of humans or animals, especially for systemic fungal infections, or other desired application. The polyene micellar formulations described herein are reduced in toxicity as compared with those polyene formulations in which there is significant occurrence of aggregated polyenes.
摘要翻译：将两性霉素B（或其他疏水性化合物）以解聚集形式包封在单甲氧基聚（乙二醇） - 磷脂胶束中（如特别例示的，磷脂为1,2-二硬脂酰-sn- 甘油基-3-磷脂酰乙醇胺）通过溶剂蒸发形成。有利地，干燥的药物 - 聚合物膜的水合在约25℃和约80℃之间进行。胶束可以用解聚状态的两性霉素B（或其他疏水性化合物）重构，并且安全地用于人或动物的真菌感染的治疗，特别是用于全身性真菌感染或其他期望的应用。与其中存在显着聚集的多烯的那些多烯配制剂相比，本文描述的多烯胶束配制剂的毒性降低。

6. 发明申请

WO2003079995A2 NEISSERIA MUTANTS, LIPOOLIGOSACCHARIDES AND IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：黑麦草，紫杉醇和免疫组化
公开(公告)号：WO2003079995A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/008795
申请日：2003-03-20
申请人： EMORY UNIVERSITY , STEPHENS, David, S. , TZENG, Yih-Ling , ZUGHAIER, SuSu , ZIMMER, Shanta
发明人： STEPHENS, David, S. , TZENG, Yih-Ling , ZUGHAIER, SuSu , ZIMMER, Shanta
IPC分类号： A61K
CPC分类号： C12N15/52 , A61K39/095 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/22 , C07K2319/23
摘要： Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene ( kpsF ) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene ( kdtA ) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene ( kdsB ) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A free of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as Escherichia coli .
摘要翻译：本文提供脑膜炎奈瑟球菌的突变菌株，其产生不含Kdo的脂质A以及不含Kdo的脂质A分子和含有来自包含基因稳定突变的不含Kdo的脂质A分子的免疫脂质A分子的灭活组合，所述突变使所选择的基因失活来自编码阿拉伯糖-5-磷酸异构酶，CMP-Kdo合成酶和CMP-Kdo转移酶的基因组。脑膜炎奈瑟球菌NMB206是在编码A5P异构酶的基因（kpsF）中具有稳定插入突变的特异性例证菌株; 菌株NMB-249是编码CMP-Kdo合成酶的基因（kdtA）中具有稳定插入突变的特异性例证菌株，并且菌株NMB259具体示例是在编码CMP-Kdo转移酶的基因（kdsB）中具有稳定插入突变的菌株。本发明还提供了使用这些遗传稳定的脑膜炎奈瑟菌突变体生产不含3-酮-3-脱氧辛酸的脂质A的方法。还描述了pYT250，在奈瑟氏球菌和肠道中如大肠杆菌中功能的质粒。

7. 发明申请

WO2011022387A8 CLONING AND EXPRESSION OF ARNOX PROTEIN TRANSMEMBRANE 9 SUPERFAMILY (TM9SF), METHODS AND UTILITY 审中-公开
公开(公告)号：WO2011022387A8
公开(公告)日：2011-02-24
申请号：PCT/US2010/045745
申请日：2010-08-17
申请人： NOX TECHNOLOGIES, INC. , MORRÉ, D. James , TANG, Xiaoyu , DICK, Sara , MEADOWS, Christiaan , MORRÉ, Dorothy M.
发明人： MORRÉ, D. James , TANG, Xiaoyu , DICK, Sara , MEADOWS, Christiaan , MORRÉ, Dorothy M.
IPC分类号： C07H21/00 , C12P21/00
摘要： Described are cell surface and circulating markers for aging related disorders (specific isoforms of NADH oxidase (arNOX)). Recombinant age-related NADH oxidase isoforms and their coding sequences and methods for detecting arNOX isoform presence and quantitation in tissues and in blood, sera, urine, saliva, perspiration and in other body fluids, are provided. Recombinant arNOX proteins are useful in preparing antigens for use in the generation of monoclonal and polyclonal antibodies as well as immunogenic compositions for diagnosis and treatment of aging disorders. DNA probes based on the DNA sequence information provide may be used to identify individuals at risk for aging disorders and for development of therapeutic interventions or anti-aging cosmetic or other formulations of benefit in slowing the aging process in mammals.

8. 发明申请

WO2007024739A2 HERBICIDE RESISTANCE GENE, COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗除草剂基因，组合物和方法
公开(公告)号：WO2007024739A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032453
申请日：2006-08-24
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , TRANEL, Patrick , HAGER, Aaron , PATZOLDT, William
发明人： TRANEL, Patrick , HAGER, Aaron , PATZOLDT, William
IPC分类号： A01H5/00 , C12N9/02 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8274 , C12N9/001
摘要： The present disclosure provides methods, recombinant DNA molecules, recombinant host cells containing the DNA molecules, and transgenic plant cells, plant tissue, seeds and plants which contain and express an herbicide resistant protoporphyrinogen oxidase such that they germinate from seed and grow in the presence of an amount of herbicide where the parent plant does not. Such plants are especially appropriate for use in agriculture or horticulture where herbicides are used to kill undesirable plants which might contaminate or compete with the transgenic plant of interest.
摘要翻译：本公开提供了方法，重组DNA分子，含有DNA分子的重组宿主细胞，以及含有和表达除草剂抗原原卟啉原氧化酶的转基因植物细胞，植物组织，种子和植物，使得它们从种子发芽并在存在下生长母本植物不含的除草剂量。这样的植物特别适用于农业或园艺，其中除草剂用于杀死可能污染或与感兴趣的转基因植物竞争的不期望的植物。

9. 发明申请

WO2005081743A2 MEMBRANE SCAFFOLD PROTEINS 审中-公开
标题翻译：膜蛋白质蛋白
公开(公告)号：WO2005081743A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/001122
申请日：2005-01-13
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , SLIGAR, Stephen, G. , BAYBURT, Tmothy, H. , SCHULER, Mary, A. , CIVJAN, Natanya, R. , GRINKOVA, Yelena, V. , DENISOV, Ilia, G. , GRIMME, Stephen, James
发明人： SLIGAR, Stephen, G. , BAYBURT, Tmothy, H. , SCHULER, Mary, A. , CIVJAN, Natanya, R. , GRINKOVA, Yelena, V. , DENISOV, Ilia, G. , GRIMME, Stephen, James
IPC分类号： C07K14/47 , C07K14/775
CPC分类号： C07K14/775 , C07K14/47
摘要： The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.
摘要翻译：本发明的膜支架蛋白（MSP）与疏水或部分疏水的蛋白质组合形成可溶性纳米级颗粒，其保留天然结构和功能; 在稳定性和保存生物活性和天然构象方面，它们比脂质体和洗涤剂胶束得到改善。在磷脂的存在下，MSP形成纳米视磷脂双层盘，MSP在双层结构域的周边稳定颗粒。颗粒双层结构允许在溶液或固体载体上操作掺入的蛋白质，包括用于诸如扫描探针显微镜或表面等离振子共振的表面敏感技术。在完整性和维持结合蛋白质的生物活性方面坚固的纳米级颗粒有助于药物和生物学研究，结构/功能相关性，结构测定，生物分离和药物发现。

10. 发明申请

WO2005041880A2 RhPV AS A MODEL FOR HPV-INDUCED CANCERS 审中-公开
标题翻译： RhPV作为HPV诱导的癌症模型
公开(公告)号：WO2005041880A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/035961
申请日：2004-10-29
申请人： SCIENCE & TECHNOLOGY CORPORATION @ UNM , OZBUN, Michelle, A.
发明人： OZBUN, Michelle, A.
IPC分类号： A61K
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/0331 , A01K2267/0337 , C12N2710/20011
摘要： Provided is an animal model system for the study of papillomaviruses, especially anogenital papillomaviruses, especially those causing anogenital and/or head and neck cancers. The Rhesus papillomavirus (especially RhPV1) is a useful model for human papillomaviruses which cause anogenital infections and cancers of the anogenital region and/or the head, neck and respiratory system.
摘要翻译：提供了用于研究乳头瘤病毒，尤其是肛门生殖器乳头瘤病毒，尤其是引起肛门和/或头颈部癌症的动物模型系统。恒河猴乳头瘤病毒（特别是RhPV1）是引起肛门生殖器感染和肛门生殖器区域和/或头颈部和呼吸系统癌症的人乳头瘤病毒的有用模型。

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