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1. 发明申请

WO2023091668A1 COMBINATIONS OF CURCUMIN AND URSOLIC ACID AND USES THEREOF 审中-公开
公开(公告)号：WO2023091668A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050401
申请日：2022-11-18
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： LISS, Michael A. , DIGIOVANNI, John , SAHA, Achinto
IPC分类号： A61P35/04 , A61K36/9066 , A61K31/56 , A61K9/20 , A23L33/105
摘要： The disclosed subject matter relates to compostions comprising ursolic acid or pharmaceutically acceptable salts thereof and curcumin or pharmaceutically acceptable salts thereof. Further, disclosed herein are methods of using ursolic acid or pharmaceutically acceptable salts thereof and curcumin or pharmaceutically acceptable salts thereof for treating, inhibiting initiation, inhibiting progression, and/or inhibiting metastasis of cancer, such as prostate cancer, in a subject.

2. 发明申请

WO2023283487A1 BEVERAGE CONTAINING CITRUS FIBER AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：WO2023283487A1
公开(公告)日：2023-01-12
申请号：PCT/US2022/036681
申请日：2022-07-11
申请人： THE COCA-COLA COMPANY , LIU, Boya , LI, Jia , GAO, Fujun , JOSHI, Tushar , DENG, Chunbo
发明人： LIU, Boya , LI, Jia , GAO, Fujun , JOSHI, Tushar , DENG, Chunbo
IPC分类号： A23L2/52 , A23C9/00 , A23L33/21 , A23L5/00 , A23G1/30 , A23L25/00
摘要： Described is a beverage comprising a milk base and 0.3‰ to 5‰ of citrus fiber based on the milk base; wherein a citrus fiber raw material used to prepare the beverage contains 50% to 100% of total dietary fiber and has a particle size D99 of 100 μm-300 μm. Methods for preparing the beverage are also disclosed. Since the indicators of the citrus fiber raw material and the ratio of the citrus fiber raw material to the milk base are strictly controlled in a preparation process, the beverage has a moderate viscosity and a good taste, and it can maintain a long-term stability without adding stabilizers such as gum.

3. 发明申请

WO2021150954A1 BACTERIAL TOPOISOMERASE INHIBITORS DERIVED FROM ISOMANNIDE 审中-公开
公开(公告)号：WO2021150954A1
公开(公告)日：2021-07-29
申请号：PCT/US2021/014708
申请日：2021-01-22
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： MITTON-FRY, Mark
IPC分类号： A23L27/00 , A23L27/20 , A23L27/26
摘要： Disclosed are bacterial topoisomerase inhibitors employing a linker derived from isomannide. Reduced hERG inhibition was observed compared to structure-matched analogues with different linkers.

4. 发明申请

WO2021042039A1 SYNTHETIC ANTIMICROBIAL PEPTIDES 审中-公开
公开(公告)号：WO2021042039A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048761
申请日：2020-08-31
申请人： AJK PHARMACEUTICAL LLC
发明人： PARANG, Keykavous , TIWARI, Rakesh , LOHAN, Sandeep , MOHAMMED, Eman , MANDAL, Dindyal
IPC分类号： A61K38/12 , A61K45/06 , A61K47/48 , A61K49/00
摘要： Synthetic peptides comprising a sequence of amino acids XnVm, wherein X represents positively charged amino acid, Y represents hydrophobic amino acid, and both n and m are greater than 2 are disclosed. In accordance with the purposes of the disclosed compositions and methods, as embodied and broadly described herein, the disclosed subject matter relates to synthetic antimicrobial peptides and methods of making and using same.

5. 发明申请

WO2021007286A1 COMPOSITIONS AND METHODS FOR CANCER THERAPY 审中-公开
公开(公告)号：WO2021007286A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/041139
申请日：2020-07-08
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： RAO, Hai
IPC分类号： A61K31/7068 , A61K38/07
摘要： Disclosed are compounds that target receptor tyrosine kinases for degradation by ubiquitinases, and the use thereof for treating cancers.

6. 发明申请

WO2020014489A2 DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS 审中-公开
公开(公告)号：WO2020014489A2
公开(公告)日：2020-01-16
申请号：PCT/US2019/041413
申请日：2019-07-11
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
发明人： BURNETTE, Pearlie , LAWRENCE, Nicholas J. , LAWRENCE, Harshani
IPC分类号： A61K31/517
摘要： Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.

7. 发明申请

WO2019148194A2 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION 审中-公开
公开(公告)号：WO2019148194A2
公开(公告)日：2019-08-01
申请号：PCT/US2019/015695
申请日：2019-01-29
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： PEI, Dehua , CHRISTMAN, John W. , KARPURAPU, Manjula , DOUGHERTY, Patrick G.
IPC分类号： A61K38/12
摘要： Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.

8. 发明申请

WO2019139961A1 INHIBITORS FOR THE Β-CATENIN/B-CELL LYMPHOMA 9 (BCL9) PROTEIN–PROTEIN INTERACTION 审中-公开
公开(公告)号：WO2019139961A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/012861
申请日：2019-01-09
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
发明人： JI, Haitao
IPC分类号： A61K31/167 , A61K31/40 , A61K31/41
摘要： Disclosed are inhibitors for the β-catenin/BCL9 interaction. The inhibitors are selective for β-catenin/BCL9 over β-catenin/cadherin interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.

9. 发明申请

WO2017062311A1 RESETTING BIOLOGICAL PATHWAYS FOR DEFENDING AGAINST AND REPAIRING DETERIORATION FROM HUMAN AGING 审中-公开
标题翻译：重新制定防止和修复人类老龄化的生物学途径
公开(公告)号：WO2017062311A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055173
申请日：2016-10-03
申请人： HUIZENGA, Joel
发明人： HUIZENGA, Joel
IPC分类号： A61P39/00 , A23L33/13 , A23L33/175 , A61K36/48
CPC分类号： A23L33/13 , A23L33/175 , A23V2002/00 , A61K31/045 , A61K31/198 , A61K31/205 , A61K31/706 , A61K31/714 , A61K33/40 , A61K36/258 , A61K2300/00 , A23V2200/302
摘要： Compositions for addressing one or more of the effects of aging are described. The compositions comprise a first component comprising repair system activator(s) such as nicotinamide adenine dinucleotide (NAD+), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine mononucleotide (NaMN), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid riboside (NAR), 1-methylnicotinamide (MNM), cyclic adenosine monophosphate (cAMP) and combinations thereof; a second component comprising methyl donor(s) such as S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, or combinations thereof; and a third component comprising antioxidant defense activators such as H 2 O 2 , N 2 S, NaSH, N a2 S, and several others, including combinations thereof. Methods of administering the disclosed compositions or separate formulations of repair system activator, methyl donors, and antioxidant defense activators are also disclosed.
摘要翻译：描述了解决一种或多种老化影响的组合物。组合物包含包含修复系统活化剂如烟酰胺腺嘌呤二核苷酸（NAD +），烟酰胺单核苷酸（NMN），烟酰胺核苷（NR），烟酸腺嘌呤单核苷酸（NaMN），烟酸腺嘌呤二核苷酸（NaAD）烟酸核苷（NAR），1-甲基烟酰胺（MNM），环磷酸腺苷（cAMP）及其组合; 包括诸如S-5'-腺苷-L-甲硫氨酸（SAM），甲硫氨酸，甜菜碱，胆碱，叶酸，维生素B12或其组合的甲基供体的第二组分; 和包含抗氧化防御活化剂如H 2 O 2，N 2 S，NaSH，Na 2 S等的第三组分，包括其组合。还公开了施用所公开的组合物或修复系统活化剂，甲基供体和抗氧化防御活化剂的单独制剂的方法。

10. 发明申请

WO2016210141A1 IMMOBILIZATION OF BIOMOLECULES BY SELF-ASSEMBLED NANOSTRUCTURES 审中-公开
标题翻译：通过自组装的纳米结构对生物分子的稳定化
公开(公告)号：WO2016210141A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039034
申请日：2016-06-23
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： PARQUETTE, Jon Robert , SATAGOPAN, Sriram , SUN, Yuan , TABITA, Fred Robert
IPC分类号： A61K47/48
CPC分类号： A61K47/64 , A61K47/542 , A61K47/6925 , B01D53/62 , B01D53/8671 , B01D53/88 , B01D2255/804 , B01D2255/90 , B01D2257/504 , B01D2258/06 , C12Y401/01039 , C12Y402/01001 , C21B13/0073 , Y02C10/04
摘要： Disclosed are nanostructures such as carboxysomes that encapsulate RubisCO and carbonic anhydrase to provide a protected environment to maximize CO 2 assimilation. Conditions are disclosed were RubisCO can be sequestered into a variety of self-assembling nanotubes. The encapsulated protein was enzymatically active and was clearly associated with the nanotubes and removed from solution based on a number of criteria. These nanostructures were also found to enhance the stability of RubisCO toward proteases and other environmental factors. These structures can be used in scalable CO 2 conversions and other processes.
摘要翻译：公开了纳米结构，例如包封RubisCO和碳酸酐酶以提供受保护的环境以最大化CO 2同化的羧基体。披露的条件是RubisCO可以隔离成多种自组装纳米管。封装的蛋白质具有酶活性，并且与纳米管明显相关，并且基于许多标准从溶液中除去。还发现这些纳米结构增强了RubisCO对蛋白酶和其他环境因素的稳定性。这些结构可用于可扩展的二氧化碳转化和其他过程。

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