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1. 发明申请

WO2023073221A1 CIRCULAR METHODS FOR MANUFACTURING PRODUCTS FROM ALGAL BIOMASS AND ATMOSPHERIC CARBON REMOVAL WITH LONG-LIVED STORAGE USING ALGAE RESIDUAL BIOMASS USING PACKING AND SPREADED SINKAGE 审中-公开
公开(公告)号：WO2023073221A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/080305
申请日：2022-10-28
申请人： THOMAS, Viji Donato , CHOQUET, Victor Adrian Daniel , SINKCO LABS
发明人： THOMAS, Viji Donato , CHOQUET, Victor Adrian Daniel
IPC分类号： A01G33/00 , C12N15/82
摘要： The invention encompasses systems and processes for the extraction of, for example, consumer, animal, and industrial end products from algal biomass. In various embodiments, the invention encompasses ecofriendly methods for selective extraction and fractionation of algal products. These components include, but are not limited to, lipids, proteins, antioxidants, synthesized by algae, or the use of these compounds for further biochemical processes for synthesis of product compounds such as ethanol or biopolymer. The invention further encompasses method for the recovery algae residual biomass (ARB), its packing and transfer the deep-sea for carbon storage. These methods include energy efficient methods of filtration and packing and spread to the ocean surface to further allow reaching the seabed.

2. 发明申请

WO2023036779A2 NUCLEIC ACID POLYMERASES 审中-公开
公开(公告)号：WO2023036779A2
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074749
申请日：2022-09-06
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： FREUND, Niklas , ARANGUNDY-FRANKLIN, Sebastian , HOLLIGER, Philipp
IPC分类号： C12N9/12 , C12N15/10 , C12P19/34
摘要： In an aspect, the invention relates to nucleic acid polymerases capable of producing non-DNA polymers. In addition, the invention relates to uses of said polymerases and to the resultant products.

3. 发明申请

WO2023036772A1 METHODS OF BIOMOLECULE DISPLAY 审中-公开
公开(公告)号：WO2023036772A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074731
申请日：2022-09-06
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： POREBSKI, Benjamin , HOLLIGER, Philipp
IPC分类号： C12Q1/6806 , C12Q1/686
摘要： The invention relates to methods of displaying biomolecules on substrates, for instance on the surface of flow cells. The invention relates to upstream, downstream, or direct methods for displaying XNA molecules, RNA molecules, and/or polypeptides on the substrate. The invention further relates to substrates displaying biomolecules that are obtained or obtainable by the methods of the invention.

4. 发明申请

WO2022269049A1 SULFONAMIDE OREXIN RECEPTOR AGONISTS AND USES THEREOF 审中-公开
公开(公告)号：WO2022269049A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067376
申请日：2022-06-24
申请人： JAZZ PHARMACEUTICALS IRELAND LIMITED , MARINELLI, Davide
发明人： CHOVATIA, Prafulkumar , BEATO, Claudia , OUVRY, Gilles
IPC分类号： C07D213/42 , C07D231/12 , C07D239/26 , C07D307/94 , C07D401/04 , C07D471/04 , A61K31/4412 , A61P25/20 , A61P43/00
摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, A, L1, L2, Y and Z are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a disease or disorder that is treatable by administration of an Orexin agonist.

5. 发明申请

WO2022234286A1 COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR IDENTIFYING OBJECTS IN AN ENVIRONMENT 审中-公开
公开(公告)号：WO2022234286A1
公开(公告)日：2022-11-10
申请号：PCT/GB2022/051150
申请日：2022-05-05
申请人： SCALPEL LTD.
发明人： PULIJALA, Yeshwanth , AHMED, Shahnawaz
IPC分类号： G06V20/52 , G06V10/20
摘要： A computer-implemented method for identifying objects in an environment is disclose. The method comprises: receiving image data representing the environment from one or more cameras; analysing the image data to detect objects in the environment and for each detected object, assigning a preliminary identification label and confidence factor to the object; receiving environmental data from one or more environmental sensors, analysing the environmental data to detect classification indicators and for each detected object, modifying the confidence factor assigned to the object if a classification indicator correlates with the preliminary identification label and/or using one or more measurement sensors to measure one or more physical characteristics relating to a set of objects at a predefined location within the environment, the set of objects being included within the detected objects, and, for each measured physical characteristic, modifying the confidence factor associated with each object in the set if the physical characteristic corresponds to an expected value for the objects found at the predefined location; and for each detected object, identifying the object by associating with it a final identification label equal to the preliminary identification label if the confidence factor assigned to the object meets a predefined criterion.

6. 发明申请

WO2022233872A1 OREXIN RECEPTOR AGONISTS AND USES THEREOF 审中-公开
公开(公告)号：WO2022233872A1
公开(公告)日：2022-11-10
申请号：PCT/EP2022/061851
申请日：2022-05-03
申请人： JAZZ PHARMACEUTICALS IRELAND LIMITED , MARINELLI, Davide
发明人： CHOVATIA, Praful , BEATO, Claudia , OUVRY, Gilles
IPC分类号： C07D498/10 , C07D471/10 , C07D513/10 , C07D515/10 , A61K31/438 , A61P43/00
摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein n, m, A1, A2, A3, A4, A5, A6, L1, L2, R1, R2, R3, Y and Z are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a disease or disorder that is treatable by administration of an Orexin agonist.

7. 发明申请

WO2022200389A1 BISPECIFIC ANTIBODIES TARGETING CD47 AND PD-L1 AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2022200389A1
公开(公告)日：2022-09-29
申请号：PCT/EP2022/057555
申请日：2022-03-22
申请人： NOVIMMUNE S.A.
发明人： CHAUCHET, Xavier , MASTERNAK, Krzysztof , SHANG, Limin , MAGISTRELLI, Giovanni , FISCHER, Nicolas
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K2039/505 , C07K16/2803 , C07K16/2827 , C07K2317/31 , C07K2317/76
摘要： This disclosure provides novel bispecific antibodies that specifically bind to CD47 and Programmed Death-Ligand 1 (PD-L1). The disclosure further relates to methods of making the bispecific antibodies and nucleic acids encoding the antibodies. The disclosure further relates to therapeutic methods for use of the bispecific antibodies in the treatment of a condition associated with malignant cells expressing CD47 and/or PD-L1 (e.g. cancer).

8. 发明申请

WO2022200387A1 BISPECIFIC ANTIBODIES TARGETING CD47 AND PD-L1 AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2022200387A1
公开(公告)日：2022-09-29
申请号：PCT/EP2022/057553
申请日：2022-03-22
申请人： NOVIMMUNE S.A.
发明人： CHAUCHET, Xavier , MASTERNAK, Krzysztof , SHANG, Limin , FERLIN, Walter , PENARRIETA, Elise
IPC分类号： A61P35/00 , C07K16/28 , C07K16/46 , A61K39/395 , A61K2039/505 , A61K39/3955 , C07K16/2803 , C07K16/2827 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This disclosure provides novel bispecific antibodies that specifically bind to CD47 and Programmed Death-Ligand 1 (PD-L1). The disclosure further relates to methods of making the bispecific antibodies and nucleic acids encoding the antibodies. The disclosure further relates to therapeutic methods for use of the bispecific antibodies in the treatment of a condition associated with malignant cells expressing CD47 and/or PD-L1 (e.g. cancer).

9. 发明申请

WO2021255189A1 COMPOSITIONS AND METHODS FOR AUGMENTING CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL THERAPIES 审中-公开
公开(公告)号：WO2021255189A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066469
申请日：2021-06-17
申请人： TIZIANA LIFE SCIENCES, PLC
发明人： SHAILUBHAI, Kunwar
IPC分类号： C12N5/0783 , C12N5/0775 , A61K35/17 , A61K39/395 , A61K2039/505 , A61K39/3955 , C07K16/2809 , C12N2501/51 , C12N2501/515 , C12N5/0636 , C12N5/0662
摘要： This disclosure relates to improving CAR-T expansion and/or survival using CD-3 antibodies alone or in combination with other co-stimulatory molecules such as an anti-IL-6 receptor monoclonal antibody, an anti-CD28 monoclonal antibody, an IL-17 monoclonal antibody or specific inhibitors of signaling pathways of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), or mammalian target of rapamycin (mTOR).

10. 发明申请

WO2021224466A1 METHODS AND KITS FOR DETERMINING THE RISK OF BREAST CANCER RECURRENCE 审中-公开
公开(公告)号：WO2021224466A1
公开(公告)日：2021-11-11
申请号：PCT/EP2021/062176
申请日：2021-05-07
申请人： ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. , UNIVERSITA DEGLI STUDI DI MILANO
发明人： DI FIORE, Pier Paolo , PECE, Salvatore
IPC分类号： C12Q1/6886
摘要： The present invention relates to methods and kits for the evaluation of risk and treatment of distant recurrence of breast cancer in a subject. The methods and kits can comprise combining the measured expression levels of a subset of genes selected from a 20-gene signature with tumor size and nodal status to determine the risk of distant recurrence.

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