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1. 发明申请

WO2011015881A2 BIOCIDAL COMPOSITION 审中-公开
标题翻译：生物组成
公开(公告)号：WO2011015881A2
公开(公告)日：2011-02-10
申请号：PCT/GB2010/051308
申请日：2010-08-06
申请人： DUO TECH LTD , BAKER, Lewis, James, Francis , BAUMBER, Marcus
发明人： BAKER, Lewis, James, Francis , BAUMBER, Marcus
CPC分类号： A01N33/12 , A01N25/02 , A01N25/30 , A01N31/02 , A01N37/44 , A01N2300/00
摘要： The biocidal composition, particularly but not exclusively a biocidal cleaning composition, comprises a water-based solution of an effective amount of one or more aliphatic alcohol, one or more detergent and one or more di-(long chain) quaternary ammonium salt. The composition is particularly characterised by an effective sporicidal activity in combination with an antibacterial and antiviral activity, via a relatively mild application method such as spray-on or wipe-on, on a range of surfaces including human skin and hard surfaces.
摘要翻译：杀生物组合物，特别是但不排他地是杀生物清洁组合物，包含有效量的一种或多种脂族醇，一种或多种洗涤剂和一种或多种二（长链）季铵盐的水基溶液。组合物的特征在于通过相对温和的施用方法如喷雾或擦拭，在包括人皮肤和硬表面在内的一系列表面上，结合抗菌和抗病毒活性，具有有效的杀芽孢活性。

2. 发明申请

WO2007113453A1 ABSORBENT HYDROGEL COMPOSITES 审中-公开
标题翻译：吸收水凝胶复合材料
公开(公告)号：WO2007113453A1
公开(公告)日：2007-10-11
申请号：PCT/GB2006/001218
申请日：2006-04-03
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
发明人： MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
IPC分类号： A61L15/60 , A61L15/26 , A61L15/42
CPC分类号： A61L15/26 , A61L15/42 , A61L15/60
摘要： The invention provides an absorbent material or article comprising an absorbent hydrogel composite sheet. The sheet includes an absorbent layer part having two major faces which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a second part which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The second part may be associated with the layer part such that the second part infiltrates some but not all of the cellular voids of the absorbent layer part over a major face of the absorbent layer part. Alternatively, the second part may be associated with the layer part such that the second part overlies a major face of the absorbent layer part. By this arrangement, some but not all of the absorbent layer part is effectively exposed for absorption of external water or other fluid through the side of the sheet corresponding to that said major face of the absorbent layer.
摘要翻译：本发明提供了一种包含吸收性水凝胶复合片材的吸收材料或制品。片材包括具有两个主表面的吸收层部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，和包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的第二部分。第二部分可以与层部分相关联，使得第二部分在吸收层部分的主表面上渗透吸收层部分的一些但不是全部的细胞空隙。或者，第二部分可以与层部分相关联，使得第二部分覆盖在吸收层部分的主表面上。通过这种布置，一些但不是全部的吸收层部分被有效地暴露以吸收外部水或其它流体通过与吸收层的所述主面对应的片材的侧面。

3. 发明申请

WO2004090156A2 TEST SYSTEM 审中-公开
标题翻译：测试系统
公开(公告)号：WO2004090156A2
公开(公告)日：2004-10-21
申请号：PCT/GB2004/001578
申请日：2004-04-08
申请人： CROWN VISION SYSTEMS LIMITED , LEHARNE, Steven , NAGLER, Martin , NEAL, Gordon , EZZI, Mufaddal , COKER, Raymond , BELL, Edward , ROTHER, Joachim , PHILLIPS, Pamela , DAVIES, Lyn , ANDREOU, Michael , SOARED, Fernando
发明人： LEHARNE, Steven , NAGLER, Martin , NEAL, Gordon , EZZI, Mufaddal , COKER, Raymond , BELL, Edward , ROTHER, Joachim , PHILLIPS, Pamela , DAVIES, Lyn , ANDREOU, Michael , SOARED, Fernando
IPC分类号： C12Q1/00
CPC分类号： C12Q1/025
摘要： An assay is provided for assaying a sample of soil, sand, sediment or other particulate material for the presence of contaminants such as polycyclic aromatic hydrocarbons (PAHs), organic pesticides, petroleum hydrocarbons, or polychlorinated biphenyls (PCBs), and preferably comprises: extracting an assayable amount of the contaminant from the particulate material into a water-miscible solvent, such as an organic alcohol, capable of dissolving the contaminant, the solvent optionally containing a surfactant; mixing the resultant solvent solution of the contaminant with water and optionally a surfactant, for example to a dilution factor between about 10 and about 25, whereby a mixture is obtained containing water, solvent, surfactant and any extracted contaminant; and exposing the bioluminescent organism Vibrio fischeri to the mixture under conditions in which the inhibition, by the contaminant, of light emitted by the organism can be related to the presence of the contaminant in the mixture. The method is sufficiently quantitative that it can be determined whether the contaminant is present in the particulate material at a concentration above or below a certain - e.g. a legally specified - level. A test kit is provided, whereby the method can be performed in the field and the result showing whether the contaminant is present at a legally acceptable or unacceptable level can be displayed.
摘要翻译：提供了一种用于测定土壤，沙子，沉积物或其他颗粒材料样品中存在污染物如多环芳烃（PAHs），有机农药，石油烃或多氯联苯（PCBs）的测定法，优选包括：提取污染物从颗粒物质分解成能够溶解污染物的水混溶性溶剂如有机醇，任选地含有表面活性剂的溶剂; 将所得到的污染物溶剂与水和任选的表面活性剂混合，例如稀释因子为约10至约25，由此得到含有水，溶剂，表面活性剂和任何提取的污染物的混合物; 以及在生物体发射的光的抑制可能与混合物中污染物的存在有关的条件下，将生物发光生物体弧菌暴露于混合物中。该方法是足够定量的，可以确定污染物是否以高于或低于某一特定浓度的浓度存在于颗粒材料中。一个法定指定级别。提供了一种测试工具，由此可以在现场进行该方法，并且可以显示显示污染物是否以法律上可接受或不可接受的水平存在的结果。

4. 发明申请

WO2004071399A2 MODULATION OF ATP PRODUCTION OR CONTENT IN THE HYPOTHALAMUS 审中-公开
标题翻译： ATP生产或内含物的调节
公开(公告)号：WO2004071399A2
公开(公告)日：2004-08-26
申请号：PCT/GB2004/000598
申请日：2004-02-16
申请人： PHYTOPHARM PLC , MACLEAN, David, B.
发明人： MACLEAN, David, B.
IPC分类号： A61K
CPC分类号： G01N33/6872 , A61K31/57 , A61K31/704 , A61K36/27 , G01N33/743
摘要： A method for the identification of agents for use in the treatment of metabolic diseases, disorders or conditions, for example obesity and diabetes, or for causing weight loss without substantial adverse health effects, in an animal in need of such treatment, comprises the step of identifying an agent that modulates ATP production or content in the hypothalamus of an animal.
摘要翻译：在需要这种治疗的动物中鉴定用于治疗代谢疾病，病症或病症（例如肥胖症和糖尿病）或用于引起体重减轻而不具有实质性不利健康影响的药剂的方法包括以下步骤：鉴定调节动物下丘脑ATP产生或内容的药剂。

5. 发明申请

WO2003082893A3 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
公开(公告)号：WO2003082893A3
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： A61K31/585
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.

6. 发明申请

WO2003082893A2 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
标题翻译： SAPOGENINS及其衍生物的治疗方法和用途
公开(公告)号：WO2003082893A2
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： C07J
CPC分类号： A61K31/58 , A61K31/655 , C07J71/00 , C07J71/0005 , Y02A50/465
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译：本发明公开了某些甾体皂草苷配基，相关化合物及其衍生物治疗非认知性神经变性，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或丧失的治疗方法和用途在没有认知，神经和神经肌肉损伤的情况下。

7. 发明申请

WO2003051408A1 HYDROGEL COMPOSITIONS COMPRISING AN ACRYLOYL MORPHOLINE POLYMER 审中-公开
标题翻译：包含丙烯酸多羟基聚合物的水凝胶组合物
公开(公告)号：WO2003051408A1
公开(公告)日：2003-06-26
申请号：PCT/GB2002/005681
申请日：2002-12-13
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , CERDAN, Carine , HOSKINS, Richard
发明人： MUNRO, Hugh, Semple , CERDAN, Carine , HOSKINS, Richard
IPC分类号： A61L15/24
CPC分类号： C08F20/58 , A61L15/425 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L26/008 , A61L26/0085 , C08L39/04
摘要： The invention provides a hydrogel composition comprising a plasticised cross-linked hydrophilic polymer of acryloyl morpholine and optionally one or more comonomers.
摘要翻译：本发明提供一种水凝胶组合物，其包含丙烯酰吗啉的可塑化的交联亲水性聚合物和任选的一种或多种共聚单体。

8. 发明申请

WO2020245573A1 METHODS AND COMPOSITIONS FOR GENERATING NITRIC OXIDE AND USES THEREOF 审中-公开
公开(公告)号：WO2020245573A1
公开(公告)日：2020-12-10
申请号：PCT/GB2020/051328
申请日：2020-06-02
申请人： THIRTY HOLDINGS LIMITED
发明人： MUNRO, Hugh Semple , WOOD, Christopher Barry
IPC分类号： C01B21/24 , A61K33/00 , A61P9/10 , A61P11/00 , A61P17/02 , A61P31/04
摘要： The invention provides a combination, kit or composition comprising: (i) one or more nitrite salt; (ii) a proton source comprising one or more acid selected from organic carboxylic acids and organic non-carboxylic reducing acids; and (iii) one or more organic polyol. On reaction of the one or more nitrite salt with the proton source in the presence of the one or more organic polyol, the combination, kit or composition provides reaction products which include nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof and which are useful, for example, in the treatment of various disorders.

9. 发明申请

WO2016156794A1 STERILISATION OF S-NITROSOTHIOLS 审中-公开
标题翻译： S-NITROSOTOLOLS的灭菌
公开(公告)号：WO2016156794A1
公开(公告)日：2016-10-06
申请号：PCT/GB2016/050772
申请日：2016-03-21
申请人： SALUPONT CONSULTING LTD
发明人： REES, Daryl , ORSI, Antonia
IPC分类号： A61L2/00 , A61K41/00 , A61L2/08 , A61K31/095 , A61K31/195 , A61K31/04
CPC分类号： A61K41/0009 , A61K31/04 , A61K31/095 , A61K31/195 , A61K38/05 , A61K41/0019 , A61L2/0029 , A61L2/0035 , A61L2/007 , A61L2202/18 , A61L2202/21
摘要： This invention provides a method of sterilising an S-nitrosothiol, for example S- nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.
摘要翻译：本发明提供了通过降解使S-亚硝基硫醇，例如S-亚硝基谷胱甘肽灭菌而不降低大约5.0％的纯度的方法。本发明允许产生无菌S-亚硝基硫醇或包含S-亚硝基硫醇的无菌药物预组合物，其中S-亚硝基硫醇为干固体形式。将无菌药物预组合物与一种或多种稀释剂，赋形剂，载体，另外的活性剂或其任何组合，例如无菌盐水混合，以制备用于使用的S-亚硝基硫醇的药物组合物。

10. 发明申请

WO2010029352A1 TREATMENT OF FIBROTIC EYE DISORDERS USING AN MMP2 INHIBITOR 审中-公开
标题翻译：使用MMP2抑制剂治疗纤维性眼病
公开(公告)号：WO2010029352A1
公开(公告)日：2010-03-18
申请号：PCT/GB2009/051148
申请日：2009-09-09
申请人： UNIVERSITY OF EAST ANGLIA , WORMSTONE, Ian Michael , DAWES, Lucy , ELDRED, Julie Ann , EDWARDS, Dylan , HODGKINSON, Lisa
发明人： WORMSTONE, Ian Michael , DAWES, Lucy , ELDRED, Julie Ann , EDWARDS, Dylan , HODGKINSON, Lisa
IPC分类号： A61P27/02 , A61P27/12 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/404 , A61K31/535
CPC分类号： A61K31/00 , A61K31/16 , A61K31/18 , A61K31/404 , A61K31/535
摘要： Inhibitors of matrix metalloproteinase 2 are used to treat or prevent a fϊbrotic disorder of the posterior capsule of the eye, for example posterior capsule opacification (PCO), or of a tissue or structure of the eye other than the lens or capsular bag.
摘要翻译：基质金属蛋白酶2的抑制剂用于治疗或预防眼后囊的纤维化紊乱，例如后囊不透明（PCO）或眼睛或胶囊袋以外的组织或结构。

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