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1. 发明申请

WO2013090518A1 WASTE WATER INSTALLATION AND METHOD FOR REDUCING HIGH CONTENT OF HARMFUL FLUIDS IN WASTE WATER 审中-公开
标题翻译：用于减少废水中有害流体含量高的废水安装和方法
公开(公告)号：WO2013090518A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069407
申请日：2012-12-13
申请人： XYLEM IP HOLDINGS LLC
发明人： HEDMARK, Per , STRANDBERG, Tore
IPC分类号： C02F3/12 , C02F1/72 , E03F5/18 , B01D19/00 , C02F3/20
CPC分类号： B01D19/0047 , B01D19/0021 , C02F1/006 , C02F1/20 , C02F1/66 , C02F2101/101 , E03F5/18
摘要： According to a first aspect the present invention relates to a waste water installation for reducing high content of harmful fluids in the waste water, comprising a vessel (2) having an inlet opening (7) for incoming waste water and an outlet opening (8) for outgoing waste water, the inlet opening (7) in the vertical direction being arranged at a level above said outlet opening (8), and a stationary distribution plate (11) that is arranged direct under said inlet opening (7) and in the vertical direction arranged at a level above said outlet opening (8), said distribution plate (11) presenting an upper surface (12) arranged to receive and distribute the from the inlet opening (79 incoming waste water and a peripheral edge (13) over which the waste water is arranged to flow. The waste water installation is characterized in that the distribution plate (11) comprises at least one distribution bracket (15) that is connected to and project upwards at an angle to the upper surface (12) of the distribution plate (11). According to a second aspect the present invention relates to a method for reducing high content of harmful fluids in waste water.
摘要翻译：根据第一方面，本发明涉及一种用于减少废水中高含量有害流体的废水装置，包括：具有用于输入废水的入口（7）和出口（8）的容器（2）对于输出废水，入口开口（7）在垂直方向上布置在所述出口（8）上方的高度，以及固定分配板（11），其直接设置在所述入口（7）的下方，并且在所述分配板（11）具有上表面（12），该上表面布置成从入口开口（79进入的废水和周边边缘（13））接收和分配所述废水装置的特征在于，所述分配板（11）包括至少一个分配支架（15），所述分配支架（15）与所述分配板（11）的上表面（12）成一角度地连接并向上突出日 e分配板（11）。根据第二方面，本发明涉及一种降低废水中有害流体含量的方法。

2. 发明申请

WO2013059603A1 APPARATUS AND PROCEDURE FOR TRAPPING EMBOLIC DEBRIS 审中-公开
标题翻译：用于追踪嵌合体的装置和程序
公开(公告)号：WO2013059603A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/061038
申请日：2012-10-19
申请人： DON MICHAEL, T. Anthony
发明人： DON MICHAEL, T. Anthony
IPC分类号： A61M1/34 , A61F2/24
CPC分类号： A61F2/013 , A61F2/24 , A61F2/2436 , A61F2002/018 , A61F2230/0067 , A61F2230/008
摘要： A collapsible and deployable filter for blocking debris and passing blood in a blood vessel in a patient's body, the filter including; a framework of a flexible material, constructed to have a radially compressed state, in which the framework is radially compressed by radial deforming forces, and a radially expanded state to obdurate an artery; and a flexible filter material secured to said framework and having pores dimensioned to prevent the passage of debris therethrough while allowing the passage of blood. The filter has, in the radially expanded state of the framework, a generally conical or frustoconical form with a large diameter end, a small diameter end opposite to the large diameter end, and a side surface extending between the ends. The filter has an opening that is free of filter material at the small diameter end or in the side surface.
摘要翻译：一种可折叠和可部署的过滤器，用于阻挡碎片并将血液传递到患者体内的血管中，所述过滤器包括：柔性材料的框架被构造成具有径向压缩状态，其中框架通过径向变形力径向压缩，并且径向膨胀状态以使动脉变得模糊; 以及柔性过滤材料，其固定到所述框架并且具有尺寸设置为防止碎屑通过而允许血液通过的孔。过滤器在框架的径向膨胀状态下具有大直径锥形或截头圆锥形，其具有大直径端，与大直径端相对的小直径端，以及在端部之间延伸的侧表面。过滤器在小直径端或侧面具有不含过滤材料的开口。

3. 发明申请

WO2014151747A1 METHODS AND COMPOSITIONS WITH IMMUNE THERAPY FOR TREATMENT OF DEMENTIA 审中-公开
标题翻译：免疫治疗方法和组合物治疗DEMENTIA
公开(公告)号：WO2014151747A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026377
申请日：2014-03-13
申请人： RAMOT AT TEL AVIV UNIVERSITY LTD. , NASVAX LTD. , GERAGHTY, Erin
发明人： SAMIRA, Sarit , RACHAMIM, Nurit , TAL, Michael , ELLIS, Ronald , RAKOVER, Idan , ELIAZ, Rom E. , SOLOMON, Beka , JONES, Timothy David , CARR, Francis Joseph , RABINOVICH-TOIDMAN, Polina , SOOLIMAN, Meital
IPC分类号： C07K14/47 , C07K16/18 , A61K38/17 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/54 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/622 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Novel antibodies, methods and compositions for treatment of a disease which is susceptible to amelioration by the blocking of APP cleavage.
摘要翻译：用于治疗易于通过阻断APP切割而改善的疾病的新型抗体，方法和组合物。

4. 发明申请

WO2014145389A1 INHIBITION OF PULMONARY FIBROSIS WITH NUTLIN-3A AND PEPTIDES 审中-公开
标题翻译：用NUTLIN-3A和PEPTID抑制肺动脉硬化
公开(公告)号：WO2014145389A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030147
申请日：2014-03-17
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： SHETTY, Sreerama , IDELL, Steven
IPC分类号： C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K31/496 , A61P43/00
CPC分类号： C07K7/06 , A61K9/0019 , A61K9/007 , A61K31/497 , A61K38/00 , A61K38/08 , A61K38/177 , C07K7/08 , A61K2300/00
摘要： In fibrotic lung fibroblasts, basal levels of p53 protein (and miR-34a) are markedly suppressed, leading to reduced p53-mediated inhibition of uPA and uPAR, or concurrent induction of PAI-1. These changes contribute to excessive FL-fibroblast proliferation and production of extracellular matrix (ECM), and, therefore, pulmonary fibrosis. These processes are reversed by treating the cells, and treating subjects suffering from idiopathic pulmonary fibrosis (IPF) with the small organic molecule nutlin-3a (NTL) or with a peptide, CSP-4 (SEQ ID NO:1), or variants or derivatives or multimers of this peptide, which increase p53 levels by inhibiting MDM2-mediated degradation of p53 protein. Use of these compounds serves as a new approach to the treatment of IPF, as they restore p53 expression and p53-mediated changes in the uPA-fibrinolytic system in FL-fibroblasts and restrict production and deposition of ECM.
摘要翻译：在纤维化肺成纤维细胞中，p53蛋白（和miR-34a）的基础水平被显着抑制，导致p53介导的uPA和uPAR抑制或PAI-1的并发诱导减少。这些变化有助于过度的FL-成纤维细胞增殖和细胞外基质（ECM）的产生，因此导致肺纤维化。这些过程通过治疗细胞和用小有机分子nutlin-3a（NTL）或用肽CSP-4（SEQ ID NO：1）或变体或特异性的方式治疗患有特发性肺纤维化（IPF）的受试者来逆转，该肽的衍生物或多聚体，其通过抑制MDM2介导的p53蛋白的降解来增加p53水平。这些化合物的使用作为治疗IPF的新方法，因为它们恢复了FL-成纤维细胞中uPA-纤维蛋白溶解系统中的p53表达和p53介导的变化，并限制了ECM的产生和沉积。

5. 发明申请

WO2011079301A1 CONTAINER CAP 审中-公开
标题翻译：集装箱盖
公开(公告)号：WO2011079301A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/062066
申请日：2010-12-23
申请人： COSTA, Giuseppe , GERAGHTY, Erin
发明人： COSTA, Giuseppe
IPC分类号： B65D1/02 , B65D47/26 , B65D47/32 , B65D51/16
CPC分类号： B65D1/0292 , B65D47/265 , B65D47/32 , B65D51/1644 , Y10S215/90
摘要： A compressible container (200) has a cap (100) configured to engage therewith. The cap (100) includes a first valve (150), preferably in the form of first and second disks (112,120), one above another, each disk having at least one hole (113,122) therethrough. The disks are rotatable with respect to one another The holes (113,122) of the first and second disks (112,120) align in a first position to create channel therethrough and misalign in the second position to close the channel. The cap (100) may also include a second valve (130) connected to the channel. The second valve (130) may comprise a ball (134) inside a conic section tube (132). The ball (134) is designed to float on the liquid (300) so that any liquid (300) attempting to exit the container cap (100) will be prevented from doing so as the second valve (130) will be closed when the liquid forces the ball (134) into engagement with the conic section tube (132).
摘要翻译：可压缩容器（200）具有被配置为与其接合的盖（100）。盖（100）包括第一阀（150），优选地为第一和第二盘（112,120）的形式，一个在另一个上，每个盘具有穿过其中的至少一个孔（113,122）。盘可以相对于彼此旋转。第一和第二盘（112,120）的孔（113,122）在第一位置对齐以产生穿过其中的通道，并且在第二位置不对准以关闭通道。盖（100）还可以包括连接到通道的第二阀（130）。第二阀（130）可以包括在锥形截面管（132）内的球（134）。球（134）被设计成漂浮在液体（300）上，使得试图离开容器盖（100）的任何液体（300）将被防止这样做，因为第二阀（130）将在液体迫使球（134）与圆锥截面管（132）接合。

6. 发明申请

WO2013096726A1 PUMP CONTROL INCLUDING CLEANING PROCEDURE OR STOPPING DEPENDING ON MOTOR LOAD 审中-公开
标题翻译：泵控制，包括清洁程序或停止依赖于电机负载
公开(公告)号：WO2013096726A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071154
申请日：2012-12-21
申请人： XYLEM IP HOLDINGS LLC
发明人： FULLEMANN, Alexander , SODERLUND, Fredrik , KARLEN, Mats
IPC分类号： F04D15/02 , F04D7/04 , F04D15/00 , F04D29/70
CPC分类号： F04D15/0254 , F04D7/04 , F04D13/08 , F04D15/0066 , F04D15/0236 , F04D29/708
摘要： The invention relates to a method for controlling a pump arrangement comprising a pump (2) having a motor (7) and a control unit (6), said motor (7), when the pump (2) is in an active state and the motor (7) is driven in a first direction, being associated with a load factor that corresponds to an operating condition of the pump arrangement; the pump arrangement also comprising means for monitoring at least one operating parameter from which the load factor of the motor (7) can be derived. The method comprises the steps of determining a real value of said at least one operating parameter, determining if an externally applied force is acting on the motor (7) to such an extent that an operating condition detrimental to the pump arrangement is initiated, effecting a state shift from the active state to an inactive state of the pump (2) if an operating condition detrimental to the pump arrangement is initiated, the state shift comprising that the control unit (6), immediately after a detrimental operating condition is initiated, abruptly breaks the driving of the motor (7) in said first direction.
摘要翻译：本发明涉及一种用于控制泵装置的方法，其包括具有马达（7）和控制单元（6）的泵（2），所述马达（7）当所述泵（2）处于活动状态时马达（7）沿第一方向被驱动，与与泵装置的运行状态对应的负载系数相关联; 所述泵装置还包括用于监测至少一个操作参数的装置，从所述至少一个操作参数可以导出所述电动机（7）的负载系数。该方法包括以下步骤：确定所述至少一个操作参数的实际值，确定外部施加的力是否作用在马达（7）上，使得启动对泵装置有害的操作条件，从而实现如果启动对泵装置有害的操作条件，状态从活动状态转移到泵（2）的非活动状态，则包含控制单元（6）在紧急有害操作条件启动之后突然间在所述第一方向断开电动机（7）的驱动。

7. 发明申请

WO2013090500A2 PROPELLER PUMP AND PUMP STATION 审中-公开
标题翻译：螺旋桨泵和泵站
公开(公告)号：WO2013090500A2
公开(公告)日：2013-06-20
申请号：PCT/US2012/069373
申请日：2012-12-13
申请人： XYLEM IP HOLDINGS LLC
发明人： BURMAN, Joergen
IPC分类号： G11C29/00
CPC分类号： F04D3/00 , F04D3/02 , F04D29/528 , F04D29/548
摘要： According to a first aspect, the present invention relates to a propeller pump comprising a pump housing and a pump core that is arranged in the pump housing and has a propeller, which together delimit a channel, and which are connected by means of a guide vane. The propeller pump is characterized in that a cross-sectional area (A2) of the channel (27) at the rear edge (30) of the guide vane (13) has a measure that is greater than, and that is less than a factor of 1,1 times, a cross-sectional area (A1) at the rear edge (29) of the blades (21) of the propeller, and that the specific rotational speed of the propeller pump is greater than 200 and less than 300. According to a second aspect, the present invention relates to a pump station comprising such a propeller pump.
摘要翻译：根据第一方面，本发明涉及一种螺旋桨泵，其包括泵壳和泵芯，所述泵壳和泵芯布置在泵壳体中并且具有螺旋桨，该螺旋桨一起限定通道，并且通过导叶连接。螺旋桨泵的特征在于，在导叶（13）的后边缘（30）处的通道（27）的横截面面积（A2）具有大于并且小于一个因子的量度是螺旋桨的叶片（21）的后边缘（29）处的横截面面积（A1），并且螺旋桨泵的比旋转速度大于200且小于300。根据第二方面，本发明涉及一种包括这种螺旋桨泵的泵站。

8. 发明申请

WO2019222483A1 TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS WITH GLYCOGEN SYNTHASE KINASE 3 FORM BETA INHIBITORS 审中-公开
公开(公告)号：WO2019222483A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032639
申请日：2019-05-16
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： TUCKER, Torry A. , IDELL, Steven
IPC分类号： A61K31/404 , C07D413/14
摘要： Pharmaceutical compositions and methods are described which rely upon glycogen synthase kinase 3 (form β; GSK 3 β) inhibitors, most preferably 9-ING-41, to inhibit fibrotic pulmonary remodeling in vivo including proliferation and differentiation of myofibroblasts to fibrotic fibroblasts in several mouse models. Therapeutic targeting of GSK-3β with the clinically useful specific inhibitor, 9-ING-41, mitigates fibrotic pulmonary remodeling in vivo and provides a mode of therapy of human IPF by specific GSK-3β inhibition with 9-ING-41.

9. 发明申请

WO2018213529A1 BALL WITH TACTILE LAYER AND METHOD OF MANUFACTURE 审中-公开
公开(公告)号：WO2018213529A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033096
申请日：2018-05-17
申请人： KESSLER CORPORATION
发明人： KESSLER, Alexander , KESSLER, Brian
IPC分类号： A63B39/06 , A63B41/08 , A63B45/00 , B29C69/00
摘要： An object with a tactile outer layer includes, for example, a ball having an outer surface and a series of protrusions or spikes on the outer surface. The protrusion each appear as a tear-dropped shape mass that includes a base having a relatively flat bottom adhered to the outer surface of the ball and a narrow tip and/or curved tail extending away from the outer surface. Manufacturing can be performed by mounting the object and utilizing injection arms that deposit elastomer globules on the object. The globules are deposited by pressure through a reservoir in the injection arm and the injection arms are then withdrawn to product the tail shape.

10. 发明申请

WO2017083005A2 SPACE PLASMA GENERATOR FOR IONOSPHERIC CONTROL 审中-公开
标题翻译：用于电离层控制的空间等离子体发生器
公开(公告)号：WO2017083005A2
公开(公告)日：2017-05-18
申请号：PCT/US2016/051841
申请日：2016-09-15
申请人： ENIG ASSOCIATES, INC.
发明人： KIM, Yi-bong , ENIG, Eric N. , BENTZ, Daniel N. , BARNARD, Michael J.
CPC分类号： H05H1/2406 , F42B12/36 , F42B12/46 , F42B12/50 , H05H2001/245
摘要： A plasma generator composed of a body of electrically conductive, ionizable material connected to conduct a current pulse and to be converted into a plasma that occupies a large volume in the ionosphere. A plasma generating system composed of a source of a high intensity current pulse and the plasma generator.
摘要翻译：等离子体发生器由导电的可离子化材料体组成，该材料被连接以传导电流脉冲并被转换为在电离层中占据大体积的等离子体。由高强度电流脉冲源和等离子体发生器组成的等离子体发生系统。

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