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1. 发明申请

WO2007123684A2 METHODS AND DEVICES FOR THAWING AND/OR IMAGING FROZEN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于研究和/或成像冷冻生物样品的方法和装置
公开(公告)号：WO2007123684A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/007915
申请日：2007-03-30
申请人： BIOTIME, INC. , VOELKER, Mark, A.
发明人： VOELKER, Mark, A.
IPC分类号： C12Q1/00 , C12M3/00 , G06T7/40
CPC分类号： G01N1/42 , A01N1/0284 , A01N1/0289 , G01N1/31 , G01N2035/00346
摘要： Methods of freezing, thawing and imaging a biological sample, one or more times, in a manner sufficient to freeze, thaw, and/or image the biological sample, while maintaining the structural integrity and/or viability of the sample are provided. Aspects of embodiments of the methods include freezing, thawing and/or imaging a biological sample under pressure in a manner sufficient to maintain the structural integrity and/or viability of the sample. Also provided are devices and systems for use in practicing the methods.
摘要翻译：提供了以足以冻结，解冻和/或成像生物样品的方式对生物样品进行一次或多次冷冻，解冻和成像的方法，同时保持样品的结构完整性和/或可行性。方法的实施方案包括以足以维持样品的结构完整性和/或可行性的方式在压力下冷冻，解冻和/或成像生物样品。还提供了用于实践方法的装置和系统。

2. 发明申请

WO2005004798A2 METHODS FOR TREATING LENTIVIRUS INFECTIONS 审中-公开
标题翻译：治疗淋巴细胞感染的方法
公开(公告)号：WO2005004798A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/018474
申请日：2004-06-09
申请人： THE J. DAVID GLADSTONE INSTITUTES , GREENE, Warner, C. , STOPAK, Kimberly, Sue , DE NORONHA, Carlos, Manuel, Clemm , CHIU, Ya-Lin , SOROS, Vanessa, B. , YONEMOTO, Wesley, Minoru
发明人： GREENE, Warner, C. , STOPAK, Kimberly, Sue , DE NORONHA, Carlos, Manuel, Clemm , CHIU, Ya-Lin , SOROS, Vanessa, B. , YONEMOTO, Wesley, Minoru
IPC分类号： A61K
CPC分类号： C12Q1/702 , G01N33/5008 , G01N33/56983 , G01N2333/155 , G01N2500/00
摘要： The present invention provides methods of identifying an agent that inhibits an activity of a lentiviral Vif protein. The present invention provides methods of identifying an agent that increases the level of active APOBEC3G in a cell. The present invention provides agents identified by a subject screening method; and further provides methods for treating lentivirus infections.
摘要翻译：本发明提供鉴定抑制慢病毒Vif蛋白活性的试剂的方法。本发明提供鉴定增加细胞中活性APOBEC3G水平的试剂的方法。本发明提供了通过受试者筛选方法鉴定的药剂; 并进一步提供治疗慢病毒感染的方法。

3. 发明申请

WO2010056438A3 SHIELDED STIMULATION AND SENSING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2010056438A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/059704
申请日：2009-10-06
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61N1/36 , A61N1/04
摘要： Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.

4. 发明授权

US12146130B2 Carbon sequestration methods and systems, and compositions produced thereby 有权
公开(公告)号：US12146130B2
公开(公告)日：2024-11-19
申请号：US16890290
申请日：2020-06-02
申请人： Blue Planet Systems Corporation
发明人： Brent R. Constantz , Mark Bewernitz , Jacob Schneider , Chris Camire
IPC分类号： C04B28/00 , B01D53/18 , B01D53/62 , B01D53/78 , C01B32/60 , C01F5/00 , C01F5/24 , C01F11/18 , C04B22/10 , C04B28/04 , C12M1/00 , C12M1/40
CPC分类号： C12M29/00 , B01D53/18 , B01D53/62 , B01D53/78 , C01B32/60 , C01F5/24 , C01F11/18 , C01F11/181 , C04B22/106 , C04B28/04 , C12M21/18 , B01D2251/402 , B01D2251/404 , B01D2257/504 , C01P2002/72 , Y02C20/40 , Y02P20/151 , Y02W30/91 , C04B28/04 , C04B22/106 , C04B28/04 , C04B18/08 , C04B22/106
摘要： Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a component thereof may then be stored or further processed, e.g., combined with a divalent alkaline earth metal cation, under conditions sufficient to produce a solid carbonate composition. Aspects of the invention further include systems for practicing the methods, as well as products produced by the methods.

5. 发明授权

US12145973B2 T-cell modulatory multimeric polypeptides and methods of use thereof 有权
公开(公告)号：US12145973B2
公开(公告)日：2024-11-19
申请号：US18388788
申请日：2023-11-10
申请人： Cue Biopharma, Inc.
发明人： Ronald D. Seidel, III , Rodolfo J. Chaparro
IPC分类号： A61K9/00 , A61K35/17 , C07K14/005 , C07K14/47 , C07K14/55 , C07K14/74 , G01N33/50 , A61K38/00 , A61K39/00
CPC分类号： C07K14/55 , A61K9/0019 , A61K35/17 , C07K14/005 , C07K14/4748 , C07K14/70539 , G01N33/5008 , A61K38/00 , A61K2039/505 , C07K2317/34 , C07K2319/30
摘要： The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.

6. 发明授权

US12145925B2 Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer 有权
公开(公告)号：US12145925B2
公开(公告)日：2024-11-19
申请号：US17376577
申请日：2021-07-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ATLASMEDX, INC.
发明人： Csaba J. Peto , David M. Jablons , Tsze Tsang , Hassan Lemjabbar-Alaoui
IPC分类号： C07D403/10 , A61P35/00 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04
CPC分类号： C07D403/10 , A61P35/00 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04
摘要： The application relates to phthalazine derivatives of formula (I) which are inhibitors of PARP1, PARP2 and/or tubulin and thus useful for the treatment of cancer. Also disclosed are pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

7. 发明授权

US12144862B2 Antibody biopharmaceutical formulations including polymer excipients 有权
公开(公告)号：US12144862B2
公开(公告)日：2024-11-19
申请号：US18200958
申请日：2023-05-23
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Eric A. Appel , Joseph L. Mann , John Klich , Catherine M. Kasse
IPC分类号： A61K47/32 , C07K16/10
CPC分类号： A61K47/32 , C07K16/1063
摘要： Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

8. 外观设计

USD1050149S1 Display screen with graphical user interface 有权
公开(公告)号：USD1050149S1
公开(公告)日：2024-11-05
申请号：US29771330
申请日：2021-02-22
申请人： Becton, Dickinson and Company
设计人： Leslie Wilson , Zachary Wentworth , Thomas James Klemz
摘要： FIG. 1 is a front view of a first embodiment of a display screen with graphical user interface;
FIG. 2 is a first front detail view of a portion of the first embodiment of the display screen with graphical user interface;
FIG. 3 is a second front detail view of a portion of the first embodiment of the display screen with graphical user interface;
FIG. 4 is a front view of a second embodiment of a display screen with graphical user interface;
FIG. 5 is a first front detail view of a portion of the second embodiment of the display screen with graphical user interface;
FIG. 6 is a second front detail view of a portion of the second embodiment of the display screen with graphical user interface;
FIG. 7 is a front view of a third embodiment of a display screen with graphical user interface;
FIG. 8 is a first front detail view of a portion of the third embodiment of the display screen with graphical user interface; and,
FIG. 9 is a second front detail view of a portion of the third embodiment of the display screen with graphical user interface.
In the drawings, the dot-dash broken lines indicate where enlargements have been taken only and form no part of the claim, and all other broken lines depict environmental subject matter only and form no part of the claim.

9. 发明授权

US12135274B2 Outlet fittings for reducing bubbles at the interface with a flow cell, and flow cytometers and methods using the same 有权
公开(公告)号：US12135274B2
公开(公告)日：2024-11-05
申请号：US17867394
申请日：2022-07-18
申请人： Becton, Dickinson and Company
发明人： Kyle Dembski
IPC分类号： G01N15/1434 , G01N15/10 , G01N15/1404 , G01N33/487
CPC分类号： G01N15/1434 , G01N15/1404 , G01N33/487 , G01N2015/1006
摘要： Outlet fittings are provided. Outlet fittings of interest include an elongate structure and an opening at a proximal end for receiving a flow stream from the distal end of a flow cell. In addition, the outlet fittings described herein are configured to reduce the formation of bubbles at the interface between the outlet fitting and the flow cell. In certain cases, outlet fittings do not include a planar surface in contact with the received flow stream. Flow cytometers and methods employing the subject outlet fittings are also provided.

10. 发明授权

US12127530B2 Manure collecting device, stable cleaning device and method 有权
公开(公告)号：US12127530B2
公开(公告)日：2024-10-29
申请号：US17800709
申请日：2021-02-17
申请人： Joz B.V.
发明人： Rob Elling
IPC分类号： A01K1/01
CPC分类号： A01K1/0128
摘要： Manure collecting device, comprising a manure pick-up device for picking up manure from a floor of an animal accommodation, and a reservoir for collecting therein manure picked up by the manure pick-up device, wherein the manure pick-up device comprises a housing, comprising a receiving opening to be arranged close to the floor for the purpose of receiving manure in the housing therethrough, a delivery opening arranged close to the reservoir for the purpose of delivering the picked-up manure to the reservoir therethrough, and an at least partially cylindrical inner wall, wherein the inner wall extends at least between the receiving opening and the delivery opening, and a rotatably movable body with a central shaft and at least one arm extending radially relative to the shaft between the shaft and the inner wall, wherein the manure pick-up device is configured such that, while the body moves in rotating manner, the manure is picked up close to the receiving opening by means of the arm and is transported through the housing to the reservoir in co-action with the inner wall.

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