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1. 发明申请

WO2018009444A1 DEUTERATED VENETOCLAX 审中-公开
公开(公告)号：WO2018009444A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040280
申请日：2017-06-30
申请人： CONCERT PHARMACEUTICALS, INC.
发明人： TUNG, Roger, D.
IPC分类号： A61K31/495 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/635 , A61K45/06 , A61P35/00 , C07B59/002 , C07B2200/05
摘要： This invention relates to deuterated forms of venetoclax, and pharmaceutically acceptable salts thereof. Certain aspects of this invention also provide pharmaceutical compositions comprising a compound of the present invention and a pharmaceutically acceptable carrier. Certain aspects of the present invention also provide the use of such compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of the anti-apoptotic activity of the B-cell lymphoma 2 (Bcl-2) protein.
摘要翻译：本发明涉及venetoclax的氘化形式及其药学上可接受的盐。本发明的某些方面还提供了包含本发明化合物和药学上可接受的载体的药物组合物。本发明的某些方面还提供了这些化合物和组合物在治疗通过给予B细胞淋巴瘤2（Bcl-2）蛋白的抗细胞凋亡活性抑制剂有益治疗的疾病和病症的方法中的用途。

2. 发明申请

WO2017106696A3 CHLORINE DIOXIDE CONTAINING MIXTURES AND CHLORINE DIOXIDE BULK TREATMENTS FOR ENHANCING OIL AND GAS RECOVERY 审中-公开
公开(公告)号：WO2017106696A3
公开(公告)日：2017-06-22
申请号：PCT/US2016/067251
申请日：2016-12-16
申请人： SABRE INTELLECTUAL PROPERTY HOLDING LLC
发明人： MASON, John, Y. , BETTE, Madeline, C. , BETTE, Kevin, M.
IPC分类号： C09K8/72 , C09K8/04 , A01N25/00 , A01N59/00 , A61K33/00 , C01B11/00 , C09K8/58 , C09K8/86 , C12N1/00
摘要： The present disclosure provides a bulk treatment for introduction into a hydrocarbon bearing formation, the bulk treatment comprising a volume of a treatment fluid comprising chlorine dioxide, wherein the volume is such that when the treatment fluid is introduced into a wellbore that penetrates the hydrocarbon bearing formation, the fluid is expected to extend into the formation to a radius that goes beyond the near wellbore region. Such a bulk treatment can act to draw out hydrocarbons from a hydrocarbon-bearing formation, thereby enhancing recovery of oil and/or gas. Also provided herein are mixtures comprising chlorine dioxide, water, an organic non-polar solvent, and optionally one or more additional components (e.g., an acid or chelating agent and/or a surfactant or cosolvent). The mixtures are useful for enhancing recovery of oil and/or gas and for removing residues that contain hydrocarbons. Apparatus for making the mixtures, and methods of making and using the mixtures, e.g., to mitigate damage and/or enhance recovery of oil and/or gas from a petroleum well, are also disclosed.

3. 发明申请

WO2017106696A2 CHLORINE DIOXIDE CONTAINING MIXTURES AND CHLORINE DIOXIDE BULK TREATMENTS FOR ENHANCING OIL AND GAS RECOVERY 审中-公开
标题翻译：含二氧化氯的混合物和二氧化氯散装处理，用于增强油气回收
公开(公告)号：WO2017106696A2
公开(公告)日：2017-06-22
申请号：PCT/US2016/067251
申请日：2016-12-16
申请人： SABRE INTELLECTUAL PROPERTY HOLDING LLC
发明人： MASON, John, Y. , BETTE, Madeline, C. , BETTE, Kevin, M.
IPC分类号： C09K8/72 , C09K8/04 , A01N25/00 , A01N59/00 , A61K33/00 , C01B11/00 , C09K8/58 , C09K8/86 , C12N1/00
CPC分类号： C09K8/04 , A61K33/20 , C01B11/00 , C09K8/58 , C09K8/86
摘要： The present disclosure provides a bulk treatment for introduction into a hydrocarbon bearing formation, the bulk treatment comprising a volume of a treatment fluid comprising chlorine dioxide, wherein the volume is such that when the treatment fluid is introduced into a wellbore that penetrates the hydrocarbon bearing formation, the fluid is expected to extend into the formation to a radius that goes beyond the near wellbore region. Such a bulk treatment can act to draw out hydrocarbons from a hydrocarbon-bearing formation, thereby enhancing recovery of oil and/or gas. Also provided herein are mixtures comprising chlorine dioxide, water, an organic non-polar solvent, and optionally one or more additional components (e.g., an acid or chelating agent and/or a surfactant or cosolvent). The mixtures are useful for enhancing recovery of oil and/or gas and for removing residues that contain hydrocarbons. Apparatus for making the mixtures, and methods of making and using the mixtures, e.g., to mitigate damage and/or enhance recovery of oil and/or gas from a petroleum well, are also disclosed.
摘要翻译：本发明提供了用于引入到含烃地层中的整体处理，所述整体处理包括一定体积的包含二氧化氯的处理流体，其中所述体积使得当处理流体被引入到穿过含烃地层的井筒，预计流体会延伸到地层中，超出近井筒区域的半径。这样的整体处理可用于从含烃地层抽出烃，从而提高油和/或气的回收率。本文还提供了包含二氧化氯，水，有机非极性溶剂和任选的一种或多种另外的组分（例如酸或螯合剂和/或表面活性剂或共溶剂）的混合物。该混合物可用于提高油和/或气体的回收率并用于去除含烃的残余物。还公开了用于制造混合物的设备以及制造和使用混合物的方法，例如以减轻损害和/或增强从石油井的油和/或气体的回收。

4. 发明申请

WO2017091593A1 REMOVAL OF HEAVY METALS FROM WATER CONTAMINATED WITH HEAVY METALS BY PRECIPITATION OF CALCIUM CARBONATE 审中-公开
标题翻译：沉淀碳酸钙从重金属污染水中去除重金属
公开(公告)号：WO2017091593A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063370
申请日：2016-11-22
申请人： CDM SMITH INC.
发明人： WHITING, Kent
IPC分类号： C02F1/52 , C02F1/66 , C02F1/62 , C02F101/20 , C02F103/10
CPC分类号： C02F1/5236 , C02F1/52 , C02F1/5209 , C02F1/5263 , C02F1/62 , C02F1/66 , C02F2101/20 , C02F2101/206 , C02F2103/10 , C02F2209/06 , C02F2209/07 , C02F2209/24
摘要： Described are methods of removing one or more heavy metals (e.g. cadmium, lead, zinc, copper, manganese, nickel) from water. A source of calcium carbonate (e.g. limestone) is added to the water, which is treated to cause coprecipitation of calcium carbonate and the one or more heavy metals. Then, the coprecipitated calcium carbonate and one or more heavy metals are separated from the water.
摘要翻译：描述了从水中除去一种或多种重金属（例如镉，铅，锌，铜，锰，镍）的方法。向水中加入碳酸钙源（例如石灰石），将其处理以引起碳酸钙和一种或多种重金属的共沉淀。然后，将共沉淀的碳酸钙和一种或多种重金属从水中分离出来。

5. 发明申请

WO2017015474A1 DEUTERATED MECLIZINE 审中-公开
标题翻译：去除了MECLIZINE
公开(公告)号：WO2017015474A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043364
申请日：2016-07-21
申请人： CONCERT PHARMACEUTICALS, INC.
发明人： GRAHAM, Philip, B. , LIU, Julie, F.
IPC分类号： C07D295/073 , A61K31/495
CPC分类号： C07D295/073 , A61K45/06
摘要： This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering meclizine and other Constitutive Androstane Receptor agonists or FGFR3 antagonists.
摘要翻译：本发明涉及麝香酸猝灭形式及其药学上可接受的盐或水合物。本发明还提供了包含本发明化合物的组合物以及这些组合物在治疗通过施用麦地利和其他基本安慰剂受体激动剂或FGFR3拮抗剂有益治疗的疾病和病症的方法中的用途。

6. 发明申请

WO2016205329A1 CHEMISTRY KITS 审中-公开
标题翻译：化学试剂盒
公开(公告)号：WO2016205329A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037573
申请日：2016-06-15
申请人： HEPATOCHEM, INC.
发明人： BAZIN, Marc
IPC分类号： B01L9/06 , C40B60/14 , G01N1/10
CPC分类号： B01L9/06 , B01J19/2445 , B01J2219/00087 , B01J2219/24 , B01L2200/023 , B01L2200/025 , B01L2300/041 , B01L2300/0861 , B01L2300/126
摘要： The invention consists of an assembly of a reaction block a holder that contains arrays of vials. The vials can contain one or more of reagents, catalysts, and solvents for carrying out the series of chemical reactions.
摘要翻译：本发明包括反应块的组件，该组件包含小瓶的阵列的保持器。小瓶可以含有一种或多种用于进行一系列化学反应的试剂，催化剂和溶剂。

7. 发明申请

WO2015119933A1 GUST ALLEVIATOR 审中-公开
公开(公告)号：WO2015119933A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/014217
申请日：2015-02-03
申请人： RICHARDSON, Albert, S.
发明人： RICHARDSON, Albert, S.
IPC分类号： B64C3/58 , B64C9/02 , B64C9/34 , B64C9/38 , B64C21/02 , B64C13/16
CPC分类号： B64C21/02 , B64C3/58 , B64C9/02 , B64C9/34 , B64C9/38 , B64C13/04 , B64C13/16 , Y02T50/166
摘要： A gust alleviating aircraft wing includes a gust alleviating wing portion on the wing. The wing portion can have a leading edge, a trailing edge, and a downwardly sloping upper surface therebetween. At least one air passageway can extend through the wing portion from the leading edge to a rear or downstream location on the downwardly sloping upper surface of the wing portion. At least one spoiler can be on the upper surface of the wing portion at the rear location for selectively movably covering and uncovering an exit location of the at least one passageway. Opening the at least one passageway is capable of diverting air flow through the at least one passageway and the wing portion for counteracting upward lift caused by a gust of wind.
摘要翻译：阵风减轻的飞机机翼在机翼上包括阵风减轻翼部分。翼部可以具有前缘，后缘和其间的向下倾斜的上表面。至少一个空气通道可以从翼缘部分延伸穿过机翼部分的向下倾斜的上表面上的前缘到后部或下游位置。至少一个扰流器可以在后部位置处的翼部分的上表面上，以选择性地可移动地覆盖和露出至少一个通道的出口位置。打开所述至少一个通道能够使空气流通过所述至少一个通道和所述翼部，以抵消由阵风引起的向上升力。

8. 发明申请

WO2014070460A8 METHODS AND KITS FOR PERFORMING IN SITU HYBRIDIZATION 审中-公开
公开(公告)号：WO2014070460A8
公开(公告)日：2014-05-08
申请号：PCT/US2013/065279
申请日：2013-10-16
申请人： CELLAY, INC.
发明人： AURICH-COSTA, Joan , EWEN, Elizabeth , GILDEA, Michael
IPC分类号： C12Q1/68
摘要： The invention relates to methods and kits for performing in situ hybridization on a biological sample on a solid surface using nucleic acid probes that are embedded in or sorbed to a dry, fibrous matrix. For example, fluorescence in situ hybridization (FISH) can be carried out using fluorescently labeled oligonucleotide probes that are provided in dry form on filter paper or glass fiber disks.

9. 发明申请

WO2014043548A1 A PHOTOBIOREACTOR WITH A THERMAL SYSTEM, AND METHODS OF USING THE SAME 审中-公开
标题翻译：具有热系统的光电感应器及其使用方法
公开(公告)号：WO2014043548A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059776
申请日：2013-09-13
申请人： JOULE UNLIMITED TECHNOLOGIES, INC.
发明人： LESHCHINER, Michael, Y. , JACOBSON, Stuart, A.
IPC分类号： C12M1/38 , C12M3/00
CPC分类号： C12M21/02 , C12M41/22
摘要： The invention relates to a photobioreactor system for a phototrophic microorganism, and culture medium therefor, comprising a reactor chamber and a thermal system. The thermal system includes a convection chamber in thermal contact with the reactor chamber and having a first port and a second port; a heat storage reservoir having a first region containing a first volume of heat exchange liquid at a first temperature and a second region containing a second volume of heat exchange liquid at a second temperature; and a flow system configured for (1) flowing heat exchange liquid from the heat storage reservoir into the first port and through the convection chamber and flowing heat exchange liquid from the convection chamber out of the second port into the heat storage reservoir; and (2) flowing heat exchange liquid from the heat storage reservoir into the second port and through the convection chamber and flowing heat exchange liquid from the convection chamber out of the first port into the heat storage reservoir. Methods of using said photobioreactor to manage the temperature of the culture medium in the photobioreactor and to manage the amount of heat stored in the reservoir are also described.
摘要翻译：本发明涉及一种用于光营养微生物的光生物反应器系统及其培养基，包括反应室和热系统。热系统包括与反应器室热接触并具有第一端口和第二端口的对流室; 蓄热容器，其具有在第一温度下包含第一体积的热交换液体的第一区域和在第二温度下包含第二体积的热交换液体的第二区域; 以及流动系统，其构造成用于（1）将热交换液体从所述蓄热容器流入所述第一端口并且通过所述对流室，并且将热交换液体从所述对流室流出所述第二端口进入所述蓄热容器; 和（2）将热交换液体从蓄热容器流入第二端口并且通过对流室，并将来自对流室的热交换液体从第一端口流出到储热容器中。还描述了使用所述光生物反应器来管理光生物反应器中的培养基的温度并管理储存在储存器中的热量的方法。

10. 发明申请

WO2012173855A2 SYSTEMS AND METHODS FOR DELIVERY OF CARBON DIOXIDE, BIOREACTOR SYSTEMS, AND USES THEREOF 审中-公开
标题翻译：二氧化碳输送系统和方法，生物反应器系统及其用途
公开(公告)号：WO2012173855A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/041272
申请日：2012-06-07
申请人： JOULE UNLIMITED TECHNOLOGIES, INC. , ST. ANGELO, David, A. , CORBETT, Michael, D. , ZHU, Yizu , ALBO, Simon , GARANT, Herve, I. , FREER, Brian, S.
发明人： ST. ANGELO, David, A. , CORBETT, Michael, D. , ZHU, Yizu , ALBO, Simon , GARANT, Herve, I. , FREER, Brian, S.
IPC分类号： C01B31/20 , C12M1/00
CPC分类号： B01D53/1425 , B01D53/1475 , B01D53/1493 , B01D53/62 , B01D53/84 , B01D2251/304 , B01D2251/306 , B01D2251/402 , B01D2257/504 , C01B32/50 , C12M43/06 , F24S20/20 , F24S80/20 , F24S2023/86 , Y02A50/2358 , Y02C10/04 , Y02E10/41 , Y02P20/134 , Y02P20/152 , Y02P20/59
摘要： Systems and methods for the production of carbon dioxide are provided that can be used directly at a bioreactor site and that can provide release and delivery of carbon dioxide in a cost-efficient manner. The methods and systems can use solar energy for the thermal dehydration or desorption of a carbon dioxide source. Further, methods and bioreactor plants for the production of carbon-based products are provided that can include the methods and systems for the production of carbon dioxide, and can allow reduced carbon-based product cost due to reduced carbon dioxide associated costs and further can allow for energy efficient temperature control of bioreactors.
摘要翻译：提供了用于生产二氧化碳的系统和方法，其可以直接用于生物反应器位置，并且可以以成本有效的方式提供二氧化碳的释放和输送。方法和系统可以使用太阳能进行二氧化碳源的热脱水或解吸。此外，提供了用于生产碳基产品的方法和生物反应器装置，其可以包括用于生产二氧化碳的方法和系统，并且可以由于降低二氧化碳相关成本而允许降低碳基产品成本，并且还可以允许用于生物反应器的节能温度控制。

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