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1. 发明申请

WO2021158547A1 RF ABLATION CANNULA WITH INJECTION PORT 审中-公开
公开(公告)号：WO2021158547A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016214
申请日：2021-02-02
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： WANG, Kevin P. , LOURO, Frank
IPC分类号： A61B18/14 , A61B17/34
摘要： In some aspects, the present disclosure pertains to RF ablation cannulas that comprise: a cannula shaft and a cannula hub that comprises an insertion port that is configured to receive an electrode shaft, a stylet shaft, or both and an injection port comprising a mating feature that is configured to interface with an injection device, and seal that is configured to form a water-tight seal around the shaft when it is inserted through the insertion port. By providing a water-tight seal around the shaft, backflow of pressured fluid around the shaft (e.g., backflow of pressurized fluid that is injected into the injection port) is prevented. Other aspects of the present disclosure pertain to systems that comprise such RF cannulas and to methods of using such systems.

2. 发明申请

WO2021158546A1 INJECTABLE IN VIVO CROSSLINKING MATERIALS FOR USE AS SOFT TISSUE FILLERS 审中-公开
公开(公告)号：WO2021158546A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016213
申请日：2021-02-02
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： DELANEY, JR., Joseph T. , BODEN, Mark W. , MURPHY, John , MOLNAR, Viktoria , DYNDIKOVA, Tatyana , ZIPP, Allison , KOLSTE, Kolbein K.
IPC分类号： A61L27/18
摘要： Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

3. 发明申请

WO2021041227A1 MULTIFUNCTIONAL NITROXIDE-MEDIATED POLYMERIZATION INITIATORS AND PRODUCTS FORMED THEREFROM 审中-公开
公开(公告)号：WO2021041227A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/047436
申请日：2020-08-21
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： DELANEY, JR., Joseph T. , GROSSO, Paul V. , KUMMAILIL, John , DYNDIKOVA, Tatyana , REHDER, Carey
IPC分类号： C08F226/10 , C08F293/00 , C08K5/32
摘要： In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.

4. 发明申请

WO2018187413A1 EMBOLI-CAPTURING CENTERING DEVICE 审中-公开
公开(公告)号：WO2018187413A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/026004
申请日：2018-04-04
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： MCGOWAN, Roger W. , WIEDMANN, Alexander J. , REINHART, Jennifer , HAVERKOST, Patrick A. , OSTROOT, Timothy A. , SANDHU, Gurpreet S , SPOON, Daniel B. , TEFFT, Brandon J.
IPC分类号： A61F2/01
摘要： In some aspects, the present disclosure pertains to self-expanding emboli-capturing centering devices for centering a medical instrument in a conduit within a patient. The centering devices comprise (a) an elongate shaft, (b) a self-expanding centering member having an open distal end and an inner surface forming a central lumen with a flared distal portion, the centering member being configured such that a fluid flowing in a distal-to-proximal direction that is received by the open distal end flows proximally along the flared distal portion of the central lumen before exiting the central lumen through one or more openings in a proximal portion of the centering member, and (c) a filter material configured to filter the fluid received by the open distal end of the centering member. Other aspects of the present disclosure pertain to systems and methods employing such centering devices.

5. 发明申请

WO2017040779A1 MOISTURE CURING ALKOXYSILANE POLYMERS 审中-公开
标题翻译：水分固化烷基聚酰亚胺
公开(公告)号：WO2017040779A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049894
申请日：2016-09-01
申请人： ARSENAL MEDICAL, INC. , ZUGATES, Gregory , KHATRI, Chetan , LOMAKIN, Joseph , WILTSEY, Craig
发明人： ZUGATES, Gregory , KHATRI, Chetan , LOMAKIN, Joseph , WILTSEY, Craig
IPC分类号： C08G77/04 , C08L83/04 , A61B17/00 , A61B17/12
CPC分类号： A61K31/80 , A61B17/12118 , A61B17/12186 , A61B17/12195 , A61B2090/064 , A61F2/07 , A61J1/1468 , A61K9/0019 , A61K49/0002 , A61M5/007 , A61M5/178 , C08G77/04 , C08G77/388 , C08L83/04 , C08L83/08
摘要： The present disclosure is directed to moisture curing formulations as well as articles, devices, systems, kits and methods based on the same.
摘要翻译：本公开涉及湿固化制剂以及其制品，装置，系统，试剂盒和基于其的方法。

6. 发明申请

WO2017004209A1 SCAFFOLD LOADING AND DELIVERY SYSTEMS 审中-公开
标题翻译： SCAFF装载和传送系统
公开(公告)号：WO2017004209A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040102
申请日：2016-06-29
申请人： 480 BIOMEDICAL, INC. , HELMICK, Marc , MERLO, Jonathan , CORE, Lee , PHAM, Quyhn , PROSTROILLO, Anthony , PAULSON, Ross , PETERSON, Danielle , PRAHL, Garrett , BEYREIS, Randall , ROGGEMANN, Michele
发明人： HELMICK, Marc , MERLO, Jonathan , CORE, Lee , PHAM, Quyhn , PROSTROILLO, Anthony , PAULSON, Ross , PETERSON, Danielle , PRAHL, Garrett , BEYREIS, Randall , ROGGEMANN, Michele
IPC分类号： A61F2/966
CPC分类号： A61F2/186 , A61F2/90 , A61F2/958 , A61F2/966 , A61F2002/9522 , A61F2002/9665
摘要： This disclosure describes, inter alia , materials, devices, kits and methods that may be used for loading scaffolds into delivery devices and delivery of scaffolds into the body of a patient, including delivery of scaffolds to the sinuses for the treatment of chronic sinusitis, among other purposes.
摘要翻译：本公开尤其描述了可用于将支架装载到输送装置中并将支架递送到患者体内的材料，装置，试剂盒和方法，包括将支架递送至用于治疗慢性鼻窦炎的鼻窦，其中其他用途

7. 发明申请

WO2013181022A1 INJECTABLE BIODEGRADABLE PARTICLES FOR CONTROLLED THERAPEUTIC AGENT RELEASE 审中-公开
标题翻译：用于控制性治疗药物释放的可注射的生物可降解颗粒
公开(公告)号：WO2013181022A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/042025
申请日：2013-05-21
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： WEBER, Jan
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61K9/146 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2400/12 , A61L2430/36 , C08L77/12
摘要： In accordance with one aspect, embolic particles are provided that comprise a biodegradable polymer and a therapeutic agent, wherein the particles are configured such that, upon administration to a body lumen of a subject, the therapeutic agent is released from the time of administration up until a first point in time that ranges anywhere from about 1 week after administration to about 4 weeks after administration, at which point in time the therapeutic agent release ceases. The particles are also configured such that particles remain present in the body lumen from the first point in time at which therapeutic agent release ceases up to a second point in time that ranges anywhere from about 2 weeks to about 12 months after the first point in time, at which point the particles are completely degraded. Other aspects pertain to methods of making such particles. Still other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.
摘要翻译：根据一个方面，提供了包含可生物降解的聚合物和治疗剂的栓塞颗粒，其中所述颗粒构造成使得当给予受试者的体腔时，治疗剂从给药时间开始释放直至在施用后约1周至给药后约4周的第一时间点，此时治疗剂释放停止。颗粒还被构造成使得颗粒从治疗剂释放停止的第一时间点保持存在于体腔中，第二时间点在第一时间点之后约2周至约12个月的范围内，此时颗粒完全降解。其他方面涉及制造这种颗粒的方法。还有其它方面涉及包含这种颗粒的可注射组合物和使用这种可注射组合物的治疗方法。

8. 发明申请

WO2013119859A1 POROUS SURGICAL FILMS 审中-公开
标题翻译：多孔手术膜
公开(公告)号：WO2013119859A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025207
申请日：2013-02-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , LI, Jianmin , GODDARD, James M. , HARRAH, Timothy Paul , RAO, Doreen , INTOCCIA, Alfred P. , LICHTE, Leo James
发明人： LI, Jianmin , GODDARD, James M. , HARRAH, Timothy Paul , RAO, Doreen , INTOCCIA, Alfred P. , LICHTE, Leo James
IPC分类号： A61L27/50 , A61L31/14 , A61F2/00
CPC分类号： A61F2/0063 , A61F2/0045 , A61F2210/0004 , A61F2250/0031 , A61F2250/0067 , A61L31/04 , A61L31/146 , A61L31/148
摘要： According to an aspect of the present invention, surgical films for soft tissue repair are provided. The surgical films comprise at least one sheet of a non-filamentous material within which pores are formed. Further aspects of the invention, among others, pertain to methods of using such surgical films and to kits containing such surgical films.
摘要翻译：根据本发明的一个方面，提供了用于软组织修复的手术膜。手术膜包括形成孔的至少一片非丝状材料。本发明的其它方面尤其涉及使用这种手术膜的方法和含有这种手术膜的试剂盒。

9. 发明申请

WO2013119830A1 SURGICAL SCAFFOLDS 审中-公开
标题翻译：外科手术
公开(公告)号：WO2013119830A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025171
申请日：2013-02-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NAGALE, Sandra , BODEN, Mark W.
发明人： NAGALE, Sandra , BODEN, Mark W.
IPC分类号： A61L27/50 , A61L31/14 , A61F2/00
CPC分类号： A61F2/0063 , A61F2/0045 , A61F2230/006 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/43 , A61L2430/30 , A61L2430/34 , F04C2270/041 , C08L75/04
摘要： According to an aspect of the present invention, surgical scaffolds for soft tissue repair are provided. The surgical scaffolds comprise a sheet of a material within which through-holes are formed. Further aspects of the invention, among others, pertain to methods of using such surgical scaffolds and to kits containing such surgical scaffolds.
摘要翻译：根据本发明的一个方面，提供了用于软组织修复的手术支架。手术支架包括形成通孔的材料片。本发明的其它方面以及其它方面涉及使用这种手术支架的方法和含有这种手术支架的试剂盒。

10. 发明申请

WO2011094313A1 COMPOSITE SURGICAL IMPLANTS FOR SOFT TISSUE REPAIR 审中-公开
标题翻译：用于软组织修复的复合外科植入物
公开(公告)号：WO2011094313A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022579
申请日：2011-01-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SHERRY, John , HARRAH, Timothy P. , LI, Jianmin , GODDARD, James
发明人： SHERRY, John , HARRAH, Timothy P. , LI, Jianmin , GODDARD, James
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2002/0068
摘要： According to one aspect of the invention, composite implants for soft tissue repair a provided which comprise (a) a substantially two-dimensional piece of biologic matrix material and (b) one or more non-absorbable synthetic polymeric filaments.
摘要翻译：根据本发明的一个方面，提供了用于软组织修复的复合植入物，其包括（a）基本上二维的生物基质材料块和（b）一种或多种不可吸收的合成聚合物长丝。

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