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1. 发明申请

WO2022182496A1 OPTIMIZING AUTONOMOUS SELF USING NON-INVASIVE MEASUREMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2022182496A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/015268
申请日：2022-02-04
申请人： HI LLC
发明人： JOHNSON, Bryan , KATES-HARBECK, Julian , FIELD, Ryan , HOUSE, Patrick , PERDUE, Katherine
IPC分类号： A61B5/16 , A61B5/375 , A61B5/00
摘要： A non-invasive self-autonomous system (10) and method of optimizing a lifestyle regimen of a person (12) containing a combination of lifestyle variables is provided. At least one value of the combination of lifestyle variables is repeatedly modified by a lifestyle optimiser (22), thereby creating different variations of the combination of lifestyle variables respectively having different sets of values. The different variations of the combination of lifestyle variables are sequentially administered to the person (12) by a peripheral device (20). Physiological activity of the person (12) is detected, possibly by a non-invasive brain-computer interface BCI (16), in response to the administration of the combination of lifestyle variables to the person. Sets of qualitative indicators of an aspect of a lifestyle of the person are derived from the detected physiological activity of the person. The lifestyle regimen of the person is optimized based on the different variations of the combination of lifestyle variables and the derived sets of qualitative indicators.

2. 发明申请

WO2021178298A1 SYSTEMS AND METHODS FOR TRAINING AND USING A NEUROME THAT EMULATES THE BRAIN OF A USER 审中-公开
公开(公告)号：WO2021178298A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/020258
申请日：2021-03-01
申请人： HI LLC
发明人： JOHNSON, Bryan , PRATT, Ethan , ALFORD, Jamu , KATNANI, Husam , KATES-HARBECK, Julian , FIELD, Ryan , LERNER, Gabriel , LARA, Antonio H.
IPC分类号： A61B5/377 , A61B5/00 , G06F3/01
摘要： A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.

3. 发明申请

WO2019103765A1 SYSTEM AND METHOD FOR SIMULTANEOUSLY DETECTING PHASE MODULATED OPTICAL SIGNALS 审中-公开
公开(公告)号：WO2019103765A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/041333
申请日：2018-07-09
申请人： HI LLC
发明人： YANG, Changhuei , MARBLESTONE, Adam , ALFORD, Jamu , SOBEK, Daniel , WENTZ, Christian
IPC分类号： A61B5/00 , A61B5/1455
摘要： An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.

4. 发明申请

WO2018144631A1 STIMULATOR SYSTEMS AND METHODS FOR OBSTRUCTIVE SLEEP APNEA 审中-公开
公开(公告)号：WO2018144631A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016287
申请日：2018-01-31
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： SURI, Harshit , CALDERON, Joseph L. , MOLNAR, Gregory Frederick , GODING, JR., George S. , ATYABI, Alanie , SCHMIDT, Siegmar , DAI, William , DEARDEN, Brian R. , KEENAN, Desmond B.
IPC分类号： A61N1/36 , A61N1/05
摘要： An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

5. 发明申请

WO2014149506A1 IMPROVED DESIGN OF MICROWAVE ACOUSTIC WAVE FILTERS 审中-公开
标题翻译：微波声波滤波器的改进设计
公开(公告)号：WO2014149506A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/019091
申请日：2014-02-27
申请人： RESONANT LLC
发明人： SILVER, Richard N. , RAIHN, Kurt F. , FENZI, Neal O. , HAMMOND, Robert B.
IPC分类号： G06F17/50 , H03H9/54 , H03H9/56 , H03H9/60 , H03H9/64
CPC分类号： H03H9/64 , G06F17/5063 , H03H9/25 , H03H9/462 , H03H9/465 , H03H9/542 , H03H9/568 , H03H9/605 , H03H9/6483 , H03H2260/00
摘要： A method of designing an acoustic microwave filter (100) comprises selecting a filter section based on frequency response requirements. The filter section includes an input (106), an output (108), and a plurality of circuit elements. The circuit elements have at least in-line acoustic resonators (102a, 104a) or in-shunt acoustic resonators (102b, 104b). The method further comprises selecting a value for each circuit element, selecting a number of filter sections, and cascading the selected number of filter sections to create a cascaded filter circuit design, such that at least one pair of immediately adjacent filter sections are connected to each other via their inputs or their outputs. The method further comprises adding parasitic effects to the cascaded filter circuit design to create a pre-optimized filter circuit design, optimizing the pre-optimized filter circuit design to create a final filter circuit design, and constructing the acoustic microwave filter based on the final filter circuit design.
摘要翻译：设计声波微波滤波器（100）的方法包括基于频率响应要求选择滤波器部分。滤波器部分包括输入端（106），输出端（108）和多个电路元件。电路元件至少具有在线声谐振器（102a，104a）或分流声谐振器（102b，104b）。该方法还包括为每个电路元件选择一个值，选择多个滤波器部分，以及级联所选数量的滤波器部分以创建级联滤波器电路设计，使得至少一对直接相邻的滤波器部分连接到每个其他通过其输入或其输出。该方法还包括向级联滤波器电路设计增加寄生效应以创建预优化滤波器电路设计，优化预优化滤波器电路设计以创建最终滤波器电路设计，以及基于最终滤波器构建声波微波滤波器电路设计。

6. 发明申请

WO2014130865A2 NEUROSTIMULATION SYSTEM HAVING INCREASED FLEXIBILITY FOR CREATING COMPLEX PULSE TRAINS 审中-公开
标题翻译：具有增加复杂脉冲串训练灵活性的神经系统
公开(公告)号：WO2014130865A2
公开(公告)日：2014-08-28
申请号：PCT/US2014/017789
申请日：2014-02-21
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： ZHU, Changfang , DOAN, Que T.
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36146 , A61N1/36167 , A61N1/36178
摘要： A neuromodulation system comprises electrical terminals configured for being respectively coupled to electrodes. The system further comprises modulation output circuitry configured for respectively outputting individual electrical pulse trains in timing channels to the electrical terminals, wherein each of the pulse trains has a modulation pulse, and at least one of the pulse trains has a charge recovery pulse associated with the modulation pulse of the respective pulse train. The neuromodulation system further comprises control circuitry configured for controlling the modulation output circuitry in a manner that sequentially outputs the modulation pulses of the respective pulse trains to a common set of the electrical terminals without an intervening charge recovery pulse, and outputting the charge recovery pulse(s) to the common set of the electrical terminals subsequent to the sequential modulation pulses, thereby creating a combined electrical pulse train at the common set of electrical terminals.
摘要翻译：神经调节系统包括被配置为分别耦合到电极的电端子。该系统还包括调制输出电路，其被配置为分别在定时通道中向电端子输出单个电脉冲串，其中每个脉冲串具有调制脉冲，并且至少一个脉冲串具有与各个脉冲串的调制脉冲。神经调节系统还包括控制电路，该控制电路经配置以按照以下方式控制调制输出电路：将各个脉冲串的调制脉冲顺序地输出到电气端子的公共组，而不需要插入电荷恢复脉冲，并输出电荷恢复脉冲 s）到顺序调制脉冲之后的电气端子的公共组，从而在公共电气端子组产生组合的电脉冲串。

7. 发明申请

WO2014035731A1 SYSTEM AND METHOD FOR IDENTIFYING AVAILABILITY OF CLINICIAN DEFINED PROGRAMMING SETTINGS FOR PATIENT 审中-公开
标题翻译：用于鉴定患者临床定义编程设置的可用性的系统和方法
公开(公告)号：WO2014035731A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/055878
申请日：2013-08-20
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： KOTHANDARAMAN, Sridhar , LUI, Mun, Pook
IPC分类号： A61N1/372 , A61N1/36 , A61B5/00
CPC分类号： A61N1/37247 , A61B2018/00577 , A61N1/3605 , A61N1/37264
摘要： An external control device for indicating whether a stimulation parameter set for use in a neurostimulator is available on a remote control in communication with the external control device is provided. The device includes a user interface configured for displaying the stimulation parameter set and an indicator that indicates whether the stimulation parameter set is available to the patient from the remote control. The device also includes control circuitry configured for, in response to input from the user (e.g., actuating the indicator), selectively turning the indicator on or off. The indicator may be an icon, and the icon may be a graphical depiction of a remote control. The user interface may be further configured for receiving additional input from the user, and the control circuitry may be further configured for, in response to the additional input from the user, programming the remote control with the stimulation parameter set.
摘要翻译：提供一种外部控制装置，用于指示在与外部控制装置通信的遥控器上是否可以使用在神经刺激器中使用的刺激参数。该装置包括被配置为显示刺激参数集的用户界面和指示刺激参数组是否可用于来自遥控器的患者的指示符。该装置还包括控制电路，其配置为响应于来自用户的输入（例如，致动指示器），选择性地使指示器打开或关闭。指示器可以是图标，并且图标可以是遥控器的图形描绘。用户接口可以被进一步配置用于从用户接收附加输入，并且控制电路还可以被配置为响应于来自用户的附加输入，用刺激参数集对遥控器进行编程。

8. 发明申请

WO2014025624A1 TECHNIQUES AND METHODS FOR STORING AND TRANSFERRING REGISTRATION, ATLAS, AND LEAD INFORMATION BETWEEN MEDICAL DEVICES 审中-公开
标题翻译：用于存储和传输医疗设备之间的注册，ATLAS和引导信息的技术和方法
公开(公告)号：WO2014025624A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/053311
申请日：2013-08-01
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： KOTHANDARAMAN, Sridhar , MOFFITT, Michael A.
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/37235 , A61B34/10 , A61B34/20 , A61B2034/107 , A61B2090/364 , A61N1/0529 , A61N1/0534 , A61N1/3606
摘要： A neurostimulator system includes a portable component configured for storing patient-specific data, and an external control device configured for obtaining the patient-specific data from the portable component. The portable component is an implantable neurostimulator, a patient's remote controller, and/or an external charger. The patient-specific data is imaging-related data. A method of storing data in a neurostimulation system includes generating patient-specific data, and storing the patient-specific data in at least one of the portable components. A method for programming the implantable neurostimulator includes receiving the patient-specific data from the portable component, simulating a volume of tissue activation for each of one or more candidate stimulation parameters, wherein the simulation is based at least in part on the patient-specific data, selecting at least one of the candidate stimulation parameters, and programming the implantable neurostimulator with the selected stimulation parameters.
摘要翻译：神经刺激器系统包括被配置为存储患者特定数据的便携式部件和被配置为从便携式部件获得患者特定数据的外部控制装置。便携式部件是可植入的神经刺激器，病人的遥控器和/或外部充电器。患者特定数据是成像相关数据。在神经刺激系统中存储数据的方法包括生成患者特定数据，并将患者特定数据存储在至少一个便携式组件中。用于编程可植入神经刺激器的方法包括从便携式部件接收患者特定数据，模拟一个或多个候选刺激参数中的每一个的组织激活的体积，其中模拟至少部分地基于患者特异性数据，选择候选刺激参数中的至少一个，以及用所选择的刺激参数对可植入神经刺激器进行编程。

9. 发明申请

WO2014004557A1 NEUROSTIMULATION SYSTEM FOR ENABLING MAGNETIC FIELD SENSING WITH A SHUT-DOWN HALL SENSOR 审中-公开
标题翻译：用于使用下降霍尔传感器实现磁场感应的神经网络系统
公开(公告)号：WO2014004557A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047684
申请日：2013-06-25
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： FELDMAN, Emanuel , PARRAMON, Jordi , BOCEK, Joseph M. , GURURAJ, Kiran
IPC分类号： A61N1/362 , A61N1/39 , A61N1/37 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/36003 , A61N1/36007 , A61N1/3605 , A61N1/36082 , A61N1/36142 , A61N1/362 , A61N1/3718 , A61N1/3925 , A61N1/3956
摘要： An implantable medical device capable of being placed between a first operational mode and a second operational mode. The medical device comprises a magnetic field sensing device configured for outputting a signal in response to sensing a magnetic field. The medical device further comprises a logic circuit configured for continuously asserting the signal during a time period when the neurostimulation device is in the first operational mode, and intermittently asserting the signal during at least one time period when the neurostimulation device is in the second operational mode. The medical device further comprises a delay circuit configured for introducing a time delay into the asserted signal, the time delay being less than the time period, but greater than each of the at least one time period. The medical device further comprises control circuitry configured for performing a function in response to receiving the delayed signal at a first input terminal.
摘要翻译：一种能够放置在第一操作模式和第二操作模式之间的可植入医疗装置。医疗装置包括被配置为响应于感测磁场而输出信号的磁场感测装置。该医疗装置还包括逻辑电路，该逻辑电路被配置为在神经刺激装置处于第一操作模式的时间周期期间连续断言信号，并且在神经刺激装置处于第二操作模式的至少一个时间段内间歇地断言该信号。该医疗装置还包括延迟电路，该延迟电路被配置为将时间延迟引入所述被确定的信号中，所述时间延迟小于所述时间段，但大于所述至少一个时间段中的每一个。医疗装置还包括被配置为响应于在第一输入端接收延迟信号而执行功能的控制电路。

10. 发明申请

WO2013138511A1 NEUROSTIMULATION SYSTEM FOR PREVENTING MAGNETICALLY INDUCED CURRENTS IN ELECTRONIC CIRCUITRY 审中-公开
标题翻译：用于防止电子电路中的磁感应电流的神经网络系统
公开(公告)号：WO2013138511A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/031015
申请日：2013-03-13
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： GURURAJ, Kiran , WEERAKOON, Pujitha , MARNFELDT, Goran N. , PARRAMON, Jordi , MURTONEN, Salomo , FELDMAN, Emanuel
IPC分类号： A61N1/08
CPC分类号： A61N1/36142 , A61N1/08 , A61N1/086 , A61N1/36 , A61N1/3605
摘要： A neurostimulation device capable of being placed between an active stimulation state and an inactive stimulation state and method of using same. The neurostimulation device comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of stimulation electrodes, a first solid-state switching device coupled to a first one of the electrical terminals, a variable power source coupled to the first switching device, and a controller configured for, when the neurostimulation device is in the inactive stimulation state, prompting the variable power source to selectively output a relatively low voltage to place the first switching device into a first open state and a relatively high voltage to place the first switching device into a second open state.
摘要翻译：能够置于主动刺激状态和非活动刺激状态之间的神经刺激装置及其使用方法。神经刺激装置包括被配置为分别耦合到多个刺激电极的多个电端子，耦合到电端子中的第一个的第一固态开关装置，耦合到第一开关装置的可变电源，以及控制器，被配置为当所述神经刺激装置处于非激活刺激状态时，促使所述可变电源选择性地输出相对低的电压以将所述第一开关装置置于第一开启状态和相对高的电压以将所述第一开关装置进入第二个开放状态。

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